Engineering Commons^™

The Varied Thermal Response Of Magnetic Iron-Oxide Nanoparticles During Induction Heating In Liquid And Solid-Liquid Phase Change Mediums, Joshua Tompkins

Graduate Theses and Dissertations

This study investigates the induction heating response of uncapped iron oxide nanoparticles sonically dispersed as a nanofluid and mechanically distributed in solid phase change materials. The nanoparticles examined have a mean diameter of 14.42 nm and are magnetically heated in an alternating magnetic field at an amplitude of 72.6 kA/m at frequencies of 217, 303, and 397 kHz. Nanoparticle characterization was undertaken through transition electron microscopy, x-ray diffraction, and dynamic light scattering when in suspension. Carrier fluids were characterized through viscosity, heat capacity, and density measurements which were used in the calorimetric calculation of the specific absorption rate (SAR) of …

Nanoceria Distribution And Effects Are Mouse-Strain Dependent, Robert A. Yokel, Michael T. Tseng, D. Allan Butterfield, Matthew L. Hancock, Eric A. Grulke, Jason M. Unrine, Arnold J. Stromberg, Alan K. Dozier, Uschi M. Graham

Pharmaceutical Sciences Faculty Publications

Prior studies showed nanoparticle clearance was different in C57BL/6 versus BALB/c mice, strains prone to Th1 and Th2 immune responses, respectively. Objective: Assess nanoceria (cerium oxide, CeO₂ nanoparticle) uptake time course and organ distribution, cellular and oxidative stress, and bioprocessing as a function of mouse strain. Methods: C57BL/6 and BALB/c female mice were i.p. injected with 10 mg/kg nanoceria or vehicle and terminated 0.5 to 24 h later. Organs were collected for cerium analysis; light and electron microscopy with elemental mapping; and protein carbonyl, IL-1β, and caspase-1 determination. Results: Peripheral organ cerium significantly increased, generally more …

Fluidization Characteristics Of Group C+ Particles: Fine Powder With Nanoparticle Modulation, Yandaizi Zhou

Electronic Thesis and Dissertation Repository

Geldart Group C particles become increasingly attractive in industry because of their small particle sizes and large specific surface areas. The main challenge in the flow and fluidization of Geldart Group C particles is their cohesive nature due to strong interparticle forces. The “nanoparticle modulation” technique was adopted to reduce the interparticle forces of Group C particles and thus significantly improved their flow and fluidization quality. Group C⁺ particles, a new type of fine particles with drastically reduced or insignificant interparticle forces, were created using the nano-modulation technique.

Fundamental studies provided a comprehensive understanding of the fluidization quality of …

Enhanced Water Electrolysis: Effect Of Temperature On The Oxygen Evolution Reaction At Cobalt Oxide Nanoparticles Modified Glassy Carbon Electrodes, Aya Akl, Hany A. Elazab, Mohamed A. Sadek, Mohamed S. El-Deab

Chemical Engineering

Water splitting producing hydrogen and oxygen gases appears promising in view of the increasing need of renewable energy sources and storage strategies. Investigation of stable and highly efficient electrocatalysts for oxygen evolution reaction (OER) is targeted in this study at cobalt oxide nanoparticle modified glassy carbon (nano-CoOx/GC) electrodes. The effect of the preparation (Tp) and measuring temperature (Tm) on the electrocatalytic activity of nano-CoOx/GC towards the OER is investigated under various operating conditions. Linear sweep voltammetry (LSV), cyclic voltammetry (CV) as well as SEM and XRD techniques were used to probe the electrocatalytic and morphological characteristics of nano-CoOx prepared under …

Nanohybrid Membrane Synthesis With Phosphorene Nanoparticles: A Study Of The Addition, Stability And Toxicity, Joyner Eke, Philip Alexander Mills, Jacob Ryan Page, Garrison P. Wright, Olga V. Tsyusko, Isabel C. Escobar

Center of Membrane Sciences Faculty Publications

Phosphorene is a promising candidate as a membrane material additive because of its inherent photocatalytic properties and electrical conductance which can help reduce fouling and improve membrane properties. The main objective of this study was to characterize structural and morphologic changes arising from the addition of phosphorene to polymeric membranes. Here, phosphorene was physically incorporated into a blend of polysulfone (PSf) and sulfonated poly ether ether ketone (SPEEK) doping solution. Protein and dye rejection studies were carried out to determine the permeability and selectivity of the membranes. Since loss of material additives during filtration processes is a challenge, the stability …

Synthesis, Self-Assembly And High-Pressure Properties Of Nanoparticles And Hybrid Nanocomposites, Lingyao Meng

