Engineering Commons^™

Mathematical Modeling Of Transient State Transdermal Drug Delivery, Alison Nickol Weltner

Theses

In this work, a two-pathway mathematical model for transdermal drug delivery with iontophoresis is presented. The partial differential equations are described and then solved. An alternative, two-pathway, three-layer model is also presented, and the implications of the coefficients within the equation are discussed. Using Franz cell iontophoretic delivery data from three drug substances (amitriptyline HCl, clomipramine HCl, and nortriptyline HCl), the two-pathway model is regressed to determine the diffusion coefficient and the concentration within the skin at the drug reservoir interface. ANOVA analysis indicates a correlation between iontophoretic current and concentration of drug within the stratum corneum.

Measurement Of The Effectiveness Of Enhanced External Counterpulsation On Heart Rate Variability For Patients With Myocardial Ischemia, Kripa Jayaraman

Theses

This thesis is a study to measure the changes in heart rate variability due to the activity of the autonomic nervous system caused by the Enhanced External Counterpulsation treatment. The treatment is a non surgical, mechanical procedure that can reduce the symptoms of angina or Congestive Heart Failure, presumably by stimulating the opening, or formation of, small branches of blood vessels (collaterals) to create a natural bypass around narrowed or blocked arteries. It has been proved that rhythms can be markers of normal functional states. Even in the absence of external perturbations, the normal heartbeat is not characterized by clockwise …

Application Of Bootstrap Resampling In Fmri, Arthika Bappal

Theses

This thesis demonstrates the use of the bootstrap resampling technique considering temporal dependency in the fMRI data to determine the reliability and confidence interval of fMRI parameters. Traditionally, the test-retest method has been used to reliably detect active voxels in the fMRI image of the brain, which is based on repetitive experimentation. The main concern with the test-retest method is the reproducibility of data over these multiple repetitions. Fatigue, habituation, motion artifacts, and repositioning errors are few of the factors, which can affect the reproducibility of data.

The conventional bootstrap resampling technique is based on the assumption that the dataset …

Effects Of Sleep Deprivation On Autonomic Nervous System, Jaeyeaon Cho

Theses

Sleep deprivation (SD) has been thought a potential factor to trigger cardiovascular events by increasing the sympathetic nervous system activity. The aim of the present study was to evaluate the relationship between sleep deprivation and the autonomic nervous system activity by means of heart rate variability (HRV) and blood pressure variability (BPV). All data were acquired in the sleep lab of Columbia University.

Data were acquired from the two groups, SD and control. Subjects in the SD group did not sleep for thirty-six hours but subjects in the control group slept at night as usual. There were five different data …

Case Studies In Disassembly Process Planning, Riteshkumar Dhimmar

Theses

The rapid advancement in technology started in last century and still continuing resulted in decreased life cycle of electronic products. It also resulted in increased product disposal rate and filling land fill space faster causing shortage of such space and consequently creates major environmental problems. So, since couple of decade environmental concern has focused on production process and environmental regulations imposed by government has watched industrial pollution. With government regulations to control environmental problems; consumers are also aware of adverse effects of product disposal forcing manufacturer to become more responsible for safe product disposal and recycling of used product.

A …

An In Vitro Evaluation Of Tyrosine Derived Polyarylates And Polycarbonate As Polymeric Scaffold For Human Mesenchymal Stem Cells Osteogenic Differentiation, Manish Suresh Godbole

Theses

Human mesenchymal stem cells (hMSCs) obtained from the adult bone marrow are multipotential cells that are capable of differentiating along several lineages. They are readily available and abundant source of cells in the field of tissue engineering. For their use in treating certain connective tissue defect or disorders, their success depends at minimum on the use of scaffolds that support differentiation. Therefore , this thesis details a study that systematically evaluated hMSC differentiation on materials that exhibit gradual range in surface properties as a first study for selecting materials as potential scaffolds. Polycarbonates and polyarylates have combinatorial libraries that exhibit …

