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Articles 181 - 210 of 366
Full-Text Articles in Biomedical Engineering and Bioengineering
Development Of A Model To Simulate The Single-Limb Stance Phase Of Walking To Determine The Limits Of Stability, Clifford Lee Hancock
Development Of A Model To Simulate The Single-Limb Stance Phase Of Walking To Determine The Limits Of Stability, Clifford Lee Hancock
Bioengineering Theses - Archive
Falls during walking are the primary cause of injuries for older persons and present a high associated cost to society due to the resulting treatment. Hence, the control of balance while moving is an essential issue especially amongst the elderly population. Better understanding of why and how these falls occur could lead to better fall prevention methods, therapies, or devices. These changes could effectively decrease overall emergency room visits, create more room in hospitals for other demands, and decrease medical costs for fall-related disabilities and deaths amongst patients overall. This study attempted to develop an inverted pendulum model of the …
Microfluidic Device For Determining Preferential Cell Migration Toward Extracellular Matrix Proteins, Neil Hall
Microfluidic Device For Determining Preferential Cell Migration Toward Extracellular Matrix Proteins, Neil Hall
Bioengineering Theses - Archive
Extracellular matrix (ECM) proteins interact with cells in bodily microenvironments by influencing their essential cellular processes in growth, survival, migration and repair after injury. In this study, a novel microfluidic device was developed to study preferential interactions of cells with multiple extracellular matrix proteins simultaneously in an unbiased manner. The implementation of PDITC-treated glass and a controlled laminar flow of multiple separated, soluble proteins was used to create an unbiased microenvironment in which ECM proteins are adsorbed on the glass surface in a manner that simultaneously exposes cells to multiple proteins, and allows them to migrate or outgrow toward the …
Recombinant Expression, Purification And Kinetic Characterization Of F₄₂₀-Cofactor Dependent Glucose-6-Phosphate Dehydrogenase From Mycobacterium Tuberculosis, Tijani Osumah
Bioengineering Theses - Archive
The FGD (F₄₂₀-dependent Glucose-6-phosphate dehydrogenase) enzyme is an F₄₂₀ Cofactor (7,8-didemethyl-8-hydroxy-5-deazariboflavin) dependent enzyme found in Mycobacterium tuberculosis, the causative agent of tuberculosis (TB). TB is still a prominent cause of illness and death worldwide. Because FGD is not found in humans, makes it a good target for drug development. By understanding the hydride transfer mechanism of the FGD in detail, we can aid in the improvement of drug targeting and development for the treatment of TB. FGD catalyzes the conversion of glucose-6-phosphate to 6-phosophogluconolactone. This project focuses on the purification and kinetic characterization of recombinant FGD using steady-state and pre-steady …
Nanomaterials For Photo-Based Diagnostic And Therapeutic Applications, Baohong Yuan, Jyothi Unnikrishna Menon, Khanh Vu, Parth V. Jadeja, Kytai Truong Nguyen, Pranjali P. Tambe
Nanomaterials For Photo-Based Diagnostic And Therapeutic Applications, Baohong Yuan, Jyothi Unnikrishna Menon, Khanh Vu, Parth V. Jadeja, Kytai Truong Nguyen, Pranjali P. Tambe
Bioengineering Faculty Publications - Archive
Photo-based diagnosis and treatment methods are gaining prominence due to increased spatial imaging resolution, minimally invasive modalities involved as well as localized treatment. Recently, nanoparticles (NPs) have been developed and used in photo-based therapeutic applications. While some nanomaterials have inherent photo-based imaging capabilities, others including polymeric NPs act as nanocarriers to deliver various fluorescent dyes or photosensitizers for photoimaging and therapeutic applications. These applications can vary from Magnetic Resonance Imaging (MRI) and optical imaging to photothermal therapy (PTT) and chemotherapy. Materials commonly used for development of photo-based NPs ranges from metal-based (gold, silver and silica) to polymer- based (chitosan, dextran, …
Investigation Of Nanoparticle Delivery To Cancer Cells By Conjugation With Various Targeting Moieties, Leila Hossein Rashidi
