Engineering Commons^™

A Comparative Study Of Cannabinoids & Cb1 Receptor Gi Signaling, Haley Kristen Andersen

Theses and Dissertations

The legalization of medical marijuana has highlighted cannabinoids as a potential, opioid-free therapeutic option for pain management; however, the rise in illicit synthetic cannabinoid-induced toxicity has demonstrated the need to outline cannabinoid molecular signaling. The cannabinoid-type 1 (CB1) receptor is an endogenous G protein-gated receptor (GPCR), well-expressed in the central nervous system (CNS) associated with modulating neuronal activity. Cannabinoid agonists bind to the CB1 receptor resulting in the inhibitory G protein (Gi) complex to dissociate into two subunits, Gβγi and Gαi. The Gαi subunit inhibits adenylyl cyclase, leading to a decrease in cyclic adenosine monophosphate (cAMP). The Gβγi subunit activates …

Geometric Analysis Of The Doppler Frequency For General Non-Stationary 3d Mobile-To-Mobile Channels Based On Prolate Spheroidal Coordinates, Michael Walter, Dmitriy Shutin, Martin Schmidhammer, David W. Matolak, Alenka Zajic

Faculty Publications

—Mobile-to-mobile channels often exhibit time-variant Doppler frequency shifts due to the movement of transmitter and receiver. An accurate description of the Doppler frequency turns out to be very difficult in Cartesian coordinates and any subsequent algebraic analysis of the Doppler frequency is intractable. In contrast to other approaches, we base our investigation on a geometric description of the Doppler frequency with the following three mathematical pillars: prolate spheroidal coordinate system, algebraic curve theory, and differential forms. The prolate spheroidal coordinate system is more appropriate to algebraically investigate the problem. After the transformation into the new coordinate system, the theory of …

Steady-State And Transient Study Of Flow Boiling In Microchannels With Microgrooves/Micronozzles, Congcong Ren

Theses and Dissertations

Microchannel flow boiling is one of the most desired cooling solutions for high power electronics. Owing to the high latent heat of vaporization, high heat fluxes can be achieved through phase-change heat transfer. However, the enhancements of (critical heat flux) CHF and heat transfer coefficient (HTC) are usually inhibited by the transitional flow patterns, which highly influence the liquid rewetting. In the past two decades, many techniques have been explored to enhance the liquid rewetting in microscale.

In this dissertation, four parallel micro-grooves fabricated on the bottom of five microchannels (W=200 μm, H=250 μm, L=10 mm) were designed to promote …

Ultrasonic Nondestructive Evaluation Using Non-Contact Air-Coupled Lamb Waves, Wenfeng Xiao

Theses and Dissertations

Ultrasonic Lamb waves have been proved as an effective nondestructive evaluation (NDE) method due to their ability to propagate a long distance with less energy loss as well as their sensitivity to various defects on the surface or inside the structure. However, there are still challenges towards using them as a rapid inspection method for complex structural geometries, various damage types, and harsh environments, such as efficiency in Lamb wave actuation and sensing, understanding of the complicated multi-modal Lamb wave propagation, and robust detection algorithms for damage quantification and evaluation. To address these challenges, this dissertation focuses on developing a …

Artificial Intelligence Approaches For Structural Health Monitoring Of Aerospace Structures, Kimberly A. Cardillo

Theses and Dissertations

Structural health monitoring (SHM) and non-destructive evaluation (NDE) have been a significant research topic to help with damage detection in aerospace structures. SHM and NDE techniques are based on extracting damage sensitive features to determine the criticality of damage and lifetime of a structure. Acoustic emission (AE) signal detection is an important technique in SHM and NDE especially for fatigue crack growth. AE signals for thin aerospace structures consist of ultrasonic guided Lamb waves that propagate through the structure. This thesis focuses on AE signal repeatability, load at which AE signals occur, feature extraction, artificial intelligence and electro-mechanical impedance of …

Volume Frequency Response Method For Determining Mass Transfer Mechanisms Of O2 In Carbon Molecular Sieve 3k172, Olivia Smithson

Theses and Dissertations

Carbon molecular sieves (CMS) have grown more desirable over the years as an adsorbent for industrial separation processes as CMS technology has advanced. CMS is commonly used in nitrogen inerting (i.e, oxygen removal from air), carbon dioxide removal from methane and oxygen purification. However, knowledge of the dynamic behavior of these gases on CMS is needed to design and operate efficient and effective separation processes. For this reason, the mass transfer resistances within the micropore at both low and high frequencies were characterized using frequency response, COMSOL Multiphysics modeling, and MATLAB optimization , because frequency response methods have demonstrated the …

