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Articles 301 - 330 of 366
Full-Text Articles in Biomedical Engineering and Bioengineering
A Novel Approach For Mri Image Classification And Image Retrieval, Ankit Vinod Master
A Novel Approach For Mri Image Classification And Image Retrieval, Ankit Vinod Master
Bioengineering Theses - Archive
OBJECTIVE: Classification of MRI image data based on its attribute characteristics is very important for storing the image data and its efficient retrieval. This project aims to find a solution to the problem of classification of the images that are stored on a hard drive and image retrieval from the image database with optimum automation in a user friendly way. METHOD: Matlab was used to create a software tool for image classification and, Java and SQL were used to create a software tool for image retrieval. RESULTS: Image classification tool could read multiple files, extract attribute values from the files …
Biodegradable Fluorescent Polymers, Santosh Gautam
Biodegradable Fluorescent Polymers, Santosh Gautam
Bioengineering Theses - Archive
Most of the works done on fluorescent polymers are focused on their potential applications in lighting industries. Much less interest has been paid for their potential application in the field of biology and biomedical engineering. Although multiple biological uses of green fluorescent proteins (GFPs) have been addressed by different groups, their potential for biomedical applications is hampered by their tendency to photobleach rapidly and their short fluorescence lifetime. Quantum dots have emerged as a potential substitute for those applications, but their cytotoxicity and lack of biodegradability restrict their use in a biological system. An ideal fluorescent material that could be …
Visible Versus Near-Infrared Light Penetration Depth Analysis In An Intralipid Suspension As It Relates To Clinical Hyperspectral Images, Tinsy John Perumanoor
Visible Versus Near-Infrared Light Penetration Depth Analysis In An Intralipid Suspension As It Relates To Clinical Hyperspectral Images, Tinsy John Perumanoor
Bioengineering Theses - Archive
We determine the penetration depth of near-infrared and visible light in a tissue phantom model using various image processing techniques and chemometrics and use these results to demonstrate the application of a multimodal hyperspectral imaging system for monitoring blood perfusion in amputation wounds. It is capable of performing a noninvasive, in vivo, quantitative analysis of human tissue in a clinical environment, in terms of the percent saturation of oxyhemoglobin. The instrument majorly consists of near-infrared and visible charge coupled devices (CCDs), lenses, liquid crystal tunable filters (LCTFs) for both the CCDs attached to their respective lenses, and a broad band …
Magnetic Drug Targeting: Development Of A Novel Drug Delivery System For Prostate Cancer Therapy, Maham Rahimi
Magnetic Drug Targeting: Development Of A Novel Drug Delivery System For Prostate Cancer Therapy, Maham Rahimi
Bioengineering Dissertations - Archive
Magnetic nanoparticles (MNPs) have been attracting a great amount of attention because of their numerous applications including contrast agents in magnetic resonance imaging (MRI), magnetic targeted drug carriers, and hyperthermia treatments for cancer. However, complications, including aggregation of MNPs, have limited their use in drug delivery applications. To overcome these limitations, several methods have been developed to coat magnetic particles. One method includes coating them with polymers to produce polymer/MNPs for increasing the MNP dispersion and stability. This method also increases the efficiency of loading and releasing drugs to specific locations for the treatment of various diseases including prostate cancer. …
Regenerative Peripheral Neurointerfacing Of Upper Extremity Prostheses, Kshitija Garde
Regenerative Peripheral Neurointerfacing Of Upper Extremity Prostheses, Kshitija Garde
Bioengineering Theses - Archive
Current robotic prosthetic devices provide limited functionality to the user as they rely on gross myogenic control and lack critical sensory feedback needed for fine movement control. Interfacing the nervous system with the robotic prosthesis would facilitate amputees to control them naturally, in resemblance to the human hand. Functional neuro-electrode connections have been demonstrated in the brain and peripheral nervous system; however, gliosis, micro hemorrhages, axonopathy and excessive inflammation limit their long-term use. We evaluated the possibility of enticing peripheral nerve regeneration through a multi-electrode array with an open architecture as an alternative to enhance longevity of nerve-electrode interface. Regenerative …
