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Biomedical Engineering and Bioengineering Commons™
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Articles 31 - 60 of 131
Full-Text Articles in Biomedical Engineering and Bioengineering
Localized Treatment Of Malignant Melanoma Using A Modified Cellulose-Based Hydrogel Loaded With Temozolomide With Increased Safety Of Human Dermal Fibroblasts And The Mechanisms Behind The Effect, Joseph Wolf
Bioengineering Dissertations - Archive
Melanoma pathophysiology is highly varied, and the initial cause of tumorigenesis is still unknown, but it is likely a combination of both epigenetic and genetic means. Further, melanoma tumors have one of the highest mutational burdens of all cancers and are largely composed of varied subpopulations within the same tumor. These two factors provide insight into why melanoma is so difficult to treat medicinally. Dacarbazine is the gold-standard of metastatic melanoma treatment, yet only has an overall response rate of 22% and no impact on survival. Temozolomide (TMZ), an analog of dacarbazine, is often viewed as a more ideal choice …
Evaluation Of A Personal Mobile Trainer System Designed For Facilitating Exercise Therapy For Traumatic Brain Injury Patients, Ahmad Fawzi G Turki
Evaluation Of A Personal Mobile Trainer System Designed For Facilitating Exercise Therapy For Traumatic Brain Injury Patients, Ahmad Fawzi G Turki
Bioengineering Dissertations - Archive
There are no effective pharmacological agents that can prevent or treat post-TBI cognitive deterioration. Previous research has shown that exercise can be an effective means of enhancing the patients condition with mild traumatic brain injury (TBI). However, compliance with the prescribed exercise regimen has been low, as TBI patients often suffer from poor executive function and need assistance with complying with their prescribed exercise program. This study aims to design, build, and test a system based on a wearable exercise tracker to assist and encourage patients by facilitating doing the prescribed exercises at a place and time that is convenient …
Porcine Neonatal Heart Extracellular Matrix As A Regeneration Platform, Karla Perez
Porcine Neonatal Heart Extracellular Matrix As A Regeneration Platform, Karla Perez
Bioengineering Dissertations - Archive
Each year, an estimated 620,000 Americans have new heart attack and suffer from myocardial infarction (MI) that results in massive heart cell death and decrease in heart function. Various therapeutic strategies, such as pharmacological treatments and reperfusion strategies, have greatly improved short-term MI survival. However, these strategies do not restore normal cardiac function due to the permanent loss of cardiomyocytes. As a promising strategy, cardiac cell therapy delivers repairing cells to damaged areas (scar tissues) to revitalize the infracted heart. However, a key challenge in cardiac cell therapy, i.e. the extremely low survival and engraftment rate of transplanted cells, must …
Biomechanical Studies Of Developing Zebrafish Heart In-Vivo, Nabid Salehin
Biomechanical Studies Of Developing Zebrafish Heart In-Vivo, Nabid Salehin
Bioengineering Dissertations - Archive
The heart is an electrically controlled mechanical pump that provides the cardiac output required by the body to function properly and flexibly adapts to changing demand and working conditions. In vertebrate embryos, the heart is the first organ that starts functioning and the function is initiated well before structural organogenesis is complete, with its early mechanical function affecting its own development. During development, the heart transforms from a valveless linear peristaltic tube into a multi-chambered pulsatile pump with blood flow regulating valves while continuing to serve the metabolic needs of the embryo. The zebrafish has emerged as a popular model …
Non-Invasive Profiling Of Molecular Markers In Brain Gliomas Using Deep Learning And Magnetic Resonance Images, Chandan Ganesh Bangalore Yogananda
Non-Invasive Profiling Of Molecular Markers In Brain Gliomas Using Deep Learning And Magnetic Resonance Images, Chandan Ganesh Bangalore Yogananda
