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Articles 931 - 960 of 2359

Full-Text Articles in Engineering

A Non-Contacting System For Rail Neutral Temperature And Stress Measurements, Katelyn Knopf Oct 2019

A Non-Contacting System For Rail Neutral Temperature And Stress Measurements, Katelyn Knopf

Theses and Dissertations

Continuous Welded Rail (CWR) has become the standard in modern railway track construction around the world because it alleviates well-documented disadvantages of rail joints in a track. CWR practice results in long segments of continuous rail in the track that will develop significant thermal elongation. To avoid the use of impractical large thermal expansion joints and limit the expected thermal elongation, the rail is anchored to the ties. Consequently, the rail is exposed to higher thermal stress demands as the rail temperature varies. At the time a CWR is laid, the rail is free of thermal stresses; the temperature at …


Evaluating Measurement Of Strain Hardening Method For Mechanical Assessment Of Geomembrane Service Life In Msw Landfills, Alaa Alsharaballi Oct 2019

Evaluating Measurement Of Strain Hardening Method For Mechanical Assessment Of Geomembrane Service Life In Msw Landfills, Alaa Alsharaballi

Theses and Dissertations

The increased household production result in more construction of municipal solid waste (MSW) landfills and lagoons. One major part of these engineering projects is high-density polyethylene (HDPE) geomembrane. Geomembrane is an impermeable layer that used along bottom and sides of landfills and lagoons to contain the leachate and to protect the groundwater. Although of their chemicals resistance and high strength, it can be aged under service conditions such as high temperature, ultraviolet (UV) light, and chemicals exposure. These conditions accelerate oxidation of geomembrane and lead to brittle behavior and stress cracking which reduce its service life.

Our objective in this …


Study Of Wire Arc Additive Manufacturing With Aluminum Alloy 2219, Sritam Kumar Dash Oct 2019

Study Of Wire Arc Additive Manufacturing With Aluminum Alloy 2219, Sritam Kumar Dash

Theses and Dissertations

This thesis discusses WAAM (wire arc additive manufacturing) technology using TIG (Tungsten Inert Gas) welding method with aluminum 2219 as the substrate and aluminum 2319 as the filler material. The most important characteristic of this method of manufacturing is very little wastage of material as it does not follow the conventional method of manufacturing where material is removed from a bigger block to finally achieve the desired shape. This method uses a layer by layer approach to build the part. Generally, in additive manufacturing, the production time may vary depending on the type of method used. The material deposition rate …


Person Identification With Convolutional Neural Networks, Kang Zheng Oct 2019

Person Identification With Convolutional Neural Networks, Kang Zheng

Theses and Dissertations

Person identification aims at matching persons across images or videos captured by different cameras, without requiring the presence of persons’ faces. It is an important problem in computer vision community and has many important real-world applica- tions, such as person search, security surveillance, and no-checkout stores. However, this problem is very challenging due to various factors, such as illumination varia- tion, view changes, human pose deformation, and occlusion. Traditional approaches generally focus on hand-crafting features and/or learning distance metrics for match- ing to tackle these challenges. With Convolutional Neural Networks (CNNs), feature extraction and metric learning can be combined in …


Modeling The Uranium-Silicon Phase Equilibria Based On Computational And Experimental Analysis, Tashiema Lixona Ulrich Oct 2019

Modeling The Uranium-Silicon Phase Equilibria Based On Computational And Experimental Analysis, Tashiema Lixona Ulrich

Theses and Dissertations

As part of Accident tolerant fuel initiative, the uranium-silicide compound, U3Si2, is under consideration as a potential replacement for conventional uranium dioxide fuel. It is of interest as its higher uranium density of 11.3 g(U)/cm3 compared to 9.7 g(U)/cm3 for UO2 may allow use of more robust, but less neutronically economical fuel cladding. The improved uranium content would not only accommodate the neutronic penalty inherent to certain accident tolerant cladding concepts but also facilitate improved reactor performance with the potential for longer fuel cycles.

