Engineering Commons^™

Tumor Targeting Gold Nanoparticles For Delivery Of Rna And Dna Oligonucleotide Therapies For Glioblastoma., Nicholas Allen

Electronic Theses and Dissertations

Glioblastoma (GBM) brain tumors are highly aggressive gliomas due to genetic and cellular heterogeneity. Current GBM treatment consists of surgical resection of the tumor combined with radio- or chemo-therapies. While these treatments have increased the life expectancy for GBM patients up to 20 months, they have had little effect on the 5-year survival rate. The complex cellular and genetic composition of the tumor makes current treatments less effective long term. One approach to developing more effective GBM treatments is to customize nanoparticle-based drug delivery systems that can directly target the aberrant gene expression patterns within a particular GBM tumor. Delivery …

Historic Downtown Streetscape Plan Price City, Utah, Patricia Beckert

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

The idea of a small-town Main Street has profound meaning within the American culture that has prevailed for the past two centuries. Historically, Main Street serves as the beating heart of a community, a place where economic, social, cultural, and civic activities are centered (Francaviglia, 1996; Main Street America, n.d.). Since the beginning of the 19th century, many factors have led to the decline of Main Streets, and despite a variety of efforts from different stakeholders, that decline has only intensified in recent decades (Isenberg, 2008; Orvell, 2014 Howard, 2015). In 1980, after a three-year project conducted by the National …

Pyrolysis—A Tool In The Wastewater Solids Handling Portfolio, Not A Silver Bullet: Benefits, Drawbacks, And Future Directions, Patrick J. Mcnamara, Zhongzhe Liu, Yiran Tong, Hari Santha, Lynne Moss, Daniel Zitomer

Civil and Environmental Engineering Faculty Research and Publications

Pyrolysis is the process whereby carbonaceous materials, such as biosolids, are heated between 400°C and 900°C in the absence of oxygen. Three main products are generated: a solid product called biochar, a py-liquid that consists of aqueous phase and non-aqueous phase liquid, and py-gas. The biochar holds value as a beneficial soil amendment and sequesters carbon. The py-liquid is potentially hazardous and needs to be dealt with (including potentially reducing it on-site via catalysis or thermal oxidation). Py-gas can be used on-site for energy recovery. Pyrolysis has gained recent interest due to concern over per- and polyfluoroalkyl substances (PFAS) in …

Using Actor-Critic Reinforcement Learning For Control Of A Quadrotor Dynamics, Edgar Adrian Torres

Theses and Dissertations

This paper presents a quadrotor controller using reinforcement learning to generate near-optimal control signals. Two actor-critic algorithms are trained to control quadrotor dynamics. The dynamics are further simplified using small angle approximation. The actor-critic algorithm’s control policy is derived from Bellman’s equation providing a sufficient condition to optimality. Additionally, a smoother converter is implemented into the trajectory providing more reliable results. This paper provides derivations to the quadrotor’s dynamics and explains the control using the actor-critic algorithm. The results and simulations are compared to solutions from a commercial, optimal control solver, called DIDO.

Slo Botanical Garden Deck, Noah E. Demer

Architectural Engineering

This project consists of the design and construction of an outdoor-use deck. This deck is to be located in the NE corner of the Sage Meadow at the San Luis Obispo Botanical Garden at 3450 Dairy Creek Rd, San Luis Obispo, CA 93405. This deck’s intended use is as a gathering area for people to congregate. Originally, the ideal deck area was proposed as 700+ square feet, but with further site and project limitations the final design was ~480 square feet. This deck has not been constructed.

A Nonlinear-Model-Based High-Bandwidth Current Sensor Design For Switching Current Measurement Of Wide Bandgap Devices, Xia Du, Liyang Du, Yuxiang Chen, Yuqui Wei, Andrea Stratta, H. Alan Mantooth

Electrical Engineering Faculty Publications and Presentations

With the growing adoption of wide bandgap devices in power electronic applications, current sensor design for switching current measurement has become more important. The demands for high accuracy, high bandwidth, low cost, compact size, and galvanic isolation pose significant design challenges. The conventional modeling approach for bandwidth analysis of current transformer sensors assumes that the magnetizing inductance remains constant, which does not always hold true in high-frequency operations. This can result in inaccurate bandwidth estimation and affect the overall performance of the current sensor. To address this limitation, this paper provides a comprehensive analysis of nonlinear modeling and bandwidth, considering …