Bioengineering Dissertations - Archive
Gliomas account for the most common malignant primary brain tumors in both pediatric and adult populations. They arise from glial cells and are divided into low grade and high-grade gliomas with significant differences in patient survival. Patients with aggressive high-grade gliomas have life expectancies of less than 2 years. Glioblastoma (GBM) are aggressive brain tumors classified by the world health organization (WHO) as stage IV brain cancer. The overall survival for GBM patients is poor and is in the range of 12 to 15 months. These tumors are typically treated by surgery, followed by radiotherapy and chemotherapy. Gliomas often consist …
Metabolic And Electrophysiological Effects Of Transcranial Photobiomodulation (Pbm) And Multi-Wavelength Pbm, Tyrell Byrom Pruitt
Metabolic And Electrophysiological Effects Of Transcranial Photobiomodulation (Pbm) And Multi-Wavelength Pbm, Tyrell Byrom Pruitt
Bioengineering Dissertations - Archive
Photobiomodulation (PBM) with near infrared light may become a non-invasive, effective clinical tool after it is understood well for its mechanism of action. In my dissertation research, I have addressed three research questions as three aims to achieve. Aim 1 was to investigate and demonstrate the reproducibility of the effects of transcranial PBM (tPBM) with 1064-nm laser delivered on the right forehead of separate groups of healthy humans measured using different experiment setups in separate sites and years. In Chapter 2, I reported sham-controlled, tPBM-induced concentration increases in oxygenated hemoglobin (∆[HbO]) and oxidized cytochrome c oxidase (∆[oxi-CCO]) in both young …
An In Vitro Model To Study The Role Of Iol: Lens Capsule Interactions In Posterior Capsule Opacification, Arjun Jaitli
An In Vitro Model To Study The Role Of Iol: Lens Capsule Interactions In Posterior Capsule Opacification, Arjun Jaitli
Bioengineering Dissertations - Archive
Posterior capsule opacification (PCO) is the most common complication associated with intraocular lens (IOL) implantation. Unfortunately, current in vitro models cannot be used to assess the potential of PCO due to their failure to simulate posterior curvature of the lens capsule (LC), contradicting observations, different testing conditions and inherent challenges associated with use of human capsular bag models, cells and other tissue substrates. To overcome such a challenge, a new system to study IOL: LC interaction and potentially predict PCO was developed in this effort. It is believed that the interactions between an IOL and the lens capsule (LC) may …
Microchannel Technology In Cancer Cell Confined-Migration Study And Its Application In Drug Screening, Qionghua Shen
Microchannel Technology In Cancer Cell Confined-Migration Study And Its Application In Drug Screening, Qionghua Shen
Bioengineering Dissertations - Archive
PDMS-based microchannel device has been explored to extend the basic platform for three-dimensional (3D) culture models of cell motility study because of its relevant stiffness and designable shape. Moreover, it is easy to add multi-functions (physical cures and biochemical cures) to one single device and provide a more physiologically relevant context to cells migrating inside channels. As recent cell motility studies have proved that cells show different migration strategies in physiologically confined three-dimensional (3D) space compared to a two-dimensional (2D) culture system. Besides, far from unique, when cancer cells are underling the migrating stage, they show increased resistance to chemo- …
Machine Learning And Deep Learning Applications In Neuroimaging, Gowtham Krishnan Murugesan
Machine Learning And Deep Learning Applications In Neuroimaging, Gowtham Krishnan Murugesan
Bioengineering Dissertations - Archive