Characterization Of Electrospun Dlplga Nanofibers For A Drug Delivery System For Intracranial Tumors And Avms, Kimberly A. Griswold

Theses

Electrospinning processes apply electric fields to a polymer solution in order to produce strands of polymer in the nanoscale range. These polymer fibers are manipulated for their porosity, high surface area, fineness and uniformity. In order to create the ideal drug delivery system for intracranial arteriovenous malformations (AVMs) and tumors, D, L poly-(lactice-poly-glycolide) (DLPLGA) nanofibers were electrospun in a tetrahydrofuran (THF) solvent. Three different concentration ratios of DLPLGA, 85/15, 80/20, and 75/25 were analyzed to obtain the prime base for drug annexation. 1 ,3-bis (2-chloroethyl)- 1 -nitrosourea (BCNU) was then codissolved with the DLPLGA nanofibers to form a homogenous solution, …

Study Of Design Tradeoffs Of Dram And Sram Memories, Using Hspice Computer Simulation, Bageshri Kale

Theses

Semiconductor random access memories are complex systems that can be described by performance parameters such as memory cycle time, access delays, storage capacity, bit packing density, chip area and retention time. In this thesis, tradeoffs between cycle time, chip area, and storage size as reflected by bit line capacitance (Cbl) were studied as a function of particular design variables: memory cell capacitance (Cc); CMOS flip-flop sense amplifier (SA) transistor sizes; and size of precharge (PC), and word line (WL) switches. Performance was optimized using circuit simulation software, HSPICE, to observe DRAM and SRAM waveforms. With TSMC 0.18 micron technology, minimum …

Voice Onset Time Variation In Stop Consonant To Vowel Transitions, Abhishek Gunvant Parikh

Theses

Reduced duration, increased consistency, and improved intelligibility are goals of reducing the motor complexity of speech for individuals with cerebral palsy having dysarthria. In this study, measurement and analysis were made to compare an individual with spastic Cerebral Palsy (CP) having dysarthria to an individual with athetoid CP having dysarthria as well as to a non-dysarthric individual. Each participant's normal speech, whispering, and speech using an artificial larynx was evaluated, utilizing the source-filter theory methodology. The plausibility of dysarthric speech duration reduction by minimizing vocalization is tested by stop consonant "P,, to vowel transitions. The data suggest that speech duration …

Extending The Boundary Method For Solving Human Motion Problems Using A 3 Dimensional Coupled Pendulum Model, Avani Janardan Patel

Theses

Mathematical modeling, an evolving area in movement analysis research, couples quantitative measures of human motion with theoretical concepts in physiology and mechanics. Literature reveals two methods to solve for human motion problems, Forward and Inverse Mechanics. In this investigation, a new approach called the Boundaty Method is adopted to solve for human motion. This approach has the advantage of being able to solve for both new motions and the net muscular joint forces required to produce those motions but only at those discrete times and body configurations that are believed to be most crucial for accomplishing the task.

The method …

Simulation Analysis Of Anti-Rollover Mechanism For Vehicles, Mohib L. Raid

Theses

Rollover accidents are considered the most significant safety problems for all classes of light vehicles, especially pickups, Sport Utility Vehicles (SUV), Light Truck Vehicle (LTV) and vans. The main objective of the research is the design of a new mechanism able to keep the vehicle stable under various road conditions and high speeds, to prevent the vehicle from rolling over and to maintain the stability for the vehicle by creating an anti-rolling torque on the vehicle body capable of turning the vehicle smoothly to stable position.

