Open Access. Powered by Scholars. Published by Universities.®
Biomedical Engineering and Bioengineering Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Bioimaging and Biomedical Optics (7)
- Life Sciences (7)
- Medicine and Health Sciences (4)
- Molecular, Cellular, and Tissue Engineering (4)
- Other Biomedical Engineering and Bioengineering (4)
-
- Bioelectrical and Neuroengineering (3)
- Biological Engineering (3)
- Biomedical Devices and Instrumentation (3)
- Electrical and Computer Engineering (3)
- Bioinformatics (2)
- Biomedical Informatics (2)
- Materials Science and Engineering (2)
- Mechanical Engineering (2)
- Neuroscience and Neurobiology (2)
- Physical Sciences and Mathematics (2)
- Signal Processing (2)
- Systems and Integrative Engineering (2)
- Translational Medical Research (2)
- Acoustics, Dynamics, and Controls (1)
- Amino Acids, Peptides, and Proteins (1)
- Analytical, Diagnostic and Therapeutic Techniques and Equipment (1)
- Animal Experimentation and Research (1)
- Applied Mathematics (1)
- Bacterial Infections and Mycoses (1)
- Behavioral Neurobiology (1)
- Biological Factors (1)
- Biomaterials (1)
- Biomechanical Engineering (1)
- Keyword
-
- Faculty (32)
- EEG (11)
- Nanoparticles (10)
- Photobiomodulation (10)
- FNIRS (8)
-
- Functional connectivity (7)
- Electroencephalography (5)
- Epilepsy (5)
- Transcranial photobiomodulation (5)
- Angiogenesis (4)
- Cancer (4)
- Functional near-infrared spectroscopy (4)
- In vivo imaging (4)
- Tissue engineering (4)
- Adhesion force (3)
- Cancer therapy (3)
- Cardiac biomechanics (3)
- Cytochrome c oxidase (3)
- Fluorescence imaging (3)
- Intraocular lens (3)
- Light reflectance spectroscopy (3)
- Machine learning (3)
- Magnetoencephalography (3)
- Metastasis (3)
- Microchannel (3)
- Migration (3)
- Myocardial infarction (3)
- Nanocomposites (3)
- Nanoparticle (3)
- PAD (3)
- Publication Year
- Publication
- Publication Type
- File Type
Articles 121 - 150 of 366
Full-Text Articles in Biomedical Engineering and Bioengineering
Interplay Between Up-Regulation Of Cytochrome-C-Oxidase And Hemoglobin Oxygenation Induced By Near-Infrared Laser, Xinlong Wang, Fenghua Tian, Sagar S. Soni, F. Gonzalez-Lima, Hanli Liu
Interplay Between Up-Regulation Of Cytochrome-C-Oxidase And Hemoglobin Oxygenation Induced By Near-Infrared Laser, Xinlong Wang, Fenghua Tian, Sagar S. Soni, F. Gonzalez-Lima, Hanli Liu
Bioengineering Faculty Publications - Archive
Photobiomodulation, also known as low-level laser/light therapy (LLLT), refers to the use of red-tonear-infrared light to stimulate cellular functions for physiological or clinical benefits. The mechanism of LLLT is assumed to rely on photon absorption by cytochrome c oxidase (CCO), the terminal enzyme in the mitochondrial respiratory chain that catalyzes the reduction of oxygen for energy metabolism. In this study, we used broadband near-infrared spectroscopy (NIRS) to measure the LLLT-induced changes in CCO and hemoglobin concentrations in human forearms in vivo. Eleven healthy participants were administered with 1064-nm laser and placebo treatments on their right forearms. The spectroscopic data were …
Functional Studies Of The Human Telomerase Holoenzyme, Mohammed E. Sayed
Functional Studies Of The Human Telomerase Holoenzyme, Mohammed E. Sayed
Bioengineering Dissertations - Archive
Telomeres are the DNA structures that cap the ends of linear chromosomes. In humans, telomeres are composed of the hexameric repeats TTAGGG. The reverse transcriptase, telomerase maintains the telomeres by adding the TTAGGG repeats to the chromosomes during cell division. In the absence of telomerase, telomere length limits the self-renewal capabilities of cells. Telomerase is expressed in approximately 90% of all human cancers, making it an almost universal therapeutic target as well as an important player in the progression from healthy to cancerous cell. The biophysical studies discussed in this thesis focus on expanding the understanding of the function and …
Intuitive Human Robot Interfaces For Upper Limb Prosthetics, Oguz Yetkin