Investigation Of Nanoparticle Delivery To Cancer Cells By Conjugation With Various Targeting Moieties, Leila Hossein Rashidi
Bioengineering Theses - Archive
Recently, mapping and profiling of specific tumor biomarkers characterizing cancer cells, followed by understanding of signal cascades involved in the pathogenesis of tumors (targeted therapy), as well as diagnosis in early stages, have become promising topics in cancer research. Since, the most considerable limitations of conventional therapies and diagnostic modalities are associated with nonspecific targeting; designing intelligent new anti-cancer nanocarries improved by targeting biomolecules could enhance therapeutic efficiencies as well as diagnosis in early stage of cancer. Active targeting which is based on the surface accessibility and the high level of expression of specific cancer antigens has attracted much attention …
Effect Of Body Mass Index On The Biomechanical Properties Of Anterior Vaginal Wall Tissue Of Prolapsed Patients, Sandra Gabriela Ochoa Lopez
Effect Of Body Mass Index On The Biomechanical Properties Of Anterior Vaginal Wall Tissue Of Prolapsed Patients, Sandra Gabriela Ochoa Lopez
Bioengineering Theses - Archive
Anterior Vaginal Wall (AVW) prolapse is a bothersome condition that affects thousands of women. Its onset and progression is not well understood but is thought to be multifactorial. Biomechanical properties of AVW tissue from prolapsed patients have been measured in-vitro using excised tissue specimens with great variability found in results, possibly from differences in tissue preparation, setting, preservation time, temperature, hydration, etc. In-vivo test using a BTC-2000TM cutometer-like device has recently been developed that measures the tissue uplift under suction pressure load. In this study, a systematical analysis of biomechanical property measurements from AVW tissues was done, including both in-vitro …
Measurement Of Transverse Relaxation Times Of Cerebral Metabolites In Brain Tumors, Akshay Madan
Measurement Of Transverse Relaxation Times Of Cerebral Metabolites In Brain Tumors, Akshay Madan
Bioengineering Theses - Archive
Proton (¹H) magnetic resonance spectroscopy (MRS) provides a non-invasive means of assessing metabolite concentration for a range of biologically important cerebral compounds in vivo. To extract quantitative information, additional data regarding proton spin relaxation phenomena is critical. Transverse relaxation times (T₂) of cellular metabolites depend on the local molecular environment in which they reside. Several neurological diseases alter the molecular environment, which may be reflected in the changes of the T₂ relaxation times. Therefore alterations in T₂ in tumors may provide important information about the local environment and a potential non-invasive diagnostic tool. Thirty-seven adult patients with gliomas and 11 …
Microfluidic Chip-Based Fabrication Of Hollow Alginate Microfiber For Enzyme Entrapment And Reaction, Uyen Hoang Thao Pham
Microfluidic Chip-Based Fabrication Of Hollow Alginate Microfiber For Enzyme Entrapment And Reaction, Uyen Hoang Thao Pham
Bioengineering Theses - Archive
This thesis demonstrates a simple process to generate alginate hollow microfibers by using a non-lithographic PDMS microfluidic device. The microfluidic device was fabricated by a novel template method in a wet lab without the support of any conventional lithography techniques. The relationships of the flow rate and the diameter of hollow alginate fibers were characterized. It was found that the outer diameter of the alginate hollow fiber was independent of the flow rate, but the core flow and sheath flow played an important role to control the internal diameter and the wall thickness of the alginate hollow microfiber. At a …
Design, Fabrication And Evaluation Of A Novel Microfluidic Based In Vitro Cell Migration Assay, Sai Sirisha Dhavala
Design, Fabrication And Evaluation Of A Novel Microfluidic Based In Vitro Cell Migration Assay, Sai Sirisha Dhavala
Bioengineering Theses - Archive