Nanoscience and Microsystems ETDs

Nanoparticles have gained significant scientific interests owing to their unique structural dimensions, size- and shape-tunable properties, and numerous fascinating applications, from opto-electronics, sensor devices, to energy, environmental, and medical fields. Furthermore, the synergistic integration of other materials, including organic polymers, with nanoparticles provides new opportunities and strategies to obtain nanocomposites with superior properties and functionalities. While there is already significant research on the synthesis and characterizations of nanoparticles and hybrid nanocomposites, some research questions, such as how to design and control the interfacial morphology in polymer/nanoparticle hybrid nanocomposites, how to synthesize metal- organic framework (MOF) nanoparticles in well-defined and uniform …

Enhanced Water Electrolysis: Effect Of Temperature On The Oxygen Evolution Reaction At Cobalt Oxide Nanoparticles Modified Glassy Carbon Electrodes, Aya Akl, Hany A. Elazab, Mohamed A. Sadek, Mohamed S. El-Deab

Chemical Engineering

Water splitting producing hydrogen and oxygen gases appears promising in view of the increasing need of renewable energy sources and storage strategies. Investigation of stable and highly efficient electrocatalysts for oxygen evolution reaction (OER) is targeted in this study at cobalt oxide nanoparticle modified glassy carbon (nano-CoOx/GC) electrodes. The effect of the preparation (Tp) and measuring temperature (Tm) on the electrocatalytic activity of nano-CoOx/GC towards the OER is investigated under various operating conditions. Linear sweep voltammetry (LSV), cyclic voltammetry (CV) as well as SEM and XRD techniques were used to probe the electrocatalytic and morphological characteristics of nano-CoOx prepared under …

Bijels Made By Solvent Transfer Induced Phase Separation: Formation Principles And Transport, Stephen Boakye-Ansah

Theses and Dissertations

Bijels are made of non-equilibrium particle-stabilized emulsions with a bicontinuous arrangement of the constituent fluid phases. They spontaneously form through arrested spinodal decomposition in mixtures of partially miscible liquids and neutrally wetting colloidal particles. Soon after their discovery over 10 years ago, Prof. Mike Cates, Lucasian Professor of Mathematics, predicted their future use as continuously operated cross-flow reactors for chemical reactions between immiscible reactants.

Towards this goal, work in this thesis focuses on designing bijels via Solvent Transfer Induced Phase Separation (STrIPS) for microfluidic transport applications. Structure-function relationships of STrIPS bijels stabilized by silane functionalized nanoparticles are developed. In-situ surfactant …

Water Purification Device And A Method Of Decontaminating A Water Supply, Dibakar Bhattacharyya, Li Xiao

Chemical and Materials Engineering Faculty Patents

A water purification device is provided in the form of a hydrogel matrix containing immobilized nanoparticles that are directly synthesized in-situ in the hydrogel matrix. The hydrogel matrix is temperature sensitive, such that swelling draws in pollutants that are captured by the nanoparticles, while deswelling releases purified water. A related method of decontaminating the water supply contaminated with a target pollutant is also disclosed.

Ultrafine Particle-Particle And Particle-Ion Interactions In Aerosol Reactors, Girish Sharma

McKelvey School of Engineering Theses & Dissertations

Aerosol science and technology has enabled the material synthesis of ‘good’ nanoparticles, as well as, addressed the problem of air pollution by developing particle capture technologies for ‘bad’ nanoparticles. For material synthesis at industrial scale, flame aerosol reactors are extensively used for large-scale industrial production of ‘good’ nanoparticles. But, there exists a knowledge gap in understanding the early stages (1-10 nm) of particle formation and growth, which is necessary for tailoring the synthesized nanoparticles’ properties. To achieve this goal, measurement tools for the characterization of 1-10 nm particles are quintessential. On the other hand, to capture ‘bad’ particles, existing control …

Tunable Luminescence Of Rare Earth Doped Nanophosphors Via Adaptive Optical Properties Of Transition Metals, Pragathi Darapaneni

LSU Doctoral Dissertations

Over the past decades, the development of light-emitting diodes (LEDs) to produce a wide range of wavelengths has revolutionized the solid-state lighting industry due to their higher energy efficiency and operational lifetimes. These LEDs employ rare earth (RE) doped phosphors due to their stable emission wavelengths which can be amplified when sensitized by other RE dopants (Yb, Ce) or shell layer passivation. However, there has been a push to replace the RE elements in LEDs due to increased socioeconomic issues. One proposed alternative, transition metal (TM) dopants, is typically avoided due to their susceptibility to the local crystal environment resulting …

Engineered Nanoparticles For Site-Specific Bioorthogonal Catalysis: Imaging And Therapy, Riddha Das