Biaxial Mechanical Characterization Of Porcine Periosteum, Phillip Daniel Warren
Biaxial Mechanical Characterization Of Porcine Periosteum, Phillip Daniel Warren
Bioengineering Theses - Archive
Periosteum is multipotent tissue responsible for cortical bone deposition and is important in fracture repair. Research indicates the periosteum is mediated by similar mechanical signals to those that mediate bone growth and remodeling. Therefore, biaxial mechanical characterization of periosteum can be very informative, indeed. This paper presents the results of the first such examination. The porcine periosteum herein has at least three distinct layers - a cellular layer, an elastin-rich layer, and a collagen-rich layer - the latter two providing structural integrity. Not surprisingly then, the general biaxial mechanical characteristics of periosteum resemble those of other collagen and/or elastin-rich membranes. …
Determining The Flow Characteristics Of A Perfusion Device For Donor Heart Transport, Michael Louis Cobert
Determining The Flow Characteristics Of A Perfusion Device For Donor Heart Transport, Michael Louis Cobert
Bioengineering Theses - Archive
Current technology has limits organ transport for transplantation to static storage, thereby reducing the reasonable distance of travel. Continuous machine perfusion has been proposed as a viable alternative to improving function and outcome. A series of studies with such a device have been developed to elucidate the method by which optimal results can be achieved. Adult mongrel dog hearts were established in a device that provided continuous perfusion of oxygenated fluid and enabled precise control of flow rate, oxygenation, and fluid temperature. The first series of experiments sought to determine an optimal flow rate for tissue perfusion at one of …
Optimization Of Reconstruction Parameters In Brain Activation Studies, Aswini Kanneganti
Optimization Of Reconstruction Parameters In Brain Activation Studies, Aswini Kanneganti
Bioengineering Theses - Archive
Diffuse Optical Imaging (DOI) is being extensively used in brain activation studies for the quantification of hemodynamic changes in the cerebral cortex. Many investigators have utilized the commercially available CW5 DOI device to attain cortical activation maps. However, the localization and spatial resolution in the resulting activation images remains poor. These limitations arise due to the large source detector separations required for light to reach the brain's surface and the limited number of detector channels in the CW5 system, which result in sparse spatial sampling of the cortical activation regions. In this thesis we assess the feasibility of using denser …
Feasibility Study Of An Ultra Fast Gated Camera To Image Biliary Tree Embedded In Adipose Tissue Using Laboratory Phantoms And Monte Carlo Simulations, Nimit Lalitkumar Patel
Feasibility Study Of An Ultra Fast Gated Camera To Image Biliary Tree Embedded In Adipose Tissue Using Laboratory Phantoms And Monte Carlo Simulations, Nimit Lalitkumar Patel
Bioengineering Theses - Archive
Every year, approximately 500,000 cholecystectomies are performed in US. As biliary tree structures are embedded in adipose tissue, they cannot be visualized directly by the surgeon, which causes inadvertent injuries to the common bile duct, vein and artery during a laparoscopic cholecystectomy. Thus there is an urge for an imaging modality which could see biliary tree structure through fatty tissue. Successful clinical implementation of an imaging system which could attain this goal would reduce surgical time, improve patient safety and minimize the risk of complications and expenses attributable to the current standard practice of intraoperative cholecystectomy. It is hoped that …
Automated Quantification Of White Matter Hyperintensity Burden Using Mprage And Flair Images From A Large Population, Keith Mcleod Hulsey
Automated Quantification Of White Matter Hyperintensity Burden Using Mprage And Flair Images From A Large Population, Keith Mcleod Hulsey
Bioengineering Theses - Archive
White Matter Hyperintensity(WMH) burden, as observed in T2 and proton weighted MR images, is associated with several health factors such as decreased cognitive ability, hypertension, diabetes and cerebrovascular disease. An algorithm was developed to automatically estimate WMH burden from pairs of MPRAGE and FLAIR images which is robust and requires essentially no operator involvement. The WMH burden estimation generated by this fully automated algorithm has been shown to correlate well with known risk factors for WMH burden.
