Engineering Commons^™

Nanoemulsions Within Liposomes For Cytosolic Drug Delivery To Multidrug-Resistant Cancer Cells, Jacob Brian Williams

Theses and Dissertations

Cancer cells that survive chemotherapy treatment often develop resistance to the administered chemotherapeutics, as well as to many other types of drugs, because the cancer cells increase their production of efflux pumps in the cell. This undesired phenomenon of resistance to cancer drugs is known as multidrug resistance. This work uses a novel drug carrier, called an eLiposome, to achieve cytosolic drug delivery to kill multidrug-resistant cancer cells. An eLiposome consists of a perfluoropentane (PFC5) emulsion droplet inside of a liposome. Folate attached to the eLiposome facilitates uptake into the cell. The PFC5 droplet is metastable at body temperature, but …

Effects Of Tethering Placement And Linker Variations On Antibody Stability On Surfaces, Rebecca Ellen Grawe

Theses and Dissertations

An antibody microarray consists of antibody bound to a surface. Antibody microarrays have great potential in many fields, particularly as a tool to detect antigens. Unfortunately, antibodies suffer from poor performance. A greater understanding of how antibodies interact with surfaces would improve microarray design and performance, but experimental methods fall short of being able to observe these interactions. Therefore molecular simulation has emerged as the primary method to study protein/surface interactions.The simulations here were coarse grain simulations performed using the model of Karanicolas and Brooks. Additionally, an advanced surface model was used that allows for different surface chemistries. PyMBAR analysis …

Evolvability And Excess Capability As A Response To Uncertain And Future Requirements, Jeffrey Douglas Allen

Theses and Dissertations

Product and system designers face many challenges in the modern world. Designing products that will be subject to emerging or uncertain requirements can be one of the most significant of these challenges. A major risk associated with emerging or uncertain requirements is premature obsolescence. Large-scale, complex engineered systems, such as, aircraft, spacecraft, large seagoing vessels, communication and power systems are especially susceptible to this issue. However, this challenge is not limited to only large-scale complex systems. Even relatively simple products can suffer from premature obsolescence and even failure to be initially accepted, due to inadequately understood or changing requirements. One …

Extending Time Until Failure During Leaking In Inflatable, Pneumatically Actuated Soft Robots, Joshua Parker Wilson

Theses and Dissertations

Soft robots and particularly inflatable robots are of interest because they are lightweight, compact, robust to impact, and can interact with humans and their environment relatively safely compared to rigid and heavy traditional robots. Improved safety is due to their low mass that results in low-energy collisions and their compliant, soft construction. Inflatable robots (which are a type of soft robot) are also robust to impact and have a high torque to weight ratio. As a result inflatable robots may be used for many applications such as space exploration, search and rescue, and human-robot interaction. One of the potential problems …

Strain Phase Separation: Formation Of Ferroelastic Domain Structures, Fei Xue, Yongjun Li, Yijia Gu, Jinxing Zhang, Long-Qing Chen

Materials Science and Engineering Faculty Research & Creative Works

Phase decomposition is a well-known process leading to the formation of two-phase mixtures. Here we show that a strain imposed on a ferroelastic crystal promotes the formation of mixed phases and domains, i.e., strain phase separation with local strains determined by a common tangent construction on the free energy versus strain curves. It is demonstrated that a domain structure can be understood using the concepts of domain/phase rule, lever rule, and coherent and incoherent strain phase separation, in a complete analogy to phase decomposition. The proposed strain phase separation model is validated using phase-field simulations and experimental observations of PbTiO …

Photovoltaic Installation In Ecuador And The Amazon, David Mulder

Construction Management

The Photovoltaic Installation in Ecuador and The Amazon is part of a collaborative effort between two major construction clubs at Cal Poly: NECA and MCAA. Four students, two from each club, traveled with two faculty to install photovoltaics for two different communities. The first project was a solar installation to provide fresh water for the community of Santa Rosa. Project number two, was a sixteen-panel installation in Shell, Ecuador for the non-profit Reach Beyond. The main goals of each project were to provide fresh water, and achieve net zero electrical consumption.