Intuitive Human Robot Interfaces For Upper Limb Prosthetics, Oguz Yetkin
Bioengineering Dissertations - Archive
Modern robotic prosthetic devices for upper limb amputees promise to alleviate an important disability, but are underutilized due to the inability to properly control them. Specifically, the devices afford more degrees of freedom (DOFs) than are con- trollable by easily decoded biological signals. These devices, such as the DEKA arm, can have as many as 18 DOFs, although six is a more typical number (control of each finger plus thumb rotation). Unfortunately, the use of these devices remains limited by the ability of users to simultaneously control more than one degree of freedom at a time with commercially deployed technology. …
Centimeter-Deep Tissue Fluorescence Microscopic Imaging, Bingbing Cheng
Centimeter-Deep Tissue Fluorescence Microscopic Imaging, Bingbing Cheng
Bioengineering Dissertations - Archive
Fluorescence microscopic imaging in centimeter-deep tissue has been highly sought-after for many years because much interesting in vivo micro-information—such as microcirculation, tumor angiogenesis, and cancer metastasis—may deeply locate in tissue. However, it is very challenging because of strong tissue light scattering. This includes: how to confine the fluorescence emission into a small volume to achieve high spatial resolution; how to increase fluorescence emission efficiency to compensate the signal attenuation caused by small emission volume and tissue scattering/absorption; and how to reduce background fluorescence noise and exclusively differentiate signal photons from background photons to increase signal-to-noise ratio (SNR) and sensitivity. Ultrasonic …
Nanosturctured Biomaterials For Tissue Regeneration And Repair, Primana Punnakitikashem
Nanosturctured Biomaterials For Tissue Regeneration And Repair, Primana Punnakitikashem
Bioengineering Dissertations - Archive
Nanostructured materials have been explored in biomedical field especially in tissue engineering over a past decade. This type of material can be processed into biomaterial scaffolds; revealed many advantages to be used in human living system such as restoring, healing, replacing and improving the function of interested tissues or organs. In this work, nanostructured materials were synthesized as a nanofibrous scaffold or nanoparticles, which were characterized and tested for their biofunctions in the regeneration of blood vessels, lung and skin tissues. Firstly, biodegradable polyurethane nanofibrous scaffolds with dipyramole were electrospun to create a vascular graft, and results demonstrated that this …
Mapping Of Prefrontal Hemodynamic Responses To Noxious Stimulation And Chronic Pain Related Resting-State Functional Networks Assessed By Fnirs, Amarnath Yennu
Mapping Of Prefrontal Hemodynamic Responses To Noxious Stimulation And Chronic Pain Related Resting-State Functional Networks Assessed By Fnirs, Amarnath Yennu
Bioengineering Dissertations - Archive
Neural representations of chronic pain are complex and are least understood. Numerous magnetic resonance imaging (MRI) studies have revealed structural and functional abnormalities in several cortical and sub-cortical regions in subjects with chronic low-back pain (CLBP). A more recent MRI study has reported that structural and functional brain abnormalities in pain-treated patients with CLBP are reversible, demonstrating that an appropriate treatment of chronic pain can restore normal brain functions for the patients. Due to high cost, non-portability, and other restrictions of MRI, the development of a complementary brain imaging tool is therefore crucial in order to improve the understanding of …
Investigation Of Copling Strength And Directionality Between Eeg And Fnirs At Resting State Using Permutation Conditional Mutual Information, Gowtham Krishnan Murugesan
Investigation Of Copling Strength And Directionality Between Eeg And Fnirs At Resting State Using Permutation Conditional Mutual Information, Gowtham Krishnan Murugesan
Bioengineering Theses - Archive