Synthesis And Characterisation Of Raman Nanotags For Molecular Detection, James Otieno Nyagilo
Synthesis And Characterisation Of Raman Nanotags For Molecular Detection, James Otieno Nyagilo
Bioengineering Theses - Archive
The realization that most diseases are preceded or accompanied by changes in the genetic and cellular level of an organism has increased with the need for imaging modalities, with the sensitivity and specificity, to quantitatively detect biomolecules at those levels. Specifically there has been a need for the development of a modality that has the ability to detect multiple biomolecules from a single sample in order to increase accuracy of molecular diagnosis and allow for early detection of terminal diseases. Surface enhanced Raman spectroscopy provides potential for such a modality. The distinct spectrum of each Raman active molecule serves as …
Visible To Near Infra Red Hyperspectral Imaging: Visualizing The Neurological And Biological Nature Of Ischemic Tissue, Swetha Suresh
Visible To Near Infra Red Hyperspectral Imaging: Visualizing The Neurological And Biological Nature Of Ischemic Tissue, Swetha Suresh
Bioengineering Theses - Archive
Diabetic Neuropathy is a neuropathic disorder which is associated with Diabetes Mellitus. It is known to result in lower limb ulcers which can lead to amputation. Nerve damage, microvascular dysfunctions and use of ill fitting shoes are significant causes for it. These abnormal dysfunctions can lead to Ischemia. We have used the Multimodal Hyperspectral Imaging System image areas of high pressure on the skin that correspond to pain and also to visualize vascular changes that are associated with this pain. The instrument majorly consists of near-infrared and visible charge coupled devices (CCDs), lenses, liquid crystal tunable filters (LCTFs) for both …
Mechanism Of Nanoparticle And Nanotube-Induced Cell Death, Syed Khaja Sohaebuddin
Mechanism Of Nanoparticle And Nanotube-Induced Cell Death, Syed Khaja Sohaebuddin
Bioengineering Theses - Archive
Recent advances in nanotechnology have lead to synthesis of high-quality nanoparticles which exhibit unique physical and chemical properties. The novel properties of these nanoparticles are widely being applied for diagnostic and therapeutic purposes and enable new means of biosensing and targeted drug delivery. However, increasing evidence has suggested that some nanoparticles may cause detrimental effects on cells and tissues. Using titanium oxide (TiO2) nanoparticles (5-10 nm diameter), silicon oxide (SiO2) nanoparticles (30 nm diameter), and multi-walled carbon nanotubes (MWCNTs) of different diameters (<8 nm, 20-30 nm, >50 nm), 0.5-2 µm in length as test subjects, we evaluated the in vitro interaction of these …
Integration Of Hyperspectral Imaging System For Optimized Data Acquisition And Control To Revolutionized Pathology Applications, Dipen Rana
Bioengineering Theses - Archive
Detecting and measuring the interactions and expression levels of tumor markers in a cancerous cell are quintessential in prognosis and management of cancer. These have propagated the need to develop better microscopic imaging techniques to understand the cellular structure and its functional behavior. Pathologist use techniques such immunohistochemistry and in situ hybridization to measure and detect these tumor marker expression levels. Fluorophores are used in these techniques as fluorescent tags to identify the tumor markers. These fluorophores have unique absorption and emission spectrum, making them useful to not only identify but also quantify the concentration levels of these markers. This …
Synthesis And Characterization Of Crosslinked Urethane Doped Polyesters For Vascular Tissue Engineering, Jagannath Dey
Synthesis And Characterization Of Crosslinked Urethane Doped Polyesters For Vascular Tissue Engineering, Jagannath Dey
Bioengineering Theses - Archive
