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Articles 211 - 240 of 366
Full-Text Articles in Biomedical Engineering and Bioengineering
Development Of A Measurement System For Quantifying Ultrasound Field Distribution Of Different Transducers, Jayanth Kandukuri
Development Of A Measurement System For Quantifying Ultrasound Field Distribution Of Different Transducers, Jayanth Kandukuri
Bioengineering Theses - Archive
Ultrasound has been widely used in many fields, such as nondestructive examination and medical imaging. Ultrasound is mostly characterized by its pressure and, dynamic pressure wave can be considered to be the foundation of ultrasound physics and imaging techniques. It is thus important for understanding ultrasound pressure properties to that of ultrasound intensity. Moreover, there are many applications that require mainly characterizing ultrasound pressure field (instead of intensity field alone). Therefore, reconstruction of an ultrasound pressure field is highly desirable not only for education but also for research. There may be some commercially available systems that can be used for …
Biophysical Assessment Of Single Cell Toxicity: Diesel Exhaust Particle-Treated Human Aortic Endothelial Cells, Kytai Truong Nguyen, Hao Xu, Yangzhe Wu, Anhong Zhou, Tian Yu, Timothy A. Gilbertson
Biophysical Assessment Of Single Cell Toxicity: Diesel Exhaust Particle-Treated Human Aortic Endothelial Cells, Kytai Truong Nguyen, Hao Xu, Yangzhe Wu, Anhong Zhou, Tian Yu, Timothy A. Gilbertson
Bioengineering Faculty Publications - Archive
Exposure to diesel exhaust particles (DEPs), a major source of traffic-related air pollution, has become a serious health concern due to its adverse influences on human health including cardiovascular and respiratory disorders. To elucidate the relationship between biophysical properties (cell topography, cytoskeleton organizations, and cell mechanics) and functions of endothelial cells exposed to DEPs, atomic force microscope (AFM) was applied to analyze the toxic effects of DEPs on a model cell line from human aortic endothelial cells (HAECs). Fluorescence microscopy and flow cytometry were also applied to further explore DEP-induced cytotoxicity in HAECs. Results revealed that DEPs could negatively impair …
Multifunctionality Of Indocyanine Green-Loaded Biodegradable Nanoparticles For Enhanced Optical Imaging And Hyperthermia Intervention Of Cancer, Kytai Truong Nguyen, Ronak H. Patel, Nimet L. Patel, Venkaiah C. Kavuri, Hanli Liu
Multifunctionality Of Indocyanine Green-Loaded Biodegradable Nanoparticles For Enhanced Optical Imaging And Hyperthermia Intervention Of Cancer, Kytai Truong Nguyen, Ronak H. Patel, Nimet L. Patel, Venkaiah C. Kavuri, Hanli Liu
Bioengineering Faculty Publications - Archive
The aim of this study was to develop and characterize multifunctional biodegradable and biocompatible poly lactic-co-glycolic acid (PLGA) nanoparticles loaded with indocyanine green (ICG) as an optical-imaging contrast agent for cancer imaging and as a photothermal therapy agent for cancer treatment. PLGA-ICG nanoparticles (PIN) were synthesized with a particle diameter of 246 11 nm, a polydispersity index of 0.10 0.03, and ICG loading efficiency of 48.75 5.48%. PIN were optically characterized with peak excitation and emission at 765 and 810 5 nm, a fluorescence lifetime of 0.30 0.01 ns, and peak absorbance at 780 nm. The cytocompatibility study of PIN …
Fabrication Of Small Diameter Vascular Graft Using Stacked Collagen Films, Sandeep Shah
Fabrication Of Small Diameter Vascular Graft Using Stacked Collagen Films, Sandeep Shah
Bioengineering Theses - Archive
Collagen I have been widely used in the field of vascular tissue engineering. They are characterized better for their interaction at the cellular level but are often limited as vascular graft due to their weak mechanical strength and thrombic property. The crosslinking chemicals or polymers support are used to overcome weak mechanical property. Crosslinking agents tend to have cytotoxic effects while blend with synthetic polymers have mismatch or compliancy issues inside the body. Here in this set of study, we used stacked collagen films and embedded drug delivery system within the film to construct small tubular conduits to meet the …