Methods For Dynamic Stabilization, Performance Improvement, And Load Power Sharing In Dc Power Distribution Systems, Hessamaldin Abdollahi

Theses and Dissertations

Modern DC power distribution systems (DC-PDS) offer high efficiency and flexibility which make them ideal for mission-critical applications such as on-board power systems of All-Electric ships, electric vehicles, More-Electric-Aircrafts, and DC Microgrids. Despite these attractive features, there are still challenges that need to be addressed. The two most important challenges are system stability and load power sharing. The stability and performance are of concern because DC-PDS are typically formed by the interconnection of several feedback-controlled power converters. The resulting interactions can lead to destabilizing dynamics. Likewise, in a DC-PDS there are several source converters that are operating in parallel to …

Computational Modeling Of Radiation Damage In A Multi-Phase Ceramic Waste Form Using Moose, Zeyu Chen

Theses and Dissertations

Ceramic waste forms have been proposed to replace the traditional glassy waste forms for long term stabilization of radionuclides. These waste forms are constantly exposed to self-irradiation emitted from the constituent radionuclides causing their material properties to change accordingly. It has been known that the radiation damage in waste forms is dominated by alpha particles emitted from transuranic (TRU) radionuclides. Since alpha particles usually have a range of 10~20 μm in such waste forms, some fraction of any non-transuranic containing phases (for a multiphase waste form) will be undamaged (or less damaged) if containing large enough grain sizes. Modeling and …

30 Ghz Path Loss Modeling And Performance Evaluation For Noncoherent M-Ary Frequency Shift Keying In The 30 Ghz Band, Mohanad Razak Mohsen

Theses and Dissertations

A candidate millimeter-wave (mmWave) frequency band and modulation scheme that could fit to many present and future applications has been presented in this work. As is being explored by industry, we also suggest the 30 GHz band as a candidate carrier frequency and non-coherent frequency shift keying (NC-FSK) as a potential modulation scheme for future communication applications. The primary applications are aimed at 5th generation (5G) cellular type systems. Propagation measurements were conducted for outdoor and indoor environments using directional horn antennas for both co-polarized and cross-polarized antenna configurations to model the path loss for our candidate band. The measurements …

Use Of Geospatial Technique To Estimate Traffic Volume On South Carolina Roads, Ryan Andrew Devine

Theses and Dissertations

Data from the Federal Highway Administration (FHWA) indicates that there is an increase in the number of vehicles on already congested roadways. For a department of transportation (DOT) to keep up with this increased demand, it is necessary for them to continuously collect and monitor traffic volume on the roads they maintain. One of the most important parameters that DOTs collect and use for traffic engineering and transportation planning studies is annual average daily traffic (AADT). The DOTs are also required to collect and report AADTs to the Federal Highway Administration annually as part of the Highway Performance Monitoring System …

Hydrogenation Of Dimethyl Oxalate To Ethylene Glycol Over Silica Supported Copper Catalysts, Xinbin Yu

Theses and Dissertations

Ethylene glycol is a bulk chemical and hydrogenation of dimethyl oxalate (DMO) on Cu/SiO2 catalysts is the final reaction step in a growing industrial syngas to ethylene glycol (StEG) process. Efforts to improve the performance of the catalysts are still ongoing and the detailed catalytic mechanism remains controversial.

In the present work, a series of 10 wt% Cu/SiO₂ is prepared.by urea hydrolysis method and indium species is introduced by incipient wetness impregnation. Reaction studies show that 0.25 wt%-0.5 wt% of indium species can dramatically enhance the performance of 10 wt% Cu/SiO₂ catalyst. Various characterizations reveal that indium species …

Evaluating The Stabilization Of Gypseous And Gypsiferous Sands Using Different Chemical Additives To Mitigate Gypsum Dissolution, Mohammed Kamil Faris

Theses and Dissertations

Gypsum, which is dihydrate calcium sulfate, (CaSO4.2H2O), is widely available in different sizes, from the size of a rock to the size of a few micrometers as a mineral, in different types of soils. It is primarily found mainly in arid and semi-arid areas around the world at different depths. Soils with gypsum and even gypsum rocks are very hard in their dry state. However, these soils and rock will experience remarkable dissolution upon wetting.