Traditional crosslinked polyester elastomers are inherently weak, and the strategy of increasing crosslink density to improve their mechanical properties makes them brittle materials. Biodegradable polyurethanes, although strong and elastic, do not fare well in dynamic environments due to the onset of permanent deformation. The design and development of a soft, strong and completely elastic (100% recovery from deformation) material for tissue engineering still remains a challenge. Herein, we report the synthesis and evaluation of a new class of biodegradable elastomers, crosslinked polyurethane-doped polyesters (CUPEs), which is able to satisfy the need for soft, strong, and elastic biomaterials. Tensile strength of …
Development Of Novel Multilayered Particles For Drug Delivery And Cell Isolation Applications, Bhanuprasanth Koppolu
Development Of Novel Multilayered Particles For Drug Delivery And Cell Isolation Applications, Bhanuprasanth Koppolu
Bioengineering Theses - Archive
The objective of this work is to develop multilayered nanoparticles for drug delivery and cell isolation applications. These particles principally consist of three layers; biodegradable polymer, thermo sensitive polymer and magnetic materials. For drug delivery, multilayered nanoparticles (MLNP) consisting of a magnetic core and two encompassing shells made up of temperature sensitive polymer, poly (N-isopropylacrylamide) (PNIPAAm), and biodegradable polymer, poly(D, L lactide-co-glycolide) (PLGA), were developed for targeted and controlled drug delivery. The PNIPAAm layer was immobilized onto magnetic nanoparticles (MNPs) via a silane coupling agent, Vinyltrimethoxysilane (VTMS), and free radical polymerization. These particles were then encapsulated with PLGA using a …
Localization Of Biliary Tree Structures By Use Of Photon Diffusion Models, Dharmendra Nadkar
Localization Of Biliary Tree Structures By Use Of Photon Diffusion Models, Dharmendra Nadkar
Bioengineering Theses - Archive
A novel computational methodology is proposed for the intraoperative localization of biliary tree structures by means of spectrally resolved near-infrared reflectance measurements. As these structures are embedded in fatty tissue, they cannot be visualized directly, which results in inadvertent injuries during a cholecystectomy operation. Localizing the biliary tree intraoperatively is therefore an important clinical problem. Successful clinical implementation of an imaging system which could attain this goal would reduce surgical time, improve patient safety, and minimize the risk of complications and expenses attributable to the current standard practice of intraoperative cholangiography. It is hoped that the work presented here will …
Large Array Emg Monitoring Of Lumbar Region Muscle Action In Discogenic Low Back Pain, Jazzmyne Ann Richardson Buckels
Large Array Emg Monitoring Of Lumbar Region Muscle Action In Discogenic Low Back Pain, Jazzmyne Ann Richardson Buckels
Bioengineering Theses - Archive
This project explored the use of large array surface electromyography (LASE) as a technique for assessing the patterns of muscular activity under standardized loading conditions in patients with lumbar disc related pain and healthy subjects. Specifically, the project evaluated quantitative parameters of visually observed patterns of muscle action proposed to clinically discriminate between groups. If such correlates exist, then, this work may lead to technology assessment for sensitivity and specificity as a diagnostic procedure. Solutions to the issues for determining the effects of low back pain (LBP) on force and moment generation in the spine as well as its effect …
A Functional Analysis Of The Mechanically And Metabolically Sensitive Components Of The Skeletal Muscle Exercise Pressor Reflex In Hypertension, Anna Katherine Leal
A Functional Analysis Of The Mechanically And Metabolically Sensitive Components Of The Skeletal Muscle Exercise Pressor Reflex In Hypertension, Anna Katherine Leal
