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Articles 241 - 270 of 366
Full-Text Articles in Biomedical Engineering and Bioengineering
Targeted Nanoparticles For Cancer Therapy: Promises And Challenge, Kytai Truong Nguyen
Targeted Nanoparticles For Cancer Therapy: Promises And Challenge, Kytai Truong Nguyen
Bioengineering Faculty Publications - Archive
No abstract provided.
Comparison Of Brain Activity In The Prefrontal Cortex During Digit Span Task Between Student Veterans With Post Traumatic Stress Disorder And Controls Using Functional Near Infrared Spectroscopy, Bejoy Mathai
Bioengineering Theses - Archive
Near Infrared Spectroscopy (NIRS) is an optical non-invasive imaging technique which makes use of infrared light at particular wavelengths to measure the changes in concentrations of oxygenated blood haemoglobin (HbO) as well as the deoxygenated blood haemoglobin (HbR). Making use of this technique to acquire measurements during different functional activities subcategorises it into the novel and fast developing field of Functional Near Infrared Spectroscopy (fNIRS). In my study I have made use of this novel imaging technique to study the pre-frontal cortex while the subject performs the functional task of digit span task consisting of the forward digit span and …
Engineered Basal Lamina Equivalent - Fabrication And Biomedical Applications, Deepika Tamuly
Engineered Basal Lamina Equivalent - Fabrication And Biomedical Applications, Deepika Tamuly
Bioengineering Theses - Archive
A novel technique based on the principle of solvent casting is developed to create uniform, ultrathin and stackable films of Collagen I/IV and ECMgel for use as Engineered Basal Lamina Equivalent. The mixture of these two proteins provides key molecular elements (laminin, collagen type IV, entactin and perlecan) in a basal lamina with strong mechanical properties (collagen type I). Rat tail derived collagen solution is mixed with ECMgel, and the solution is cast onto PDMS molds and air dried in a custom built air tunnel. The dried membranes are briefly UV cross-linked, peeled off from the PDMS mold to be …
Implementation Of A Pain Generator Controlled By Pressure And Feasability In Its Applications For Functional Near-Infrared Spectroscopy, Pamela Agwa Tebebi
Implementation Of A Pain Generator Controlled By Pressure And Feasability In Its Applications For Functional Near-Infrared Spectroscopy, Pamela Agwa Tebebi
Bioengineering Theses - Archive
Pain is a sensory and emotional experience as a result of possible or definite tissue damage. The level of pain is subjective to the individual's consciousness of sensory stimuli. Pain stimuli can be noxious (i.e., potentially damaging) or innocuous (i.e., normally not painful). Therefore, pain perception can be based on the degree of the stimuli. Studies have been done using brain imaging modalities to assess pain. Functional Near-infrared spectroscopy (fNIRS) is a noninvasive imaging tool and has been used to study the hemodynamic variations in the brain induced by a variety of activations. This research was a feasibility study to …
Investigation Of Brain Activity In Prefrontal Cortex Under Noxious Pain Stimuli And During Psychological Test Using Functional Near Infrared Spectroscopy, Sabin Khadka
Bioengineering Theses - Archive
Functional Near Infrared Spectroscopy (fNIRS) is a non-invasive functional neuroimaging technique, which measures changes in oxy-hemoglobin (HbO) and deoxy-hemoglobin (HbR) concentrations based on the principle of near infrared spectroscopy. For my thesis, I have utilized fNIRS in the prefrontal regions to study cognitive functions under noxious pain and during a psychological test. The fNIRS signals were acquired from the prefrontal cortex (PFC) in order to investigate the hemodynamic response under noxious pain stimuli. The measurement consisted of two different visits separated by seven to ten days with two different levels of pain intensity. From the observations, PFC shows significant deactivation …
Evaluation Of Spatial Resolution And Localization Accuracy Of Absorbing Heterogenity Embedded In Homogenous And Layered Turbid Media Using Functional Near Infrared Spectroscopy, Niranjana Nandakumar
Evaluation Of Spatial Resolution And Localization Accuracy Of Absorbing Heterogenity Embedded In Homogenous And Layered Turbid Media Using Functional Near Infrared Spectroscopy, Niranjana Nandakumar
Bioengineering Theses - Archive
Functional Near-Infrared Spectroscopy (fNIRS) is a non-invasive widely used technique for imaging the brain activation patterns in the cerebral cortex of neonates and adults. For the fNIRS imaging of these brain activation patterns, it is common to assume the head geometry as a homogenous medium due to the resulting computational simplicity of the image reconstruction problem. In reality the head is not a simple homogenous medium and prior research has been conducted to show that light propagates differently in a spatially heterogeneous model of the head compared to a homogenous one, which alters the sensitivity of NIR light detection on …