Microfabrication and microfluidic devices have been recognized as potential platforms for cell-based and drug screening studies. Human glioblastoma multiforme (hGBM) cells migrate inside the central nervous system (CNS) in narrow space constrictions and rarely metastasize through bloodstream. Hence, microfluidic devices consisting of narrow channels are considered as suitable models to study cell migration in vitro. Further the migratory capability of each individual cell could be easily obtained and quantified using such system. This effort presents the design and development of an alternative microfluidic system that provides an integrated array of channels for screening multiple drugs simultaneously. This system is an …
Reliable Frontal Cortex Activity For An Oral Stroop Task Using Functional Near Infrared Spectroscopy, Matthew Allen Cloud
Reliable Frontal Cortex Activity For An Oral Stroop Task Using Functional Near Infrared Spectroscopy, Matthew Allen Cloud
Bioengineering Theses - Archive
Analysis tools such as HomER and NIRS-SPM for functional Near-Infrared systems are commercially or freely available; however, they are difficult for clinicians to use as an assessment tool. One barrier to their use is the reliability of a given functional test. Intraclass correlation coefficients (ICC) provide a measure of group and individual reliability. NIRS-SPM was extended with ICC to assess a two part modified Stroop task. The protocol was repeated once every two weeks over a period of one month. Changes in neural activity attributed to inhibition of distraction, show significant covariance to the protocol with moderate to strong reliability …
Auto-Fluorescence Lifetime And Light Reflectance Spectroscopy For Breast Cancer Diagnosis: Potential Tools For Intraoperative Margin Detection, Vikrant Sharma, Shivaranjani Shivalingaiah, Yan Peng, David Euhus, Zygmunt Gryczynski, Hanli Liu
Auto-Fluorescence Lifetime And Light Reflectance Spectroscopy For Breast Cancer Diagnosis: Potential Tools For Intraoperative Margin Detection, Vikrant Sharma, Shivaranjani Shivalingaiah, Yan Peng, David Euhus, Zygmunt Gryczynski, Hanli Liu
Bioengineering Faculty Publications - Archive
This study investigates the use of two spectroscopic techniques, auto-fluorescence lifetime measurement (AFLM) and light reflectance spectroscopy (LRS), for detecting invasive ductal carcinoma (IDC) in human ex vivo breast specimens. AFLM used excitation at 447 nm with multiple emission wavelengths (532, 562, 632, and 644 nm), at which autofluorescence lifetimes and their weight factors were analyzed using a double exponent model. LRS measured reflectance spectra in the range of 500-840 nm and analyzed the spectral slopes empirically at several distinct spectral regions. Our preliminary results based on 93 measured locations (i.e., 34 IDC, 31 benign fibrous, 28 adipose) from 6 …
Improving Optical Contact For Functional Near-Infrared Brain Spectroscopy And Imaging With Brush Optodes, Bilal Khan, Chester Wildey, Robert Francis, Fenghua Tian, Mauricio R. Delgado, Hanli Liu, Duncan Macfarlane, George Alexandrakis
Improving Optical Contact For Functional Near-Infrared Brain Spectroscopy And Imaging With Brush Optodes, Bilal Khan, Chester Wildey, Robert Francis, Fenghua Tian, Mauricio R. Delgado, Hanli Liu, Duncan Macfarlane, George Alexandrakis
Bioengineering Faculty Publications - Archive
A novel brush optode was designed and demonstrated to overcome poor optical contact with the scalp that can occur during functional near infrared spectroscopy (fNIRS) and imaging due to light obstruction by hair. The brush optodes were implemented as an attachment to existing commercial flat-faced (conventional) fiber bundle optodes. The goal was that the brush optodes would thread through hair and improve optical contact on subjects with dense hair. Simulations and experiments were performed to assess the magnitude of these improvements. FNIRS measurements on 17 subjects with varying hair colors (blonde, brown, and black) and hair densities (0–2.96 hairs/mm2 ) …
Sparsity Enhanced Spatial Resolution And Depth Localization In Diffuse Optical Tomography, Venkaiah C. Kavuri, Zi-Jing Lin, Fenghua Tian, Hanli Liu
Sparsity Enhanced Spatial Resolution And Depth Localization In Diffuse Optical Tomography, Venkaiah C. Kavuri, Zi-Jing Lin, Fenghua Tian, Hanli Liu
Bioengineering Faculty Publications - Archive
No abstract provided.
