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Full-Text Articles in Engineering

Decoding The Future: Integration Of Artificial Intelligence In Web Development, Dhiraj Choithramani Apr 2024

Decoding The Future: Integration Of Artificial Intelligence In Web Development, Dhiraj Choithramani

Harrisburg University Dissertations and Theses

The thesis explores AI's profound impact on web development, particularly in front-end and back-end processes. AI revolutionizes UI prototyping by automating design creation, enhancing both efficiency and aesthetics. It also aids in code review, content generation, and process flow experimentation, streamlining development workflows. Through AI-driven tools like GitHub's Copilot and Wix ADI, developers benefit from coding assistance and innovative design capabilities. Despite some challenges, AI's evolving role promises to reshape web development, offering unprecedented efficiency and user-centric solutions.


Improved Modeling And Application Of Data Assimilation In Gas Influx Management During Managed Pressure Drilling, Chen Wei Apr 2024

Improved Modeling And Application Of Data Assimilation In Gas Influx Management During Managed Pressure Drilling, Chen Wei

LSU Doctoral Dissertations

The management of gas influxes in a drilling well has been considered one of the most critical topics for maintaining petroleum drilling safety and efficiency. Reliable modeling of gas influx behaviors in a wellbore or a marine riser greatly benefits the improved understanding of a gas kick event and the development of optimized influx management strategies. However, the current studies on transient multiphase flow modeling show varying limitations on both the model rigorousness and the overall numerical efficiency. Meanwhile, the existence of great system uncertainties, such as the unclear influx sizes and distributions in the well/riser, has brought significant challenges …


Mechanical Characterization And Evaluation Of Additively Manufactured Titanium 5v-5mo-5al-3cr Alloy, Zachary Casias Apr 2024

Mechanical Characterization And Evaluation Of Additively Manufactured Titanium 5v-5mo-5al-3cr Alloy, Zachary Casias

Mechanical Engineering ETDs

Ti-5V-5Mo-5Al-3Cr (Ti-5553) is a near beta titanium alloy commonly used in aerospace applications. It is currently being explored for additive manufacturing (AM), but the fatigue behavior of this AM alloy needs to be well-understood for adoption in aerospace applications. The present work examines the tensile and fatigue behavior of LPBF manufactured Ti-5553. The effect of post-print heat treatments, effects of surface roughness, and print defects on the mechanical properties of AM Ti-5553 were also evaluated. Fatigue lives of as-LPBF and BAA material are nearly identical, and both are far below the fatigue lives of conventionally manufactured Ti-5553 of 350 MPa. …


Multiscale Characterization Of Dislocation Development During Cyclic Bending Under Tension In Commercially Pure Titanium, Nathan R. Miller Apr 2024

Multiscale Characterization Of Dislocation Development During Cyclic Bending Under Tension In Commercially Pure Titanium, Nathan R. Miller

Theses and Dissertations

Continuous bending under tension (CBT) has been shown to increase room temperature elongation-to-failure (ETF) in various sheet metals past that of simple tension (ST). In commercially pure titanium (CP-Ti) Grade 4, up to 3x extended elongation over ST has been achieved. A greater understanding of deformation mechanisms in CBT would allow for its elongation-enhancing effects to be more fully exploited in HCP and other metals, creating potential for new forming strategies. While most of the extended ETF has been attributed to delayed localization via incremental deformation inherent to the CBT process, together with compressive stabilization and relaxation of mechanical strain …


A Framework For Managing System Resources And Pricing In Multi-Provider Edge Computing Environments, Matthew Paul Salcido Apr 2024

A Framework For Managing System Resources And Pricing In Multi-Provider Edge Computing Environments, Matthew Paul Salcido

Electrical and Computer Engineering ETDs

Multi-provider multi-user multi-access edge computing provides a recent market driven networking paradigm facilitating the user data offloading process. In this thesis, we introduce the AGORA framework, which employs a sophisticated multi-leader multi-follower Stackelberg game that jointly optimizes the data offloading, computing resource allocation, and computing resource pricing, all facilitated through a non-cooperative game-theoretic approach. In order to support the aforementioned modeling and approach, a novel utility function that quantifies the users satisfaction, factoring in the computing service cost, and an innovative profit function for the MEC providers is introduced, emphasizing the market penetration and the computing service provision costs. Numerical …


Application Of High-Deflection Strain Gauges To Characterize Spinal-Motion Phenotypes Among Patients With Clbp, Spencer Alan Baker Apr 2024