The Influence Of Myoblast Implantation On Arteriogenesis In Mice With Diet-Induced Obesity, Rayana Gutierrez

Biomedical Engineering

Peripheral arterial occlusive disease (PAOD) is characterized by atherosclerosis, which is the buildup of plaque, consisting largely of cholesterol, in the arterial walls. This plaque accumulation eventually blocks blood flow to the limbs, causing symptoms such as intermittent claudication and tissue death in cases of critical limb ischemia. The body compensates for the reduced perfusion by enlarging pre-existing bypass arteries, known as collaterals, in a process called arteriogenesis. However, in many cases, collateral networks constructed through arteriogenesis fail to enlarge sufficiently or function effectively in patients. Therefore, the development of a therapeutic intervention specifically targeting this process would offer a …

Floating Offshore Wind Turbine Project, Courtney Huitt, Cormack Williams

Civil and Environmental Engineering

Offshore wind is a developing industry in the Central Coast with the advent of the future offshore wind project planned off the north coast of San Luis Obispo County. This senior design project aligns with the recently leased wind energy project as a detailed study on the structural design, geotechnical design, and construction of a single 14 MW floating offshore wind turbine (FOWT) located 40 km NW of Morro Bay (NOAA buoy 46028). A preliminary design of a spar FOWT is presented in this project as a solution to the rapidly increasing water depth off the coast of Morro Bay, …

The Bridge Newsletter Spring 2023, Missouri University Of Science And Technology

The Bridge Newsletter

-Virtual reality in architectural engineering
-Steel Bridge team wins fifth consecutive competition
-S&T Volleyball star ‘jumps’ at research opportunity
-Benavides legacy continues

Iot Health Devices: Exploring Security Risks In The Connected Landscape, Abasi-Amefon Obot Affia, Hilary Finch, Woosub Jung, Issah Abubakari Samori, Lucas Potter, Xavier-Lewis Palmer

School of Cybersecurity Faculty Publications

The concept of the Internet of Things (IoT) spans decades, and the same can be said for its inclusion in healthcare. The IoT is an attractive target in medicine; it offers considerable potential in expanding care. However, the application of the IoT in healthcare is fraught with an array of challenges, and also, through it, numerous vulnerabilities that translate to wider attack surfaces and deeper degrees of damage possible to both consumers and their confidence within health systems, as a result of patient-specific data being available to access. Further, when IoT health devices (IoTHDs) are developed, a diverse range of …

Irrigation-As-A-Service For Smallholder Farmers, Ishani Lal

Department of Agricultural Economics: Dissertations, Theses, and Student Research

Irrigation is a crucial management practice that can help increase food security among smallholders globally while mitigating climate change impacts. High-efficiency irrigation technologies such as drip kits and sprinkler systems are relatively expensive and smallholder farmers cannot afford them to buffer crop yields against low precipitation. In many developing countries, farmers participate in robust informal markets for renting and sharing of irrigation equipment. Such services may be operated by farmers or via a third party such as irrigation start-ups, water user associations, non-governmental organizations, or even government agencies. These services are referred to collectively as Irrigation-as-a-Service (IaaS).

The objective of …

Engineering Of Microparticle Encapsulated Antioxidant To Mitigate Oxidative Stress In Vitro And In Vivo, Kayla Ney

Department of Agricultural and Biological Systems Engineering: Dissertations, Theses, and Student Research

Chronic low back pain (cLBP) is one of the leading causes of years lived with disability in the United States. Current treatments for cLBP have variable results across the patient population, and many patients struggle to find consistent relief. Most current treatments focus on the symptom of pain, not the root cause. In painful degenerated discs, oxidative stress and inflammation function in a vicious cycle and perpetuate degeneration, damage, and pain. Therefore, oxidative stress and inflammation are important targets in addressing the source of pain. This work characterizes an antioxidant, BuOE, encapsulated in a chondroitin sulfate microparticle as a novel …

Reynolds-Averaged Navier-Stokes Cfd Simulation Of High-Speed Boundary Layers, Michael Tullis