The dissolution phenomenon, which takes place in soils that contain gypsum, creates different geotechnical problems within the soil’s profile, along with foundation issues for structures …

Exploration And Evaluation Of Novel Cathode Materials For Intermediate-To-Low Temperature Solid Oxide Fuel Cells, Chunyang Yang

Theses and Dissertations

Solid oxide fuel cells (SOFCs) have attracted considerable attentions due to its high conversion efficiency, fuel flexibility, and clean nature. However, the high cost and poor long-term stability induced by the high operating temperature (> 800 °C) of the conventional SOFCs hinder the further application. Therefore, lowering operating temperature to intermediate temperature range (IT, 650-800 °C) or even low temperature range (LT, 400-650 °C) is of practical importance for realizing SOFCs’ full commercial potential. Nevertheless, due to the large activation energy associated with oxygen reduction reaction (ORR), cathode polarization resistance becomes the dominate loss limiting SOFCs performance as operating temperature …

Autonomous Drone-Based Sensor Package Deployment To The Underside Of Structures, Sabrina Rose Carroll

Theses and Dissertations

The objective of this project is to design, develop and experimentally test an Unmanned Aircraft System (UAS, commonly known as a drone) for the deployment of sensor packages to the underside of structures. This work begins with an in-depth review of existing automation techniques for various drone applications focusing on applications requiring interaction with the environment. Further reviewed is the impact of structures above the UAS during flight on the behavior of the aircraft.

Considering these topics, the development of a custom drone is presented to address the difficulties of delivering a package to the underside of a structure. Starting …

Lamb Wave Nondestructive Evaluation And Imaging On Plate-Like Structures, Zhaoyun Ma

Theses and Dissertations

Structure components are designed with a certain service life and damage may occur, or they may come with manufacture defects. Such damage and defects may lead to structural failure if not detected in time. To ensure the structural safety and prevent catastrophic failure, effective inspection is critical for in-time maintenance. Nondestructive evaluation (NDE) and structural health monitoring (SHM) have been widely applied for damage inspection and evaluation in various industries due to their noninvasive nature. Lamb wave based NDE/SHM has become the most popular ultrasonic methods that has been proved effective in different engineering applications that can be used to …

Mathematical Modeling Of Lithium-Sulfur Batteries, Niloofar Kamyab

Theses and Dissertations

Energy storage market transformed by utilization of lithium-ion batteries, will demand high and affordable deliverable energy in the near future which it would be impossible for the current employed technologies to meet those needs Among new generation of lithium batteries, high theoretical energy density, good low-temperature performance, and abundance of inexpensive nontoxic raw material, make the lithium-sulfur batteries (LiS) a promising candidate to outperform the current lithium-ion batteries and transform the technology of the future. However, the problems and challenges that LiS batteries are currently facing with, which stem from the inherent complex mechanism of these cells, are hindering their …

Acoustic And Ultrasonic Beam Focusing Through Aberrative And Attenuative Layers, Hossain Ahmed

Theses and Dissertations

Ultrasonic nondestructive evaluation (NDE) is a well-established technique to assess material properties and material state in noninvasive way. However, conventional NDE technologies are limited by the thick top coatings over the structure and, therefore, require time consuming removal and replacement of the coatings to perform the inspection. In biological application, although ultrasonic NDE is a safer method in compared to other radioactive non-invasive techniques, aberration of acoustic beams is more common as it encounters multiple tissue layers of complex geometry with nonhomogeneous properties. These limit the use of ultrasonic NDE in engineering and biological applications. To alleviate this problem, recently …

Development Of A Cfd Model For The Drying Of Aluminum-Clad Spent Nuclear Fuel, Nathaniel Cooper

Theses and Dissertations

The United States Department of Energy (DOE) currently manages approxi- mately 2500 metric tons of heavy metal (MTHM) of spent nuclear fuel (SNF), pri- marily from naval sources and domestic research reactors, and has agreements in place to accept 10,000 MTHM of aluminum-clad SNF from foreign reactors by 2029. However, due to the closure and the Yucca Mountain site and difficulties in the vitrification process, the majority of this fuel is expected to be placed in intermediate dry storage.

Before being placed in interim storage, all assemblies must be subjected to a drying process, either by forced gas recirculation (FGR) …

Bio-Oils From Vacuum Ablative Pyrolysis Of Torrefied Tobacco Residues, Nattawut Khuenkaeo, Blake Macqueen, Thossaporn Onsree, Sangu Daiya, Nakorn Tippayawong, Jochen A. Lauterbach

Faculty Publications

Fast pyrolysis, in combination with torrefaction pretreatment, was used to convert tobacco residues to value-added bio-fuels and chemicals. Tobacco plant residues were torrefied at 220, 260, and 300 °C, before being pyrolyzed at 450, 500, 550, and 600 °C in a rotating blade ablative reactor under vacuum conditions to test the effects on product yields. With torrefaction, tobacco residues thermally decomposed 20-25% w/w at low temperatures. Torrefaction and pyrolysis temperatures were found to markedly affect pyrolytic product yields of bio-chars and bio-oils, while having no effect on gas-phase products. Bio-oil yields exhibited a direct relation with pyrolysis temperature and an …