Application Of High-Deflection Strain Gauges To Characterize Spinal-Motion Phenotypes Among Patients With Clbp, Spencer Alan Baker

Theses and Dissertations

Chronic low back pain (CLBP) is a nonspecific and persistent ailment that entails many physiological, psychological, social, and economic consequences for individuals and societies. Although there is a plethora of treatments available to treat CLBP, each treatment has varying efficacy for different patients, and it is currently unknown how to best link patients to their ideal treatment. However, it is known that biopsychosocial influences associated with CLBP affect the way that we move. It has been hypothesized that identifying phenotypes of spinal motion could facilitate an objective and repeatable method of determining the optimal treatment for each patient. The objective …


Time-Dependent Strain-Resistance Relationships In Silicone Nanocomposite Sensors, Alex Mikal Wonnacott Apr 2024

Time-Dependent Strain-Resistance Relationships In Silicone Nanocomposite Sensors, Alex Mikal Wonnacott

Theses and Dissertations

Flexible high-deflection strain gauges have been demonstrated as cost-effective and accessible sensors for capturing human biomechanical deformations. However, the interpretation of these sensors is notably more complex compared to conventional strain gauges, partially owing to the viscoelastic nature of the strain gauges. On top of the non-linear viscoelastic behavior, dynamic resistance response is even more difficult to capture due to spikes in resistance during strain changes. This research examines the relationships between stress, strain, and resistance in nanocomposite sensors during dynamic strain situations. Under the assumption that both macroscopic stress and resistance are governed by microscopic stress concentrations at the …


High Data Rate Signal Processing Architectures And Compilation Strategies For Scalable, Multi-Gigabit Digital Systems, Daniel Alexander Nybo Apr 2024

High Data Rate Signal Processing Architectures And Compilation Strategies For Scalable, Multi-Gigabit Digital Systems, Daniel Alexander Nybo

Theses and Dissertations

In this study we present a high-performance computing architecture and hardware acceleration strategy for a heterogeneous multi-gigabit computing system. The system architecture integrates a BeeGFS distributed file system, capable of achieving 80 Gbps of sustained write throughput across five nodes, essential for managing the high data volumes generated by a 25 high performance computer (HPC) compute cluster. To ensure operational efficiency and scalability, the tasks performed on the Linux compute cluster consisting of 30 nodes are automated using Ansible, facilitating seamless deployment, management, and updates. We present compilation strategies for a hardware accelerated Polyphase Filter Bank (PFB) channelization routine optimized …


Phase Separation And Morphology Evolution Of Multiphase Polymeric Systems, Rami Naser Fahmi Alhasan Apr 2024

Phase Separation And Morphology Evolution Of Multiphase Polymeric Systems, Rami Naser Fahmi Alhasan

Theses and Dissertations

This dissertation explores the intricate world of soft materials through a powerful synergy of theoretical frameworks and cutting-edge computational simulations. The research investigates how processing history, thermodynamics, and kinetics intertwine to influence the behavior and manipulation of these materials. A cornerstone of the work is the establishment of a generalized Gibbs--Duhem relationship, ensuring thermodynamic consistency within the employed models. This not only clarifies existing ambiguities but also lays the groundwork for future models with a robust thermodynamic foundation. This dissertation explores the influence of processing history on soft materials through three in-depth case studies, unveiling the critical role of processing …


A Spatial Data Framework For Indoor Positioning Using Machine Learning Techniques, Venkateswari P Apr 2024

A Spatial Data Framework For Indoor Positioning Using Machine Learning Techniques, Venkateswari P

Theses and Dissertations

The last few years have seen an increase in interest in indoor positioning and localization as potential research and development areas. WiFi is a strong substitute that supports positioning based on indoor floor plans. In this thesis, the Principal Featured - Kohonen Deep Structure (PF-KDS) model is developed to position WiFi devices more accurately and efficiently for indoor floor planning. Initially, spatial data analysis is conducted using the Principal Feature Enhanced Auto-Encoder algorithm, extracting principal features for dimensionality reduction.