A Multimodality Dlp® Imaging System For Clinical Surgery, Michael Lee Mangum
A Multimodality Dlp® Imaging System For Clinical Surgery, Michael Lee Mangum
Bioengineering Theses - Archive
With 1.38 million new cases and 450,000 deaths worldwide due to breast cancer, there is a clear need for safe and complete surgical intervention for the treatment of breast cancer. Imaging solutions have been created and developed to help plastic surgeons during breast reconstructive surgery. However, these solutions were implemented separately depending on their particular modality, which can result in higher costs for hospital and patient use. The digital micromirror device (DMD) developed by Texas Instruments has been shown to exhibit spectral control of light at a digital level, and could theoretically allow for the incorporation of multiple imaging modalities …
Three-Dimensional Multimedium Computational Model For Drug Delivery Using Finite Element Analysis, Eduardo Martinez
Three-Dimensional Multimedium Computational Model For Drug Delivery Using Finite Element Analysis, Eduardo Martinez
Bioengineering Theses - Archive
Approximately 2.8% of trauma patients present peripheral nerve injury, which can result in loss of motor function. Current strategies for peripheral nerve repair had focused on the development of synthetic nerve conduits that provide physical guidance. One advantage of the synthetic nerve conduits is that the conduit can be utilize as a delivery system and gain the ability to deliver neurotrophic factors, which have an effect on controlling the survival, migration, proliferation, and differentiation of different neural cell types. Currently there is no method to quantify the concentration of growth factors in the nerve conduit during the implantation time. In …
Quantification Of Functional Near Infrared Spectroscopy To Assess Cortical Reorganization In Children With Cerebral Palsy, Fenghua Tian, Mauricio R. Delgado, Bilal Khan, Sameer C. Dhamne, George Alexandrakis, Mario I. Romero, Linsley Smith, Dahlia Reid, Hanli Liu, Nancy J. Clegg
Quantification Of Functional Near Infrared Spectroscopy To Assess Cortical Reorganization In Children With Cerebral Palsy, Fenghua Tian, Mauricio R. Delgado, Bilal Khan, Sameer C. Dhamne, George Alexandrakis, Mario I. Romero, Linsley Smith, Dahlia Reid, Hanli Liu, Nancy J. Clegg
Bioengineering Faculty Publications - Archive
No abstract provided.
Magnetic Resonance Spectroscopy Study Of Metabolic Profiles In Brain Tumors, Aditya Manoj Patel
Magnetic Resonance Spectroscopy Study Of Metabolic Profiles In Brain Tumors, Aditya Manoj Patel
Bioengineering Theses - Archive
Metabolic profiles in brain tumors were measured using proton (1H) magnetic resonance spectroscopy (MRS) at 3T. Spectra were obtained from normal tissues and tumor mass regions of 6 low-grade gliomas, 7 anaplastic astrocytomas and 23 glioblastoma (GBM) patients, using PRESS at two echo times (TE = 54 and 112 ms). Glutamate (Glu), glutamine (Gln) and lactate (Lac) were well resolved at TE = 112 ms. The ratio of Gln and Glu concentrations, [Gln]/[Glu], was elevated significantly (p < 0.05) in all the tumor types compared to normal tissue. Elevation of Gln was confirmed through [Gln]/[water]; the ratio was increased in all the three tumor types but the increase was significant only in GBM. Glycine (Gly) was increased significantly in GBM. Alanine was detectable from GBM only, indicating its elevation for most malignant tumor. Other observations included significant increases in choline (Cho) and Lac (p < 0.05) and decrease in NAA (N-acetylaspartate), in consistent with prior studies. The creatine to water ratio was observed to decrease in tumor patients but was not significant. Myo-inositol (mIns) was observed to decrease in low grade patients as compared to normal tissue, but was seen to increase with grade of tumor, but was not significant. [Lac]/[water] was significantly higher and [Cho]/[Lac] significantly lower for GBM patients indicating the increase in Lac as compared to normal tissue.Treatment had a significant impact on tumor cells. After radiation therapy the Lac was observed to be elevated significantly and decrease after bevacizumab treatment. [Cho]/[Cr], [Cho]/[NAA], [Gln]/[Glu] and [Cho]/[Gly] was reduced significantly after the bevacizumab treatment. Gly was not detectable after Bevacizumab treatment. Some of the patients showed no infiltrating tumor cells after successful surgery and therapy with ratios close to that of normal tissue. These observations can help in characterizing the effect of various therapies on brain metabolites and tumor cells.