Bio-Oils From Vacuum Ablative Pyrolysis Of Torrefied Tobacco Residues, Nattawut Khuenkaeo, Blake Macqueen, Thossaporn Onsree, Sangu Daiya, Nakorn Tippayawong, Jochen A. Lauterbach

Faculty Publications

Fast pyrolysis, in combination with torrefaction pretreatment, was used to convert tobacco residues to value-added bio-fuels and chemicals. Tobacco plant residues were torrefied at 220, 260, and 300 °C, before being pyrolyzed at 450, 500, 550, and 600 °C in a rotating blade ablative reactor under vacuum conditions to test the effects on product yields. With torrefaction, tobacco residues thermally decomposed 20-25% w/w at low temperatures. Torrefaction and pyrolysis temperatures were found to markedly affect pyrolytic product yields of bio-chars and bio-oils, while having no effect on gas-phase products. Bio-oil yields exhibited a direct relation with pyrolysis temperature and an …

First-Order Comprehensive Adjoint Method For Computing Operator-Valued Response Sensitivities To Imprecisely Known Parameters, Internal Interfaces And Boundaries Of Coupled Nonlinear Systems: Ii. Application To A Nuclear Reactor Heat Removal Benchmark, Dan Gabriel Cacuci

Faculty Publications

This work illustrates the application of a comprehensive first-order adjoint sensitivity analysis methodology (1st-CASAM) to a heat conduction and convection analytical benchmark problem which simulates heat removal from a nuclear reactor fuel rod. This analytical benchmark problem can be used to verify the accuracy of numerical solutions provided by software modeling heat transport and fluid flow systems. This illustrative heat transport benchmark shows that collocation methods require one adjoint computation for every collocation point while spectral expansion methods require one adjoint computation for each cardinal function appearing in the respective expansion when recursion relations cannot be developed between the corresponding …

First-Order Comprehensive Adjoint Method For Computing Operator-Valued Response Sensitivities To Imprecisely Known Parameters, Internal Interfaces And Boundaries Of Coupled Nonlinear Systems: I. Mathematical Framework, Dan Gabriel Cacuci

Faculty Publications

This work presents the first-order comprehensive adjoint sensitivity analysis methodology (1st-CASAM) for computing efficiently the first-order sensitivities (i.e., functional derivatives) of operator-valued responses (i.e., model results) of general models of coupled nonlinear physical systems characterized by imprecisely known or and/or uncertain parameters, external boundaries, and internal interfaces between the coupled systems. The explicit mathematical formalism developed within the 1st-CASAM for computing the first-order sensitivities of operator-valued response to uncertain internal interfaces and external boundaries in the models’ phase–space enables this methodology to generalize all of the previously published methodologies for computing first-order response sensitivities. The computational resources needed for using …

Cyber Social Threats 2020 Workshop Meta-Report: Covid-19, Challenges, Methodological And Ethical Considerations, Ugur Kursuncu, Yelena Mejova, Jeremy Blackburn, Amit Sheth

Publications

Online platforms have been increasingly misused by ill-intentioned actors, affecting our society, often leading to real-world events of social significance. On the other hand, recog-nizing the narratives related to harmful behaviors is challeng-ing due to its complex and sensitive nature. The Cyber SocialThreats Workshop 2020 aimed to stimulate research for thechallenges on methodological and ethical considerations indeveloping novel approaches to analyze online harmful con-versations, concerning social, cultural, emotional, commu-nicative, and linguistic aspects. It provided a forum to bringtogether researchers and practitioners from both academiaand industry in the areas of computational social sciences, so-cial network analysis and mining, natural language process-ing, …

Large-Scale Flow In Micro Electrokinetic Turbulent Mixer, Keyi Nan, Zhongyan Hu, Wei Zhao, Kaige Wang, Jintao Bai, Guiren Wang

Faculty Publications

In the present work, we studied the three-dimensional (3D) mean flow field in a micro electrokinetic (μEK) turbulence based micromixer by micro particle imaging velocimetry (μPIV) with stereoscopic method. A large-scale solenoid-type 3D mean flow field has been observed. The extraordinarily fast mixing process of the μEK turbulent mixer can be primarily attributed to two steps. First, under the strong velocity fluctuations generated by μEK mechanism, the two fluids with different conductivity are highly mixed near the entrance, primarily at the low electric conductivity sides and bias to the bottom wall. Then, the well-mixed fluid in the local region convects …