Following this, the Kohonen Self- Organizing Deep Structured Learning technique is devised for precise position estimation by considering a new path …


Research On 3d Printing Resin Exposure Properties And Its Application On Centrifugal Microfluidic Platform Based On Fluorescence Detection, Zheng Qiao Apr 2024

Research On 3d Printing Resin Exposure Properties And Its Application On Centrifugal Microfluidic Platform Based On Fluorescence Detection, Zheng Qiao

LSU Doctoral Dissertations

This dissertation encapsulates significant advancements in the field of SLA 3D printing and centrifugal microfluidics. Central to the research is the development of a novel mathematical model for predicting trapped resin thickness in SLA 3D printing, a groundbreaking contribution that addresses a critical aspect of printing intricate structures. This model, the first to establish a mathematical relationship for resin thickness, is rooted in a comprehensive study of the resin curing process. The research leverages the concept of 'critical dosage' for resin curing, leading to a more refined and theoretically grounded approach for calculating curing thickness. Experimentation further validates the model, …


Combined Radiation And Convection In Developing Flow In A Parallel Plate Channel With Real Gas Behavior, Kyle Davis Pulsipher Apr 2024

Combined Radiation And Convection In Developing Flow In A Parallel Plate Channel With Real Gas Behavior, Kyle Davis Pulsipher

Theses and Dissertations

The laminar, thermally developing flow of gases in a two-dimensional parallel plate channel is studied here. Using computational fluid dynamics (CFD), the combined effects of convection and real gas radiation are explored. Gas mixtures composed of H2O, CO2, and N2 are considered. To account for radiation in the participating medium, the Spectral Line Weighted-sum-of-gray-gases model is used. The model formulation, verification, and validation are provided through published articles written by the primary author. The predictions made for the case of combined convection and radiation are compared to the solution for the classical pure convection case, known as the Graetz solution. …


Quantifying And Characterizing The Behavior Of Dissolved And Suspended Icp-Oes Detectible Elements In Utah Lake, Rachel Ann Valek Apr 2024

Quantifying And Characterizing The Behavior Of Dissolved And Suspended Icp-Oes Detectible Elements In Utah Lake, Rachel Ann Valek

Theses and Dissertations

For Utah Lake in Utah, USA, we analyzed a uniquely comprehensive and longitudinal water quality dataset that extended over two summer sampling seasons. We measured 61 parameters using Inductively Coupled Plasma Optical Emission Spectrometry (ICP-OES), YSI ProDSS water sondes, and laboratory procedures to quantify and characterize dissolved and suspended behavior of trace elements in Utah Lake. We analyzed the data using principal component analysis (PCA) and multidimensional scaling (MDS) to understand the lake geochemistry and inform Utah Lake management decisions regarding nutrients and algal blooms. We found that 1) sediments rich in phosphorus (P) act as a source for bioavailable …


A Multi-Directional Smart Hip Implant With Wireless Connectivity For Enhanced Health Monitoring, Leila Donyaparastlivari Apr 2024

A Multi-Directional Smart Hip Implant With Wireless Connectivity For Enhanced Health Monitoring, Leila Donyaparastlivari

Mechanical Engineering Theses

The thesis presents the culmination of the smart hip implant project, which signifies a significant stride in orthopedic technology. By integrating piezoelectric and triboelectric systems into conventional implants, this study demonstrates the feasibility and effectiveness of creating intelligent implants. Through a meticulous design process and rigorous testing, novel configurations were developed to optimize energy harvesting efficiency and enable precise detection of mechanical loads experienced during various physical activities. The application of Finite Element Analysis provided critical insights into the localization of contact points, informing the strategic placement of harvesters within the implant for enhanced performance. Utilizing a cam follower and …


Strategies To Decrease Separation Rates Among Highly Skilled Manufacturing Employees To Gain A Competitive Advantage, Rebecca J. Mileham Apr 2024

Strategies To Decrease Separation Rates Among Highly Skilled Manufacturing Employees To Gain A Competitive Advantage, Rebecca J. Mileham

Walden Dissertations and Doctoral Studies

Company leaders have a decreased competitive advantage when losing their highly skilled manufacturing employees due to separation from the company. Grounded in Herzberg’s two-factor theory, the purpose of this qualitative single-case study was to explore strategies aeronautical leaders used to decrease separation rates among highly skilled manufacturing employees to gain a competitive advantage. The participants comprised eight frontline managers in southern California with 2 years or more experience using strategies to decrease separation in their organization. Data were collected through face-to-face semistructured interviews and analyzed using thematic analysis, resulting in four themes: pay and promotion; benefits and feedback; treatment from …


Investigating Which Muscles Are Most Responsible For Tremor Through Both Experimental Data And Simulation, Daniel Benjamin Free Apr 2024