The U-Si system has been the subject of various studies that mainly focused on thermophysical properties, …


Bison Simulation-Based Identification Of Important Design Criteria For U3si2 Fuels With Composite-Monolithic Duplex Sic Cladding, Jacob A. Yingling Oct 2019

Bison Simulation-Based Identification Of Important Design Criteria For U3si2 Fuels With Composite-Monolithic Duplex Sic Cladding, Jacob A. Yingling

Theses and Dissertations

Accident Tolerant Fuels (ATF) require a combination of fuel and cladding which have comparable longevity characteristics to UO2 while improving resistance to radiological release during and after accidents. U3Si2 has been proposed for use in ATF concepts for its high uranium density and high thermal conductivity which provide improved fuel performance. However, some of U3Si2’s material properties are not well understood. One such property, thermal creep of U3Si2, is an important contributing factor to U3Si2’s viability as an ATF. No experimentally derived thermal creep model is published for U3Si2, and previous analyses of compressive thermal creep experimental data lack statistical …


Quantifying And Elucidating The Effect Of Co2 On The Thermodynamics, Kinetics And Charge Transport Of Aemfcs, Yiwei Zheng Oct 2019

Quantifying And Elucidating The Effect Of Co2 On The Thermodynamics, Kinetics And Charge Transport Of Aemfcs, Yiwei Zheng

Theses and Dissertations

Anion exchange membrane fuel cells (AEMFCs) have shown significant promise to provide clean, sustainable energy for grid and transportation applications – and at a lower theoretical cost than more established proton exchange membrane fuel cells (PEMFCs). Adding to the excitement around AEMFCs is the extremely high peak power that can now be obtained (> 3 W cm-2) and continuously improving durability (1000+ h), which has made the future deployment of AEMFCs in real-world applications a serious consideration. For some applications (e.g. automotive), the most critical remaining practical issue with AEMFCs is understanding and mitigating the effects of atmospheric CO2 (in …


Adipose Tissue Engineering: A Therapeutic Strategy For The Treatment Of Obesity And Glucose Intolerance, Michael A. Hendley Oct 2019

Adipose Tissue Engineering: A Therapeutic Strategy For The Treatment Of Obesity And Glucose Intolerance, Michael A. Hendley

Theses and Dissertations

Despite available treatment options, the number of people afflicted by type 2 diabetes has steadily risen for decades. Nearly 90% of the diabetic population also suffers from obesity and the link between the two diseases is undeniable. Characterized by rapid expansion of the adipose tissue and improper lipid storage, the mishandling of lipids by adipose tissue promotes the diabetic state. Excess lipids, unable to be properly stored, build up in peripheral tissues promoting insulin resistance and type 2 diabetes. Therapeutic strategies designed to address adipose tissue lipid handling could represent a promising treatment strategy for obesity associated type 2 diabetes. …


Enhanced Heat Transfer In Spray Cooling Through Surface Modifications: An Experimental And Computational Study, Azzam Saadi Salman Oct 2019

Enhanced Heat Transfer In Spray Cooling Through Surface Modifications: An Experimental And Computational Study, Azzam Saadi Salman

Theses and Dissertations

Today, dissipating high heat flux safely is one of the greatest challenges for thermal engineers in thermal management systems, and it becomes a critical barrier to technological developments for many engineering applications. Due to technological advances and aggressive micro-miniaturization of electronic components, the surface area of most devices has shrunk while the computational power increased exponentially. Therefore, the amount of heat dissipated from surfaces has increased significantly. Numerous cooling techniques have been introduced to replace the traditional air cooling systems and to maintain the efficiency and reliability of electronic components. Microelectronics work efficiently and safely at surface temperatures of < 100 ℃ and 125 ℃ for general and defense applications, respectively. One of the proposed alternative schemes is spray cooling, which is considered one of the most advanced cooling methods. It is used for high and ultra-high heat flux dissipation, as it can dissipate 150-200 W/cm2 while maintaining the surface temperature within this range. Also, spray cooling removes a large amount of energy at a lower liquid flow rate compared to other cooling techniques, such as jet impingement and microchannel heat sink. The thermal performance of spray cooling systems can be enhanced either actively or passively. Active enhancement is a very efficient technique; however, it adds more pumping power. The present work focuses on three main objectives: evaluating and analyzing spray cooling performance, developing a three-dimensional numerical multi-phase model for heat transfer process in spray cooling and enhancing the thermal performance of spray cooling passively.