Mechanical Engineering Undergraduate Honors Theses

This paper presents an investigation of Reynolds-averaged Navier-Stokes (RANS) turbulence models used in computational fluid dynamics (CFD) simulations of boundary layer flow and heat transfer in high Mach number flows. This study evaluates an industry standard RANS turbulence model (k-omega SST) and a recently proposed modification to that model (Danis and Durbin [1]), and quantifies the accuracy for predicting high Mach number boundary layer flow. The test cases were previously documented by Duan et al. (2018), who used direct numerical simulation (DNS) to calculate boundary layer flow of an ideal gas over a flat plate at freestream Mach numbers ranging …

Investigation Of Dynamic Hybrid Rans-Les Turbulence Modeling For Cfd Simulation Of A Normal Jet In Crossflow, Cole Simmonds

Mechanical Engineering Undergraduate Honors Theses

The jet in crossflow is a canonical flow feature in many natural and engineered systems, ranging from pollutant dispersal in exhaust discharge to film cooling of high-temperature components in modern propulsion systems. The ability to computationally predict the flow features of jets in crossflow accurately and efficiently is therefore important for analysis and design for a wide variety of applications. In this study the capabilities of the dynamic hybrid RANS-LES (DHRL) turbulence modeling technique are investigated and compared to an industry standard Reynolds-averaged Navier-Stokes model (k-omega SST) in order to quantify the accuracy and computational cost of the two approaches. …

Photovoltaics, Batteries, And Silicon Carbide Power Electronics Based Infrastructure For Sustainable Power Networks, Prahaladh Paniyil

All Dissertations

The consequences of climate change have emphasized the need for a power network that is centered around clean, green, and renewable sources of energy. Currently, Photovoltaics (PV) and wind turbines are the only two modes of technology that can convert renewable energy of the sun and wind respectively into large-scale power for the electricity network. This dissertation aims at providing a novel solution to implement these sources of power (majorly PV) coupled with Lithium-ion battery storage in an efficient and sustainable approach. Such a power network can enable efficiency, reliability, low-cost, and sustainability with minimum impact to the environment.

The …

Study Of Different Heat Treatments And Aging Conditions For Observing Microstructures And Mechanical Properties Of Lpbf Fabricated F357 Alloy, Victor Adrian Medrano Balderas

Open Access Theses & Dissertations

Aluminum F357 is a widely used material for casting in the aerospace and additive manufacturing industry. Heat treatments are commonly applied to some aluminum alloys to modify their properties. With a further study on the aging and performance of the F357 with 3D printing technology, several industries benefit from this; military, automotive, and aerospace are some examples because of the numerous components cast in service. This work presents the mechanical properties of F357 specimens fabricated with EOS technology and subjected to heat treatments. Heat treatment conditions were applied to tensile specimens and tested. Furthermore, the specimens were subjected to artificial …

Dual Crosslinked Poly(Acrylamide-Co-N-Vinylpyrrolidone) Microspheres With Re-Crosslinking Ability For Fossil Energy Recovery, Jingyang Pu, Baojun Bai, Jiaming Geng, Na Zhang, Thomas P. Schuman

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

Microspheres have been proposed to be applied in controlling wastewater production for mature oilfields and migrating leakage for gas and nuclear waste storage. However, it remains challenging for stacked microspheres to maintain strong blocking ability in micron-sized small pores or fractures. In this study, a novel microsphere was developed with comprehensive properties including high deformability and long re-crosslinking time upon tunable swelling ratio for the applications. A dual covalent and physical crosslinking strategy was used to develop novel microspheres reinforced by a hydrogen bond (H-bond, between pyrrole ring and amide group) and coordination bond (between chromium acetate (CrAc) and carboxyl …

Repeated Low-Level Blast Exposure Alters Urinary And Serum Metabolites, Austin Sigler, Jiandong Wu, Annalise Pfaff, Olajide Adetunji, Paul Ki-Souk Nam, Donald James, Casey Burton, Honglan Shi

Chemistry Faculty Research & Creative Works

Repeated exposure to low-level blast overpressures can produce biological changes and clinical sequelae that resemble mild traumatic brain injury (TBI). While recent efforts have revealed several protein biomarkers for axonal injury during repetitive blast exposure, this study aims to explore potential small molecule biomarkers of brain injury during repeated blast exposure. This study evaluated a panel of ten small molecule metabolites involved in neurotransmission, oxidative stress, and energy metabolism in the urine and serum of military personnel (n = 27) conducting breacher training with repeated exposure to low-level blasts. The metabolites were analyzed using HPLC—tandem mass spectrometry, and the Wilcoxon …

