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Biomedical Engineering and Bioengineering Commons™
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Articles 121 - 150 of 155
Full-Text Articles in Biomedical Engineering and Bioengineering
Microfluidic E. Coli Detection, Kyle Pietrzyk, Scott Fukuoka, Andres Maldonado-Liu, Andy Ly
Microfluidic E. Coli Detection, Kyle Pietrzyk, Scott Fukuoka, Andres Maldonado-Liu, Andy Ly
Interdisciplinary Design Senior Theses
In both developed and developing countries, there is a need for a fast diagnostic system to detect pathogens within a fluid sample. In developing a microfluidic platform, which utilizes a microfluidic chip and an optical detection method, doors may be opened for new methods of determining pathogen concentration in fluid. Most biological reactions are not instantaneous. A flow-controlling mechanism with no power requirement may be implemented in the microfluidic platform. As a proof-of-concept, our device uses a microfluidic chip, smartphone, and microlens to detect E. coli concentrations in water. The detection method is based on the latex agglutination assay which …
Innovations In Traumatic Hemorrhage, Joseph Anthony Ikaika Choy, Nicholas Domek, John “Patrick” Tavelli
Innovations In Traumatic Hemorrhage, Joseph Anthony Ikaika Choy, Nicholas Domek, John “Patrick” Tavelli
Bioengineering Senior Theses
Traumatic hemorrhagic injuries present a great problem to humanity and a challenge to medicine in the modern world. Current methods of treating these injuries in the field are ineffective and often extremely overkill or injurious. These methods are particularly inadequate when applied to the continuous high pressure bleeding that occurs from arterial wounds. Our project focuses on lowering the barriers to entry to innovation in the field of bleeding treatment by creating a low cost model of the human circulatory system. This model can function as a low-cost testing platform for novel bleeding treatments developed by companies and individuals that …
Mums: Mobile Urinalysis For Maternal Screening, Blair Koeneman, Amy Miller, Joe Neumeyer, Jake Prince
Mums: Mobile Urinalysis For Maternal Screening, Blair Koeneman, Amy Miller, Joe Neumeyer, Jake Prince
Interdisciplinary Design Senior Theses
Pregnant women in low-income communities often lack access to the necessary healthcare for successful births. This is frequently due to the high costs of medical care, the remote location of patients, and the infrequency of primary care medical visits. To address this inequity, we have created a mobile application and imaging unit that allows for the low-cost implementation of urinalysis testing, which will aid in the detection of warning signs for prenatal health risks. From a single photo taken with a tablet camera, our application digitizes the results of a standard urinalysis test strip, displays the test results, and tracks …
Experimental Investigation Of Mechanical And Thermal Properties Of Silica Nanoparticle-Reinforced Poly(Acrylamide) Nanocomposite Hydrogels, Josergio Zaragoza, Nasim Babhadiashar, Victor O’Brien, Andrew Chang, Matthew Blanco, Aitor Zabalegui, Hohyun Lee, Prashanth Asuri
Experimental Investigation Of Mechanical And Thermal Properties Of Silica Nanoparticle-Reinforced Poly(Acrylamide) Nanocomposite Hydrogels, Josergio Zaragoza, Nasim Babhadiashar, Victor O’Brien, Andrew Chang, Matthew Blanco, Aitor Zabalegui, Hohyun Lee, Prashanth Asuri
Bioengineering
Current studies investigating properties of nanoparticle-reinforced polymers have shown that nanocomposites often exhibit improved properties compared to neat polymers. However, over two decades of research, using both experimental studies and modeling analyses, has not fully elucidated the mechanistic underpinnings behind these enhancements. Moreover, few studies have focused on developing an understanding among two or more polymer properties affected by incorporation of nanomaterials. In our study, we investigated the elastic and thermal properties of poly(acrylamide) hydrogels containing silica nanoparticles. Both nanoparticle concentration and size affected hydrogel properties, with similar trends in enhancements observed for elastic modulus and thermal diffusivity. We also …
A Tale Of Two Nucleases: Using Talens To Edit The Genome Of C. Elegans, Clare Bartlett, Kriszten Kocmond, Erin Root
A Tale Of Two Nucleases: Using Talens To Edit The Genome Of C. Elegans, Clare Bartlett, Kriszten Kocmond, Erin Root
Bioengineering Senior Theses