Evaluation Of Effect Of Extrusion Process Variables On Mechanical Properties Of Extruded Collagen Tubes And Effect Of Post Extrusion Treatments, Mayank K. Patel

Theses

This study evaluated the effect of extrusion process variable on mechanical properties of extruded collagen tubes made using a specialized extruder, made by ZOKO Corporation of Czechoslovakia. Three extrusion variables were considered; extrusion speed, linear draw rate and rotation speed. Using Taguchi L₄ matrix, a design of experiment (DOE) was run. Two mechanical properties, wall thickness and estimated elastic modulus, were considered as response of this DOE. Data was analyzed statically to evaluate the effect of extrusion variables on both these properties. Result of this study showed that linear draw rate of the extrusion process has the highest influence …

Fabrication Of Nanofiber Scaffolds By Electrospinning And It's Potential For Tissue Engineering, Shobana Shanmugasundaram

Theses

Electrospinning is a fabrication process that uses an electric field to control the deposition of polymer fibers on to a target substrate. This electrospinning strategy can be used to fabricate fibrous polymer mats composed of fiber diameters ranging from several microns down to tens of nanometers. This study assesses the potential of electrospinning, as an alternative scaffold fabrication technique for tissue engineering applications. In this study, electrospinning is adapted to produce tissue-engineering scaffolds of two different size ranges composed of non-woven poly-L-lactide (PLLA) nanofibers and as a first study, the potential use of these scaffolds as tissue engineering scaffolds was …

Si-Sio2 Interface Behavior In N-Mosfets With Screening Potential During High-Field Injection, Purushothaman Srinivasan

Theses

This work investigates the screening of hot carrier stress degradation in n-channel MOSFETs when the devices were exposed to plasma processing. Devices with various antenna ratios were subjected to current stress (both gate injection and substrate injection) while the source and drain terminals were reverse biased by a screening potential followed by hot carrier stress. It was observed that screening of the drain edge was effective for both gate injection and substrate injection at different screening potentials. The hot carrier lifetime is directly related to interface state density (Dit), measured by charge pumping method. The results suggest that hot electron …

Particle Size Dependence On Immobilized Molecular Sensors : Assay Of Nucleic Acid Probes Attached To Paramagnetic Particles, Celin Sunny

Theses

Nanotechnology is concerned with materials and systems whose structure and components exhibit novel and significantly improved physical, chemical and biological properties, phenomena and processes due to their nano scale size.

The transition from micro scale to nano scale leads to a number of changes in physical properties, possibly including new physical principles, some of which may be yet to be discovered. One of the major factors in this is the increase in ratio of surface area to volume.

This thesis research uses the increase in ratio of surface area to volume property of going from macro to micro to nano …

Spinning Of Collagen Fibers And Characterizing Thermal, Mechanical, Tensile And Structural Properties, Grace Evangelin Tatagiri

Theses

Collagen is the most important building block in the entire animal world. It plays an important role in regeneration of broken bones and wound healing, also helps grow blood vessels to feed the healing areas. The use of synthetic materials has been extensive, but these materials have there own limits and drawbacks. Poor biocompatibility of these materials is the main issue and often result in inflammations. Hence collagen is being heralded as one of the most appropriate replacement as an implantable material. The reasons being that it is a naturally occurring material, exhibits high biocompatibility low antigenicity and host response. …

Human Factors Approach Towards Improving Readability Of Bus Schedules, Anand Tharanathan

Theses

Due to an increasing concern over the readability of existing bus schedules of a public transportation agency the schedule format was redesigned. Two prototype schedules were designed based on the gathered information from the literature survey, focus group meetings and data from other public transportation agencies' schedules. One of the prototypes was designed by giving primary importance to the direction of travel and was named the directional prototype schedule. The other prototype was designed by giving primary importance to the day of the week, and was named weekday / weekend prototype schedule. A time based laboratory experiment and a subjective …

A Statistical Ultra Wideband Indoor Channel Model And The Effects Of Antenna Directivity On Multipath Delay Spread And Path Loss In Ultra Wideband Indoor Channels, Jason Anthony Dabin