Bioengineering Theses - Archive
Background - In hypertension, physical activity creates a risk for adverse cardiac events by causing exaggerated increases in mean arterial pressure (MAP) and heart rate (HR). One physiological mechanism responsible for this cardiovascular hyperactivity is the exercise pressor reflex (EPR). The EPR is a neural pathway originating in skeletal muscle that contributes to cardiovascular regulation during exercise. The EPR is composed of two afferent arms: one is comprised of mostly mechanically sensitive, group III afferent fibers that respond to muscle stretch and pressure, and the other is predominantly metabolically sensitive, group IV afferent fibers that respond to the chemical milieu …
Development Of A Broadband Multi-Channel Nirs System For Quantifying Absolute Concentrations Of Hemoglobin Derivatives And Reduced Scattering Coefficients, Dheerendra Kashyap
Development Of A Broadband Multi-Channel Nirs System For Quantifying Absolute Concentrations Of Hemoglobin Derivatives And Reduced Scattering Coefficients, Dheerendra Kashyap
Bioengineering Dissertations - Archive
Near infrared spectroscopy (NIRS) has been widely applied to investigate hemoglobin oxygenations of muscles, brain and breast tumors. Steady state reflectance techniques developed previously have been restricted to determination of relative concentrations. To overcome these limitations, this dissertation describes the development, validation and applications of broadband, steady-state, optical spectroscopic systems and algorithms to quantify absolute concentrations of hemoglobin derivatives and reduced light scattering coefficients using (1) thin optical probes with small (100 μm - 1 mm) source-detector separations and (2) a large separation (< 4 cm) probe.. A recently developed mathematical model by Zonios and Dimou for reflectance at small source-detector separations was used to develop techniques to quantify chromophore concentrations and light scattering coefficients (Chap. 2). Blood-intralipid phantom models were used to determine empirical coefficients to model reflectance spectra. This technique was further applied to quantify hemodynamic changes during formalin- induced pain behaviors in rats (Chap. 3). To overcome limitations in penetration depth and investigated tissue volume, another approach to quantify concentrations of chromophores in tissues at large source-detector separations was also developed. This novel approach uses the process of second differential spectroscopy to quantify concentrations of deoxygenated hemoglobin with respect to the tissue water content. Based on such quantification, an adaptation of the ant colony optimization algorithm was utilized to quantify absolute concentrations of other constituent tissue chromophores. The developed techniques were validated with the reflectance measurements from blood-intralipid phantoms and further applied to monitoring of ex vivo human prostate lesions and of rat brain tumor growth in vivo (Chap. 4). In the second stage of my doctoral development, a multi-channel, broadband, steady-state, NIRS imaging system was developed to determine spatial distributions of hemoglobin concentrations and reduced light scattering coefficients. The imager was calibrated with laboratory phantoms to eliminate deterministic instrumentation bias of CCD-spectrometers, optical fibers, and multiplexer channels. Calibration procedures also include determinations of the source strength and boundary coefficients in order to obtain accurate image reconstructions. A multi-wavelength, spectrally constrained reconstruction algorithm was developed to obtain tomographic maps of hemoglobin derivative concentrations and reduced scattering coefficients, using laboratory tissue phantoms. The developed imaging system and reconstruction algorithms were validated with both static and dynamic multi-tube phantoms.