First, …


Computational Wave Field Modeling In Anisotropic Media, Sajan Shrestha Oct 2019

Computational Wave Field Modeling In Anisotropic Media, Sajan Shrestha

Theses and Dissertations

In this thesis, a meshless semi-analytical computational method is presented to compute the ultrasonic wave field in generalized anisotropic material while understanding the physics of wave propagation in detail. To understand the wave-damage interaction in an anisotropic material, it is neither feasible nor cost-effective to perform multiple experiments in the laboratory. Hence, recently the computational nondestructive evaluation (CNDE) received much attention to performing the NDE experiments in a virtual environment. In this thesis, a fundamental framework is constructed to perform the CNDE experiment of a thick composite specimen in a Pulse-Echo (PE) and through-transmission mode. To achieve the target, the …


Molecular Modeling Of Tethered Polyelectrolytes For Novel Biomedical Applications, Merina Jahan Oct 2019

Molecular Modeling Of Tethered Polyelectrolytes For Novel Biomedical Applications, Merina Jahan

Theses and Dissertations

Current research trends throughout the world focus on designing intelligent materi- als and systems for diverse applications in all courses of life. Biomaterials research encompasses a major part in this revolution due to the increased effort in fulfilling unmet medical needs to treat complex physiological and neurodegenerative disorders. Polymers play inevitable roles in these research endeavors for their ubiquitous pres- ence in biological systems. Therefore, it is crucial to understand how the polymeric molecules interact within diverse biological environments, to efficiently engineer them for various drug delivery and biosensing systems. The use of experimental design and selection of different polymers …


Using A Nondispersive Wave Propagation For Measuring Dynamic Fracture Initiation Toughness Of Materials: Experimental And Numerical Based Study, Ali Fahad Fahem Oct 2019

Using A Nondispersive Wave Propagation For Measuring Dynamic Fracture Initiation Toughness Of Materials: Experimental And Numerical Based Study, Ali Fahad Fahem

Theses and Dissertations

Fracture mechanics has been a subject of great interest in the engineering community for decades. During this period, fracture parameters such as Stress Intensity Factor (SIF), J-integral, and Crack-Tip Opening Displacement (CTOD) have been developed and used to characterize the fracture properties of most engineering materials under quasi-static loading condition. Usually, these properties are obtained experimentally by using standard methods such as ASTM E399, E1820 or E1920 to evaluate the stress intensity factor ������ ������������, elastic-plastic toughness ������ ������������ and crack tip opening displacement (CTOD) respectively. Conversely, most critical engineering applications are subjected to a sudden or high strain rate …


A Novel And Inexpensive Solution To Build Autonomous Surface Vehicles Capable Of Negotiating Highly Disturbed Environments, Jason Moulton Oct 2019

A Novel And Inexpensive Solution To Build Autonomous Surface Vehicles Capable Of Negotiating Highly Disturbed Environments, Jason Moulton

Theses and Dissertations

This dissertation has four main contributions. The first contribution is the design and build of a fleet of long-range, medium-duration deployable autonomous surface vehicles (ASV). The second is the development, implementation, and testing of inex-pensive sensors to accurately measure wind, current, and depth environmental vari- ables. The third leverages the first two contributions, and is modeling the effects of environmental variables on an ASV, finally leading to the development of a dynamic controller enabling deployment in more uncertain conditions.