Targeted Delivery Of Carbon Nanotubes To Cancer Cells, Pavitra Chakravarty
Targeted Delivery Of Carbon Nanotubes To Cancer Cells, Pavitra Chakravarty
Bioengineering Dissertations - Archive
CD22 is broadly expressed on human B cell lymphomas. Monoclonal anti-CD22 antibodies (MAbs) alone, or coupled to toxins, have been used to selectively target these tumors both in severe combined immunodeficient (SCID) mice with xenografted human lymphomas and in patients. Single-walled carbon nanotubes (CNTs) attached to antibodies or peptides represent another approach to targeting cancer cells. CNTs convert absorbed near-infrared (NIR) light into heat, which can thermally ablate cells in the vicinity of the CNTs. We have made MAb-CNT constructs where the MAb was either noncovalently or covalently coupled to CNTs, and investigated their ability to bind specifically to cells …
Post-Operative Renal Function Analysis Using Visible Dlp® Hyperspectral Imaging System, Abhas Thapa
Post-Operative Renal Function Analysis Using Visible Dlp® Hyperspectral Imaging System, Abhas Thapa
Bioengineering Theses - Archive
Surgical and clinical settings in medical hospitals strive to keep up with technological innovations in order to improve the current healthcare scenario. Hyperspectral imaging (HSI) is a novel technology that addresses this problem. HSI is a non-invasive imaging technique that can provide information on both structural and functional conditions of tissue. This information is very useful particularly in live surgical procedures wherein the surgeons can get real-time feedback of the anatomical and functional changes of tissue, as they perform the operation. Currently available HSI systems are extremely slow and thus impractical for time restricted surgical or clinical uses. Hence, DLP® …
Enhanced Endothelialization On Surface Modified Poly(L-Lactic Acid), Hao Xu
Enhanced Endothelialization On Surface Modified Poly(L-Lactic Acid), Hao Xu
Bioengineering Dissertations - Archive
Current synthetic vascular grafts and polymer-coated drug-eluting stents (DES) have certain limitations, such as thrombosis and restenosis due to the incomplete recovery of vascular endothelial cells on their luminal sides. Surface modification of these materials is a viable method to enhance the endothelialization on them. In this study, we proposed several way to modify poly(L-lactic acid) (PLLA), a promising material for vascular prostheses to enhance the endothelialization on its surface. In the first method, we modified the material surface with deposition of poly(vinylacetic acid) (PVAA) using plasma polymerization. PVAA having different surface densities of -COOH group or film thickness were …
Wide Field Of View Imaging Of Premotor And Sensorimotor Cortex Activation Patterns By Functional Near Infrared Spectroscopy, Pankaj Chand
Wide Field Of View Imaging Of Premotor And Sensorimotor Cortex Activation Patterns By Functional Near Infrared Spectroscopy, Pankaj Chand
Bioengineering Theses - Archive
Functional near infrared spectroscopy (fNIRS) is a non-invasive optical technique which can measure concentration changes of oxygenated (HbO), deoxygenated (HbR), and total hemoglobin (HbT) in brain tissue that are induced by neuronal activation. A major hindrance at present for brain optical imaging research is the limited field of view (FOV) size, which is restricted due to the limited number of source-detector pairs that current fNIRS hardware technology and cost considerations allow. As a result it is challenging to simultaneously capture hemodynamic changes in the premotor, motor and sensory cortex as some of these activations can occur outside the available FOV. …
Novel Animal Model And In Vivo Imaging System To Study Inflammatory Response-Mediated Cancer Metastasis, Cheng-Yu Ko
Novel Animal Model And In Vivo Imaging System To Study Inflammatory Response-Mediated Cancer Metastasis, Cheng-Yu Ko
Bioengineering Dissertations - Archive
Cancer metastasis is the leading cause of death in cancer patients. A vast majority of cancer-related mortality is attributed to this rather than the primary tumor itself, making the understanding of cancer metastasis critically important. Inflammatory responses have been implicated to play an important role in cancer metastasis. However, the investigation of the relationship between inflammation and cancer cell migration is limited by the lack of a reproducible cancer metastasis animal model. To fill the gap, we have recently developed an animal model. This model is composed of a two-step procedure. First, poly-L lactic acid (PLA) microspheres were implanted subcutaneously …