Doctoral Dissertations

Bioorthogonal catalysis offers a strategy for chemical transformations complementary to bioprocesses and has proven to be a powerful tool in biochemistry and medical sciences. Transition metal catalysts (TMCs) have emerged as a powerful tool to execute selective chemical transformations, however, lack of biocompatibility and stability limits their use in biological applications. Incorporation of TMCs into nanoparticle monolayers provides a versatile strategy for the generation of bioorthogonal nanocatalysts known as “nanozymes”. We have fabricated a family of nanozymes using gold nanoparticles (AuNPs) as scaffolds featuring diverse chemical functional groups for controlled localization of nanozymes in biological environments, providing unique strategies for …

Microfiltration Membrane Pore Functionalization Approaches For Chloro-Organic Remediation To Heavy Metal Sorption, Mohammad Saiful Islam

Theses and Dissertations--Chemical and Materials Engineering

Microfiltration polyvinylidene fluoride (PVDF) membranes have distinct advantage for open structure in terms of high internal surface area and ease of access in the pore domain. Functionalization of PVDF membranes with different functional groups (-COOH, -OH, -SH) enables responsive (pH, temperature) properties to membrane, tuning of effective pore size, controlling permeate flux. PVDF microfiltration membrane functionalization with suitable responsive polymer such as poly acrylic acid (PAA) to incorporate carboxyl (-COOH) group enables further modification of functionalized PAA-PVDF membranes for different application ranging from catalysis, bio reactor to heavy metal sorption platform. As a catalytic reactor bed, this PAA-PVDF membranes are …

Formulation Strategies To Enhance Solubility And Permeability Of Small Molecules For Drug Delivery Applications, Pradeep Kumar Bolla

Open Access Theses & Dissertations

All the new chemical entities/drug molecules intended for therapeutic use must be administered using an appropriate delivery system/dosage form to achieve maximum bioavailability. However, designing a drug delivery system is complex as several factors such as lipophilicity, molecular mass, crystallinity, ionic charge, polymorphic forms and hydrogen bonding) affect the solubility and permeability of these molecules. Biopharmaceutics drug classification system (BCS) categorizes the existing drugs into four classes based on the aqueous solubility and membrane permeability and it is reported that >70% of the drugs are poorly soluble and belong to BCS class II and BCS class IV. Several physical, chemical …

Investigation On Nanoparticle Based Combination Therapy For Targeted Cancer Treatment, Muhammad Raisul Abedin

Doctoral Dissertations

“The current treatment methods in cancer are associated with toxicity in healthy tissues, partial therapeutic response, drug resistance and finally recurrence of the disease. The cancer drugs are challenged by non-specific binding, undesired toxicity in healthy cells, low therapeutic index and finally poor therapeutic outcome. In this work, a targeted nanoscale therapeutic system Antibody Drug Nanoparticle (ADN) was engineered to selectively inhibit the breast cancer cell growth with reduced toxicity in healthy cells. The ADNs were designed by synthesizing rod shaped anoparticles using pure chemotherapeutic drug and covalently conjugating a therapeutic monoclonal antibody (mAb) on the surface of the drug …

Enhanced Water Electrolysis: Effect Of Temperature On The Oxygen Evolution Reaction At Cobalt Oxide Nanoparticles Modified Glassy Carbon Electrodes, Aya Akl, Hany A. Elazab, Mohamed A. Sadek, Mohamed S. El-Deab

Chemical and Biochemical Engineering Faculty Research & Creative Works

Water splitting producing hydrogen and oxygen gases appears promising in view of the increasing need of renewable energy sources and storage strategies. Investigation of stable and highly efficient electrocatalysts for oxygen evolution reaction (OER) is targeted in this study at cobalt oxide nanoparticle modified glassy carbon (nano-CoOx/GC) electrodes. The effect of the preparation (Tp) and measuring temperature (Tm) on the electrocatalytic activity of nano-CoOx/GC towards the OER is investigated under various operating conditions. Linear sweep voltammetry (LSV), cyclic voltammetry (CV) as well as SEM and XRD techniques were used to probe the electrocatalytic and morphological characteristics of nano-CoOx prepared under …

Formulation And Validation Of Nanoparticle Controlled Delivery For Chemotherapeutic Drug Products, Shani L. Levit

Theses and Dissertations

Taxol, a formulation of paclitaxel (PTX), is one of the most widely used anticancer drugs, particularly for treating recurring ovarian carcinomas following surgery. Clinically, PTX is used in combination with other drugs such as lapatinib (LAP) to increase treatment efficacy. Delivering drug combinations with nanoparticles has the potential to improve chemotherapy outcomes. In this study, we use Flash NanoPrecipitation, a rapid, scalable process to encapsulate weakly hydrophobic drugs (logP in vitro. Encapsulating either PTX or LAP into nanoparticles increases drug potency. When PTX and LAP are co-loaded in the same nanoparticle, they have a synergistic effect that is greater than …