Self-Assmbled Lithography-Free Fabrication Of Microchannels And Microfluidics In Polymers, Wintana Tadesse Kahsai
Self-Assmbled Lithography-Free Fabrication Of Microchannels And Microfluidics In Polymers, Wintana Tadesse Kahsai
Bioengineering Theses - Archive
Rapid, reliable and easy to implement approaches are needed for fabrication of circular microchannels in polymeric microfluidics. PDMS has been a choice of material in microfluidics and it is being used as prototype due to its unique property such as flexibility and transparency. Traditional method of fabrication such as photolithography and soft lithography are complicated and time consuming. In this thesis, a non-lithography and bottom-up self-assembled approach is shown. The resulting devices can have uses in many applications such as assays, biosensing, separation of mixtures, micro-mixing and bioreactors. This thesis presents novel approaches of manufacturing self-assembled microchannels in polydimethyleneoxide (PDMS) …
Effect Of Ascorbic Acid On Cdte Quantum Dots And Investigation Of Different Chemical Sensors On Cdtehg Quantum Dots, Yamini Chitrala
Effect Of Ascorbic Acid On Cdte Quantum Dots And Investigation Of Different Chemical Sensors On Cdtehg Quantum Dots, Yamini Chitrala
Bioengineering Theses - Archive
The objective of my thesis is to investigate the effect of ascorbic acid on CdTe quantum dots, which is an antioxidant. It was observed that the quantum dots recovered their luminescence intensity after the interaction of the ascorbic acid, where the intensity was quenched by the photosensitizer. The luminescence intensity increased gradually for 0.1mM- 0.5mM concentration of ascorbic acid and remained stable with higher concentrations of the antioxidant. Also, it was observed that under some reaction conditions like pH, temperature and concentration, ascorbic acid had a great influence on its photoluminescence. In the second part of the research project, I …
Cytotoxicity Evaluation Of Methacrylate-Based Resins For Clinical Endodontics In Vitro, Chul Ahn, Aniket S. Wadajkar, Qiang Zhu, Esteban G. Garza, Lynn A. Opperman, Larry L. Bellinger, Takashi Komabayashi
Cytotoxicity Evaluation Of Methacrylate-Based Resins For Clinical Endodontics In Vitro, Chul Ahn, Aniket S. Wadajkar, Qiang Zhu, Esteban G. Garza, Lynn A. Opperman, Larry L. Bellinger, Takashi Komabayashi
Bioengineering Faculty Publications - Archive
This study examines the cytotoxicity of Super-Bond C&B (SB-C&B), Super-Bond RC Sealer (SB-RC), MetaSEAL (Meta), and AH Plus Sealer (AH+). Freshly mixed and set materials (100 mg) were prepared in vitro and placed in cell culture medium (1 mL) for the working time and for 6 h, respectively. L929 cells seeded into 96-well plates at 5,000 cells/ well were incubated with the eluted medium (200 μL) for 24 h. Cells cultured with medium alone served as the control. Cytotoxicity was evaluated by MTS assay and analyzed with ANOVA. In the freshly mixed group, the average ± SD (%) for cell …
5 Cm Gap Injury Repair: Growth Factor Support And Functional Analysis In A Rabbit Common Peroneal Nerve Model, Princy K. Prasad
5 Cm Gap Injury Repair: Growth Factor Support And Functional Analysis In A Rabbit Common Peroneal Nerve Model, Princy K. Prasad
Bioengineering Theses - Archive
Nerve conduits have shown to successfully bridge nerve gaps of ≤ 3 cm; however repair of longer, mixed or motor nerve gaps still remains a clinical challenge. In order to study regeneration techniques in clinically relevant long gaps, larger animal models are required. Standardized methods to evaluate functional outcome are necessary to clinically translate experimental treatments. In this study, the capability of the biodegradable and transparent cross-linked doped polyester elastomer (CUPE) to serve as a nerve conduit material in a multiluminal nerve conduit across a 5 cm gap in a rabbit common peroneal nerve model was evaluated. The effect of …
Near Infrared Quantitative Phase Imaging Of Cellular Manipulation Under Different Physio-Chemical Environments, Bipin Joshi
Near Infrared Quantitative Phase Imaging Of Cellular Manipulation Under Different Physio-Chemical Environments, Bipin Joshi