Mechanisms Of Biomaterial Mediated Fibrotic Responses And Strategies To Improve Tissue Reactions To Biomaterial Implants, Paul Todd Thevenot
Mechanisms Of Biomaterial Mediated Fibrotic Responses And Strategies To Improve Tissue Reactions To Biomaterial Implants, Paul Todd Thevenot
Bioengineering Dissertations - Archive
Despite considerable advancements in biomaterial synthesis and modification techniques, most tissue engineering scaffolds elicit fibrotic reactions resulting in implant encapsulation, secluding cells and/or therapeutic agents within a thick collagenous matrix. Therefore, strategies to minimize these responses while improving the functionality of recruited/transplanted cells are required. This work set out to improve the host response to biomaterials and identify what cellular responses were attributed to biomaterial-mediated fibrosis. Two strategies were investigated involving two different targets. In the first approach, PLGA scaffolds were RFGD modified to bear -NH2 (amine), -COOH (carboxyl), and -OH (hydroxyl) groups altering surface wettability and charge properties. Surface …
Investigation Of End-Tidal Carbon Dioxide (Etco₂) And Heart Rate Variations During Sleep Apnea, Aditya Bashaboyina
Investigation Of End-Tidal Carbon Dioxide (Etco₂) And Heart Rate Variations During Sleep Apnea, Aditya Bashaboyina
Bioengineering Theses - Archive
Sleep Apnea is a sleep disorder where limitation or cessation of breathing occurs. It is characterized by abnormalities in the respiratory pattern and quantity of ventilation during sleep. According to a study 4% of men and 2% of women have sleep apnea, which is a sizable sector of the adult population. To analyze end-tidal CO₂ and heart hate variations due to apnea, 8 hr polysomnography (Sleep Consultant. Inc, Fort Worth, Texas) was performed on limited sleep apnea subjects and breath hold maneuvers were performed in awake subjects. In the simulated apnea study, 16 volunteer subjects (age: 29 ± 5 yrs, …
Multi-Ligand Nanoparticles For Targeted Drug Delivery To The Injured Vascular Wall, Soujanya Kona
Multi-Ligand Nanoparticles For Targeted Drug Delivery To The Injured Vascular Wall, Soujanya Kona
Bioengineering Dissertations - Archive
Pathological conditions like coronary artery disease, acute myocardial infarction, stroke, and peripheral artery diseases as well as cardiovascular interventions used in the treatment of coronary artery diseases such as angioplasty and stenting, damage/injure the blood vessel wall, leading to inflamed or activated endothelial cells that have been implicated in events leading to thrombosis, inflammation, and restenosis. Oral administration of anti-coagulant and anti-inflammatory drugs causes systemic toxicity, bleeding, patient incompliance, and inadequate amounts of drugs at the injured area. Though drug-eluting stents have shown therapeutic benefits, complications such as in-stent restenosis and late thrombosis still remain and are a cause for …
Development Of Orchestrated Stem Cell-Based Regeneration (Oscer) -Strategies To Recruit And Differentiate Autologous Stem Cells For Tissue Regeneration, Ashwin Nair
Bioengineering Dissertations - Archive
Stem cell therapy has shown great promise in curing diseases. However, clinical application of stem cell therapy is often hindered by the lack of reliable sources and convenient methods to recover stem cells. Our laboratory has recently discovered that adult stem cells can be actively recruited via inflammatory chemokines/growth factor. My research was aimed towards the development of a new technology - "Orchestrated Stem Cell-based Regeneration" or OSCeR - to induce stem cell-mediated tissue regeneration by blending stem cell therapy and tissue engineering technology. This work has led to a series of interesting findings as listed below. Shortly after implantation, …
Quantitative Variation Of Blood Pressure Dynamics During Sleep Apnea, Raichel Mary Alex
Quantitative Variation Of Blood Pressure Dynamics During Sleep Apnea, Raichel Mary Alex
Bioengineering Theses - Archive
Sleep Apnea is one of the major sleep disorders characterized by complete cessation or decline in breathing for about 10s or more during sleep, thereby adversely affecting the quality of sleep. Studies show that about 6 % of the US adult population suffers from obstructive sleep apnea, which in turn plays a major role in the development of hypertension, heart failure, stroke and is also responsible for reduced performance in everyday activities due to lack of quality sleep. In this study the physiological response to sleep apnea were determined using beat to beat blood pressure in both healthy subjects and …