Genetic engineering is an emerging technology that offers the potential to prevent, treat, or cure genetic diseases. The technology can permanently alter the genome, providing an alternative therapy to drugs and surgery. Specifically, gene therapy is a promising treatment option for many incurable genetic diseases, such as cystic fibrosis and muscular cell dystrophy. Our project gives rise to a better understanding of TALENs and its uses in the genetic engineering field. TALENs, transcription activator-like effector nucleases, are a genetic engineering technology that can be used for targeted gene modification. They are engineered proteins that can bind to specific sequences of …
Micro-Motion Controller Ii, Bergren Antell, Michael Mcnaul, Steve Shushnar
Micro-Motion Controller Ii, Bergren Antell, Michael Mcnaul, Steve Shushnar
Bioengineering Senior Theses
The purpose of this project was to improve upon the functionality of a micro-motion controller designed by another senior design group at this university. The original controller design facilitated motion in only two dimensions, and by modifying the platform of the design to accommodate another axis of rotation, we were able to achieve a full range of 3-D motion in our own product. Additionally, we designed a new system in which a motor could be mounted on the base plate of the device which would rotate the upper platform on its own through a simple belt-and-pulley system. And lastly, we …
Micro-Motion Controller, Kapoor Karan, Chu Cameron, Adem Sandeep
Micro-Motion Controller, Kapoor Karan, Chu Cameron, Adem Sandeep
Bioengineering Senior Theses
Micro-motions in surgical applications are small motions in the range of a few millimeters and are common in ophthalmic surgery, neurosurgery, and other surgeries which require precise manipulation over short distances. Robotic surgery is replacing traditional open surgery at a rapid pace due to the obvious health benefits, however, most of the robotic surgical tools use robotic motion controllers that are designed to work over a large portion of the human body, thus involving motion of the entire human arm at shoulder joint. This requirement to move a large inertial mass results in undesirable, unwanted, and imprecise motion. This senior …
Assured Bacterial Detection Towards Paper-Based Microfluidic Chip For Resource-Limited Areas, William Leineweber, Mallory Williams
Assured Bacterial Detection Towards Paper-Based Microfluidic Chip For Resource-Limited Areas, William Leineweber, Mallory Williams
Bioengineering Senior Theses
There is a significant and urgent need for affordable, fast, and accurate pathogen detection methods in resource-limited settings. Currently, accurate pathogen detection methods are dependent upon special equipment or reagents, specialized training to operate such equipment, electricity or cold storage, or sterile environments not feasible outside of the laboratory. Here we present a functionalized cellulose paper device towards an autonomous 3- dimensional microfluidics chip to detect bacterial pathogens. The microfluidic device utilizes a nucleic acid sandwich assay that detects the presence of bacterial RNA through complementary strand binding. An oligonucleotide “capture strand” immobilizes the targeted RNA sequence to the device, …
Fickian-Based Empirical Approach For Diffusivity Determination In Hollow Alginate-Based Microfibers Using 2d Fluorescence Microscopy And Comparison With Theoretical Predictions, Maryam Mobed-Miremadi, Sabra Djomehri, Mallika Keralapura, Melanie Mcneil
Fickian-Based Empirical Approach For Diffusivity Determination In Hollow Alginate-Based Microfibers Using 2d Fluorescence Microscopy And Comparison With Theoretical Predictions, Maryam Mobed-Miremadi, Sabra Djomehri, Mallika Keralapura, Melanie Mcneil
Bioengineering
Hollow alginate microfibers (od = 1.3 mm, id = 0.9 mm, th = 400 µm, L = 3.5 cm) comprised of 2% (w/v) medium molecular weight alginate cross-linked with 0.9 M CaCl2 were fabricated to model outward diffusion capture by 2D fluorescent microscopy. A two-fold comparison of diffusivity determination based on real-time diffusion of Fluorescein isothiocyanate molecular weight (FITC MW) markers was conducted using a proposed Fickian-based approach in conjunction with a previously established numerical model developed based on spectrophotometric data. Computed empirical/numerical (Dempiricial/Dnumerical) diffusivities characterized by small standard deviations for the 4-, 70- and …
A Novel 2.5d Culture Platform To Investigate The Role Of Stiffness Gradients On Adhesion-Independent Cell Migration, Mark-Phillip Pebworth, Sabrina A. Cismas, Prashanth Asuri
A Novel 2.5d Culture Platform To Investigate The Role Of Stiffness Gradients On Adhesion-Independent Cell Migration, Mark-Phillip Pebworth, Sabrina A. Cismas, Prashanth Asuri
Bioengineering