Feasibility Study Of Using Recyclable Polyethylene (Pet) Materials As Coarse Aggregate For Concrete Mixtures, Philip M. Angelo

Construction Management

The feasibility of using recyclable household plastics, specifically those made of polyethylene, commonly used in water and soda bottles, as a replacement for concrete coarse aggregate, was assessed. A method was developed for cutting polyethylene materials into fibrous strips. These strips were then used as a replacement for the rock coarse aggregate in batches of concrete. Standard 6” x 12” test cylinders were made using the concrete mixture and subject to destructive compressive testing in order to yield the compressive strength of the concrete mix 7, 14, 21, and 28 days after pouring. Three mixtures were tested, one control with …

Carpenters Apprenticeship Internship: Student And Industry Perspectives, Chris Falco

Construction Management

The Carpenters Apprenticeship Internship program is designed to provide students the opportunity to work as a construction laborer and get hands-on work experience. The goal of this study is to address the perceived benefits of the Carpenters Apprenticeship Internship with respect to the students, the industry members, and the union. In looking at the benefits this opportunity presents, any value that is aligned among the parties involved will be highlighted to convey the mutual advantages. Lastly, the demand among students for experience such as this will be assessed to see what the perceived value of labor experience is among students …

Technology Adoption By California Central Coast Contractors, Nicholas A. English

Construction Management

Technology is trending in Construction, but it is unclear if smaller contractors have kept up with these trends like larger national companies have. This survey of San Luis Obispo County specialty and general contractors queried technology adoption, specific software use, estimator age, and opinions of various estimating attributes. It found that the majority of contractors use traditional estimating and quantity takeoff methods, the majority of contractors are 31 years old or older, and that local estimators value experience and knowledge as opposed to computer expertise. Local contractors recognize the value technology can provide, but have not adopted it in a …

Construction Of A Chicken Coop For Use By An Early Education Facility, Luke Cypress

Construction Management

There is a demand in the early education field for methods of exposing early learners to where our food comes from and how it’s produced. An excellent source of this exposure is commonly utilized in an onsite chicken-coop. These coops are in essence working farms, producing eggs and in some cases meat. While coops are not prohibitively expensive they often fall outside the scope of normal operating or educational budgets and can be difficult to fund. The purpose of this project was to identify a school that could use and benefit from a coop at no cost to the school. …

Kihefo Vocational Center: Kabale, Uganda, Jason Matthew Angerer

Construction Management

Journeyman International (JI) is a non-profit organization which acts as a platform for bringing together volunteer Architects, Designers, Engineers, and Construction Managers with humanitarian projects around the world. Kigezi Healthcare Foundation (KIHEFO) a non-profit NGO located in Kabale, Uganda is a client seeking to build a vocational center to educate the workforce of Uganda. The center will include multi-purpose class rooms, a dining hall, rabbit farm, carpentry shop, and living complex. The Architect on the project was Courtney Wedel from Cal Poly. As the Construction Manager on the project my responsibilities include; Design Assist, Feasibility Analysis, Scheduling, Estimating, and Managing …

A Case Study On Achieving 100% Customer Satisfactory Homes In Production Home Building, Garrett Whitlock

Construction Management

No abstract provided.

Enhancements In Localized Classification For Uterine Cervical Cancer Digital Histology Image Assessment, Peng Guo, Haidar A. Almubarak, Koyel Banerjee, R. Joe Stanley, L. Rodney Long, Sameer K. Antani, George R. Thoma, Rosemary E. Zuna, Shelliane R. Frazier, Randy Hays Moss, William V. Stoecker

Electrical and Computer Engineering Faculty Research & Creative Works

Background: In previous research, we introduced an automated, localized, fusion-based approach for classifying uterine cervix squamous epithelium into Normal, CIN1, CIN2, and CIN3 grades of cervical intraepithelial neoplasia (CIN) based on digitized histology image analysis. As part of the CIN assessment process, acellular and atypical cell concentration features were computed from vertical segment partitions of the epithelium region to quantize the relative distribution of nuclei.