Bioengineering Theses - Archive
Quantitative phase imaging using Digital Holographic Microscopy (DHM) is emerging as a label-free and wide-field method of characterizing cells with high spatio-temporal resolution. In parallel, silicon based micromechanical and electronic devices are allowing both manipulation (e.g. electrical stimulation, mechanical actuation) as well as characterization (electrical and mechanical) of micro and nano-scopic samples. This has revolutionized development of lab-on-a-chip devices for high throughput analysis of cells and molecules for diagnosis of disease and screening of drug-effects. However, very little progress has been made in optical (e.g. fluorescence, Raman etc) characterization of samples on these silicon-based devices. Especially, wide-field high-resolution optical imaging …
Detecting Clinical Biomarkers Using Diffusion Tensor Imaging, Tejasvi Gundapuneedi
Detecting Clinical Biomarkers Using Diffusion Tensor Imaging, Tejasvi Gundapuneedi
Bioengineering Theses - Archive
Diffusion tensor imaging (DTI), a modality of MRI that measures water diffusion properties noninvasively, is highly sensitive to subtle structural changes of white matter. It provides a unique and noninvasive method for delineating in-vivo architecture of human brain white matter. Four metrics derived from DTI, fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AxD) and radial diffusivity (RD), have been widely used to quantitatively characterize the white matter disruption in mental disorders and degenerative diseases. An atlas-based approach incorporating a digital white matter atlas and registration and skeletonization functions of tract-based spatial statistics (TBSS) has been developed recently. This approach …
Electrospun Biodegradable Polymeric Membranes For Post-Surgery Anti-Adhesion Applications, Pouriska Kivanany
Electrospun Biodegradable Polymeric Membranes For Post-Surgery Anti-Adhesion Applications, Pouriska Kivanany
Bioengineering Theses - Archive
Abdominal adhesion is a prevalent, troublesome condition occurring after surgical procedures and can cause a variety of side effects such as, abdominal pain with a highly associated cost ($1.3 billion annually for) for expensive surgical removal. Many companies and research groups have studied and developed techniques to prevent adhesion after surgery; however, none have been completely effective or practical for use. Current materials have many drawbacks, such as the inability to degrade, poor surgical handling, and attracting bacteria. Up to 93% of patients receiving abdominal surgeries will develop abdominal adhesions, and a viable treatment option needs to be developed to …
Involvement Of Mixed Lineage Leukemia And Homeobox Proteins In Dna Damage Recognition And Repair, Somdutta Chakraborty
Involvement Of Mixed Lineage Leukemia And Homeobox Proteins In Dna Damage Recognition And Repair, Somdutta Chakraborty
Bioengineering Theses - Archive
Deoxyribonucleic Acid (DNA) molecules are informational molecules, encoding genetic information which is indispensable in the development and functioning of living organisms. DNA encodes for most proteins essential for all bodily functions and a few of which are known to be involved in the DNA Damage Response/ Repair mechanism. DNA damage recognition and repair is crucial and the cell has an innate mechanism of repairing it. Unrepaired DNA damage leads to genetic mutation or even cancers, which are sustained by further cell division and genetic multiplication. Other researchers have already confirmed the involvement of several proteins and histones like PARP and …
Evaluation Of Tissue Response From The Regenerative Multielectrode Array (Remi) Implant Using Atf-3 And Cjun, Sarita Bhetawal
Evaluation Of Tissue Response From The Regenerative Multielectrode Array (Remi) Implant Using Atf-3 And Cjun, Sarita Bhetawal
Bioengineering Theses - Archive