Current studies investigating the role of biophysical cues on cell migration focus on the use of culture platforms with static material parameters. However, migrating cells in vivo often encounter spatial variations in extracellular matrix stiffness. To better understand the effects of stiffness gradients on cell migration, we developed a 2.5D cell culture platform where cells are sandwiched between stiff tissue culture plastic and soft alginate hydrogel. Under these conditions, we observed migration of cells from the underlying stiff substrate into the alginate matrix. Observation of migration into alginate in the presence of integrin inhibition as well as qualitative microscopic analyses …
Mobile Audiometry Application, Kevin Nguyen, Shweta Panditrao
Mobile Audiometry Application, Kevin Nguyen, Shweta Panditrao
Interdisciplinary Design Senior Theses
The Mobile Audiometry Application hopes to utilize the ubiquity of the mobile device by providing a means of healthcare focused on audiometry. This application enables a mobile device to perform audiometric testing to detect a user's hearing range, and notify the user whether he or she is suffering from hearing loss. This project seeks to fulfill a social need for increased access to hearing testing by providing a portable, affordable, and reliable screening tool that is accurate. The result was sleek application that provided a calibration method, executed an audiometry test using accurate and calibrated files, displayed the results graphically, …
Engineering An In Vitro Metastasis Platform, Justus Carlisle, Mark-Phillip Pebworth
Engineering An In Vitro Metastasis Platform, Justus Carlisle, Mark-Phillip Pebworth
Bioengineering Senior Theses
Although metastasis is the primary cause of cancer deaths and results in 90% of all cancer fatalities currently, all attempts to discover anti-metastatic drugs have failed. Many of the traditional methods of studying cell migration, using two-dimensional (2D) platforms, only study two-dimensional migration, which is fundamentally different and more multifaceted than the three-dimensional migration that occurs in vivo. To more accurately capture this in vivo variation, we developed a two-and-a-half-dimensional (2.5D) cell culture platform to better study three-dimensional (3D) migration. This platform consists of a layer of alginate on top of a monolayer of cells grown on tissue culture polystyrene …
Talens: Genome Surgery, Carson Harms, Serena Lerkantitham
Talens: Genome Surgery, Carson Harms, Serena Lerkantitham
Bioengineering Senior Theses
Genetic engineering has always held great opportunity for the field of gene therapy. If the cause of a genetic disease can be determined, correction of this gene would allow for an efficient and permanent cure. However, current technologies utilizing engineered retroviruses have serious drawbacks that significantly limit their practical applications for gene therapy. In this project we investigate a novel genetic editing technology called TALENs. By utilizing a modular protein isolated from a plant pathogen that can be quickly and efficiently redesigned to recognize and bind to any desired sequence of DNA combined with a nuclease, we can target a …
Genome Editing Of Human Ipscs Using The Cas9 System, Cade Ellis Ito, Nick Wolfe
Genome Editing Of Human Ipscs Using The Cas9 System, Cade Ellis Ito, Nick Wolfe
Bioengineering Senior Theses
Recent research advancements in induced pluripotent stem cells (iPSCs) have broadened their capacity for research in specific disease models3 need for effective and robust techniques to detect cell differentiation. Two techniques currently exist to determine cell type; morphology and immunostaining. Although they have been used by researchers for many years, these methods can be unreliable, time-consuming, and very uneconomical. We seek to create a technology that will be more accurate and efficient in detecting differentiation of iPSCs. This will allow researchers greater speed in screening for specific differentiation products, further increasing the utility of iPSCs in medical research. We will …
Reverse Protein Engineering Of Firefly Luciferase, Kahler Bugtong, Skyler Herczeg, Abraham Munoz, Alexandra Obata
Reverse Protein Engineering Of Firefly Luciferase, Kahler Bugtong, Skyler Herczeg, Abraham Munoz, Alexandra Obata
Bioengineering Senior Theses
Firefly luciferase is a bioluminescent protein commonly used as a bioluminescent tag in biological studies and applications. However, because the protein is fairly large in size, it is sometimes larger than the molecules it is intended to measure and is therefore not a sufficient tag in smaller applications. The active site of firely luciferase is also not well understood, making it difficult to engineer the protein without affecting its bioluminescent activity. In this paper, we discuss the experimental methods of Reverse Protein Engineering: a bioengineering technology that reduces the size of a protein while retaining its original function. This involves …