The motivation for designing and building a new ASV comes from the lack of availability of a flexible and modular platform …


Cybersecurity Issues In The Context Of Cryptographic Shuffling Algorithms And Concept Drift: Challenges And Solutions, Hatim Alsuwat Oct 2019

Cybersecurity Issues In The Context Of Cryptographic Shuffling Algorithms And Concept Drift: Challenges And Solutions, Hatim Alsuwat

Theses and Dissertations

In this dissertation, we investigate and address two kinds of data integrity threats. We first study the limitations of secure cryptographic shuffling algorithms regarding preservation of data dependencies. We then study the limitations of machine learning models regarding concept drift detection. We propose solutions to address these threats.

Shuffling Algorithms have been used to protect the confidentiality of sensitive data. However, these algorithms may not preserve data dependencies, such as functional de- pendencies and data-driven associations. We present two solutions for addressing these shortcomings: (1) Functional dependencies preserving shuffle, and (2) Data-driven asso- ciations preserving shuffle. For preserving functional dependencies, …


Challenges In Large-Scale Machine Learning Systems: Security And Correctness, Emad Alsuwat Oct 2019

Challenges In Large-Scale Machine Learning Systems: Security And Correctness, Emad Alsuwat

Theses and Dissertations

In this research, we address the impact of data integrity on machine learning algorithms. We study how an adversary could corrupt Bayesian network structure learning algorithms by inserting contaminated data items. We investigate the resilience of two commonly used Bayesian network structure learning algorithms, namely the PC and LCD algorithms, against data poisoning attacks that aim to corrupt the learned Bayesian network model.

Data poisoning attacks are one of the most important emerging security threats against machine learning systems. These attacks aim to corrupt machine learning models by con- taminating datasets in the training phase. The lack of resilience of …


Wireless Rf Induced Energy Absorption And Heating Of Lanthanum-Nickel Alloy In The Near-Field, Michael Dillon Lindsay Oct 2019

Wireless Rf Induced Energy Absorption And Heating Of Lanthanum-Nickel Alloy In The Near-Field, Michael Dillon Lindsay

Theses and Dissertations

This thesis will investigate whether and how a synthetic metal-magnetic alloy absorbs enough near-field electromagnetic (EM) radiation for heating. Although resistive elements could be used for indirect heating, a wireless radio frequency (RF) method is explored because of its advantages in its non-intrusive nature and its ability to direct or focus energy within a specific area. For our case, the RF heating process relies on the materials ability to absorb sufficient RF energy due to the induced currents. We expect there to be significant surface resistance due to the conductivity and magnetic permeability of the material and thus heat. This …


Experimental Investigations Of Levee Breach Flows, Ibrahim Adil Ibrahim Oct 2019

Experimental Investigations Of Levee Breach Flows, Ibrahim Adil Ibrahim

Theses and Dissertations

Two individual but related problems involving levee breach flow are studied. The first one involves experimental and dynamic modeling of steady flow through a levee breach, and the second one involves experimental investigation of flood management by an engineered levee breach. Both studies are conducted in the Hydraulics Laboratory, the University of South Carolina.

In the first problem, an idealized levee breach on a trapezoidal embankment was studied. Flow data including water depths, surface velocities, and flow discharges were collected from 28 experiments considering different cases of breach width and downstream water depth. Ultrasonic sensors were used to record the …


Development Of A National-Scale Big Data Analytics Pipeline To Study The Potential Impacts Of Flooding On Critical Infrastructures And Communities, Nattapon Donratanapat Oct 2019

Development Of A National-Scale Big Data Analytics Pipeline To Study The Potential Impacts Of Flooding On Critical Infrastructures And Communities, Nattapon Donratanapat

Theses and Dissertations

With the rapid development of the Internet of Things (IoT) and Big data infrastructure, crowdsourcing techniques have emerged to facilitate data processing and problem solving particularly for flood emergences purposes. A Flood Analytics Information System (FAIS) has been developed as a Python Web application to gather Big data from multiple servers and analyze flooding impacts during historical and real-time events. The application is smartly designed to integrate crowd intelligence, machine learning (ML), and natural language processing of tweets to provide flood warning with the aim to improve situational awareness for flood risk management and decision making. FAIS allows the user …


