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Articles 31 - 46 of 46
Full-Text Articles in Engineering
Scanning Electron Microscopy (Sem) Investigation Of Morphology Changes In The Reduction Of Silica Nanoparticles To Elemental Silicon, Allison M. Cairns
Scanning Electron Microscopy (Sem) Investigation Of Morphology Changes In The Reduction Of Silica Nanoparticles To Elemental Silicon, Allison M. Cairns
University Honors Theses
The application of silicon nanoparticles varies from energy storage materials, to drug-delivery, and molecular recognition. Various chemical and physical properties of the Si nanoparticles arise from their morphology. This paper aims to reveal the morphology of Si nanoparticles following magnesiothermic reduction of silica (SiO2) nanoparticles. Two sets of SiO2 nanoparticles were used, commercially available NanoXact nanoparticles and laboratory-synthesized Stöber nanoparticles. A Zeiss Sigma VP FEG SEM was used to examine the morphology. Following the magnesiothermic reduction, the nanoparticles were etched with HF. Ten sets of images were taken of both Stöber and NanoXact nanoparticles: 1,2: the SiO …
Nanoparticle Treatment To Counter Reactive Oxygen Species After Traumatic Brain Injury, Brandon Mcdonald, Forrest Kievit
Nanoparticle Treatment To Counter Reactive Oxygen Species After Traumatic Brain Injury, Brandon Mcdonald, Forrest Kievit
UCARE Research Products
Traumatic brain injury (TBI) is defined as damage to the brain, resulting from an external mechanical force, such as an impact to the head (Kievit et. al, 2016).There are several examples that could result in a potential TBI; such as falling with contact to the head, car accidents and even physical activities including football, wrestling, and boxing. Because of the several different scenarios that an individual could impact their head, TBI’s have become an all too common aspect of everyday life. TBI is currently the leading cause of death and disability in children and adults under the age of 45, …
Tunable Luminescence Of Rare Earth Doped Nanophosphors Via Adaptive Optical Properties Of Transition Metals, Pragathi Darapaneni
Tunable Luminescence Of Rare Earth Doped Nanophosphors Via Adaptive Optical Properties Of Transition Metals, Pragathi Darapaneni
LSU Doctoral Dissertations
Over the past decades, the development of light-emitting diodes (LEDs) to produce a wide range of wavelengths has revolutionized the solid-state lighting industry due to their higher energy efficiency and operational lifetimes. These LEDs employ rare earth (RE) doped phosphors due to their stable emission wavelengths which can be amplified when sensitized by other RE dopants (Yb, Ce) or shell layer passivation. However, there has been a push to replace the RE elements in LEDs due to increased socioeconomic issues. One proposed alternative, transition metal (TM) dopants, is typically avoided due to their susceptibility to the local crystal environment resulting …
Engineered Nanoparticles For Site-Specific Bioorthogonal Catalysis: Imaging And Therapy, Riddha Das
Engineered Nanoparticles For Site-Specific Bioorthogonal Catalysis: Imaging And Therapy, Riddha Das
Doctoral Dissertations
Bioorthogonal catalysis offers a strategy for chemical transformations complementary to bioprocesses and has proven to be a powerful tool in biochemistry and medical sciences. Transition metal catalysts (TMCs) have emerged as a powerful tool to execute selective chemical transformations, however, lack of biocompatibility and stability limits their use in biological applications. Incorporation of TMCs into nanoparticle monolayers provides a versatile strategy for the generation of bioorthogonal nanocatalysts known as “nanozymes”. We have fabricated a family of nanozymes using gold nanoparticles (AuNPs) as scaffolds featuring diverse chemical functional groups for controlled localization of nanozymes in biological environments, providing unique strategies for …
Identified Gold Nanoforms In Geogenic And Technogenic Mineral Raw Material, A.E. Vorobev, U.F. Nasirov, К.А Vorobev
Identified Gold Nanoforms In Geogenic And Technogenic Mineral Raw Material, A.E. Vorobev, U.F. Nasirov, К.А Vorobev
Gorniy vestnik Uzbekistana
The main forms of nanoparticles of gold are considered, specification of its main types is given (colloidal, cluster, etc.), factors of its losses at enrichment are described.