Resolution And Localization In Single Molecule Microscopy, Sripad Ram
Resolution And Localization In Single Molecule Microscopy, Sripad Ram
Bioengineering Dissertations - Archive
Rayleigh's criterion is extensively used in optical microscopy to determine the resolution of microscopes. Despite its widespread use, it is well known that this criterion is based on heuristic notions and can be surpassed in a regular optical microscope. The inadequacy of Rayleigh's criterion has necessitated a reassessment of the resolution limits of optical microscopes. The thesis proposes a new resolution criterion that overcomes the limitations of Rayleigh's criterion. The new result predicts that there is no resolution limit, but that the resolvability depends on the number of detected photons. Analytical tools are introduced to estimate the distance from microscopy …
Spatial Resolution And Biliary Tissue Classification Properties Of A Near Infrared Light Imaging Probe, Praveen Kumar Gulaka
Spatial Resolution And Biliary Tissue Classification Properties Of A Near Infrared Light Imaging Probe, Praveen Kumar Gulaka
Bioengineering Theses - Archive
Approximately 500,000 Gallbladder Surgeries or Laparoscopic Cholecystectomies are performed annually to remove the Gallbladder. This surgery becomes necessary due to formation of gall stones. As biliary tract tissues are embedded in fat, differentiating them from neighboring tissues and blood vessels is critical in helping surgeons during laparoscopic cholecystectomy to avoid post-surgical complications. Optical spectroscopy (in both visible and near infrared regions) is investigated as a possible technique to identify biliary tract tissues and blood vessels. Such reflectance measurements provide information of effective attenuation, which is an index of optical properties of the tissue.Specifically, optical reflectance measurements were made on biliary …
Characterization Of A Hyperspectral Imager: A Diagnostic Tool For Monitoring Retinal Diseases, Nirad Zinzuwadia
Characterization Of A Hyperspectral Imager: A Diagnostic Tool For Monitoring Retinal Diseases, Nirad Zinzuwadia
Bioengineering Theses - Archive
We developed a novel hyperspectral slit lamp ophthalmoscope for visualizing vascular changes for clinical monitoring of retinal diseases, for example, diabetic retinopathy. The device consists of a visible charge couple device, CCD, and liquid crystal tunable filter, LCTF, coupled to the standard clinical slit lamp ophthalmoscope. The LCTF is used as a spectral light source illuminating the retina with different wavelengths of light that are recorded by the CCD and stored as a series of wavelength dependent images of the retina. Chemometric analysis produces a gray scale encoded image for the percentage of oxyhemoglobin at each pixel within the field …
Detection Of Positive Cancer Margins Intra-Operatively During Nephrectomy And Prostatectomy Using Optical Reflectance Spectroscopy, Disha Laxman Peswani
Detection Of Positive Cancer Margins Intra-Operatively During Nephrectomy And Prostatectomy Using Optical Reflectance Spectroscopy, Disha Laxman Peswani
Bioengineering Theses - Archive
In recent years optical spectroscopies have become the basis for popular research activity directed towards the development of novel, noninvasive technologies for tissue diagnostics. The motivation for my research was to eliminate the need for surgical removal of tissue samples for biopsy and histology. With the help of an optical probe placed on or near the surface of the tissue, Near Infrared (NIR) spectroscopy can provide diagnostic signatures, non-invasively and in real time. While the ultimate goal vi is the elimination of the need to remove tissue samples, this technology can also be used to provide additional guidance during laparoscopic …
Foreign Body Reactions To Neural Implants In The Brain, Parisa Lotfi
Foreign Body Reactions To Neural Implants In The Brain, Parisa Lotfi
Bioengineering Theses - Archive
Neural implants have been used and studied for many decades. They are applied to record neural signals or to locally deliver drugs. Unfortunately, foreign body reaction and accompanied glial scar formation often lead to implant failure. The lack of knowledge about the molecular mechanism governing foreign body reactions in the brain significantly hinders the development of brain implantable devices with improved safety and biocompatibility. To study the immune responses to brain implants, a novel animal model has been developed and used for the following investigation. Our studies have established cell recruitment time courses of astrocytes, microglial cells, lymphocytes, monocytes and …
Functionalized Nanoparticles For The Selective Killing Of Cancer Cells, Paul Todd Thevenot
Functionalized Nanoparticles For The Selective Killing Of Cancer Cells, Paul Todd Thevenot