The motivation of study is to combine multimodality approach EEG-fNIRS to study relationship between neural activity and hemodynamic response applying information theory concepts. Investigating human brain function can be improved by employing a multimodal neuroimaging approach. Since each neuroimaging modality has its own characteristic features especially in terms of spatial and temporal resolution integrating fNIRS responses with EEG could accurately characterize the neurovascular coupling in cortical regions selected as part of the brain network involved in motor and cognitive behavior. Simultaneous recording of fNIRS-EEG is therefore an important resource for studying aspects of neurovascular coupling and its relationship with pathological …
Investigating Causal Interactions In The Human Brain Using Eeg And Fnirs, Borzou Alipourfard
Investigating Causal Interactions In The Human Brain Using Eeg And Fnirs, Borzou Alipourfard
Bioengineering Theses - Archive
It is necessary for distributed neural assemblies to work in collaboration to achieve the most elementary brain functions. Activities within segregated neural assemblies are integrated to process an incredibly diverse collection of cognitive tasks. Measures such as correlation, cross-correlation, coherence and phase delay make limited use of the information that is available with the advanced multichannel and multimodal recordings of the brain’s activity. They can also give spurious and false results. Most importantly, these bivariate measures are not capable of describing the interaction among multiple neural assemblies and the effective connectivity among them. Through causality analysis, we can identify these …
Prefrontal Responses To Stroop Tasks In Subjects With Post-Traumatic Stress Disorder Assessed By Functional Near Infrared Spectroscopy, Amarnath Yennu, Fenghua Tian, Alexa Smith-Osborne, Robert J. Gatchel, Fu Lye Woon, Hanli Liu
Prefrontal Responses To Stroop Tasks In Subjects With Post-Traumatic Stress Disorder Assessed By Functional Near Infrared Spectroscopy, Amarnath Yennu, Fenghua Tian, Alexa Smith-Osborne, Robert J. Gatchel, Fu Lye Woon, Hanli Liu
Bioengineering Faculty Publications - Archive
No abstract provided.
An Actomyosin Driven, Pressure Based Adhesion Model Of Confined Glioblastoma Multiforme Cell Migration, Jamie Wright
An Actomyosin Driven, Pressure Based Adhesion Model Of Confined Glioblastoma Multiforme Cell Migration, Jamie Wright
Bioengineering Dissertations - Archive
Glioblastoma multiforme (GBM) is the most aggressive and common form of glial tumors arising in the support cells of the brain. Cell migration plays a critical role in undermining the surgical resection of tumors. Peripheral cells freely detach and invade the surrounding tissue, preferentially collecting and migrating within confined, mechanically distinct environments such as along the borders of white matter tracts and vasculature. These tracks have been mimicked experimentally using small, rectangular PDMS micro-channels. GBM cells will readily enter and migrate through these micro-channels in the absence of any chemoattractant, even without specific cell-substrate adhesion (integrins) if channel dimensions decrease …
Interactive Analytical Tool For Quantitative Corneal Confocal Imaging In Vivo, Madhavi Tippani
Interactive Analytical Tool For Quantitative Corneal Confocal Imaging In Vivo, Madhavi Tippani
Bioengineering Theses - Archive
The objective of this study was to develop an interactive software application for image reconstruction and analysis of the corneal data from an in vivo confocal microscope (Heidelberg Retinal Tomograph with Rostock Corneal Module, HRT-RCM). The optical sectioning ability of confocal microscopy gives high resolution optical section images at different depths within a thick tissue, thereby eliminating the need for physical sectioning. This ability of 4-dimensional (x,y,z and t) imaging makes confocal microscopy uniquely suited for imaging the cornea at the cellular level. The new program was developed to overcome the drawbacks of the original application “Confo” developed in the …