Molecular And Device Engineering Towards The Study Of Potential Anti-Mrsa Agents, Powell Fansler, Karla Geisse, Ryan Marshall
Molecular And Device Engineering Towards The Study Of Potential Anti-Mrsa Agents, Powell Fansler, Karla Geisse, Ryan Marshall
Bioengineering Senior Theses
At the intersection of bio-device engineering and bio-pharmaceutical studies, our project involved the design of a hydraulic manifold to be used in isothermal titration calorimetry (ITC), with the ultimate goal of using ITC to study the thermodynamic binding parameters of potential anti-Methicillin Resistant Staphylococcus aureus (MRSA) agents to our drug target, Sortase A. The hydraulic manifold redesign included the analysis of materials such as high density polyethylene (HDPE), polytetrafluorethylene (PTFE, ‘Teflon’), and polycarbonate as well as the implementation of a new construct of the manifold itself. Sortase A is a transpeptidase found in Gram-positive bacteria and catalyses the attachment of …
Design Of A Methane-To-Methanol Conversion Device, Pankti Doshi, Jessica Garcia
Design Of A Methane-To-Methanol Conversion Device, Pankti Doshi, Jessica Garcia
Bioengineering Senior Theses
The purpose of this project was to develop a device that will make natural gas, primarily methane, an efficient and economical fuel alternative as the world’s petroleum supply is diminished. Presently, methane gas is too costly and dangerous to convert to methanol. The direct oxidation of methane can reduce the processing and transportation costs creating a competitive alternative to petroleum. This device will be marketable to companies interested in alternative fuel sources competitive with petroleum. Entrepreneurs are then expected step in and develop a global market. With the development of our prototypes and running methane and oxygen (or atmospheric oxygen) …
Electrochemical Detection Of Arsenic Using A Microfluidic Sensing Platform, Ben Demaree, Allie Sibole, Jessica Vandergiessen
Electrochemical Detection Of Arsenic Using A Microfluidic Sensing Platform, Ben Demaree, Allie Sibole, Jessica Vandergiessen
Bioengineering Senior Theses
Arsenic contamination of groundwater is a global health problem affecting millions of people. Long-term exposure to arsenic has been linked to a variety of cancerous and non-cancerous health effects. Current diagnostic technologies for arsenic quantification are limited to either inaccurate colorimetric methods or expensive, off-site lab assays, which are unsuitable for resource-limited settings. To address this need for an affordable and rapid means of sensitive arsenic detection, our design project focuses on the design and fabrication of the first point-of-use microfluidic device capable of electrochemical detection and quantification of arsenic levels in groundwater sources. We fabricate our device rapidly and …
Designing A Biomimetic Primary Cell-Based 3d Culture System For Neurotoxicity Screening, Teresa Cauvel, Jessca Kosit, Nicolo Mendoza
Designing A Biomimetic Primary Cell-Based 3d Culture System For Neurotoxicity Screening, Teresa Cauvel, Jessca Kosit, Nicolo Mendoza
Bioengineering Senior Theses
Culturing neurons in vitro is a challenging task because they are a highly specialized cell type that reside in a complex and unique environment in the body. The aim of the research presented in the following thesis was to design a biomimetic, three-dimensional scaffold capable of (1) promoting primary neuron maturation and axonal outgrowth and (2) serving as a system for toxicology screening. In the system presented here, neurons were cultured in three-dimensional hydrogels, simulating the physiological environment that these cells experience within the body. In doing so, a biologically relevant response was elicited upon their exposure to acrylamide, a …
Protein Engineering Of Luciferase To Enhance Bioluminescent Properties, Charles Schwab, Peter Wittig
Protein Engineering Of Luciferase To Enhance Bioluminescent Properties, Charles Schwab, Peter Wittig
Bioengineering Senior Theses
Bioluminescence is the ability of naturally occurring organisms to emit light. Many instances of bioluminescence have been identified ranging from fireflies to bacteria. The protein responsible for bioluminescence in all of these organisms is luciferase. The exact function and structure of this protein are still unknown to this day. This project aims at better understanding luciferase as well as enhancing its bioluminescent properties. In order to work with luciferase, we had to isolate all of the genes necessary for bioluminescence. The six genes necessary for bioluminescence are Lux A,B,C,D,E,G. We isolated each of these genes from original bacterial DNA. We …
Microchip Capillary Electrophoresis, Scott Hardy, Daniel Schull, Mark Vinopal