Innovations In ¹H Mr Tissue Oximetry: New Probes And Pulses, Ujjawal Rastogi
Innovations In ¹H Mr Tissue Oximetry: New Probes And Pulses, Ujjawal Rastogi
Bioengineering Theses - Archive
Low oxygenation level (hypoxia) of tissue leads to cellular dysfunction, damage and poor response to therapy. Quantitative measurement of tissue oxygenation is critical not only for the study of tissue physiology, but could also help improve efficacy of therapeutic procedures. Our group has previously developed and implemented a novel approach to quantify oxygen tension in tissue using ¹H MRI, known as “PISTOL” (Proton Imaging of Siloxanes to map Tissue Oxygenation Levels). It exploits a linear relationship between the longitudinal relaxation rate (R1) and oxygen tension (pO₂) of a reporter molecule (probe). Due to close proximity of fat (~ 1 ppm) …
A Study Of The Physiological Effects Of Sleep Apnea On Cerebral Blood Flow Velocity, Gauri Bhave
A Study Of The Physiological Effects Of Sleep Apnea On Cerebral Blood Flow Velocity, Gauri Bhave
Bioengineering Theses - Archive
It is estimated that sleep apnea is prevalent in the US in about 18 million people. The prevalence rate is approximately 6% in the US. Sleep apnea reduces the quality of life of patients. Sleep apnea is characterized by repetitive pauses in breathing during sleep. Recent studies also show loss of gray matter in people diagnosed with sleep apnea. To study the physiological effects of sleep apnea on cerebral blood flow velocity (CBFV), CBFV was measured in subjects simulating apnea. Sixteen volunteers (29 ± 5 yr and BMI 24.1±4.8, 9M and 7F) were recruited as control subjects. We measured CBFV …
An Investigation Of Peripheral Blood Volume And Oxygen Saturation Change In Obstructive Sleep Apnea, Swathi Iyer
An Investigation Of Peripheral Blood Volume And Oxygen Saturation Change In Obstructive Sleep Apnea, Swathi Iyer
Bioengineering Theses - Archive
Obstructive sleep apnea (OSA) is a type of sleep disordered breathing in which the airway collapse partially or fully and causes arousal to resume breathing. In a 2009 National sleep foundation poll of 1000 people, 63% of men and 50% of the females showed signs of sleep apnea. It also showed that subjects with sleep apnea have high risk of high blood pressure, stroke and mental disorders such as depression especially in female. Also by another group of researcher it has been shown that the prevalence of OSA is 4% in male and 2% in female. It has been also …
In Vivo Tracking Of Mesenchymal Stem Cell Recruitment To Tissue Scaffolds, Manwu Sun
In Vivo Tracking Of Mesenchymal Stem Cell Recruitment To Tissue Scaffolds, Manwu Sun
Bioengineering Theses - Archive
The term "Stem cells" has been extensively used to describe precursor undifferentiated cells that have the capacity to self-renew and can also give rise to multiple tissue types. Many studies have been shown improved functional outcome after treated with stem cell therapy. However, almost all of these investigations were analyzed based on histological evaluations which are time-consuming, expensive and fail to provide 3 dimensional and real-time information about stem cell responses. Therefore, there is a need for the development of new method to investigate the migration of stem cells in vivo. Recent evidence supports that fluorescence imaging system offer both …
Attenuation Based Quantification Of Interstitial Lung Disease Using High Resolution Computed Tomography And Correlation With Pulmonary Function Tests, Snehal S. Watharkar
Attenuation Based Quantification Of Interstitial Lung Disease Using High Resolution Computed Tomography And Correlation With Pulmonary Function Tests, Snehal S. Watharkar
Bioengineering Theses - Archive
Interstitial lung disease (ILD) is a chronic and progressive pulmonary disease of the lung parenchyma resulting in fibrotic scar formation of the pulmonary alveoli. The pathologic changes in the lung result in restrictive impairment of lung function. High resolution computed tomography (HRCT) of the chest has become an essential technique in diagnosing and assessing the extent of ILD. Clinical evaluation by HRCT is usually qualitative, leading to inter-observer variability particularly in detecting early disease. We propose a quantitative attenuation-based analysis to standardize the assessment of regional lung disease. We hypothesize that early ILD is associated with greater regional heterogeneity than …