Real-Time Detection Of Implant-Associated Neutrophil Responses Using A Formyl Peptide Receptor-Targeting Nir Nanoprobe, Jun Zhou, Tsai Yi-Ting, Hong Weng, Ewin N. Tang, Ashwin Nair, Dave P. Digant, Liping Tang
Real-Time Detection Of Implant-Associated Neutrophil Responses Using A Formyl Peptide Receptor-Targeting Nir Nanoprobe, Jun Zhou, Tsai Yi-Ting, Hong Weng, Ewin N. Tang, Ashwin Nair, Dave P. Digant, Liping Tang
Bioengineering Faculty Publications - Archive
Neutrophils play an important role in implant-mediated inflammation and infection. Unfortunately, current methods which monitor neutrophil activity, including enzyme measurements and histological evaluation, require many animals and cannot be used to accurately depict the dynamic cellular responses. To understand the neutrophil interactions around implant-mediated inflammation and infection it is critical to develop methods which can monitor in vivo cellular activity in real time. In this study, formyl peptide receptor (FPR)-targeting nearinfrared nanoprobes were fabricated. This was accomplished by conjugating near-infrared dye with specific peptides having a high affinity to the FPRs present on activated neutrophils. The ability of FPR-targeting nanoprobes …
Investigations Into Causes Of Failure Of Regenerative Peripheral Nerve Interfaces, R. Collins Watson
Investigations Into Causes Of Failure Of Regenerative Peripheral Nerve Interfaces, R. Collins Watson
Bioengineering Dissertations - Archive
All highly selective methods of neural interfacing for mental control of a robotic prosthesis tested to date have exhibited high rates of failure over time. Regenerative peripheral nerve interfaces (RPNIs) may offer the greatest potential among the proposed technologies for providing the number of degrees of freedom necessary to control a robotic limb, but are unacceptable for clinical use due to several shortcomings of current technology: (1) all RPNIs tested to date have exhibited signal loss over time due to biological mechanisms of rejection of implanted electrodes; (2) all chronically tested interfaces have suffered from high rates of device failure …
Pleiotrophin Enhance Nerve Regeneration Across Long Gap Peripheral Nerve Defects, Swarup Narayan Dash
Pleiotrophin Enhance Nerve Regeneration Across Long Gap Peripheral Nerve Defects, Swarup Narayan Dash
Bioengineering Dissertations - Archive
Peripheral nerve injuries resulting in extensive loss in nerve continuity pose a challenge in reconstructive surgery. Autografts still remain the treatment of choice for nerve defects despite the need of donor nerve harvest and the associated morbidity of this procedure. In contrast to short gap injuries, isografts achieve sub normal functional recovery for gaps longer than a critical 30 mm length, and simple tubularization methods fail completely. The regenerative failure of peripheral nerves through long gaps can be postulated to the lack of appropriate growth substrate and trophic support. We hypothesize that for successful nerve regeneration across long-gap nerve defects, …
Magnetic-Based Theranostic Nanoparticles For Prostate Cancer Management, Aniket Sharadrao Wadajkar
Magnetic-Based Theranostic Nanoparticles For Prostate Cancer Management, Aniket Sharadrao Wadajkar
Bioengineering Dissertations - Archive
With an increasing rate of cancers, the need for effective cancer management has led to the development of theranostic systems for diagnosis and therapy. Conventional techniques for cancer management have limited success due to inaccurate diagnosis and treatment side effects. Development of magnetic-based theranostic nanoparticles (MBTN) may overcome these limitations with the advantages of magnetic nanoparticles (MNPs) such as magnetic targeting, hyperthermia, and magnetic resonance imaging (MRI) contrast agents; and advantages of polymer coatings for carrying payloads and allowing bioconjugation for active targeting applications. Aim of this research was to develop multifunctional MBTNs for prostate cancer management. First, biodegradable photoluminescent …
A Novel Minimally Invasive Dual-Modality Fiber Optic Probe For Prostate Cancer Detection, Vikrant Sharma