Computer Vision Algorithm Development And Biomedical Applications, Vasant Kearney
Computer Vision Algorithm Development And Biomedical Applications, Vasant Kearney
Bioengineering Dissertations - Archive
Supervising Professor: Liping Tang and Weihua Mao This study focuses on the development and analysis of novel computer vision algorithms for biomedical applications. Chapter 2 focuses on developing a 2D Canny edge-based DIR algorithm to register in vivo white light images taken at various time points. Using a mouse model, the accuracy of the canny edge-based DIR algorithm was tested using evaluation metrics, a ground truth synthetic scenario, and fluorescent gamma analysis. The results indicate that the Canny edge-based DIR algorithm performs better than all other algorithms. Chapter 3 focuses on the development of a novel longitudinal fluorescent signal tracking …
Investigation Of Prefrontal Cognition Responses To Transcranial Laser Stimulation In Ptsd Using Functional Near Infrared Spectroscopy, Dev Rajanikant Patel
Investigation Of Prefrontal Cognition Responses To Transcranial Laser Stimulation In Ptsd Using Functional Near Infrared Spectroscopy, Dev Rajanikant Patel
Bioengineering Theses - Archive
In recent years low level laser therapy (LLLT) has been of great research interest because of its therapeutic applications in psychiatry, neurology and ophthalmology. In-vivo transcranial delivery of LLLT has shown to induce beneficial metabolic effects and increase in cognitive functions and hence has been found to be useful in treating neurodegenerative disorders. The aim of this study was to evaluate effects of LLLT on prefrontal cognitive functions, namely attention and short term memory, over six sessions on veterans with Post-Traumatic Stress Disorder (PTSD), using near infrared spectroscopy (fNIRS). In this study the subjects were instructed to perform two neurocognitive …
Diffused Correlation Spectroscopy For Measurement Of Blood Perfusion During Low Level Laser Therapy (Lllt), Soni Sagar
Diffused Correlation Spectroscopy For Measurement Of Blood Perfusion During Low Level Laser Therapy (Lllt), Soni Sagar
Bioengineering Theses - Archive
Near infrared stimulation or Low Level Laser Therapy (LLLT) is an innovative technique shown to effect the microvasculature hemodynamics. The aim of this study is to use Diffused Correlation Spectroscopy (DCS) to evaluate the physiological effects of LLLT on blood perfusion. This study is divided into two parts: the fist part is the development of DCS system and the second part is investigating the effects of LLLT on biological tissue. DCS is an emerging non-invasive technique to probe deep tissue hemodynamics. DCS uses time-averaged intensity autocorrelation function for the fluctuations caused due to the moving scatterers (RBCs) in biological tissue. …
Manipulating The K-Space For Reduction Of Respiratory Induced Motion Artifacts, Maida Ranjbar
Manipulating The K-Space For Reduction Of Respiratory Induced Motion Artifacts, Maida Ranjbar
Bioengineering Theses - Archive
Respiratory induced motion artifacts, particularly those occurring in the abdomen and lung, pose a hefty problem in current diagnostic MR imaging. Application of images plagued with such artifacts not only hinder diagnosis, but may result in the enforcement of undesirably large safety margins in radiation therapy due to un-captured tumor characteristics that are concealed by the artifact. While several methods such as gated scans, breath-hold scans, variation of the K-Space acquisition trajectory, and reducing the scan time via partial acquisition or parallel imaging have been proposed as a solution, a robust and yet simple to implement remedy still remains to …
Dimensionality Reduction Based Optimization Algorithm For Sparse 3-D Image Reconstruction In Diffuse Optical Tomography, Tanmoy Bhowmik, Hanli Liu, Zhou Ye, Soontorn Oraintara
Dimensionality Reduction Based Optimization Algorithm For Sparse 3-D Image Reconstruction In Diffuse Optical Tomography, Tanmoy Bhowmik, Hanli Liu, Zhou Ye, Soontorn Oraintara
Bioengineering Faculty Publications - Archive
No abstract provided.