Microchip Capillary Electrophoresis, Scott Hardy, Daniel Schull, Mark Vinopal
Bioengineering Senior Theses
For the study of neuromodulation in Cancer borealis we have designed a microfluidic device to separate and detect bioamine concentrations with a high temporal resolution. Our goal is to use this device to measure the concentration of continuous bioamine microdialysis samples directly from the pericardial cavity (the area surrounding the heart) of Cancer borealis. The microfluidic device that we designed is made from polydimethylsiloxane (PDMS) and exhibits an off-channel configuration of capillary electrophoresis (CE) by incorporating micellar electrokinetic chromatography (MEKC). CE is used to separate bioamines based on charge and size due to the applied electrical potential. In the off-channel …
Function, Structure, And Stability Of Enzymes Confined In Agarose Gels, Prashanth Asuri, Jeffrey Kunkel
Function, Structure, And Stability Of Enzymes Confined In Agarose Gels, Prashanth Asuri, Jeffrey Kunkel
Bioengineering
Research over the past few decades has attempted to answer how proteins behave in molecularly confined or crowded environments when compared to dilute buffer solutions. This information is vital to understanding in vivo protein behavior, as the average spacing between macromolecules in the cell cytosol is much smaller than the size of the macromolecules themselves. In our study, we attempt to address this question using three structurally and functionally different model enzymes encapsulated in agarose gels of different porosities. Our studies reveal that under standard buffer conditions, the initial reaction rates of the agarose-encapsulated enzymes are lower than that of …
Mechanical Properties Of Hydrated Acoustically Sensitive Alginate-Based Microcapsules Confined In A Microfluidic Device As A Function Of Size And Composition, Maryam Mobed-Miremadi, Mallika Keralapura, Tiffany Fong, Rogel Camba
Mechanical Properties Of Hydrated Acoustically Sensitive Alginate-Based Microcapsules Confined In A Microfluidic Device As A Function Of Size And Composition, Maryam Mobed-Miremadi, Mallika Keralapura, Tiffany Fong, Rogel Camba
Bioengineering
Understanding the mechanical properties of alginate-based microcapsules according to size and chemical composition allows researchers to zero in on the treatment and methods required to engineer optimized implantable alginate-based artificial cells for chemotherapy. Cross-linked medium viscosity alginate capsules ranging from 1.1% (w/v)-1.8% (w/v) in composition and 200 μm-1200 μm in size, encapsulating ultrasound contrast agents and blue dextran were compressed within a 40 μm high polydimethylsiloxane microfluidic device and subsequently examined using 2D microscopy for strain deformation aimed at the calculation of poisson ratios and volume loss postcompression. Results indicate a decrease in Poisson ratio as a function of alginate …
Advances In Homology Directed Genetic Engineering Of Human Pluripotent And Adult Stem Cells, Kalpith Ramamoorthi, Donald Curtis, Prashanth Asuri
Advances In Homology Directed Genetic Engineering Of Human Pluripotent And Adult Stem Cells, Kalpith Ramamoorthi, Donald Curtis, Prashanth Asuri
Bioengineering
The ability to introduce precise genomic modifications in human cells has profound implications for both basic and applied research in stem cells, ranging from identification of genes regulating stem cell self-renewal and multilineage differentiation to therapeutic gene correction and creation of in vitro models of human diseases. However, the overall efficiency of this process is challenged by several factors including inefficient gene delivery into stem cells and low rates of homology directed site-specific targeting. Recent studies report the development of novel techniques to improve gene targeting efficiencies in human stem cells; these methods include molecular engineering of viral vectors o …
Cross-Linked Alginate Film Pore Size Determination Using Atomic Force Microscopy And Validation Using Diffusivity Determinations, Cheryl Simpliciano, Larissa Clark, Behrokh Asi, Nathan Chu, Maria Mercado, Steven Diaz, Michel Goedert, Maryam Mobed-Miremadi
Cross-Linked Alginate Film Pore Size Determination Using Atomic Force Microscopy And Validation Using Diffusivity Determinations, Cheryl Simpliciano, Larissa Clark, Behrokh Asi, Nathan Chu, Maria Mercado, Steven Diaz, Michel Goedert, Maryam Mobed-Miremadi
Bioengineering
The deficit of organ donors has fueled the need for advances in tissue engineering and regenerative medicine. Microencapsulation in alginate immuno-isolation membranes has been used to treat many disabling metabolic disorders, namely, phenylketonuria, kidney failure and diabetes mellitus. Systematic nutrient flux determinations are hindered by the lack of experimental data on alginate-based membrane topography and the pore size thus preventing the full therapeutic potential of the bio-membranes to be reached. In this study, samples of cross-linked alginate membranes were subjected to the following analytical characterization: 1) pore size characterization using atomic force microscopy operated in contact mode to detect and …