Theses

Ultra-wideband (UWB) indoor frequency domain channel measurements have been performed in the 2 GHz to 6 GHz frequency band using three different transmitter/receiver (Tx/Rx) antenna combination pairs. The effects of antenna directivity on path loss and multipath propagation in the channel were analyzed extensively for various omni-directional and directional antenna combinations. A statistical model of the path loss in the channel is presented, where the parameters in the model (i.e., path loss exponent and shadow fading statistics) are dependent on the particular Tx/Rx antenna combination. Time domain statistics of the channel (i.e., mean delay spread and RMS delay spread) are …

A Kinematic Analysis Of Hand Configurations In Static And Dynamic Fingerspelling, Gillian B. Sherry

Theses

The focus of this study was the investigation of target handshapes in American Sign Language fingerspelling in order to determine whether there was a difference between static canonical structures and structures produced in the context of a movement sequence. This was achieved by measuring the joint angles of a signing hand with an 18-sensor CyberGlove® by Virtual Technologies, Inc.

A discriminant analysis was used to identify targets that occurred at points of minimum angular joint velocity. A multivariate analysis of variance with planned compansons was then applied to these dynamic data along with the static data to test the hypothesis. …

Supply Chain Risk Analysis, Venkata R. Kallepalli

Theses

A new decision support system is proposed and developed that will help sustaining business in a high-risk business environment. The system is developed as a web application to better integrate the supply chain entities and to provide a common platform for performing risk analysis in a supply chain. The system performs a risk analysis and calculates risk factor with each activity in the supply considering its interrelationship with other activities. Bayesian networks along with fault tree structures are embedded in the system and logical rules are used to perform a qualitative fault tree analysis, as the data required to calculate …

Parametric Synthesis Of Sign Language, Jerome Allen

Theses

The isolation of the deaf community from mainstream society is in part due to the lack of knowledge most hearing people have of sign language. To most, there seems to be little need to learn a language that is spoken by such a small minority unless perhaps a relative is unable to hear. Even with a desire to learn, the task may seem insurmountable due to the unique formational and grammatical rules of the language.

This linguistic rift has led to the call for an automatic translation system with the ability to take voice or written text as input and …

Design And Implementation Of Heart Rate Variability Measures In The Time Domain, Binoy John Mathews

Theses

The following study was conducted to design and implement computer programs to derive five time domain and two frequency domain Heart Rate Variability (HRV) measures from 24 hour Holter monitor recordings and to generate activity plots that display the variation of three of the five time domain measures and two frequency domain measures over a period of 24 hours.

Working with known pre and post experimental ECG data taken from a cyclical exercise program, standard parameters in both the time and frequency domains were derived using programs designed in Labview 7.0 engineering software package. Five parameters in the time domain …

An Investigation Of Position And Force During Gait-Mimicking Finger Motions, Matthew Stephen Noesner

Theses

Spinal cord injuries are extremely debilitating, often leaving the injured person without the ability to use their legs (paraplegia) and sometimes, without the ability to use their arms and legs (tetraplegia or quadriplegia). Currently, primitive forms of feed-forward functional electrical stimulation (FES) and special orthotics are available for persons with paraplegia. However, these forms of FES do not allow the individual to actually control their movements on a real-time basis, nor do they offer the ability for the injured person to sense the ground on which they stand.

It is the goal of the researchers at the Neuromuscular Engineering Laboratory, …

Supply Chain Risk Mitigation, Roshan R. Pai

Theses

In recent years, especially post 9/11, there has been an increasing awareness for securing business supply chains against probable disruptions. With globalization and lean inventories, the efficiency of supply chain has greatly enhanced over the years, but at the expense of new vulnerabilities. Supply chain vulnerabilities have resulted in disruptions to the economic stability and security. As a result, risk analysis and mitigation has now grown to become one of the key links to business stabilization. To ensure business continuity, it is necessary to identify key assets (physical and operational) within the supply chain and secure them against probable threats. …

Extrusion And Evaluation Of Degradation Rate And Porosity Of Small Diameter Collagen Tubes, Bipinkumar G. Patel