Methods: Feature data was extracted from 610 individual segments from 61 images for epithelium classification into categories of Normal, CIN1, CIN2, and CIN3. The classification results were compared against CIN labels obtained from two pathologists …

Sugarcane Bagasse Hydrolysis Enhancement Using Bsa, Antonio Carlos Freitas Dos Santos

Open Access Theses

Lignocellulose is composed of polysaccharides linked to lignin and other aromatic compounds, making the sugars not readily available to fermentation. This entails that biomass must go through the unit operations of pretreatment and enzyme hydrolysis. Pretreatment opens the structure to allow the enzymes to act on and hydrolyze cellulose and hemicellulose to glucose and/or xylose which in turn are fermented to ethanol. Concomitantly, the enzymes interact with soluble phenols and insoluble solids derived from lignin that inhibit hydrolysis. This leads to high enzyme loadings and higher production costs. Soluble phenols can be eliminated through washing. Insoluble lignin, however, demands another …

Indiana Local Road And Bridge Conditions, Indiana Ltap

Indiana Local Technical Assistance Program (LTAP) Publications

In response to an appilcation requirement for the Community Matching Grant Fund Program, 354 asset management plans for roads and bridges were submitted in 2016 which contain the current conditions of local agency roads and bridges. This report describes these conditions and suggests the funding levels necessary to improve and maintain these assets at defined condition levels over a ten-year period. A ten-year horizon was used so as to correspond to previous LTAP studies performed in 2003 and 2009. The ten-year time period is also comparable to other Indiana studies.

Practical Knowledge In Electrical Engineering : Applying Lessons From Industry To The Classroom., Tayce Lassiter

Electronic Theses and Dissertations

Objective: To identify and develop solutions for known gaps in existing electrical engineering curricula, by creating instruction modules applicable in a variety of settings. These instructional packages include: conductor sizing, conduit routing, how to read and create a P&ID, arc flash calculations, and area classification. With regards to conductor sizing, the importance of specifying the correct size of conductor, the standard sizes of conductors, the types of conductor insulation, and finally detail the calculations of conductor sizing and voltage drop will be discussed. The conduit routing module will introduce the student to basic guidelines of conduit routing as well as …

Process Development For The Fabrication Of Semiconductor Devices And Circuits Using Spin-On Dopant, Richard R. Ryan

UNLV Theses, Dissertations, Professional Papers, and Capstones

Traditional approaches to semiconductor device fabrication are expensive and time consuming, making them out of reach for most universities and colleges. The objective of this thesis is to develop a process by which semiconductor devices and circuits can be implemented completely in-house using spin-on dopants (SODs), and low-cost transparency masks, to significantly reduce the lead time, complexity, and cost associated with device fabrication. This will allow hands on fabrication experience for students at universities and colleges without the traditional expensive device fabrication facilities. In addition, it will also allow students and professors to design, fabricate and test semiconductor devices and …

Pendulum Based Impact Testing Of Athletic Helmets Using The Nocsae Headform, Bradley Thorne

UNLV Theses, Dissertations, Professional Papers, and Capstones

Concussions in organized sports can have detrimental short-term and long-term effects on player’s health. The focus of this research is the development of a new state of the art test and certification standard for protective headgear. Baseball helmets and soccer soft headgear were used in these tests, but the ultimate goal is to create a universal set of test guidelines for all types of protective headgear. Modifications to current test standards outlined by the National Operating Committee on Standards for Athletic Equipment (NOCSAE) employed the use of a pendulum impactor, which facilitated additional measurements during head impact tests using a …

Assessing Fuel Burn Inefficiencies In Oceanic Airspace, Stephen Builta

Open Access Theses

Increasing the efficiency of aircraft operations offers a shorter term solution to decreasing aircraft fuel burn than fleet replacement. By estimating the current airspace inefficiency, we can get an idea of the upper limit of savings. Oceanic airspace presents a unique opportunity for savings due to increased separation differences vs. overland flight.