Stacked Modelling Framework, Kareem Abdelfatah Oct 2019

Stacked Modelling Framework, Kareem Abdelfatah

Theses and Dissertations

The thesis develops a predictive modeling framework based on stacked Gaussian processes and applies it to two main applications in environmental and chemical en- gineering. First, a network of independently trained Gaussian processes (StackedGP) is introduced to obtain analytical predictions of quantities of interest (model out- puts) with quantified uncertainties. StackedGP framework supports component- based modeling in different fields such as environmental and chemical science, en- hances predictions of quantities of interest through a cascade of intermediate predic- tions usually addressed by cokriging, and propagates uncertainties through emulated dynamical systems driven by uncertain forcing variables. By using analytical first and …


Discovery Of Materials Through Applied Machine Learning, Travis Williams Oct 2019

Discovery Of Materials Through Applied Machine Learning, Travis Williams

Theses and Dissertations

Advances in artificial intelligence technology, specifically machine learning, have cre- ated opportunities in the material sciences to accelerate material discovery and gain fundamental understanding of the interaction between certain the constituent ele- ments of a material and the properties expressed by that material. Application of machine learning to experimental materials discovery is slow due to the monetary and temporal cost of experimental data, but parallel techniques such as continuous com- positional gradients or high-throughput characterization setups are capable of gener- ating larger amounts of data than the typical experimental process, and therefore are suitable for combination with machine learning. A …


Preparation Of Activated Biochar-Supported Magnetite Composite For Adsorption Of Polychlorinated Phenols From Aqueous Solutions, Byung-Moon Jun, Yejin Kim, Jonghun Han, Yeomin Yoon, Chang Min Park Sep 2019

Preparation Of Activated Biochar-Supported Magnetite Composite For Adsorption Of Polychlorinated Phenols From Aqueous Solutions, Byung-Moon Jun, Yejin Kim, Jonghun Han, Yeomin Yoon, Chang Min Park

Faculty Publications

For this study, we applied activated biochar (AB) and its composition with magnetite (AB-Fe3O4) as adsorbents for the removal of polychlorophenols in model wastewater. We comprehensively characterized these adsorbents and performed adsorption tests under several experimental parameters. Using FTIR, we confirmed successful synthesis of AB-Fe3O4 composite through cetrimonium bromide surfactant. We conducted adsorption tests using AB and AB-Fe3O4 to treat model wastewater containing polychlorophenols, such as 2,3,4,6-Tetrachlorophenol (TeCP), 2,4,6-Trichlorophenol (TCP), and 2,4-Dichlorophenol (DCP). Results of the isotherm and the kinetic experiments were well adapted to Freundlich’s isotherm model and the …


Fkrr-Mvsf: A Fuzzy Kernel Ridge Regression Model For Identifying Dna-Binding Proteins By Multi-View Sequence Features Via Chou's Five-Step Rule, Yi Zou, Yije Ding, Jijun Tang, Fei Guo, Li Peng Sep 2019

Fkrr-Mvsf: A Fuzzy Kernel Ridge Regression Model For Identifying Dna-Binding Proteins By Multi-View Sequence Features Via Chou's Five-Step Rule, Yi Zou, Yije Ding, Jijun Tang, Fei Guo, Li Peng

Faculty Publications

DNA-binding proteins play an important role in cell metabolism. In biological laboratories, the detection methods of DNA-binding proteins includes yeast one-hybrid methods, bacterial singles and X-ray crystallography methods and others, but these methods involve a lot of labor, material and time. In recent years, many computation-based approachs have been proposed to detect DNA-binding proteins. In this paper, a machine learning-based method, which is called the Fuzzy Kernel Ridge Regression model based on Multi-View Sequence Features (FKRR-MVSF), is proposed to identifying DNA-binding proteins. First of all, multi-view sequence features are extracted from protein sequences. Next, a Multiple Kernel Learning (MKL) algorithm …