Theses

The limited availability of autografts and failure of small diameter synthetic vascular grafts has stimulated continuing efforts to develop small diameter vascular grafts based on natural materials. The small diameter collagen tubes were extruded using bovine collagen type I. The biodegradation rate was determined and compared for small diameter collagen tubes crosslinked with glutaraldehyde and N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride (EDC) and Nhydroxysuccinimide (NHS) to evaluate physio-chemical properties. The samples were also evaluated for their surface area and porosity using mercury porosimeter. The noncrosslinked tubes almost completely degraded after 2 hours. The tubes crosslinked with EDC/NHS degraded slower than the ones crosslinked with …

Biomimetic Sensor For In-Vivo Applications, Daya I. Sooryadas

Theses

The development of sensitive specific devices (e.g., molecular sensors) for the detection, diagnosis and monitoring of diseases, drug discovery, environmental detection of pollutants and/or biological agents has been an active area of research. A molecular sensor is a biomolecule or biomimetic molecule that performs two distinct functions in detecting target molecules. The sensor molecule recognizes a target molecule and specifically binds to it. This specific binding generates a signal in response to the event of target binding that can be then detected. The long term vision of this thesis research work is to develop a specific recognition ligand for detecting …

Processing And Optimization Of Natural Fiber Reinforced Composites Using Date Palm Fibers, Khalifa Musabbeh Suwaidan Hamad Al-Kaabi

Theses

During the last twenty years, ecological concerns have resulted in a renewed interest in natural materials. Composite materials usually depend on using man-made fibers as the reinforcing element. The possibility of using natural fibers instead of synthetic fibers is gaining acceptance among users. This work aims to investigate the possibility of extracting natural fibers from date palm trees to be used as reinforcement with polymeric materials. The objective was achieved by characterizing fibers through different chemical, physical and mechanical tests and using different treatment methods in order to modify the fiber properties. Date Palm Fibers (DPF) exhibit a cylindrical shape …

Synthesis And Characterization Of Polyaniline And Poly (3-Methylthiophene) As Conducting Polymers, Fatma Khalifa Obaid Dalmouk

Theses

The performance of materials in general depends on their properties. There is a continuous need of new materials to meet the technological revolution that was witnessed by the end of last century. In this work, a new class of materials was synthesized. The host matrix is an Organic Conducting Polymer (OCP) of either poly(3-methylthiophene) (PMT) or poly(aniline) (PAN). The synthesis of OCP is achieved using electrochemical methods of applying constant potential or cyclic voltammetry at a platinum or graphite substrate in an acetonitrile containing tetra-alkyl-ammonium salt. The set up is three-electrode system of a platinum counter electrode and a silver/silver …

Bulk Polymerization And Structure-Property Relationship Of Medical Grade Polyurethane, Mariam Nasser Al-Saedi

Theses

Polyurethanes as biomaterials have been used in the augmentation and repair of the human body with great success. The choice of material for a particular application often hinges on the body's response to the polymer, the mechanical and thermal properties of the polymer and the stoichiometric ratio of active ingredients used in the synthesis.

A large number of polyurethanes used in medical applications are polyester-based and cannot be used in long-term implant applications because they are very susceptible to hydrolysis. Other medical-grade polyurethanes, which are suitable for implants are polyether-based which might to some extent, suffer from environmental stress cracking …

Investigation Of Heart Rate Variability During Sleep Apnea, Sekar Subramanian

Theses

Sleep apnea is a disorder, where there are repetitive pauses in respiratory flow of at least 10 seconds or longer duration, and which occur more than five times per hour. Apnea has strong modulating effects on the autonomic nervous system, with prominent heart rate variation. It can be assumed that during sleep, internal influences (sympathetic and parasympathetic nervous system activities) dominate the autonomic nervous system; in addition repetitive apneas are accompanied by a pronounced increase in average heart rate. The aim of this study was to investigate the heart rate variability using spectral analysis and time-frequency analysis during sleep apnea. …