Deep Learning (DL) tools have the potential to analyze large datasets and extract meaningful insights to enhance patient outcomes. Radiological images such as MRI and CT, often contain complex patterns that can be difficult and time consuming to evaluate manually. Deep learning algorithms can improve treatment decisions and patient care beyond the realm of research. The goal of this dissertation is to apply advanced deep learning methods in three distinct domains of neuroimaging, 1.fMRI Analysis, 2. MR Image Synthesis, and 3. Clinical applications in brain tumors. First, we developed a new fMRI network inference method named as BrainNET using Machine …
In Vivo Ultrasound-Switchable Fluorescence Imaging And Its Applications, Tingfeng Yao
In Vivo Ultrasound-Switchable Fluorescence Imaging And Its Applications, Tingfeng Yao
Bioengineering Dissertations - Archive
The conventional fluorescence imaging has limited spatial resolution in centimeters-deep tissue because of the tissue’s high scattering property. Ultrasound-switchable fluorescence (USF) imaging, a new imaging technique, was recently proposed to realize high-resolution fluorescence imaging in centimeters-deep tissue. Although promising results were achieved in tissue-mimic phantoms or tissue samples, the in vivo USF imaging had not been realized so far. There were two major challenges in realizing in vivo USF imaging. First, the lack of stable near-infrared (NIR) USF contrast agents in a biological environment and the lack of data about their biodistributions. Second, the previous USF imaging systems adopted a …
The Biomechanics Of Cardiac Elastin And Its Role In Bioengineering, Sara R. Mcmahan
The Biomechanics Of Cardiac Elastin And Its Role In Bioengineering, Sara R. Mcmahan
Bioengineering Dissertations - Archive
Elastin is an essential structural protein responsible for the elasticity of many tissues, including skin, lungs, blood vessels, and other highly dynamic tissues and organs in the body. In the heart, cardiac elastin has been largely ignored as one of the key players in heart health and functionality. In this study, we will fill the knowledge gap with novel experiments and biomechanical investigations that will allow us to understand the roles of elastin in cardiac biomechanics, as well as explore the bioengineering applications of elastin-rich cardiac tissues. For Aim 1, we performed a biomechanical and ultrastructural comparison of the elastin-rich …
Impact Of Muscular Fatigue And Its Modulation Using Transcranial Photobiomodulation (Tpbm) On The Human Brain Measured By Functional Near-Infrared Spectroscopy (Fnirs), Elizabeth Lyde Urquhart
Impact Of Muscular Fatigue And Its Modulation Using Transcranial Photobiomodulation (Tpbm) On The Human Brain Measured By Functional Near-Infrared Spectroscopy (Fnirs), Elizabeth Lyde Urquhart
Bioengineering Dissertations - Archive
When performing exercise, the brain must register and simultaneously integrate input from feedforward (i.e., central command) and feedback (e.g., exercise pressor reflex) neural mechanisms to make appropriate cardiovascular adjustments to meet metabolic demands. Muscle fatigue occurs during prolonged exercise and is characterized by a reduction in force-generating capability of the muscle. Fatigue comprises of two components: central and peripheral fatigue. Peripheral fatigue is produced at or distal to the neuromuscular junction whereas, central fatigue originates in the central nervous system. However, central fatigue’s contribution to peripheral fatigue is less understood and functional neuroimaging is being investigated as a tool to …
Targeting The Oligomannose Biomarker Present On Distinct Subsets Of Non-Hodgkin Lymphomas, Butaek Lim
Targeting The Oligomannose Biomarker Present On Distinct Subsets Of Non-Hodgkin Lymphomas, Butaek Lim
Bioengineering Dissertations - Archive
Subtypes of B cell non-Hodgkin’s lymphomas, including follicular lymphomas, have shown a unique high oligomannose presentation on their immunoglobulins that will interact with natural receptors of the innate immunity, reportedly causing stimulation and proliferation. From next generation deep sequencing of the variable heavy and light chain sequences of follicular lymphoma involved tissue sections, we identified the consensus variable sequences possessing glycosylation sites at the complementarity determining region. Using this information, we developed a cell line, referred to here as BZ, which displays the consensus variable segments as part of a surface antibody (IgM) and confirmed its presentation of high oligomannose …