Currently available peripheral nerve regenerative interfaces such as the sieve and the micro-channel regenerative electrode, intended to be used for the control and natural feel from advanced robotic prosthetic devices, eventually fail due to nerve damage due to axonopathy. The Regenerative Multi-electrode array (REMI) developed in our lab overcomes this limitation by providing a non-obstructive pathway for regenerating axons. However, it is possible that the mismatch at the electrode-tissue interface may cause axonal injury during limb stretching. In order to determine if micro-motion at the REMI causes neuronal injury I evaluated the nuclear expression of Activating Transcription Factor 3 (ATF-3), …
Surface Modification Of Magnetic Nanoparticles For Formulation Of Photoluminescent Polymer-Coated Magnetic Nanoparticles To Detect And Treat Cancers, Tejaswi Dhanpal Kadapure
Surface Modification Of Magnetic Nanoparticles For Formulation Of Photoluminescent Polymer-Coated Magnetic Nanoparticles To Detect And Treat Cancers, Tejaswi Dhanpal Kadapure
Bioengineering Theses - Archive
Cancer has been one of the leading causes of death worldwide that necessitates the development of theranostic systems for effective cancer management. Previously, we developed biodegradable-photoluminescent polymer coated magnetic nanoparticles (BPLP-MNPs) as a theranostic system for cancer management. These BPLP-MNPs were highly stable with excellent biocompatibility and consisted of magnetic targeting and imaging capabilities. However, these particles experienced reduced fluorescence due to the presence of dark/blackness of MNPs, which absorbs excited/emitted light. Therefore, it was hypothesized that surface modification on MNPs can overcome this limitation and enhance fluorescence for BPLP-MNPs.The goal of this research was therefore to employ various surface …
Micromotion And Scarring Do Not Contribute To Failure Of Regenerative Peripheral Neural Interfacing, Nivedita Khobragade
Micromotion And Scarring Do Not Contribute To Failure Of Regenerative Peripheral Neural Interfacing, Nivedita Khobragade
Bioengineering Theses - Archive
Neuroprosthetics facilitate amputees with motor function restoration by interfacing nervous system with artificial limb and enabling control of the prosthetic device by volitional thought. Though such neurointerfacing provides dexterity nearly mimicking natural limb agility, the clinical viability of such prosthetics is limited by the lack of long-term reliability. In central nervous system, these implants fail due to foreign body reaction and glial scar formation around the implant. The cause of decrease in active sites of interfacing in peripheral nervous system, which is less invasive than central nervous system implantation, has not been established. Recently an open architecture, regenerative peripheral neural …
Methodology Of Citrate-Based Biomaterial Development And Application, M. Richard Tran
Methodology Of Citrate-Based Biomaterial Development And Application, M. Richard Tran
Bioengineering Dissertations - Archive
Biomaterials play central roles in modern strategies of regenerative medicine and tissue engineering. Attempts to find tissue-engineered solutions to cure various injuries or diseases have led to an enormous increase in the number of polymeric biomaterials over the past decade. The breadth of new materials arises from the multiplicity of anatomical locations, cell types, and mode of application, which all place application-specific requirements on the biomaterial. Unfortunately, many of the currently available biodegradable polymers are limited in their versatility to meet the wide range of requirements for tissue engineering. Therefore, a methodology of biomaterial development, which is able to address …
Investigation Of Neural Correlates Between Perception Of Pain And Hemodynamic Response Measured In The Pre-Frontal Cortex Using Functional Near Infra-Red Spectroscopy, Venkatagiri Krishnamurthy
Investigation Of Neural Correlates Between Perception Of Pain And Hemodynamic Response Measured In The Pre-Frontal Cortex Using Functional Near Infra-Red Spectroscopy, Venkatagiri Krishnamurthy
Bioengineering Dissertations - Archive