Spectroscopic Investigations On Pvdf-Fe2o3 Nanocomposites, Dorina M. Chipara, Victor Kuncser, Karen Lozano, Mataz Alcoutlabi, Elamin Ibrahim, Mircea Chipara
Spectroscopic Investigations On Pvdf-Fe2o3 Nanocomposites, Dorina M. Chipara, Victor Kuncser, Karen Lozano, Mataz Alcoutlabi, Elamin Ibrahim, Mircea Chipara
Mechanical Engineering Faculty Publications and Presentations
Polyvinylidene fluoride-iron oxide (PVDF-Fe2O3) nanocomposites have been obtained my melt mixing of PVDF with Fe2O3 nanoparticles. The interactions between the polymeric matrix and the nanofiller have been investigated by wide angle X-ray scattering (WAXS), Fourier transform infrared spectroscopy (FTIR), and Raman spectroscopy, using both red and green excitations (lasers). WAXS, FTIR, and Raman spectra confirm that all samples contain α PVDF as the major crystalline form of the polymeric matrix. Experimental data revealed small changes in the positions of X-ray lines as well as modifications of the width of X-ray lines upon loading by Fe2O3 nanoparticles. FTIR and Raman spectra …
Microfiltration Membrane Pore Functionalization Approaches For Chloro-Organic Remediation To Heavy Metal Sorption, Mohammad Saiful Islam
Microfiltration Membrane Pore Functionalization Approaches For Chloro-Organic Remediation To Heavy Metal Sorption, Mohammad Saiful Islam
Theses and Dissertations--Chemical and Materials Engineering
Microfiltration polyvinylidene fluoride (PVDF) membranes have distinct advantage for open structure in terms of high internal surface area and ease of access in the pore domain. Functionalization of PVDF membranes with different functional groups (-COOH, -OH, -SH) enables responsive (pH, temperature) properties to membrane, tuning of effective pore size, controlling permeate flux. PVDF microfiltration membrane functionalization with suitable responsive polymer such as poly acrylic acid (PAA) to incorporate carboxyl (-COOH) group enables further modification of functionalized PAA-PVDF membranes for different application ranging from catalysis, bio reactor to heavy metal sorption platform. As a catalytic reactor bed, this PAA-PVDF membranes are …
Tunable Refractive Index Through Spatially Modified Nanoparticle Films For Long-Range Spr Biosensing Applications, Stephen Joshua Binderup
Tunable Refractive Index Through Spatially Modified Nanoparticle Films For Long-Range Spr Biosensing Applications, Stephen Joshua Binderup
Graduate Research Theses & Dissertations
Despite optics and refraction being among the oldest scientific principles, material limitations have prevented scientists from taking full advantage of the potential this technology holds. Indeed, films with designer optical properties have potential for use in exotic cloaking architectures, advanced waveguides, and precise optical biosensors. This thesis focuses on the fabrication methodology for making thin films with refractive index tuned to a desired value through self-assembly of amorphous nanoparticle films made of organosilicate materials. The inclusion of a slowly evaporating polymer phase along with the organosilicate nanoparticles results in nanopores formed within the film, which effectively reduce the film’s refractive …
Formulation Strategies To Enhance Solubility And Permeability Of Small Molecules For Drug Delivery Applications, Pradeep Kumar Bolla
Formulation Strategies To Enhance Solubility And Permeability Of Small Molecules For Drug Delivery Applications, Pradeep Kumar Bolla
Open Access Theses & Dissertations
All the new chemical entities/drug molecules intended for therapeutic use must be administered using an appropriate delivery system/dosage form to achieve maximum bioavailability. However, designing a drug delivery system is complex as several factors such as lipophilicity, molecular mass, crystallinity, ionic charge, polymorphic forms and hydrogen bonding) affect the solubility and permeability of these molecules. Biopharmaceutics drug classification system (BCS) categorizes the existing drugs into four classes based on the aqueous solubility and membrane permeability and it is reported that >70% of the drugs are poorly soluble and belong to BCS class II and BCS class IV. Several physical, chemical …
Investigation On Nanoparticle Based Combination Therapy For Targeted Cancer Treatment, Muhammad Raisul Abedin
Investigation On Nanoparticle Based Combination Therapy For Targeted Cancer Treatment, Muhammad Raisul Abedin
Doctoral Dissertations
“The current treatment methods in cancer are associated with toxicity in healthy tissues, partial therapeutic response, drug resistance and finally recurrence of the disease. The cancer drugs are challenged by non-specific binding, undesired toxicity in healthy cells, low therapeutic index and finally poor therapeutic outcome. In this work, a targeted nanoscale therapeutic system Antibody Drug Nanoparticle (ADN) was engineered to selectively inhibit the breast cancer cell growth with reduced toxicity in healthy cells. The ADNs were designed by synthesizing rod shaped anoparticles using pure chemotherapeutic drug and covalently conjugating a therapeutic monoclonal antibody (mAb) on the surface of the drug …
Nanotechnologies: A Review Of Inventions And Utility Models. Part V, L. A. Ivanov, L. D. Xu, E. S. Bokova, A. D. Ishkov
Nanotechnologies: A Review Of Inventions And Utility Models. Part V, L. A. Ivanov, L. D. Xu, E. S. Bokova, A. D. Ishkov
Information Technology & Decision Sciences Faculty Publications
The article provides an abstract review of patents. The results of creative activity of scientists, engineers and specialists, including inventions in the field of nanotechnology and nanomaterials, being implemented, allow achieving a significant effect in construction, housing and community services, and related sectors of the economy. For example, the invention "A method to produce dry construction mixtures" refers to manufacturing of building materials, in particularly, to manufacture of dry construction mixtures (DCM) by the method of joint mechanoactivation of cement and dolomite, with further modification of them with carbon nanostructures (CNT). The technical result of the given method of mixing …
Extracellular Matrix Nanoparticles Effects On The Lung In Vivo, Brittaney E. Ritchie
Extracellular Matrix Nanoparticles Effects On The Lung In Vivo, Brittaney E. Ritchie
Theses and Dissertations
Acute respiratory distress syndrome (ARDS) is a life-threatening condition that causes diffuse alveolar damage and a loss of the extracellular matrix (ECM). This leads to pulmonary edema and lung function deterioration. Our lab has created decellularized porcine lung, electrosprayed ECM nanoparticles that have been previously shown to have pro-regenerative capabilities in vitro.