Modulation Of Physiologic Responses Of Insulin Secreting Cells Using Electrical And Photostimulation, Caleb Nathaniel Liebman
Modulation Of Physiologic Responses Of Insulin Secreting Cells Using Electrical And Photostimulation, Caleb Nathaniel Liebman
Bioengineering Dissertations - Archive
Islet transplantation is a surgical procedure aimed at providing insulin independence to those suffering with Type I diabetes. Prior to implantation, a therapeutic window exists ex vivo where the cells can be treated in order to improve the procedure’s efficacy. It is well established that physical stimuli are able to affect cellular functionality. Thus the work herein is designed to elucidate the effects and mechanisms by which the insulin secreting β-cells respond to non-invasive electric field stimulation and photobiomodulation. Insulin secreting β-cells are an electrically active cell type and utilize their calcium dynamics to control insulin secretion. The calcium dynamics …
Nanoparticle-Based Approaches In Cardiovascular Diseases, Aneetta E. Kuriakose
Nanoparticle-Based Approaches In Cardiovascular Diseases, Aneetta E. Kuriakose
Bioengineering Dissertations - Archive
Percutaneous coronary intervention (PCI) such as balloon angioplasty and stent placement are commonly employed for myocardial revascularization. These strategies, however, injure the arterial wall initiating a cascade of inflammatory responses that culminates in restenosis. Attempts are currently being made to improve the stents/balloon designs such that they suppress the inflammatory responses and support/enhance in situ reendothelialization. But the healing of the injured artery remains a major challenge. Therefore, in this work, we propose to characterize and identify a suitable fluorescent nanoparticle system that has potential to be used as vascular drug carriers. We also developed nanoparticles (NPs) that could enhance …
Novel Quantification Of Neurovascular Coupling (Nvc) To Predict Brain Injury In Neonates With Hypoxic Ischemic Encephalopathy, Yudhajit Das
Novel Quantification Of Neurovascular Coupling (Nvc) To Predict Brain Injury In Neonates With Hypoxic Ischemic Encephalopathy, Yudhajit Das
Bioengineering Dissertations - Archive
Birth asphyxia is a global burden in clinical neonatal care. It results from deprivation of oxygen to a newborn infant that lasts too long during the birth causing physical harm to the brain. The asphyxia insult impairs fetal cerebral blood flow and results in a distinctive neonatal encephalopathy (NE). Hypoxic-ischemic encephalopathy (HIE) accounts for a significant proportion of encephalopathic newborns. Currently there is no reliable quantitative metric is available to predict outcome of neurological injury in neonates with HIE at the bedside in the first day of life. My dissertation targets on this gap by developing novel quantification methods of …
Whole-Head Functional Brain Imaging Of Economic Risk Decision Making And Transcranial Photobiomodulation With Fnirs And Eeg, Hashini I. Wanniarachchi Kankanamalage
Whole-Head Functional Brain Imaging Of Economic Risk Decision Making And Transcranial Photobiomodulation With Fnirs And Eeg, Hashini I. Wanniarachchi Kankanamalage
Bioengineering Dissertations - Archive
Functional near-infrared spectroscopy (fNIRS) and electroencephalography (EEG) are two non-invasive brain imaging or mapping modalities that allow us to measure cerebral hemodynamic and electrophysiological changes in the human brain, respectively. LABNIRS is a cutting-edge, whole-head, optical brain mapping system with 40 pairs of light sources (at 780 nm830 nm) and 40 detectors, forming up to 133 detection channels. In my study, whole-head LABNIRS and 64-channel EEG were utilized to investigate respective alterations in response to risk decision- making under business context and to non-invasive photobiomodulation. As the first part of my study, I utilized fNIRS (i.e., LABNIRS) as a tool …
Photobiomodulation And Stem Cell Differentiation: Application To Modulate Adipogenesis Through Cellular And Nuclear Morphology, Andrew Redmond Mccolloch