The Trm2h : Detecting Protein-Protein Interactions By Engineering The Cell As A Biosensor, Elyse Shimomura, Paulina Perezalonso
The Trm2h : Detecting Protein-Protein Interactions By Engineering The Cell As A Biosensor, Elyse Shimomura, Paulina Perezalonso
Bioengineering Senior Theses
Protein-protein interactions regulate key cellular functions and cell signaling pathways in the body; biological systems can be disrupted by protein interactions or lack of interactions that cause cell dysfunction and can lead to disease or illness. However, studying these interactions is complex and difficult to quantify. In this project, we examine the interaction of two putative cancer biomarkers, Bax and PDCDS, using the tetracycline repressor-based mammalian two-hybrid system (trM2H). This in vivo system engineers the cell as a biosensor using methods of DNA cloning and mammalian cell transfections that easily detects and quantities the interaction of two proteins by the …
Analyzing Surface Protein Expression And Internalization, William Truong, Josergio Zaragoza
Analyzing Surface Protein Expression And Internalization, William Truong, Josergio Zaragoza
Bioengineering Senior Theses
G-protein coupled receptors (GPCRs) are currently the largest class of membrane receptors and are targeted by a majority of the modern drug therapeutics. In addition, they partake in many physiological and pathological processes such as inflammation, growth, and hormone responses. Most importantly, GPCRs are targets of many disease-specific pathways such as Alzheimers, hypertension, leukemia, and depression. As a result, there is an immense interest in studying GPCRs as this area provides further knowledge into the specific disease pathways and allows the discovery of novel therapeutics. In order to have a better understanding of pathways, scientists have studied GPCR activation. The …
Amperometric Detection Of Bioamines In Cancer Borealis Using Microchip Capillary Electrophoresis Integrated With Micellar Chromatography, Ajay Fernandez, Jason Howard, Christina Shuh
Amperometric Detection Of Bioamines In Cancer Borealis Using Microchip Capillary Electrophoresis Integrated With Micellar Chromatography, Ajay Fernandez, Jason Howard, Christina Shuh
Bioengineering Senior Theses
In order to study neuromodulation in Cancer borealis, commonly known as the Jonah crab, we designed a microchip capillary electrophoretic (CE) device with micellar electrokinetic chromatography (MEKC) to separate bioamines and detect their concentrations using amperometric detection (AD). The analysis will be used to characterize the bioamines: dopamine, octopamine, tyramine, serotonin, norepinephrine, and gammaaminobutyric acid (GABA). The device measures the concentration of bioamines in microdialysate samples taken directly from the pericardial cavity of the crab. The research on Jonah crabs will be applied to enhance our understanding of the crab neurology. Since the structure and in some instances, the function …
Microfluidic Detection Of Arsenic Contamination In Groundwater, Mary Reynolds, Kyle Perricone
Microfluidic Detection Of Arsenic Contamination In Groundwater, Mary Reynolds, Kyle Perricone
Bioengineering Senior Theses
The difficulty of detecting small quantities of arsenic in water currently threatens the health of millions of people worldwide, as long-term exposure to arsenic has been associated with both cancerous and noncancerous health risks. Existing technologies make it possible to very accurately quantify arsenic levels in water; however the expense, extensive training, and off-site analysis required by these methods impede wide scale use. Here, we report on research to develop an affordable and point-of-use microfluidic platform capable of detecting trace amounts of arsenic in groundwater samples. We intend this device to meet the World Health Organization's (WHO's) ASSURED criteria for …
Uniflow: A Collapsible Prostatic Stent To Treat The Symptoms Of Benign Prostatic Hyperplasia, Brett Simons, Senn Foote, Doug Yoon
Uniflow: A Collapsible Prostatic Stent To Treat The Symptoms Of Benign Prostatic Hyperplasia, Brett Simons, Senn Foote, Doug Yoon
Bioengineering Senior Theses
BPH is a widespread problem that currently does not have any highly effective and cheap solutions. We propose a solution involving a collapsible and durable stent for insertion in to the urethra to aid in urination by opening the urethra only when needed.