In this study, the ECM nanoparticle effects on young murine lungs were tested in vivo. An ECM nanoparticle suspension, previously used for the in vitro studies, was aerosolized intratracheally into the lungs using a microsprayer. 24 hours later, the lung mechanics, bronchoalveolar lavage fluid, and histology …
Electrospun Fibers With Smart Delivery Of Therapeutic Agents, Zahra Mahdieh
Electrospun Fibers With Smart Delivery Of Therapeutic Agents, Zahra Mahdieh
Graduate Student Theses, Dissertations, & Professional Papers
Electrospinning is the most widely studied technique of producing fibers. Delivery of nanoparticles and therapeutic agents from electrospun fibers have potential uses in various fields including drug delivery, filtration, and cosmetics. However, controlling the delivery rate remains the main challenge. In the current study, core-shell structure fibers were developed with zinc oxide nanoparticles applied in the shell composition to improve the pore structure (release pathway) and mechanical stability. Fine-tuned delivery rates were achieved via loading different sizes of silver nanoparticles (Ag NP) inside the fiber core. In vitro drug release assays showed fast, slow, and intermediate delivery rates of 20 …
Enhanced Water Electrolysis: Effect Of Temperature On The Oxygen Evolution Reaction At Cobalt Oxide Nanoparticles Modified Glassy Carbon Electrodes, Aya Akl, Hany A. Elazab, Mohamed A. Sadek, Mohamed S. El-Deab
Enhanced Water Electrolysis: Effect Of Temperature On The Oxygen Evolution Reaction At Cobalt Oxide Nanoparticles Modified Glassy Carbon Electrodes, Aya Akl, Hany A. Elazab, Mohamed A. Sadek, Mohamed S. El-Deab
Chemical and Biochemical Engineering Faculty Research & Creative Works
Water splitting producing hydrogen and oxygen gases appears promising in view of the increasing need of renewable energy sources and storage strategies. Investigation of stable and highly efficient electrocatalysts for oxygen evolution reaction (OER) is targeted in this study at cobalt oxide nanoparticle modified glassy carbon (nano-CoOx/GC) electrodes. The effect of the preparation (Tp) and measuring temperature (Tm) on the electrocatalytic activity of nano-CoOx/GC towards the OER is investigated under various operating conditions. Linear sweep voltammetry (LSV), cyclic voltammetry (CV) as well as SEM and XRD techniques were used to probe the electrocatalytic and morphological characteristics of nano-CoOx prepared under …
Classification And Biological Identity Of Complex Nano Shapes, Luca Boselli, Hender Lopez, Wei Zhang, Qi Cai, Valeria A. Giannone, Jingji Li, Alirio Moura, João M. De Araujo, Jennifer Cookman, Valentina Castagnola, Yan Yan, Kenneth A. Dawson
Classification And Biological Identity Of Complex Nano Shapes, Luca Boselli, Hender Lopez, Wei Zhang, Qi Cai, Valeria A. Giannone, Jingji Li, Alirio Moura, João M. De Araujo, Jennifer Cookman, Valentina Castagnola, Yan Yan, Kenneth A. Dawson
Articles
Everywhere in our surroundings we increasingly come in contact with nanostructures that have distinctive complex shape features on a scale comparable to the particle itself. Such shape ensembles can be made by modern nano-synthetic methods and many industrial processes. With the ever growing universe of nanoscale shapes, names such as “nanoflowers” and “nanostars” no longer precisely describe or characterise the distinct nature of the particles. Here we capture and digitise particle shape information on the relevant size scale and create a condensed representation in which the essential shape features can be captured, recognized and correlated. We find the natural emergence …
Formulation And Validation Of Nanoparticle Controlled Delivery For Chemotherapeutic Drug Products, Shani L. Levit
Formulation And Validation Of Nanoparticle Controlled Delivery For Chemotherapeutic Drug Products, Shani L. Levit
Theses and Dissertations
Taxol, a formulation of paclitaxel (PTX), is one of the most widely used anticancer drugs, particularly for treating recurring ovarian carcinomas following surgery. Clinically, PTX is used in combination with other drugs such as lapatinib (LAP) to increase treatment efficacy. Delivering drug combinations with nanoparticles has the potential to improve chemotherapy outcomes. In this study, we use Flash NanoPrecipitation, a rapid, scalable process to encapsulate weakly hydrophobic drugs (logP in vitro. Encapsulating either PTX or LAP into nanoparticles increases drug potency. When PTX and LAP are co-loaded in the same nanoparticle, they have a synergistic effect that is greater than …