Photobiomodulation And Stem Cell Differentiation: Application To Modulate Adipogenesis Through Cellular And Nuclear Morphology, Andrew Redmond Mccolloch
Bioengineering Dissertations - Archive
Mesenchymal stem cells (MSCs) are of great interest in regenerative medicine due to their capability to self-renew and differentiate to various lineages. Typically, differentiation to specific cell types has relied on the use of growth factors and other reagents to provide an environment conducive to the desired cell type. More recently, orthogonal cues other than chemical factors have been elucidated to regulate the lineage commitment. For example, the cell shape, cellular mechanics and substrate stiffness have been found to play a role in determining the fate of MSCs. However, it remains still elusive how the morphological and mechanical changes in …
Nanoparticle-Mediated Controlled Myocardial Drug Delivery: A New Treatment For Hypertrophic Cardiomyopathy, Michelle Katherine Mcgrath Copeland
Nanoparticle-Mediated Controlled Myocardial Drug Delivery: A New Treatment For Hypertrophic Cardiomyopathy, Michelle Katherine Mcgrath Copeland
Bioengineering Dissertations - Archive
Hypertrophic cardiomyopathy (HCM) is a genetic disease of the sarcomere, resulting in overgrowth of the septum that separates the left and right ventricles. HCM can affect as many as 1/200 people, making it the most common genetic cardiomyopathy in the general population, as well as the most common cause of sudden cardiac death (SCD). In severe HCM cases, cardiothoracic surgeons perform septal myectomy to remove the excess tissue. However, many patients are poor surgical candidates and require another, less invasive treatment option. In these cases, alcohol septal ablation (ASA) is performed. With ASA, cardiologists deliver pure alcohol through a catheter …
Development Of Medical Devices For Osteoarthritis Diagnosis, Antimicrobial, Wound Closure, And Wound Ph Milieu Monitoring, Shuxin Li
Bioengineering Dissertations - Archive
Nanotechnology has been widely used in the field of biomedical engineering. For example, nanoparticles have been employed for targeted drug delivery due to their retention effect, increased permeability, site-specific targeting, and avoiding phagocytosis as foreign materials. Moreover, nanotools, such as liposomes, Q-dots, dendrimers, micelles, and carbon nanotubes, have been developed for disease diagnosis and treatment. Generally, the application of nanotechnology can be categorized as follows: nanomedicine, tissue regeneration, biomarker/biosensors, nanorobots, and gene therapy. In the past four years, I have been focusing on developing nanotechnology for diagnosis and treatment of many diseases such as osteoarthritis, open wound, and infection. Based …
Design, Development, And Validation Of A Novel Optical Imaging Device For Biomedical Applications, Ashley Christine Dacy
Design, Development, And Validation Of A Novel Optical Imaging Device For Biomedical Applications, Ashley Christine Dacy
Bioengineering Dissertations - Archive
Fluorescence and luminescence imaging are two promising optical techniques for diagnosing a variety of critical pathologies in vivo, including wound healing, inflammation, and vascular diseases. Despite this, there is a lack of imaging devices in research and commercially available that are capable of these imaging modalities in large animal applications. This work describes the progressive development of several optical imaging devices to fill this void, culminating in a final design with robust fluorescence and luminescence functionality designed for large animal and human applications. These devices are used to gather new data about various physical parameters in small and large animal …
Ultrasound Switchable Fluorescence Imaging Based On A Time Gated Iccd Camera, Shuai Yu
Ultrasound Switchable Fluorescence Imaging Based On A Time Gated Iccd Camera, Shuai Yu
Bioengineering Dissertations - Archive