Multi-Objective Genetic Algorithm Based Energy Management System Considering Optimal Utilization Of Grid And Degradation Of Battery Storage In Microgrid, V. Vignesh Babu, J. Preetha Roselyn, Prabha Sundaravadivel

Electrical Engineering Faculty Publications and Presentations

This paper develops intelligent energy management in Microgrid using forecasting-based multi-objective optimization using genetic algorithm framework. In this work, the energy storage system is included in Microgrid network, which is essential for effective energy management and smooth power transfer. The developed model incorporates the forecasted values of solar PV and wind generation obtained using time series long short-term memory network for the next 24 h and provides the optimal values of battery and grid powers to meet the deficit of power to meet the demand in the Microgrid. The proposed model incorporates grid power consumption cost and battery degradation cost …

Evaluating The Impact Of Broadband Access And Internet Use In A Small Underserved Rural Community, Javier Valentín-Sívico, Casey I. Canfield, Sarah A. Low, Christel Gollnick

Engineering Management and Systems Engineering Faculty Research & Creative Works

Having adequate access to the internet at home enhances quality-of-life for households and facilitates economic and social opportunities. Despite increased investment in response to the COVID-19 pandemic, millions of households in the rural United States still lack adequate access to high-speed internet. In this study, we evaluate a wireless broadband network deployed in Turney, a small, underserved rural community in northwest Missouri. In addition to collecting survey data before and after this internet intervention, we collected pre-treatment and post-treatment survey data from comparison communities to serve as a control group. Due to technical constraints, some of Turney's interested participants could …

An Introduction To Autocad For Beginners, Zoe L. Mahaney

Construction Management

This paper aims to outline the process of developing and creating an online instructional video tutorial for beginner level individuals who hope to learn and utilize AutoCAD software. AutoCAD, developed by Autodesk, is a computer-aided design software that provides users with the ability to create and edit digital 2D and 3D designs, which is more efficient than traditional hand-drawn models. The main objective of this project is to provide the public with access to learning and navigating AutoCAD software on their own, for personal gain. Construction Management students at Cal Poly have the opportunity to learn and use AutoCAD as …

Review Of Magnetic Properties And Texture Evolution In Non-Oriented Electrical Steels, Yizhou Du, Ronald J. O'Malley, Mario F. Buchely

Materials Science and Engineering Faculty Research & Creative Works

Electrical steels can be classified into two groups: grain-oriented (GO) and non-oriented (NGO) electrical steel. NGO electrical steels are mainly considered as core materials for different devices, such as electric motors, generators, and rotating machines. The magnetic properties and texture evolution of NGO electrical steels depend on multiple factors (such as chemical content, heat-treatment, and rolling process) making the development of new products a complex task. In this review, studies on the magnetic properties of NGO electrical steels and the corresponding texture evolution are summarized. The results indicate that further research is required for NGO electrical steels to ensure high …

A Hyperbaric Aerodynamic Levitator For Containerless Materials Research, Sydney E. Boland, Stephen K. Wilke, Jonathan A. Scott, Sarah M. Schlossberg, Alex Ivaschenko, Richard J.K. Weber, David W. Lipke

Materials Science and Engineering Faculty Research & Creative Works

A hyperbaric aerodynamic levitator has been developed for containerless materials research at specimen temperatures exceeding 2000 °C and pressures up to 10.3 MPa (1500 psi). This report describes the prototype instrument design and observations of the influence of specimen size, density, pressure, and flow rate on levitation behavior. The effect of pressure on heat transfer was also assessed by studying the heating and cooling behavior of levitated Al2O3 liquids. A threefold increase in the convective heat transfer coefficient was estimated as pressure increased to 10.3 MPa. The results demonstrate that hyperbaric aerodynamic levitation is a promising technique for containerless materials …

Personal Protective Equipment Usage And Injury Type, Nathan Giannini

Construction Management

Workers in the construction industry have many injuries both minor and life-altering. The industry suffers from injuries of all kinds such as falls, electrocution, and being struck by flying objects. To protect against this, workers wear certain types of personal protective equipment (PPE) on construction sites as a last line of defense. The equipment available such as hard hats, safety glasses, gloves, respirators, and hearing protection either protects against acute injuries (those that occur instantly) or chronic injuries (those that occur over time). This study investigates whether the type of injury that PPE protects against, acute or chronic, affects the …