Wavelet Coherence Analysis Of Dynamic Cerebral Autoregulation In Neonatal Hypoxic–Ischemic Encephalopathy, Fenghua Tian, Takashi Tarumi, Hanli Liu, Rong Zhang, Lina Chalak
Wavelet Coherence Analysis Of Dynamic Cerebral Autoregulation In Neonatal Hypoxic–Ischemic Encephalopathy, Fenghua Tian, Takashi Tarumi, Hanli Liu, Rong Zhang, Lina Chalak
Bioengineering Faculty Publications - Archive
Cerebral autoregulation represents the physiological mechanisms that keep brain perfusion relatively constant in the face of changes in blood pressure and thus plays an essential role in normal brain function. This study assessed cerebral autoregulation in nine newborns with moderate-to-severe hypoxic–ischemic encephalopathy (HIE). These neonates received hypothermic therapy during the first 72 h of life while mean arterial pressure (MAP) and cerebral tissue oxygenation saturation (SctO2) were continuously recorded. Wavelet coherence analysis, which is a time-frequency domain approach, was used to characterize the dynamic relationship between spontaneous oscillations in MAP and SctO2. Wavelet-based metrics of phase, coherence and gain were …
Transcranial Laser Stimulation Improves Human Cerebral Oxygenation, Fenghua Tian, Snehal Niwrutti Hase, F. Gonzalez-Lima, Hanli Liu
Transcranial Laser Stimulation Improves Human Cerebral Oxygenation, Fenghua Tian, Snehal Niwrutti Hase, F. Gonzalez-Lima, Hanli Liu
Bioengineering Faculty Publications - Archive
Transcranial laser stimulation of the brain with near-infrared light is a novel form of non-invasive photobiomodulation or low-level laser therapy (LLLT) that has shown therapeutic potential in a variety of neurological and psychological conditions. Understanding of its neurophysiological effects is essential for mechanistic study and treatment evaluation. This study investigated how transcranial laser stimulation influences cerebral hemodynamics and oxygenation in the human brain in vivo using functional near-infrared spectroscopy (fNIRS).
Magnetic Resonance Imaging Of Cerebrovascular Reactivity Using Gas Inhalation Challenges, Harshan Ravi
Magnetic Resonance Imaging Of Cerebrovascular Reactivity Using Gas Inhalation Challenges, Harshan Ravi
Bioengineering Dissertations - Archive
Cerebrovascular reactivity (CVR) is a measure of dilation capacity of cerebral vasculature. It is an important biomarker for the vascular functionality and integrity, and may have clinical indications in stroke, atherosclerosis, Moyamoya disease, multiple sclerosis, brain tumor, and other neurological disorders. The most commonly used approach to measure CVR is by applying a physiological maneuver to alter the arterial carbon dioxide (CO2) concentration (e.g. inhaling a small amount of CO2 which is a potent vasodilator), while continuously acquiring BOLD MR images. However, the current method suffers from several limitations related to specificity, sensitivity, and physiological modeling of the measured signal. …
An Investigation Of The Relation Between Sleep Disordered Breathing And Cognitive Function, Nazaneen Mousavi
An Investigation Of The Relation Between Sleep Disordered Breathing And Cognitive Function, Nazaneen Mousavi
Bioengineering Theses - Archive
Obstructive sleep apnea (OSA) is one of the most prevalent sleep related breathing disorders, with an estimated amount 17% of affected adults in the U.S. Research has linked OSA to mood and cognitive disorders, including Alzheimer’s disease. Structural changes in the brain have also been found to be associated with OSA. Several studies have shown deterioration of cognition in OSA patients because of structural and physiological changes due to apnea. The purpose of this research is to study the correlational relationships between cognitive measures and 1) quantitative measures of sleep quality; 2) measures of sleep disordered breathing; and 3) hypoxia …
Quantification And Normalization Of Noise Variance With Sparsity Regularization To Enhance Diffuse Optical Tomography, Jixing Yao, Fenghua Tian, Yothin Rakvongthai, Soontorn Oraintara, Hanli Liu
Quantification And Normalization Of Noise Variance With Sparsity Regularization To Enhance Diffuse Optical Tomography, Jixing Yao, Fenghua Tian, Yothin Rakvongthai, Soontorn Oraintara, Hanli Liu
Bioengineering Faculty Publications - Archive