Limited Data Rolling Bearing Fault Diagnosis With Few-Shot Learning, Ansi Zhang, Shaobo Li, Yuxin Cui, Wanli Yang, Rongzhi Dong, Jianjun Hu Aug 2019

Limited Data Rolling Bearing Fault Diagnosis With Few-Shot Learning, Ansi Zhang, Shaobo Li, Yuxin Cui, Wanli Yang, Rongzhi Dong, Jianjun Hu

Faculty Publications

This paper focuses on bearing fault diagnosis with limited training data. A major challenge in fault diagnosis is the infeasibility of obtaining sufficient training samples for every fault type under all working conditions. Recently deep learning based fault diagnosis methods have achieved promising results. However, most of these methods require large amount of training data. In this study, we propose a deep neural network based few-shot learning approach for rolling bearing fault diagnosis with limited data. Our model is based on the siamese neural network, which learns by exploiting sample pairs of the same or different categories. Experimental results over …


Post-Treatment Of Nanofiltration Polyamide Membrane Through Alkali-Catalyzed Hydrolysis To Treat Dyes In Model Wastewater, Byung-Moon Jun, Yeomin Yoon, Chang Min Park Aug 2019

Post-Treatment Of Nanofiltration Polyamide Membrane Through Alkali-Catalyzed Hydrolysis To Treat Dyes In Model Wastewater, Byung-Moon Jun, Yeomin Yoon, Chang Min Park

Faculty Publications

This research focused on the influence of post-treatment using alkali-catalyzed hydrolysis with a full-aromatic nanofiltration (NF) polyamide membrane and its application to the efficient removal of selected dyes. The post-treated membranes were characterized through Fourier transform infrared spectroscopy, goniometry, and zeta-potential analysis to analyze the treatment-induced changes in the intrinsic properties of the membrane. Furthermore, the changes in permeability induced by the post-treatment were evaluated via the measurement of water flux, NaCl rejection, and molecular weight cutoff (MWCO) under different pH conditions and post-treatment times. Major changes induced by the post-treatment in terms of physicochemical properties were the enhancement of …


Communication: First-Principles Evaluation Of Alkali Ion Adsorption And Ion Exchange In Pure Silica Lta Zeolite (Vol 149, 131102, 2018), Vancho Kocevski, Benjamin D. Zeidman, Charles H. Henager Jr., Theodore M. Besmann Aug 2019

Communication: First-Principles Evaluation Of Alkali Ion Adsorption And Ion Exchange In Pure Silica Lta Zeolite (Vol 149, 131102, 2018), Vancho Kocevski, Benjamin D. Zeidman, Charles H. Henager Jr., Theodore M. Besmann

Faculty Publications

Using first-principles calculations, we studied the adsorption of alkali ions in pure silica Linde Type A (LTA) zeolite. The probability of adsorbing alkali ions from solution and the driving force for ion exchange between Na+ and other alkali ions at the different adsorption sites were analyzed. From the calculated ion exchange isotherms, we show that it is possible to exchange Na+ with K+ and Rb+ in water, but that is not the case for systems in a vacuum. We also demonstrate that a solvation model should be used for the accurate representation of ion exchange in an LTA and that …


Transverse Vibration Of Clamped-Pinned-Free Beam With Mass At Free End, Jonathan Hong, Jacob Dodson, Simon Laflamme, Austin Downey Aug 2019

Transverse Vibration Of Clamped-Pinned-Free Beam With Mass At Free End, Jonathan Hong, Jacob Dodson, Simon Laflamme, Austin Downey