Investigating Which Muscles Are Most Responsible For Tremor Through Both Experimental Data And Simulation, Daniel Benjamin Free

Theses and Dissertations

Tremor affects millions of people and many patients desire alternative treatment options to medication or neural surgery. Peripheral suppression techniques are gaining greater use, but are currently applied in a trial-and-error method. To optimize these techniques, the muscles most responsible for an individual patient's tremor need to be identified. In this dissertation, I explored two parallel paths that both could aid in identifying muscles responsible for tremor. The first method utilizies measured data and a technique (coherence) that quantifies the frequency dependent correlation between two signals. Using coherence to identify muscles contributing to tremor requires at least two parts: an …


Improving Criticality Safety Benchmark Coverage By Developing A Benchmark Evaluation Of The Unm Agn-201m Reactor, Rowdy Davis Apr 2024

Improving Criticality Safety Benchmark Coverage By Developing A Benchmark Evaluation Of The Unm Agn-201m Reactor, Rowdy Davis

Nuclear Engineering ETDs

This research aimed to improve the benchmark coverage of the International Criticality Safety Benchmark Evaluation Project (ICSBEP) handbook and the International Reactor Physics Experiment Evaluation Project (IRPhEP) with respect to High-Assay, Low-Enriched Uranium Fuel (HALEU). This was accomplished by creating a benchmark of the University of New Mexico’s Aerojet General Nucleonics model 201-M reactor and submitting it to the ICSBEP. This research then aimed to quantify to what extent this benchmark improves coverage of the benchmark suites for HALEU and TRISO fuel applications. This investigation utilized WHISPER, TSUNAMI-IP, and TSURFER with 36 application cases developed in SCALE and 2,929 experiments …


Investigating The Role Of Fluid Shear Stress During Metastasis On Enhanced Breast Cancer Extravasation, Alejandra M. Ham Apr 2024

Investigating The Role Of Fluid Shear Stress During Metastasis On Enhanced Breast Cancer Extravasation, Alejandra M. Ham

LSU Master's Theses

In 2022, ~288,000 American women were diagnosed with metastatic breast cancer which was the leading cause of patient mortality with ~43,000 American women succumbing to the disease. Women can be diagnosed with four different molecular subtypes of breast cancer: luminal A, luminal B, human epithelial growth receptor type 2 enriched (HER2+), and triple-negative breast cancer (TNBC). TNBC accounts for ~12% of all breast cancers, yet it has the worst outcomes. TNBC is highly invasive, with ~46% of TNBC patients developing metastatic disease. A further understanding of metastatic TNBC is needed to provide a greater understanding of how to treat this …


Assessment Of Engineering Performance And Environmental Impacts Of High Reclaimed Asphalt Pavement (Rap) Asphalt Mixtures In Flexible Pavements, Ibrahim A.I.E. Elnaml Apr 2024

Assessment Of Engineering Performance And Environmental Impacts Of High Reclaimed Asphalt Pavement (Rap) Asphalt Mixtures In Flexible Pavements, Ibrahim A.I.E. Elnaml

LSU Doctoral Dissertations

Due to the critical role of asphalt pavements in national infrastructure development, there is a pressing need to investigate more sustainable materials and approaches. The use of natural aggregates and asphalt binders in asphalt pavement presents sustainability challenges due to the depletion of finite resources. Recycling Asphalt Pavement (RAP) offers a promising sustainable solution by substituting virgin aggregates and asphalt binders with recycled ones. However, increasing RAP contents in asphalt mixtures (>25%) can lead to premature cracking, insufficient durability, and limited longevity due to the presence of aged RAP-asphalt binder. To address these concerns, the application of novel recycling …


What Effect Does Standards-Based Grading Versus Traditional Grading Have On Standardized Tests For Fifth-Grade Students In Mathematics In Arkansas?, Ruby Dean Apr 2024

What Effect Does Standards-Based Grading Versus Traditional Grading Have On Standardized Tests For Fifth-Grade Students In Mathematics In Arkansas?, Ruby Dean

ATU Theses and Dissertations 2021 - Present

WHAT EFFECT DOES STANDARDS-BASED GRADING VERSUS TRADITIONAL

GRADING HAVE ON STANDARDIZED TESTS FOR FIFTH GRADE STUDENTS IN MATHEMATICS IN ARKANSAS?