Conventional reconstruction of diffuse optical tomography (DOT) is based on the Tikhonov regularization and the white Gaussian noise assumption. Consequently, the reconstructed DOT images usually have a low spatial resolution. In this work, we have derived a novel quantification method for noise variance based on the linear Rytov approximation of the photon diffusion equation. Specifically, we have implemented this quantification of noise variance to normalize the measurement signals from all source-detector channels along with sparsity regularization to provide high-quality DOT images. Multiple experiments from computer simulations and laboratory phantoms were performed to validate and support the newly developed algorithm. The …
Multiregional Functional Near-Infrared Spectroscopy Reveals Globally Symmetrical And Frequency-Specific Patterns Of Superficial Interference, Yujin Zhang, Fulun Tan, Xu Xu, Lian Duan, Hanli Liu, Fenghua Tian, Chao-Zhe Zhu
Multiregional Functional Near-Infrared Spectroscopy Reveals Globally Symmetrical And Frequency-Specific Patterns Of Superficial Interference, Yujin Zhang, Fulun Tan, Xu Xu, Lian Duan, Hanli Liu, Fenghua Tian, Chao-Zhe Zhu
Bioengineering Faculty Publications - Archive
Linear regression with short source-detector separation channels (S-channels) as references is an efficient way to overcome significant physiological interference from the superficial layer for functional nearinfrared spectroscopy (fNIRS). However, the co-located configuration of Schannels and long source-detector separation channels (L-channels) is difficult to achieve in practice. In this study, we recorded superficial interference with S-channels in multiple scalp regions. We found that superficial interference has overall frequency-specific and globally symmetrical patterns. The performance of linear regression is also dependent on these patterns, indicating the possibility of simplifying the Schannel configurations for multiregional fNIRS imaging.
Dynamic Functional Connectivity Revealed By Resting-State Functional Near-Infrared Spectroscopy, Zhen Li, Hanli Liu, Jingping Xu, Wenli Liu, Fenghua Tian, Yong He, Haijing Niu, Xuhong Liao
Dynamic Functional Connectivity Revealed By Resting-State Functional Near-Infrared Spectroscopy, Zhen Li, Hanli Liu, Jingping Xu, Wenli Liu, Fenghua Tian, Yong He, Haijing Niu, Xuhong Liao
Bioengineering Faculty Publications - Archive
No abstract provided.
Non-Invasive Biomedical Imaging And Radiobiology Investigations In Pre-Clinical Prostate Tumor Models, Derek A. White
Non-Invasive Biomedical Imaging And Radiobiology Investigations In Pre-Clinical Prostate Tumor Models, Derek A. White
Bioengineering Dissertations - Archive
Oxygen deficiency (hypoxia) in prostate tumors can hinder the biological effectiveness of radiotherapy. Therefore the ability to assess tumor hypoxia non-invasively in vivo in man could significantly improve therapy outcome. Magnetic resonance (MR) imaging is increasingly applied in clinical evaluation of prostate cancer. Therefore, an oxygen sensitive technique would be very attractive and the utility of oxygen-enhanced MRI (OE-MRI) has shown promise for predicting tumor growth delay in syngeneic rat prostate tumors following radiotherapy. In this dissertation, the overall goal was to investigate a potential imaging biomarker for predicting tumor response to image-guided radiotherapy (IGRT). First, I used in vivo …
Development Of Atlas-Guided Diffuse Optical Tomography To Investigate Age-Dependent Human Cognitive Functions Under Risk Decision Making, Lin Li
Bioengineering Dissertations - Archive
To better understand the age effect on neural correlates under risk decision-making stimulations, studies using advanced neuroimaging with a sufficient statistical power are desired. Diffuse optical tomography (DOT) of human brain functions is an emerging non-invasive neuroimaging technology. Compared to magnetic resonance imaging (MRI), DOT is more cost-effective, more portable, and easier to conduct studies targeting on different age groups. However, current DOT is limited by its low spatial resolution and depth accuracy. It is thus imperative to develop a technique that can improve imaging quality of DOT and be used to investigate age-dependent human brain functions under risk decision …
An Investigation Of The Effect Of Obstructive Sleep Apnea On Cerebral Hemodynamics In Relation With Systemic Hemodynamics, Raichel Mary Alex
An Investigation Of The Effect Of Obstructive Sleep Apnea On Cerebral Hemodynamics In Relation With Systemic Hemodynamics, Raichel Mary Alex