Ultrasound switchable fluorescence (USF) imaging has been proposed as a novel imaging modality which provides microscopic fluorescence imaging in centimeter-deep tissue. USF is possible to reveal many interesting phenomena such as microcirculation, tumor angiogenesis, and cancer metastasis and diagnose early-stage cancer. USF adopts a focused ultrasound (FU) to repetitively switch “on” fluorescent agents in tissue, and the USF photons scatter out and are captured by a detector. A USF image provides acoustic resolution and optical sensitivity. In USF, there are two key components: 1) an excellent USF contrast agent; and 2) a sensitive USF imaging system. The major challenge of …
Novel Analysis Of Wavelet Coherence And Phase-Amplitude Coupling To Investigate The Human Brain At Four Vigilance States, Seyedeh Parisa Rabbani
Novel Analysis Of Wavelet Coherence And Phase-Amplitude Coupling To Investigate The Human Brain At Four Vigilance States, Seyedeh Parisa Rabbani
Bioengineering Dissertations - Archive
Despite breakthroughs in the field of neuroimaging, there remain many unanswered questions about brain functions and activities and their underlying physiological processes. In my dissertation research, I examined brain functions while human subjects experienced four vigilance states: (1) resting state with eyes open, (2) resting awake state with eyes closed, (3) sleep stage 1 and (4) sleep stage 2. Simultaneous dual modality measurements using electroencephalography (EEG) and functional near infrared spectroscopy (fNIRS) were acquired during the aforementioned vigilance states. Specifically, I examined brain processes from two different perspectives: brain hemodynamics (blood flow) and electrophysiology (brain waves). My dissertation had three …
Development And Investigation Of Fluorescence Imaging Probes, Bahar Saremi
Development And Investigation Of Fluorescence Imaging Probes, Bahar Saremi
Bioengineering Dissertations - Archive
Fluorescence imaging has attracted much attention due to high sensitivity, spatial and temporal resolution, and fast acquisition time, for imaging biomolecular processes and for diagnosis of diseases such as cancer in early stages. Fluorescence imaging in centimeter-deep tissue suffers from low spatial resolution because of the strong scattering of light. On the other hand ultrasound imaging benefits from 1000 times less scattering in the tissue and deep penetration. Ultrasound switchable fluorescence imaging is a relatively new imaging modality that combines the sensitivity of optical imaging with the depth of penetration of ultrasound imaging while preserving the resolution by only eliciting …
Lung Cancer Targeted Chemotherapy Via Herceptin Based Chimeric Antigen Receptor (Car) Engineered T Cell Membrane Coated Synthetic Nanoparticles, Serkan Yaman
Bioengineering Dissertations - Archive
Cell membrane-derived nanoparticles recently caught attention due to their desirable features in drug delivery such as mimicking properties of native tissue and cells, avoiding systemic clearance, and alleviating foreign body responses. Besides nanoparticle technology, adoptive immunotherapy has emerged for its promising treatment modalities, including cancer specificity. Our long-term goal for this research is to develop a biomimetic drug carrier based on chimeric antigen receptor (CAR) transduced T cell membranes. In the study, anti-cancer drug afatinib loaded poly(D,L-lactide-co-glycolide) (PLGA) nanoparticles (NPs) co-extruded with anti her-2 based chimeric antigen receptor (CAR) Jurkat T cell membranes. Anti her-2 CAR-T cells were produced by …
Development Of Medical Devices For Diagnosing Cartilage Injury And Metastatic Cancers, Yi Hui Huang
Development Of Medical Devices For Diagnosing Cartilage Injury And Metastatic Cancers, Yi Hui Huang
Bioengineering Dissertations - Archive
My research focused on applying biomedical engineering techniques to diagnose different diseases and conditions. The results of these work led to one published paper and two submitted manuscripts which are summarized in Chapters 2, 3 &4. Briefly, in Chapter 2, my work laid emphasis on developing a method for early detection of cartilage injury. An apoptotic cell-detecting probe was fabricated by the conjugation of the apoptotic cell-binding peptide (CQRPPR) and a sulfo-cyanine7 N-hydroxysuccinimide ester (Cy7 dye). Both in vitro and ex vivo examination showed an excellent relationship between the number of apoptotic chondrocytes and probe binding affinity. Finally, using a …