Ruby Earlene Dean

This study examined the effects of standards-based grading and traditional grading on standardized tests for fifth grade students in mathematics in Arkansas. The purpose of the study was to determine whether the type of grading system (traditional or standards-based) used to assess student progress makes a difference on the ACT Aspire results in fifth grade in mathematics. The information gleaned from this study will provide school leaders and teachers with information to make more informed decisions to …


Multi Base Station Energy Efficient Cluster-Aware Routing For Wireless Sensor Networks With Realtime Data Backup, Martinaa M Apr 2024

Multi Base Station Energy Efficient Cluster-Aware Routing For Wireless Sensor Networks With Realtime Data Backup, Martinaa M

Theses and Dissertations

Wireless Sensor Networks (WSNs) is created, stemming from their applications in distinct areas. This research focuses on implementing an efficient clustering and routing protocols to maximize the lifespan of the WSN by proposing a novel method known as the Energy Efficient Cluster-aware Routing Protocol (EECR). The proposed method comprises of three steps: cluster formation, cluster head (CH) selection, and multi-hop data transmission. The factors needed are residual energy, the minimum distance to the base station (BS), and the minimum Load Count as given in the Energy and Distance CH selection algorithm. The shortest pathway is estimated by the Energy Route …


Profiling Of Voltage-Gated Sodium Channel Subtype Expression And Resulting Susceptibility To Targeted Osmotic Lysis In Cancer, Spencer Gerard Lemoine Apr 2024

Profiling Of Voltage-Gated Sodium Channel Subtype Expression And Resulting Susceptibility To Targeted Osmotic Lysis In Cancer, Spencer Gerard Lemoine

LSU Doctoral Dissertations

Cancer is a disease characterized by a wide array of dysregulated cellular function, activity, and growth. At times, specific dysregulations associated with cancer can be exploited as avenues of potential treatment. The sodium handling mechanisms and their associated proteins in cancer have received closer attention recently closely as such a potential mechanism to exploit for treating advanced cancer. Some novel treatments aim to inhibit the expression or activity of these sodium handling proteins in an attempt to prevent the cancer from advancing or becoming more aggressive; however, such approaches have had limited success. Targeted osmotic lysis (TOL) is a new …


Thermal Frontal Polymerization – Applications In Coatings And Composites, Maria Martinez Apr 2024

Thermal Frontal Polymerization – Applications In Coatings And Composites, Maria Martinez

LSU Doctoral Dissertations

Thermal frontal polymerization has long been used as a method to cure composites and coatings. However, this is the first time these applications have been used without the use of a catalyst, for the case of composites and coatings.

Chapter 2 discusses how to optimize cure-on-demand, thin layer coatings, using frontal polymerization. Previously, for the use of curing thin layer coating using thermal FP, it was known to just make the formulation viscous enough, as this would prevent premature quenching caused by heat loss. It was discovered that for a given layer thickness, a minimum viscosity and initiator concentration were …


Remote Sensing Of Residential Landscape Irrigation In Weber County, Utah, Annelise Marie Capener Apr 2024

Remote Sensing Of Residential Landscape Irrigation In Weber County, Utah, Annelise Marie Capener

Theses and Dissertations

Irrigation of residential properties in urban settings is typified by small and irregular areas, many untrained water users, limited end-use metering, and differing groundcover in contrast to agricultural settings. This makes analyzing irrigation patterns to promote efficient water use challenging. Analysis of Irrigation by Remote Sensing (AIRS) combines multispectral aerial imagery, evapotranspiration data, and ground-truthed measurements to overcome these challenges. We demonstrate the application of AIRS on eight neighborhoods in West Haven, Utah, using 0.6 m National Agriculture Imagery Program (NAIP) and 0.07 m drone imagery, reference evapotranspiration (ET), and water meter data from Weber Basin Water Conservancy District (WBWCD). …


Exploration Of Characteristic Curve In Fox Float 3 Shock Dampers To Expedite Shock Damp Tuning., Joshua R. Moore Apr 2024

Exploration Of Characteristic Curve In Fox Float 3 Shock Dampers To Expedite Shock Damp Tuning., Joshua R. Moore

Honors College Theses

The shock absorber is an integral part of a vehicle suspension system and has a strong influence on its performance, especially in the case of motorsports. It is important to study the force versus velocity relationship, commonly known as the characteristic curve of the shock absorber both during compression and rebound. Vendor-supplied characteristics often reflect the behavior of the shock absorber in a particular setting. However, during the installation, the settings inside the shock absorber are adjusted to increase the human comfort level and performance of the vehicle. This may change the characteristic curve of the shock. The available data …