Development Of Magnetic-Based Core-Shell Nanoparticles For Drug Delivery Applications In Melanoma Skin Cancer, Zarna A. Bhavsar
Development Of Magnetic-Based Core-Shell Nanoparticles For Drug Delivery Applications In Melanoma Skin Cancer, Zarna A. Bhavsar
Bioengineering Theses - Archive
Melanoma skin cancer is the most dangerous form of skin cancer and the major cause of deaths related to skin cancer worldwide. Conventional chemotherapeutic treatment is not very effective and faces many problems such as low response rate, development of multidrug resistance, and severe side effects. In order to address these limitations and improve melanoma treatment efficacy, development of a multifunctional nanoparticulate drug delivery system is desired. Thus, we aimed towards the development of magnetic-based core-shell nanoparticles (MBCS NPs) for dual drug release and dual targeting of melanoma tumors. The synthesized nanoparticles were composed of Poly (Lactic-co-glycolic acid) (PLGA) particle …
A Novel Injectable Porous Hydrogel Composite Scaffold For Bone Tissue Engineering, Parvathi Nair
A Novel Injectable Porous Hydrogel Composite Scaffold For Bone Tissue Engineering, Parvathi Nair
Bioengineering Theses - Archive
Over the past decade there has been an increasing use of bone grafts for orthopedic applications. With the aging US population, the need for suitable bone grafts substitutes has also increased. The aim of this study was to develop a novel in situ crosslinkable hydrogel composite for tissue-engineering critical-sized bone defects. This system consists of a newly developed water-soluble biodegradable hydrogel Poly ((ethylene glycol) maleate citrate) (PEGMC) and hydroxyapatite (HA). The PEGMC/HA system is completely injectable and can be crosslinked in situ into crosslinked PEGMC/HA (CPEGMC/HA) hydrogel composite with or without poly (ethylene glycol) diacrylate (PEGDA) as a crosslinker. The …
Microfluidic Systems For Studying Cell Motility, Srikanth Vasudevan
Microfluidic Systems For Studying Cell Motility, Srikanth Vasudevan
Bioengineering Theses - Archive
It is very imperative to develop new in vitro platforms that can help in studying the complex interactions that occur between cell-Extracellular Matrix proteins and also during the process of cell migration in vivo. Such tools would facilitate in better understanding of the mechanisms that are employed by the cells during growth and migration. There are two devices that are presented in this study; 1) Multi-biomolecule coated lane device for unbiased cell preferential migration and 2) Novel Microchannel device for real time monitoring of tumor cell migration.The Multi-biomolecule coated lane device is a basic in vitro platform that helps in …
Incorporation Of Vascular Endothelial Growth Factor And Pleiotrophin Into A Multiluminal Biosynthetic Nerve Implant For The Repair Of Peripheral Nerve Long Gap Defects, An Hai Nguyen
Bioengineering Theses - Archive
To repair a fully transected nerve without putting undue tension on the nerve stumps, and too circumvent many of the obvious problems of using harvested nerve grafts synthetic nerve guides have been used in the clinical setting. Thus far this strategy has met with minimal success for the repair of short defects (i.e. 1 - 2.5 cm) while any defect larger than 3 cm have failed. We hypothesize that neurotorphic support, early vascularization, and contact guidance are needed to successfully regenerate a nerve across a long-gap defect. To this end we proposed a biosynthetic nerve implant (BNI) with a multiluminal …
Magnetically Anchored "Reduced Trocar" Laparoscopy: Evolution Of Surgical Robotics, Richard Bergs
Magnetically Anchored "Reduced Trocar" Laparoscopy: Evolution Of Surgical Robotics, Richard Bergs
Bioengineering Theses - Archive
Laparoscopic surgery has become increasingly popular over the last few years due to its benefits; lower morbidity, less perceived pain, better cosmesis results, and less hospital time. For the surgeon however, there are fundamental issues that can make a laparoscopic procedure more difficult than simple open surgery; loss of tactile feel, limited working envelope, high demand for hand-eye coordination, and one trocar-port required for each tool. A revolutionary concept of using magnetics to support tooling across the abdominal wall was conceived by Dr. Jeffrey Cadeddu and his colleagues at the University of Texas Southwestern Medical Center. Collectively referred to as …