Faculty Publications

Engineering systems undergoing extreme and harsh environments can often times experience rapid damaging effects. In order to minimize loss of economic investment and human lives, structural health monitoring (SHM) of these high-rate systems is being researched. An experimental testbed has been developed to validate SHM methods in a controllable and repeatable laboratory environment. This study applies the Euler-Bernoulli beam theory to this testbed to develop analytical solutions of the system. The transverse vibration of a clamped-pinned-free beam with a point mass at the free end is discussed in detail. Results are derived for varying pin locations and mass values. Eigenvalue …


The Roussopoulos And Schwinger Functionals For Nuclear Systems Involving Imprecisely Known Fluxes And Parameters: Distinctions And Equivalences, Dan Gabriel Cacuci Jul 2019

The Roussopoulos And Schwinger Functionals For Nuclear Systems Involving Imprecisely Known Fluxes And Parameters: Distinctions And Equivalences, Dan Gabriel Cacuci

Faculty Publications

For over 60 years, the Roussopoulos and Schwinger functionals have been used in many works and textbooks under the assumption that they provide “second-order accurate” trial functions for the forward and adjoint fluxes when computing reaction rates and/or particle detector responses in source-driven nuclear systems. The Schwinger functional has been employed as a particularly useful form of the Roussopoulos functional for systems in which the forward and adjoint particle fluxes were normalized. When using these functionals, however, the expressions for the approximate fluxes were postulated arbitrarily while the system parameters were unrealistically assumed to be perfectly well known. This work …


Personalized Product Evaluation Based On Gra-Topsis And Kansei Engineering, Huafeng Quan, Shaobo Li, Hongjing Wei, Jianjun Hu Jul 2019

Personalized Product Evaluation Based On Gra-Topsis And Kansei Engineering, Huafeng Quan, Shaobo Li, Hongjing Wei, Jianjun Hu

Faculty Publications

With the improvement of human living standards, users’ requirements have changed from function to emotion. Helping users pick out the most suitable product based on their subjective requirements is of great importance for enterprises. This paper proposes a Kansei engineering-based grey relational analysis and techniques for order preference by similarity to ideal solution (KE-GAR-TOPSIS) method to make a subjective user personalized ranking of alternative products. The KE-GRA-TOPSIS method integrates five methods, including Kansei Engineering (KE), analytic hierarchy process (AHP), entropy, game theory, and grey relational analysis-TOPSIS (GRA-TOPSIS). First, an evaluation system is established by KE and AHP. Second, we define …


Role Of Epigenetic, Molecular And Cellular Pathways In The Regulation Of Inflammation, William James Becker Jul 2019

Role Of Epigenetic, Molecular And Cellular Pathways In The Regulation Of Inflammation, William James Becker

Theses and Dissertations

Dysregulated inflammation is at the heart of countless human diseases. Graft rejection is the process by which an organ from an incompatible donor is rejected by the recipient whose immune cells attack the foreign tissue. Colitis is an inflammatory disorder caused by undue chronic inflammation in the colon and rectum that can progress to cancer. Colitis incidence is on the rise, especially in developing nations and Asia; and the list of patients who need organ transplants grow by the day. Therapies for both graft rejection and colitis are limited to immunosuppressive drugs that leaves patients vulnerable to infection, heart disease, …


Astrocyte Sensitivity To Dopamine In Culture And Ex Vivo, Ashley L. Galloway Jul 2019

Astrocyte Sensitivity To Dopamine In Culture And Ex Vivo, Ashley L. Galloway

Theses and Dissertations

Dopamine is critical for processing of reward and etiology of drug addiction. Astrocytes throughout the brain express dopamine receptors, but consequences of astrocytic dopamine receptor signaling are not well established. This thesis illustrates effects of dopamine on cultured astrocytes and astrocytes in brain slices (ex vivo). In striatal cultures, extracellular dopamine triggered changes in astrocytic Ca2+ signaling and rapid concentration-dependent stellation of astrocytic processes that was not a result of dopamine oxidation, but instead relied on both cAMP-dependent and cAMP-independent dopamine receptor signaling. To isolate possible mechanisms underlying these structural and functional changes, whole-genome RNA sequencing was …