Formulation, Characterization, And In Vivo Immunogenicity Evaluation Of Heat-Stabilized Dissolvable Polymeric Microneedles, Aidan Lane Leyba Apr 2024

Formulation, Characterization, And In Vivo Immunogenicity Evaluation Of Heat-Stabilized Dissolvable Polymeric Microneedles, Aidan Lane Leyba

Biomedical Engineering ETDs

Since its introduction, vaccination has improved health outcomes tremendously. However, modern vaccination efforts are still difficult to implement, particularly in developing countries with warm climates. This includes complex and expensive cold-chain management of vaccines to maintain stability, a lack of medical personnel to administer parental vaccines, and needle phobia. As an alternative, dissolvable microneedles have recently been studied for their simple and painless application. In this thesis, I present a novel manufacturing process for polymer-based dissolvable microneedles, loaded with virus-like particles vaccines conjugated to TRIO or Sialokinin peptides to target malaria and arboviruses, respectively. We have performed multiple characterization studies …


Electrochemical Phosphorus Recovery From The Anaerobically Digested Sludge: Mechanism, Performance, Application, And Solids Disposal, Zixuan Wang Apr 2024

Electrochemical Phosphorus Recovery From The Anaerobically Digested Sludge: Mechanism, Performance, Application, And Solids Disposal, Zixuan Wang

McKelvey School of Engineering Graduate Student Theses & Dissertations

Phosphorus (P) is life’s bottleneck element and an essential nutrient for food production. However, phosphate rock is a non-renewable resource and its geological distribution is highly uneven, making P recovery a crucial step for a circular economy. Approximately 55% of mined phosphorus ends up in centralized wastewater treatment plants (WWTPs), where up to 90% is captured in the sludge. This sludge, treated in anaerobic digesters to produce anaerobically digested sludge (ADS), emerges as a viable secondary source for phosphorus recovery. Recovering phosphorus from ADS typically involves leaching and separation. Leaching mobilizes phosphates from sludge solid phase into a liquid phase, …


Assessment Of Improvement In Unpaved Roadway Performance Using 3d Geogrids Under Cyclic Loading, Munibhaskar Pagadala Apr 2024

Assessment Of Improvement In Unpaved Roadway Performance Using 3d Geogrids Under Cyclic Loading, Munibhaskar Pagadala

Doctoral Dissertations and Master's Theses

Geogrids have been used for decades to improve the performance in both paved and unpaved road construction. This research focuses on quantifying the performance and optimizing the design of unpaved roadways using the results from an extensive cyclic triaxial testing program. Twenty-seven cyclic triaxial tests were performed, consisting of unreinforced (control) and reinforced samples using two types of 3D geogrids: Grid1 and Grid2. The samples measured 150 mm in diameter and a height of 300 mm. The tests were run under different loading sequences ranging from 41 kPa to 55 psi (6 psi to 8 psi of confining stress and …


Trend Tour, Aaron Ancheta, Khushboo Gupta, Xiomara Quinonez Apr 2024

Trend Tour, Aaron Ancheta, Khushboo Gupta, Xiomara Quinonez

Computer Science and Engineering Senior Theses

Choosing outfits as a college student can prove challenging – especially for new college students and students new to the area where their college is. Trend Tour, our web-based application, displays what the fashion trends are in the user's college and near their area. This helps the user with ideas on how to dress. Furthermore, the user can change the color, silhouette, and/or accessories of outfits they want to see at that college and near their area. This web application aims to help college students feel more confident and comfortable.


Novel Nano-Binders Treating Alzheimer’S Disease, Katie Ching, Sophie Criscione Apr 2024

Novel Nano-Binders Treating Alzheimer’S Disease, Katie Ching, Sophie Criscione

Bioengineering Senior Theses

The objective of our project is to engineer exosomes to be an effective therapeutic agent as a possible new treatment option for the neurodegenerative disease, Alzheimer’s Disease (AD). Among the various causes of AD, we are focusing on treating the pathogenesis linked to the build-up of amyloid-beta plaques in the brain, which disrupts neural connections and ultimately kills nerve cells. Currently, the most widely available treatment options for AD only provide symptomatic relief and targeting amyloid plaques in the brain is a promising new therapeutic approach in the field. Even the partial clearance of plaques could significantly improve the prognosis …