Application Of Tissue Engineering Techniques For Treating Cartilage Injury And Diagnosing Cancer Metastasis, Amirhossein Hakamivala
Application Of Tissue Engineering Techniques For Treating Cartilage Injury And Diagnosing Cancer Metastasis, Amirhossein Hakamivala
Bioengineering Dissertations - Archive
This study focuses on the application of tissue engineering techniques for the diagnosis of cancer metastasis, cartilage regeneration, and modeling of lymph node metastasis. Chapter 1 is an overview of tissue engineering strategies, and it describes how each chapter relates to the central theme. Chapter 2 describes the development of 3D lymph node (LN) mimetic for studying prostate cancer metastasis. The overall objective of this chapter was to develop a biosystem with the ability to mimic metastatic LN condition. Studies were first designed to uncover the critical cells types and chemokines responsible for cancer metastasis to the LNs. An LN …
Development Of An In Vitro Tbi Models And Validation Of Nanodelivery For Restoration Of Disrupted Brain Endothelium, Edidiong I. Inyang
Development Of An In Vitro Tbi Models And Validation Of Nanodelivery For Restoration Of Disrupted Brain Endothelium, Edidiong I. Inyang
Bioengineering Dissertations - Archive
Blast-induced traumatic brain injury (bTBI) is a serious concern among military personnel and their families. Although the mechanisms responsible for disruption to the brain are not well understood, the development of reliable diagnosis along with effective therapeutic treatment is urgently warranted. Recent findings suggest that shockwaves produced by a blast can generate micron-size bubbles that subsequently collapse in the brain tissue. The collapse of microbubbles (referred to as microcavitation) may compromise the integrity of the blood-brain barrier (BBB). Moreover, addiction to the psycho-stimulant drugs (PSDs), e.g. cocaine and alcohol which are known to cause toxicity due to oxidative stress, can …
Mathematical Modeling Of Blood Pressure And Cerebral Blood Flow Using Photoplethysmography Signal, Armin Soltan Zadi
Mathematical Modeling Of Blood Pressure And Cerebral Blood Flow Using Photoplethysmography Signal, Armin Soltan Zadi
Bioengineering Dissertations - Archive
Continuous and non-invasive monitoring of blood pressure (BP) and cerebral blood flow (CBF) has numerous clinical and health maintenance applications. Of particular interest is monitoring of BP and CBF during events that stress the cardiovascular system such as cessation of breathing during sleep apnea. Current means and methods of continuous measurement of these signals are either invasive or require expensive equipment. Therefore, investigation of new methods of continuous estimation of the BP and CBF are of high interest. One attractive alternative is to use photoplethysmography (PPG) technique to estimate BP and CBF, as PPG is shown to be able to …
The Hip-Spine Effect: How Pathological Femoro-Pelvic Interactions Contribute To Abnormal Lumbar Spine Loading, Anthony Nicholas Khoury
The Hip-Spine Effect: How Pathological Femoro-Pelvic Interactions Contribute To Abnormal Lumbar Spine Loading, Anthony Nicholas Khoury
Bioengineering Dissertations - Archive
ABSTRACT THE HIP-SPINE EFFECT: HOW PATHOLOGICAL FEMORO-PELVIC INTERACTIONS CONTRIBUTE TO ABNORMAL LUMBAR SPINE LOADING Anthony Nicholas Khoury, Ph.D. The University of Texas at Arlington, 2019 Supervising Professor: Hal David Martin Cheng-Jen Chuong Lumbar pathology has been shown to explain hip pain, as hip pathology is involved in the development of lumbar pain by the disruption of normal lumbopelvic kinematics. Hip pathologies that contribute to lumbar pain include flexion deformities, osteoarthritis, congenital hip dislocation, and limited hip range of motion. To date there is a paucity of research that actively looks to investigate the symbiotic relationship between the hip and the …