A Novel Minimally Invasive Dual-Modality Fiber Optic Probe For Prostate Cancer Detection, Vikrant Sharma
Bioengineering Dissertations - Archive
Prostate cancer is the most common form of cancer in males, and is the second leading cause of cancer related deaths in United States. In prostate cancer diagnostics and theapy, there is a critical need for a minimally invasive tool for in vivo evaluation of prostate tissue. Such a tool finds its niche in improving TRUS (trans-rectal ultrasound) guided biopsy procedure, surgical margin assessment during radical prostatectomy, and active surveillance of patients with a certain risk levels. This work is focused on development of a fiber-based dual-modality optical device (dMOD), to differentiate prostate cancer from benign tissue, in vivo. dMOD …
Methodology Of Citric Acid Based Functional Biomaterial Development And Application, Yi Leaf Zhang
Methodology Of Citric Acid Based Functional Biomaterial Development And Application, Yi Leaf Zhang
Bioengineering Dissertations - Archive
Biomaterials play critical roles in modern strategies of biomedical applications, such as tissue engineering, and theranostic therapy. Attempts to design ideal biomaterials for each specific application have led to an enormous increase in the number of polymeric biomaterials. Different biomedical applications require specific functionality of biomaterials. Unfortunately, the limited versatility of currently available biodegradable polymers fails to meet the wide range of requirement for biomedical applications. Therefore, a methodology of functional biomaterials development would be beneficial to the biomaterial field. It has been proved that citric acid can be utilized as a key element in the development of novel biodegradable …
Phase Sensitive Spectral Domain Interferometry For Label Free Biomolecular Interaction Analysis And Biosensing Applications, Sajal Chirvi
Phase Sensitive Spectral Domain Interferometry For Label Free Biomolecular Interaction Analysis And Biosensing Applications, Sajal Chirvi
Bioengineering Dissertations - Archive
Biomolecular interaction analysis (BIA) plays vital role in wide variety of fields, which include biomedical research, pharmaceutical industry, medical diagnostics, and biotechnology industry. Study and quantification of interactions between natural biomolecules (proteins, enzymes, DNA) and artificially synthesized molecules (drugs) is routinely done using various labeled and label-free BIA techniques. Labeled BIA (Chemiluminescence, Fluorescence, Radioactive) techniques suffer from steric hindrance of labels on interaction site, difficulty of attaching labels to molecules, higher cost and time of assay development. Label free techniques with real time detection capabilities have demonstrated advantages over traditional labeled techniques. The gold standard for label free BIA is …
Application Of Scanning Correlation Spectroscopy Techniques To Quantify Dna Double Strand Break Repair Kinetics In The Living Cell After Exposure To Γ-Rays And Radiomimetic Chemicals, Salim Abdisalaam
Bioengineering Dissertations - Archive
The kinetics of most proteins involved in DNA damage sensing, signaling and repair following ionizing radiation exposure cannot be quantified by current live cell fluorescence microscopy methods. This is because most of these proteins, with only few notable exceptions, do not attach in large numbers at DNA damage sites to form easily detectable foci in microscopy images. As a result a high fluorescence background from freely moving and immobile fluorescent proteins in the nucleus masks the aggregation of proteins at sparse DNA damage sites. Currently, the kinetics of these repair proteins are studied by laser-induced damage and Fluorescence Recovery After …
Development Of Sers Nanoprobes For Multiplexed And Multi-Modality Molecular Diagnosis Of Cancer, James Otieno Nyagilo
Development Of Sers Nanoprobes For Multiplexed And Multi-Modality Molecular Diagnosis Of Cancer, James Otieno Nyagilo
Bioengineering Dissertations - Archive