Bioengineering Theses - Archive
The use of nanoparticles for cancer imaging and drug delivery has produced some success in improving the efficacy and safety of cancer chemotherapy. It is generally believed that the efficiency of nanoparticle-based cancer therapy would be greatly improved if such particles could be designed to directly interact with and eradicate tumor. Many recent studies have revealed that surface functionality plays an important role in particle:cell interactions. Using titanium dioxide (TiO2) nanoparticles (21 nm diameter) as test subjects, nanoparticles with different functional groups, hydroxyl (-OH), amine (-NH2), and carboxyl (-COOH) were produced and used in this investigation. An in vitro cell …
Cytotoxic Evaluation And Factorial Analysis Of 3d Photopolymerizable Thermoresponsive Composite Nanoparticle Hydrogels For Controlled Drug Delivery In Restenosis And Wound Healing, Abhimanyu Rajaram Sabnis
Cytotoxic Evaluation And Factorial Analysis Of 3d Photopolymerizable Thermoresponsive Composite Nanoparticle Hydrogels For Controlled Drug Delivery In Restenosis And Wound Healing, Abhimanyu Rajaram Sabnis
Bioengineering Theses - Archive
To develop a smart drug delivery system for restenosis and wound healing applications, we investigated photopolymerizable composite nanoparticle hydrogels which can release the drug in a temperature-responsive manner. Our novel system consisting of thermoresponsive poly(N-isopropylacrylamide-co-acrylamide) (PNIPA-AAm) nanoparticles and poly(ethylene glycol) diacrylate (PEGDA) as photo cross-linker can be formed in situ in presence of ultraviolet (UV) light and Irgacure 2959 photoinitiator (PI). The main aims of this project were to investigate the system cytotoxicity and optimize drug release characteristics by performing biocompatibility and factorial analysis studies, respectively. We evaluated the cell survival of human vascular smooth muscle cells and NIH/3T3 fibroblasts …
Investigation Of Brain Activities Using Two State-Of-The-Art Diffuse Optical Imagers, Suresh Prajapati
Investigation Of Brain Activities Using Two State-Of-The-Art Diffuse Optical Imagers, Suresh Prajapati
Bioengineering Theses - Archive
Near-Infrared Spectroscopy (NIRS) and diffuse optical imaging (DOI) are increasingly used to detect hemodynamic changes in the cerebral cortex induced by brain activity. The new commercially available DOI systems CW5 and DYNOT have large number of sources and detectors; by arranging them in specific patterns, one can cover most of the adult head. This study is a preliminary step in understanding CW5 and DYNOT and exploring their capabilities for various purposes. My work is divided in to three major parts. The first goal of this study was to study changes in hemodynamic response of brain during Breath holding, using both …
Gas Permeation Through Nanoporous Polycarbonate Track- Etched Membranes: Pulsed Plasma Polymerization Of Thin Coatings To Modulate Gas Permeability, Christopher Lewis Chapman
Gas Permeation Through Nanoporous Polycarbonate Track- Etched Membranes: Pulsed Plasma Polymerization Of Thin Coatings To Modulate Gas Permeability, Christopher Lewis Chapman
Bioengineering Theses - Archive
Polycarbonate track-etched membranes (PCTE) of 50nm and 100nm pore size, precoated with Poly Vinyl Pyrrolidone (PVP), were surface treated with either Vinyl Acetic acid (VAA) or Perfluorohexane (C6F14) using a low duty cycle pulsed plasma polymerization technique. The effects of this surface treatment on gas permeation properties of the PCTE were addressed. Plasma coating thickness was controllably varied and resulted in gradual reduction of O2 and CO2 permeability as thickness increased from 10nm to 100nm. Plasma coating material, permeant gas, membrane pore size, and crosslink density were also varied in order to gain insight into the permeation properties of the …
Tissue And Vascular Oxygenation Dynamics Determined By Optical Approaches And Mri, Mengna Xia
Tissue And Vascular Oxygenation Dynamics Determined By Optical Approaches And Mri, Mengna Xia
Bioengineering Dissertations - Archive
Tumor oxygenation is a crucial factor to determine the efficiency of non-surgery therapy, such as radiotherapy and chemotherapy. Therefore, various approaches have been applied to tumor in order to improve the tumor oxygen level. Breathing oxygenrich gas with normobaric or hyperbaric pressure has been demonstrated to overcome hypoxia, but with marginal success. Therefore, the outcome would be improved greatly, if the responsive tumors were identified a priori. Two non-invasive techniques were applied to monitor tumor oxygenation dynamics simultaneously when rats were exposed to hyperoxic gas intervention. 19F MRI provides tumor tissue oxygen tension (pO2) images, while Near Infrared Spectroscopy (NIRS) …