Perception of pain is multi-dimensional, comprising three major psychological dimensions: sensory-discriminative, motivational-affective and cognitive-evaluative. This dissertation study investigates the cognitive evaluation of pain, by acquiring functional Near Infra-Red Spectroscopic (fNIRS) measurements from the prefrontal cortex (PFC) areas, during mechanical and thermal pain stimulation induced on the subject's volar forearm. Clustered-wise analysis on the oxy-hemoglobin (HbO) response from specific PFC areas was followed by categorizing the resulting HbO response into early (0.1-12sec) and late (12.1-25sec) phases. For each respective phase, regression analysis was carried between the HbO-derived parameters and behaviorally measured pain rating. The major findings of this study include: (1) …
Novel Applications Of Compressed Sensing To Magnetic Resonance Imaging And Spectroscopy, Sairam Geethanath
Novel Applications Of Compressed Sensing To Magnetic Resonance Imaging And Spectroscopy, Sairam Geethanath
Bioengineering Dissertations - Archive
In this work, three novel applications of compressed sensing to MRI have been developed and implemented which accomplish reduction in acquisition time, thereby also enabling increased spatial and/or temporal resolution. The first application is for reducing the acquisition time of conventional 1H magnetic resonance spectroscopic imaging (MRSI), which requires alongeracquisition time than conventional MRI. The implementation involved exploiting the inherent sparsity of the MRSI data in the wavelet domain by the use of Daubechies wavelet. This was demonstrated on an in vitro phantom, 6 healthy human brain MRSI data sets, 2 brain and prostate cancer data sets. The reconstructions were …
Novel ¹H Mr Probes To Interrogate The Tumor Microenvironment, Praveen Kumar Gulaka
Novel ¹H Mr Probes To Interrogate The Tumor Microenvironment, Praveen Kumar Gulaka
Bioengineering Dissertations - Archive
The term "tumor microenvironment" usually refers to the description of the physiological and metabolic conditions within solid tumors (primary or metastatic), and is significantly different from that of normal tissues. Assessment of factors like pH, tissue oxygen tension (pO2) and gene expression in the tumor microenvironment and the ability to image them in vivo can provide useful prognostic information. For example, hypoxia (low pO2), typically distributed heterogeneously in solid tumors, is known to affect both radiation sensitivity and the development of metastases thereby influencing the response to treatment. This dissertation research focuses on the evaluation of novel probes to interrogate …
Wireless Closed-Loop Feedback Systems For Automatic Detection And Suppression Of Nociceptive Signals, Aydin Farajidavar
Wireless Closed-Loop Feedback Systems For Automatic Detection And Suppression Of Nociceptive Signals, Aydin Farajidavar
Bioengineering Dissertations - Archive
Chronic pain is an important public health issue. Several approaches have been implemented for management of chronic pain, including surgical implantation of neurostimulators. Neurostimulators have been used in clinics for spinal cord implantation and they have been suitable for relieving certain types of pains, such as neuropathic pain in leg or arm, complex regional pain, and refractory angina. The stimulation at spinal cord has little relieving effects on syndromes such as facial pain, cluster headache, phantom limb pain, and post stroke pain. For treating such syndromes, electrical stimulation of deep brain structures such as thalamic nuclei (e.g. ventroposterolateral (VPL) or …
Cell Specific Guidance Of Nerve And Vascular Regeneration Through Sustained Growth Factor Release, Parisa Lotfi
Cell Specific Guidance Of Nerve And Vascular Regeneration Through Sustained Growth Factor Release, Parisa Lotfi
Bioengineering Dissertations - Archive
Regenerative peripheral nerve interfaces have been proposed as viable alternatives for the natural control of robotic prosthetic devices. However, sensory and motor axons at the neural interface are of mixed submodality types, which difficult the specific recording from motor axons and the eliciting of precise sensory modalities through selective stimulation. Here we evaluated the possibility of using type-specific neurotrophins to preferentially entice the regeneration of defined axonal populations from injured peripheral nerves. Segregation of mixed sensory fibers from dorsal root ganglion neurons was evaluated in vivo by compartmentalized diffusion delivery of nerve growth factor (NGF) and neurotrophin-3 (NT-3), to preferentially …
