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Full-Text Articles in Engineering
Understanding The Effects Of Plasma Assisted Nanoparticle Deposition For The Enhancement Of Optical And Electrochemical Response, Apurva Sonawane
Understanding The Effects Of Plasma Assisted Nanoparticle Deposition For The Enhancement Of Optical And Electrochemical Response, Apurva Sonawane
FIU Electronic Theses and Dissertations
In this work, the effects of atmospheric plasma treatment on morphology, optical, and electrochemical properties of 10 ± 3nm spherical silver and gold nanoparticles (AgNPs and AuNPs) functionalized substrates were studied. The nanoparticles (NPs) were deposited on substrates by drop-casting, aerosol spray, and a low-temperature atmospheric plasma-assisted aerosol jet. The reduction in nanoparticle size was observed, which was explained by the redox reaction that occurs on the nanoparticle surface. This phenomenon was evident by the presence of AgO, Ag2O, and AuOx Raman peaks in the treated sample. The surface charge changed as a result of plasma treatment, …
Cancer Biomarker Detection In Human Plasma By Integrating Surface Acoustic Wave And Metal-Enhanced Fluorescence, Yuqi Huang
USF Tampa Graduate Theses and Dissertations
This thesis includes data and discussion about the technique of metal-enhanced fluorescence (MEF) to lower the detection limit of carcinoembryonic antigen (CEA). The detection limit goes down to 100pg/mL level when using MEF substrate made by rapid thermally annealed silver film covered by silica, which has great promise in diagnosing certain types of cancer that uses CEA as detection biomarker, such as pancreatic cancer and colon cancer. To further address the issue of background noises from non-specifically bound proteins (NSB) in complex media, such as plasma, serum, urine and blood, MEF is integrated with surface acoustic wave (SAW) streaming in …
Formulation Strategies To Enhance Solubility And Permeability Of Small Molecules For Drug Delivery Applications, Pradeep Kumar Bolla
Formulation Strategies To Enhance Solubility And Permeability Of Small Molecules For Drug Delivery Applications, Pradeep Kumar Bolla
Open Access Theses & Dissertations
All the new chemical entities/drug molecules intended for therapeutic use must be administered using an appropriate delivery system/dosage form to achieve maximum bioavailability. However, designing a drug delivery system is complex as several factors such as lipophilicity, molecular mass, crystallinity, ionic charge, polymorphic forms and hydrogen bonding) affect the solubility and permeability of these molecules. Biopharmaceutics drug classification system (BCS) categorizes the existing drugs into four classes based on the aqueous solubility and membrane permeability and it is reported that >70% of the drugs are poorly soluble and belong to BCS class II and BCS class IV. Several physical, chemical …