Importance of cancer diagnosis and staging through molecular biomarker detection is evident in the increasing number of molecular biomarkers being discovered that are associated with specific cancers types with their role in disease severity and progression being elucidated. Development of molecular imaging modalities capable of simultaneously detecting multiple molecular biomarkers will have a major impact on research, detection, diagnosis, treatment and monitoring of cancer. Combining molecular imaging with high resolution structural imaging can potentially deliver a cancer diagnostic imaging platform with superior resolution and sensitivity. Nanotechnology, specifically in the form of functionalized metal nanoparticles exhibit unique chemical and electromagnetic properties …
Micro-Device For Selective Isolation And Cytology Of Cancer Cells, Yuan Wan
Micro-Device For Selective Isolation And Cytology Of Cancer Cells, Yuan Wan
Bioengineering Dissertations - Archive
Early detection and isolation of circulating tumor cells (CTCs) can enable early cancer diagnosis and more effective therapeutics. Aptamers have emerged as probe molecules that have binding affinities comparable to antibodies but specificities better than those of antibodies. Epidermal Growth Factor Receptor (EGFR) is the most frequently overexpressed receptor in all human malignancies. The expression levels of EGFR in cancer cells can be over 100 times higher than those in normal cells. It is an attractive target for cancer therapy and cancer cell isolation.This dissertation focuses on two different areas: developing strategies for anti-EGFR aptamer based cancer cell isolation, and …
Development Of Gelatin Microbubble Based Plga Scaffold For Application In Bone Tissue Engineering, Krishna M. Shah
Development Of Gelatin Microbubble Based Plga Scaffold For Application In Bone Tissue Engineering, Krishna M. Shah
Bioengineering Theses - Archive
The overall goal of the study was to develop a delivery system for a potential bone tissue engineering application focusing on fabrication of gelatin microbubble (MB) based PLGA scaffolds capable of recruiting Mesenchymal stem cells (MSCs) and delivering bioactive molecules. Challenges associated with inefficient use of stem cells, scaffolding techniques and poor understanding of the role of growth factors hinders the success of tissue engineering strategies. A major challenge with the use of autologous stem cells is its low proliferation and migratory capacity. Our lab previously established that using a biomaterial implant, autologous MSCs can be directed and recruited in …
Development Of Magnetic-Based Multi-Layer Microparticles For Stem Cell Isolation, Enrichment And Detachment, Sonia Santimano
Development Of Magnetic-Based Multi-Layer Microparticles For Stem Cell Isolation, Enrichment And Detachment, Sonia Santimano
Bioengineering Theses - Archive
Stem cells have been studied and used in several cell-based therapies for regenerative medicine, 3D tissue-engineered scaffolds, and in vitro models for drug screening and testing. For instance, cell based therapy via the use of stem cells like Endothelial Progenitor Cells (EPCs) to treat patients with cardiovascular diseases, including ischemic heart disease, in-stent restenosis, and peripheral arterial occlusive disease. In addition, Circulating Cancer Cells (CSCs) have been used as an indication of cancer progression-free survival and for studying the mechanisms of tumor formation, metastasis, and anti-cancer drug screening. Due to their extensive diagnostic and therapeutic potential, various techniques have been …
Quantification And Comparisons Of Motion Metrics For Finger Tapping Performed By Children With Cerebral Palsy Before And After Therapy With Two Motion Tracking Camera Systems, Ankita H. Chainani
Quantification And Comparisons Of Motion Metrics For Finger Tapping Performed By Children With Cerebral Palsy Before And After Therapy With Two Motion Tracking Camera Systems, Ankita H. Chainani
Bioengineering Theses - Archive