Photosynthetically Active Protoplasts For Power Scavenging, Absorbance And Optical Density Analysis, Ahmed Shahid
Photosynthetically Active Protoplasts For Power Scavenging, Absorbance And Optical Density Analysis, Ahmed Shahid
Bioengineering Theses - Archive
Plants and photosynthetic bacteria hold protein molecular complexes that can efficiently harvest photons. This paper presents fundamental studies to harness photochemical activities by converting photonic energy into electrical energy. The electrical behavior of protoplast extracted from Arabidopsis plants was characterized in the presence and absence of light. The photo-induced reactions of photosynthesis were measured using a patch clamp measurement system at a constant voltage. This research also reports the absorbance and optical density measurements showing very large bandwidth for extracted protoplasts. The optical measurements were performed on the protoplast Arabidopsis and showed absorption bands at a number of wavelengths. The …
An Investigation Of Support Vector Machine Classifier In Detecting Nocturnal Airway Obstruction From Spontaneous Heart Rate Combined With Ecg Morphology Changes, Harshan Ravi
Bioengineering Theses - Archive
Sleep apnea is a sleep disordered breathing resulting from limitation or cessation to breathing for 10 or more seconds. The prevalence of sleep apnea has increased exponentially in the past decade. The increase in epidemic in sleep apnea is associated with increase in the cases of obesity. It is estimated that 12-18 million of American adults suffer from sleep apnea, which is a sizable sector of the adult population. Sleep apnea is risk factor for hypertension, type II diabetes, and congestive heart failure. Sleep apnea may go undiagnosed for a long period of time after its onset due to complexity …
Characterization Of Multifunctional Biodegradable - Biocompatible Icg-Loaded Nanoparticles And Their Feasibility For Prostate Cancer Imaging And Phototherapy, Ronak Patel
Bioengineering Theses - Archive
Prostate cancer is the most common male cancer in the United States, and the second leading cause of cancer death in men. The conventional diagnostic procedures use an invasive approach to collect the biopsy tissue samples. Also, treatments currently used include radiotherapy, chemotherapy and surgical removal of the prostate associated with high risks of surgical complications. Among all the imaging modalities, Near Infrared (NIR) optical imaging could be a possible candidate for minimally invasive diagnosis of prostate cancer with avoidance of harmful radiation and relatively low cost. This motivation brings the development of multifunctional polymeric (di- lactide-co-glycolic acid) (PLGA) Nanoparticles …
Organic Biocompatible Nanolayered Polymerization Of Solid-State Devices, Sri Divya Vidyala
Organic Biocompatible Nanolayered Polymerization Of Solid-State Devices, Sri Divya Vidyala
Bioengineering Theses - Archive
Nanotechnology plays a major role in today's society due to its convergence of nanoscale which is the level of atoms and molecules as a part of miniaturization trend. The interference between biomedical and nanotechnology are of intense research. It concerns about the utilization of miniature biological systems such as nucleic acids, proteins, cells and cellular components to fabricate functional organic and inorganic nanostructures. This research work focuses on the process of developing a simple method to obtain fluorinated organic nanocoating which can be used to coat 3D structures and also explain the extended applications of the coating in the fields …
Substrate Stiffness Adjustable Pdms Device/Array For Understanding Its Effect On Cell Growth, Differentiation And Migration, Chetan Bhuwania
Substrate Stiffness Adjustable Pdms Device/Array For Understanding Its Effect On Cell Growth, Differentiation And Migration, Chetan Bhuwania
Bioengineering Theses - Archive