Recent Advances In Hydrothermal Carbonisation: From Tailored Carbon Materials And Biochemicals To Applications And Bioenergy, Sabina A. Nicolae, Heather Au, Pierpaolo Modugno, Hui Luo, Anthony E. Szego, Mo Qiao, Liang Li, Wang Yin, Hero J. Heeres, Nicole Berge, Maria Magdalena Titirici

Faculty Publications

Introduced in the literature in 1913 by Bergius, who at the time was studying biomass coalification, hydrothermal carbonisation, as many other technologies based on renewables, was forgotten during the "industrial revolution". It was rediscovered back in 2005, on the one hand, to follow the trend set by Bergius of biomass to coal conversion for decentralised energy generation, and on the other hand as a novel green method to prepare advanced carbon materials and chemicals from biomass in water, at mild temperature, for energy storage and conversion and environmental protection. In this review, we will present an overview on the latest …

Is It Safe For My Child’S Asthma?, Utkarshani Jaimini, Amit Sheth, Krishnaprasad Thirunarayan, Maninder Kalra, Marco Valtorta

Publications

kHealth-Asthma, a personalised digital healthcare framework is developed to address the above shortcomings by continuous monitoring of the child’s digital phenotype, indoor, and outdoor environmental data. The kHealth-Asthma study has recruited 140 children (ongoing) with an aim to complete recruitment of 150 children. The study period is either 1 month or 3 month depending on the choice of the study participant. kHealth-Asthma collects 29 multi-modal parameters leading to 1852 data points per patient per day (i.e. deployment: 1 month:1852*30=55,560 data points per patient and 3 month:1852*90=166,680 data points per patient). The digital phenotype collected using the kHealth-Asthma generates a Digital …

Advances In Materials Design For All-Solid-State Batteries: From Bulk To Thin Films, Gene Yang, Yuxi Ma, Myoungseok Lee, Evan Helfrick, Dahyun Oh, Dongkyu Lee

Faculty Publications

All-solid-state batteries (SSBs) are one of the most fascinating next-generation energy storage systems that can provide improved energy density and safety for a wide range of applications from portable electronics to electric vehicles. The development of SSBs was accelerated by the discovery of new materials and the design of nanostructures. In particular, advances in the growth of thin-film battery materials facilitated the development of all solid-state thin-film batteries (SSTFBs)—expanding their applications to microelectronics such as flexible devices and implantable medical devices. However, critical challenges still remain, such as low ionic conductivity of solid electrolytes, interfacial instability and difficulty in controlling …

Thermoresponsive Nanogels Based On Different Polymeric Moieties For Biomedical Applications, Sobhan Ghaeini-Hesaroeiye, Hossein Razmi Bagtash, Soheil Boddohi, Ebrahim Vasheghani-Farahani, Esmaiel Jabbari

Faculty Publications

Nanogels, or nanostructured hydrogels, are one of the most interesting materials in biomedical engineering. Nanogels are widely used in medical applications, such as in cancer therapy, targeted delivery of proteins, genes and DNAs, and scaffolds in tissue regeneration. One salient feature of nanogels is their tunable responsiveness to external stimuli. In this review, thermosensitive nanogels are discussed, with a focus on moieties in their chemical structure which are responsible for thermosensitivity. These thermosensitive moieties can be classified into four groups, namely, polymers bearing amide groups, ether groups, vinyl ether groups and hydrophilic polymers bearing hydrophobic groups. These novel thermoresponsive nanogels …

New Models For Truck Appointment Problem And Extensions, Mohammad Torkjazi

Theses and Dissertations

The problematic issues surrounding gate congestion at marine container terminals have been well documented. Random truck arrivals at maritime container terminals are one of the primary reasons for gate congestion. Gate congestion negatively affects the terminal’s and drayage firms’ productivity and the surrounding communities in terms of air pollution and noise. To alleviate gate congestion, more and more terminals in the U.S. are utilizing a truck appointment system (TAS).

The first study proposes a novel approach for designing a Truck Appointment System (TAS) intended to serve both the marine container terminal operator and drayage operators. The aim of the proposed …

Expansion Microscopy: A New Approach To Microscopic Evaluation, Ashley Ferri

Theses and Dissertations

Optical microscopy resolution is limited by the wavelengths of light and the series of microscope lenses and other optical components used to create a magnified image of cell structures in a sample. Often the cell structures are smaller or closer together than the resolution limits of a light microscope. In 2015 the Boyden group at the Massachusetts Institute of Technology (MIT) created a sample preparation technique, expansion microscopy which involves embedding biological samples in a crosslinked, swellable, hydrogel polymer that allows for uniform physical separation of cell components so that they can subsequently be resolved by light microscopy. Using the …