Bioengineering Dissertations - Archive
Obstructive Sleep Apnea (OSA) is a major sleep disorder affecting approximately 18 million adults in the US. Recent studies have observed cognitive impairments and brain structural changes in OSA subjects where these deficits were related to peripheral hypoxia and sleep fragmentation. Nonetheless, underlying cerebral hemodynamics and cerebral oxygenation might play an important role in the development of these impairments. Hence, in this study it is hypothesized that 1) OSA induces significant variations in cerebral hemodynamics, and 2) level of variations in cerebral hemodynamics can be related to the changes in systemic hemodynamics. To test these hypotheses, 8 hours of nocturnal …
Hemodynamic Responses To Thermal Stimulation In The Prefrontal Cortex Of The Brain Measured By Fnirs, Koumudi Chari
Hemodynamic Responses To Thermal Stimulation In The Prefrontal Cortex Of The Brain Measured By Fnirs, Koumudi Chari
Bioengineering Theses - Archive
Although FMRI has marked its importance in the neurological research by understanding the brain activities, FNIRS has also set a new standard in the brain imaging study research with non-invasive and easy to use technology. FNIRS is a portable, inexpensive optical imaging method that measures the changes in the oxygenated and de-oxygenated hemoglobin of the brain that results from the neurological activity. In this study, FNIRS has been used to study the pain processing in humans by measuring the pre-frontal cortex area of the brain. Eight (n=8) healthy subjects were induced with pain using a thermal stimulator device with temperatures …
An Investigation Of The Covariations Between Variations In Exhaled Carbon Dioxide And Cerebral Blood Flow Levels During Apnea, Varun Ajay Kanal
An Investigation Of The Covariations Between Variations In Exhaled Carbon Dioxide And Cerebral Blood Flow Levels During Apnea, Varun Ajay Kanal
Bioengineering Theses - Archive
Sleep apnea is a breathing disorder characterized by repetitive reduction or cessation of breathing during sleep. It is estimated that that around 17% of adults suffer from mild to severe sleep disordered breathing. The aim of this study was to investigate the level of correlation between variations in exhaled CO2 and cerebral blood flow (CBF) during apnea. It is difficult to measure the CBF during sleep. This relationship was found in an effort to substitute the measurement of the changes in CBF with the changes in the CO2. The relationship between these two physiological parameters was first studied in healthy …
Transcranial Near Infrared Spectroscopy And Stimulation Of Prefrontal Cognitive Functions In Young Adults, Snehal Niwrutti Hase
Transcranial Near Infrared Spectroscopy And Stimulation Of Prefrontal Cognitive Functions In Young Adults, Snehal Niwrutti Hase
Bioengineering Theses - Archive
Transcranial near infrared stimulation or Low Level Laser Therapy (LLLT) is an innovative technique shown to control neuronal function in cell cultures, animal models and clinical conditions. The aim of this study was to use near infrared spectroscopy (NIRS) to evaluate the physiological and functional effects of LLLT on prefrontal cognitive functions in young healthy adults. This study was divided into two parts: the first part investigated the physiological effects of LLLT and the second investigated the functional effects.The aim of the first part of this study was to explore how a single session of LLLT altered the hemodynamic status …
Measurement Of Cerebral Blood Flow Using Arterial Spin Labeling Method Across Lifespan, Ciwen Wang
Measurement Of Cerebral Blood Flow Using Arterial Spin Labeling Method Across Lifespan, Ciwen Wang
Bioengineering Theses - Archive
Arterial Spin Labeling (ASL) is one family of perfusion-weighted contrast imaging techniques of Magnetic Resonance Imaging (MRI) that measures cerebral blood flow by labeling spins in arterial blood with inversion and then waiting for a certain period of time for the labeled arterial blood to enter the imaging plane, and then acquiring MR image at the image plane. In compare with PET, ASL is a noninvasive new technology. But as a new technology, it is not very commonly used because of the relatively low signal to noise ratio, less robust mechanism, and more important, there is no standard for clinical …