Designing A Work-Life Balance Learning Module For Cal Poly Construction Management Department, Alex Jones

Construction Management

The construction industry is known to create a highly stressful work environment given its unpredictability and mental/time demanding nature, which creates challenges for professionals to maintain a healthy work-life balance. This senior project aims to research and identify the key areas that foster this stress and propose a learning module for the Cal Poly Construction Management Department to implement into class curriculum. Having this learning module taught to students will raise awareness of the topic for future industry professionals and equip them with the tools to maintain a healthy equilibrium between their work demands and personal life. The learning module …

Detection Of Toxic Aldehydes In Aerosols Of Electronic Cigarettes., Ellie Bess Reed

Electronic Theses and Dissertations

Over the past decade, use of electronic cigarettes (e-cigarettes) has increased in the younger generations of the United States. With the broad range of flavors and devices distributed on the market, American youth are prime marketing targets for the e-cigarette industry. To create a more regulated market, research of this thesis has been conducted on newer generations of e-cigarette “MOD” devices to examine how e-cigarette battery power output and coil temperature, concentrations of propylene glycol and vegetable glycerin, added flavorings (strawberry, mango, and menthol), and the presence of nicotine affect generation of aerosol particles and aldehydes in aerosols emitted by …

The Study Of Corrosion On Additive-Manufactured Metals., Braydan Daniels

Electronic Theses and Dissertations

The purpose of this study was to investigate and compare the corrosion mechanisms between wrought and additive-manufactured (3D-printed) copper and stainless steel. The experimental procedure consisted of measuring the open circuit potential, electrochemical impedance spectroscopy, linear sweep voltammetry, Tafel analysis, surface topology, and scanning electron microscopy for each metal within salt water, tap water, sulfuric acid, and synthetic body fluid (excluding copper in synthetic body fluid).

Overall, printed stainless steel was more corrosion-resistant than wrought stainless steel in tap water and synthetic body fluid based on OCP, LSV, and surface topology results. Additionally, printed copper was more corrosion-resistant than wrought …

An Approach For Verification Of Traffic Speed Deflectometer Measurements, Mahsa Beizaei

Open Access Theses & Dissertations

Recent research studies have shown the usefulness and applicability of Traffic Speed Deflectometers (TSD) in support of the network-level pavement management process. There are, however, no accepted procedures for verification and validation of the TSD measurements to be utilized by practitioners. To address this need, TSD measurements may be verified with the data obtained by widely accepted road-testing equipment, Falling Weight Deflectometer (FWD). In this study, TSD and FWD operations on pavement sections were simulated employing the finite layer approach which resulted in the development of a comprehensive database of pavement responses. Using the established numerical simulation database, theoretical relationships …

A Multiple Model Approach To Bridge Deterioration Modeling, Jin A. Collins

Open Access Theses & Dissertations

Bridge Management Systems (BMSs) have been used to support decision-making in bridgeprojects, including maintenance, rehabilitation, and replacement under financial constraints. These decisions are predicated on the ability to estimate bridgesâ?? future condition states to optimize bridge network systems' performance. Deterioration models are commonly used tools to help transportation agencies make predictions of future condition states of infrastructure facilities, schedule capital investments, and make comparative decisions. Numerous deterioration models have been developed over the last few decades. In particular, Markov chain models utilize bridge data collected from the National Bridge Inventory (NBI) database to make predictions. The accuracy of predictions is …

Development Of A Cost-Constrained Intelligent Prosthetic Knee With Real-Time Machine Learning, Predictive Stumble Control, Lucas Jonathan Galey

Open Access Theses & Dissertations

The field of biomechatronics is evolving quickly with advances in computer science, biology, and electrical and mechanical engineering. Coupled with increased interests in machine learning (ML) across all industry sectors, there are opportunities to leverage advanced analytics in uniquely complex problems. This study aimed to deploy real-time ML predictions in a novel microprocessor-controlled prosthetic knee (MPK) device capable of identifying and responding to stumble-events to reduce amputee fall prevalence. Innately, stumbling is a chaotic event. Current MPKs operate by detecting gait characteristics and reacting to preprogrammed states. While these systems are beneficial in significant ways, such as energy expenditure and …