We assess fuel burn inefficiency by comparing estimated fuel burn for real world flights with the estimated optimal fuel burn. For computing fuel burn, we use the Base of Aircraft Data (BADA) with corrections based on research by Yoder (2005). Our fuel burn results show general agreement with …

Multimedia Techniques For Construction Education And Training, Wayne A. Bunnell

Open Access Theses

The current profession of civil engineering often focuses education and training on code compliance rather than constructability and construction techniques. Also, it is well accepted that it takes a decade or more for engineers to develop a high-level project construction understanding and many state departments of transportation rely on in-field training for entry-level inspectors, with little or no education provisions for contractors. This research investigated the use of time-lapse photography to develop training and education material that will improve the understanding of project construction and crucial quality control specifications of an entry-level engineer, contractor, or inspector. Overall, the project team …

Size Scaling Of Strength And Toughness For 3d Printed Polymer Specimens, Darren Thomas Bell

Open Access Theses

To find material systems that offer low density and high strength, stiffness or toughness, hierarchically designed material systems have provided a promising research area. This thesis lays the groundwork for designing efficient micro-architectured material systems by characterizing size effects for 3d printed polymer parts. Two methods were used to analyze data from 3-point bend tests for specimens of varying size: the load-separation method was used for finding the point of crack growth initiation and Bazant’s method was used to find shape independent strength at failure. The strength values were used as inputs for finding size independent material constants within a …

Mechanism Of Shot Peening Enhancement For The Fatigue Performance Of Aa7050-T7451, Daniel James Chadwick

Open Access Theses

Shot peening is a dynamic cold working process involving the impingement of peening media onto a substrate surface. Shot peening is commonly employed as a surface treatment technique within the aerospace industry during manufacturing, in order to improve fatigue performance of structural components. The compressive residual stress induced during shot peening is understood to result in fatigue crack growth retardation, improving the performance of shot peened components. However, shot peening is a compromise between the benefit of inducing a compressive residual stress and causing detrimental surface damage. Due to the relatively soft nature of AA7050-T7451, shot peening can result in …

Printing 3d Lithium-Ion Microbattery Using Stereolithography, Qiming Chen

Open Access Theses

Microbatteries have been gained a lot of importance since the development of micro- and nanotechnologies. Integrating the microbattery system will enable a variety of applications, such as implantable biomedical devices and wireless sensor networks. In this paper, we demonstrated a new method to fabricate three dimensional lithium-ion microbattery using stereolithiography. A UV-curable gel polymer electrolyte resin is first synthesized and characterized. The electrolyte resin is then applied to build into 3D architecture by stereolithography. The gel electrolyte structure is designed into a zigzag shape in order to improve the contact area between electrode and electrolyte. Battery's active material, LiFePO4 (LFP) …

Tangible Interaction As An Aid For Object Navigation In 3d Modeling, Sanmathi Dangeti

Open Access Theses

This study introduced an interaction technique that used tangible interaction for 3D modeling. A hybrid interaction technique using a Kinect camera and a smartphone with a gyroscope was developed for the navigating objects in a 3D modeling software. It was then tested on 20 participants categorized as amateurs who had basic 3D/ CAD modeling experience and 20 participants categorized as the experts who had extensive experience working with the modeling software. This research study presents the need for existence of such interaction technique, gaps from the related previous studies, statistical findings from the current study and possible reasons for the …

Taming Tail Latency For Erasure-Coded, Distributed Storage Systems, Jingxian Fan

Open Access Theses

Nowadays, in distributed storage systems, long tails of responsible time are of particular concern. Modern large companies like Bing, Facebook and Amazon Web Service show that 99.9th percentile response times being orders of magnitude worse than the mean. With the advantages of maintaining high data reliability and ensur- ing enough space eciency, erasure code has become a popular storage method in distributed storage systems. However, due to the lack of mathematical models for analyzing erasure-coded based distributed storage systems, taming tail latency is still an open problem.