The quantification of any improvements in the use of a paretic arm after children with cerebral palsy (CP) undergo rehabilitation is currently done by occupational therapists who administer a series of manual ability tests and assign a subjective score for each test task performed. In this work the hypothesis was explored of whether quantification of hand motion metrics by motion tracking while children with CP performed a hand tapping task could be used as a more quantitative surrogate for assessing how well these children control the use of their hand. To that end, two children with CP, both classified as …
Spectrophotometric Quantification Of Bilirubin In Sclera Of The Eye Using Visible Dlp® Hyperspectral Imaging, Naveen Balaji Balasubramanian
Spectrophotometric Quantification Of Bilirubin In Sclera Of The Eye Using Visible Dlp® Hyperspectral Imaging, Naveen Balaji Balasubramanian
Bioengineering Theses - Archive
In clinical settings doctors strive to give best care to the patients by looking for methods to diagnose the illness early to intervene with the necessary treatment. In the case of patients with liver problems (e.g. cirrhosis, hepatitis) an early indicator of impaired liver function is an increased concentration of bilirubin in the blood circulation. Bilirubin concentration is currently quantified by blood sampling, which is invasive, and it would be desirable to have a technology that quantifies bilirubin non-invasively. The goal of this work was to help address this clinical need and develop a methodology for determining non-invasively a measure …
Antimicrobial Properties Of Citric Acid Based Polymers, Lee-Chun Su
Antimicrobial Properties Of Citric Acid Based Polymers, Lee-Chun Su
Bioengineering Theses - Archive
A series of citric acid derived polymers synthesized in our lab were investigated and compared for their physiochemical and antimicrobial properties. We selected citric acid based polymers since citric acid is a product of natural metabolism. These polymers are not only biocompatible but also possess an antimicrobial effect. In polymer synthesis, citric acid (CA) provides profound functional groups available for binding and crosslinking to allow the controllable crosslinking degrees of polymers. A number of citric acid based polymers has been synthesized and studied for their chemical, mechanical, and biological characteristics for use in various biomedical applications. Since bacterial infections became …
Regenerative Peripheral Nerve Interfacing Of Sensory Modalities, Nilanjana T. Dutta
Regenerative Peripheral Nerve Interfacing Of Sensory Modalities, Nilanjana T. Dutta
Bioengineering Theses - Archive
Peripheral neural interfaces (PNI) has proved potential to record motor commands for the control of these prosthetic limbs, together with stimulation of specific sensory axons, so as to transmit specific sensory sub-modalities. Although PNI is hypothesized to provide adequate sensory feedback, realizing this degree of specificity is not fully established. Recently, a regenerative multi-electrode interface (REMI) was reported to be capable of recording peripheral nerve activity from a transected nerve. This study is aimed at interfacing neural activity specific to sensory sub-modalities, such as thermal pain, mechanoception and limb stretching using the REMI, in a freely moving animal. In the …
Characterization Of Immune Response And Peripheral Nerve Regeneration Of Implanted Regenerative Multi-Electrode Interface Post-Subchronic Amputation, Camilo Andres Sanchez Useche
Characterization Of Immune Response And Peripheral Nerve Regeneration Of Implanted Regenerative Multi-Electrode Interface Post-Subchronic Amputation, Camilo Andres Sanchez Useche
Bioengineering Theses - Archive
Interfacing high degree-of-freedom robotic prosthetics directly to the peripheral nervous system aims at improving the quotidian life of amputees. Despite advancements in robotics that have lead to human-like upper limb prosthetics, long-term interfacing has not been accomplished, thus voiding them from clinical use. Interfacing electrodes in the central nervous system fail due to the foreign body reaction and glial scar formation at the site of implantation. Concrete mechanisms for the failure of long-term Interfacing at the peripheral nervous level remain unclear. A regenerative multi-electrode interface (REMI) which allows for action potential recording as early as 7 days and provides support …