The mechanical properties of the cellular environment play an important role in the functioning of the cell. Cells attach to the extracellular matrix or other surrounding cells, thus sensing their mechanical properties and tune their own internal mechanical properties accordingly. A number of in vitro studies have been performed to study various cellular mechanical phenomena, but most of them employ a very stiff substrate such as glass or plastic that does not encompass the physiologically relevant range. Also, for tissues of the nervous system, the relationship between the substrate stiffness and the cellular behavior is less understood. In this study, …
Diagnosis Of Breast Cancer Using Auto-Flourescence Lifetime And Light Reflectance Spectroscopy: A Potential Tool For Positive Margin Assessment, Shivaranjani Shivalingaiah
Diagnosis Of Breast Cancer Using Auto-Flourescence Lifetime And Light Reflectance Spectroscopy: A Potential Tool For Positive Margin Assessment, Shivaranjani Shivalingaiah
Bioengineering Theses - Archive
Malignant Breast Neoplasm (MBN) or breast cancer is a heterogeneous cancer type originating in the breast tissue. Surgery is considered the primary treatment for breast cancer, with many early stage patients being cured without recurrence. The goals of the surgery include complete resection of the primary tumor, with negative margins to reduce the risk of local recurrences. Further, pathological staging of the tumor and axillary lymph nodes are carried out to extract necessary prognostic information. Surgery works well in case of complete Mastectomies. However, the biggest challenge for this technique is determining adequate margins on the partial mastectomy (lumpectomy) specimen. …
A Viscoelastic Model For Human Prolapsed Vaginal Wall Tissue, Milton Ma
A Viscoelastic Model For Human Prolapsed Vaginal Wall Tissue, Milton Ma
Bioengineering Theses - Archive
Pelvic organ prolapse (POP) affects thousands of elderly women each year. Improvements in surgical repair could benefit from the understanding of the biomechanical properties of the vaginal wall (VW) tissues to better tailor the needed repair. VW tissue property has been measured by uniaxial tensile test on excised fresh human anterior VW tissues. Data available, however, are limited to elastic modulus obtained in vitro. Recently, in vivo biomechanical data of VW from POP patients have been obtained by adapting a cutometer-like device, the BTC-2000TM (SRLI). The Voigt and Standard Linear models in conjunction with the framework of quasi-linear viscoelasticity theory …
3-Dimensional Scanning And Reconstruction Using A Modified Hrt-Rcm Corneal Confocal Microscope, Saurabh Vaidya
3-Dimensional Scanning And Reconstruction Using A Modified Hrt-Rcm Corneal Confocal Microscope, Saurabh Vaidya
Bioengineering Theses - Archive
The HRT II - Rostock Corneal Module (HRT II-RCM) provides excellent resolution, contrast and optical sectioning capability for cornea imaging. It offers the most detailed views of cornea structure and pathology. However, the major limitation of this microscope is its scanning method. It has a threaded dial on the front side of the microscope which is coupled to the objective, and this dial has to be rotated manually to change the focal plane and to scan through the cornea.The dial is within inches of the cornea. During the scans, manual control causes serious interference and degrades the quality of the …
Optimization Of Hydrogel System For Complex Wound Healing, Nikhil Vilas Aphale
Optimization Of Hydrogel System For Complex Wound Healing, Nikhil Vilas Aphale
Bioengineering Theses - Archive
Various conventional therapies and preventive measures have been developed and used for treating complex wounds; however, patients with complex wounds still develop wound infection and consist of delayed wound healing. These limitations necessitate the development of a novel therapeutic system, which is cost effective, easily apply onto the complex wounds, and consists of an efficient therapeutic nature. An in situ forming hydrogel system, made up of a novel biodegradable elastomer poly (ethylene glycol) maleate citrate (PEGMC), was designed and optimized for complex wound healing. Biocompatibility of this hydrogel system was studied by determining the toxicity of both the formation factors, …