In this research, we quantify tail latency in such systems by deriving a …

An Investigation Of Composite Failure Analyses And Damage Evolution In Finite Element Models, Ann M. Frappier

Open Access Theses

This paper presents a composite conical structure used commonly in flight-qualification testing. This structure’s overall load-displacement behavioral response is characterized. Mixed-mode multidelamination in a layered composite specimen is considered in Abaqus/Explicit through both the Virtual Crack Closure Technique and Cohesive Elements. The Virtual Crack Closure Technique and Cohesive Elements are compared against experimental test results presented in literature. Further, a thorough comparison in which the effects of failure criteria type, through-thickness mesh density, and finite element type on the progressive failure response of this composite assembly is discussed. Lastly, Abaqus/Standard and Helius PFA are compared in order to gain confidence …

Uncertainty Quantification On Industrial High Pressure Die Casting Process, Jiahong Fu

Open Access Theses

High pressure die casting (HPDC) is a famous manufacturing technology in industry. This manufacturing process is simulated by commercial code to shed the light on the quality of casting product. The casting product quality might be affected by the uncertainty in the simulation parameter settings. Thus, the uncertainty quantification on HPDC process is significant to improve the casting quality and the manufacturing efficiency.

In this work, three uncertainty quantifications and sensitivity analyses on the A380 aluminum alloy HPDC process of intermediate speed plate are performed. The material thermophysical properties, boundary conditions of the model, and operational as well as artificial …

Thermal Transport In Lithium Ion Batteries: An Experimental Investigation Of Interfaces And Granular Materials, Aalok Jaisheela Uday Gaitonde

Open Access Theses

Increasing usage and recent accidents due to lithium-ion (Li-ion) batteries exploding or catching on fire has inspired research on the characterization and thermal management of these batteries. In cylindrical 18650 cells, heat generated during the battery's charge/discharge cycle is poorly dissipated to the surrounding through its metallic case due to the poor thermal conductivity of the jelly roll, which is spirally wound with many interfaces between electrodes and the polymeric separator. This work presents a technique to measure the thermal conduction across the metallic case-plastic separator interface, which ultimately limits heat transfer out of the jelly roll.

The polymeric separator …

Design Of Nitroxide-Based Radical Polymer Materials For Electronic Applications, Martha E. Hay

Open Access Theses

Radical polymers represent a new class of organic electronic materials that rely on an oxidation-reduction (redox) reaction to transport charge. That is, stable radical sites pendant to the polymer backbone communicate electronically through a rapid oxidation-reduction reaction. This redox mechanism has previously been established as effective for charge-storage applications (e.g., secondary batteries). When applied in the solid state, radical polymers demonstrate electrical conductivity on par with that of first-generation conjugated polymer electronic materials. This initial success has prompted interest in developing design rules for radical polymers. Specifically, this thesis explores the impact of radical density in a polymer …

Design And Plan Of A Modified Hydroponic Shipping Container For Research, John A. Houtman

Open Access Theses

As the world’s population continues to increase, food production will need to increase in order to meet the predicted rise in food demand. However, with increased pressure on cropland available from environmental effects and urbanization, new innovative methods of crop production need to be researched in order to increase agricultural production with limited land. This research focuses on the design of a single form of urban agriculture that is considered Zfarming and has the potential to produce quality urban agricultural produce through ground-based measures. This project produced detailed step-by-step analysis of the design process, develop variability within the modified hydroponic …