Engineering Commons^™

Polymer Microparticles For Encapsulation And Presentation Of Anti-Inflammatory Agents For Inflammatory Diseases, Christopher Isely

Theses and Dissertations

Inflammatory diseases have a huge economic impact on the healthcare system. Incidence of obesity and muscle atrophy, two high profile inflammatory diseases, continues to increase. Anti-inflammatory agents are potential therapeutics for these diseases. Resveratrol is a polyphenol that has anti-inflammatory effects; however, resveratrol suffers from low bioavailability and hasn’t had impressive clinical results when delivered orally. Mannose is a monosaccharide that also has anti-inflammatory effects, however, effects are highest when mannose is presented on the surface of a support the size of a bacteria. Incorporation of resveratrol and mannose into biodegradable polymer microparticles could be a feasible approach to overcome …

Defining The Pathophysiology Of Gut Humoral Immunodeficiency, Ahmed Dawood Mohammed

Theses and Dissertations

Mucosal antibodies maintain gut homeostasis by promoting spatial segregation between host tissues and luminal microbes. Antibody-deficiency is the most common form of primary immunodeficiency observed in humans. In antibody-deficient humans, abnormal composition of the gut microbiota ('dysbiosis') is associated with chronic inflammatory responses and gastrointestinal complications. However, the mechanisms by which dysbiosis promotes inflammatory disease are poorly defined. In the studies described in this dissertation, we utilize CD19-/- mice as a model of antibody deficiency to test the hypothesis that antibody deficiency negatively impacts gut physiology under steady-state conditions. Chapter #1 is an overview of B cell development and how …

Mechanism Of Therapeutic Efficacy Of New Drugs In Glioblastoma, Firas Hameed Khathayer

Theses and Dissertations

Glioblastoma is the most malignant and prevalent brain tumor in adults. It can grow and spread quickly causing harm to brain health. The deregulation of epigenetic mechanisms is considered the main agent in the developing of GBM. One of the enzymes involved in epigenetic alternation and cancer development are histone deacetylases enzyme (HDAC) by removal acetyl group from histone and create condensed chromatin that suppresses transcription gene to histone and non-histone proteins involved in tumorigenesis. Histone deacetylase inhibitors (HADCi) are the most common therapeutic methods for many types of cancer treatments. In the present study, we used relative HDAC inhibitor …

Hydrothermal Synthesis And Structural Investigation Of A Crystalline Uranyl Borosilicate, Kristen A. Pace, Vladislav V. Klepov, Mark D. Smith, Travis Williams, Gregory Morrison, Jochen A. Lauterbach, Scott T. Misture, Hans Conrad Zur Loye

Faculty Publications

The relevance of multidimensional and porous crystalline materials to nuclear waste reme-diation and storage applications has motivated exploratory research focused on materials discovery of compounds, such as actinide mixed-oxoanion phases, which exhibit rich structural chemistry. The novel phase K1.8 Na1.2 [(UO2)BSi4 O12 ] has been synthesized using hydrothermal methods, rep-resenting the first example of a uranyl borosilicate. The three-dimensional structure crystallizes in the orthorhombic space group Cmce with lattice parameters a = 15.5471(19) Å, b = 14.3403(17) Å, c = 11.7315(15) Å, and V = 2615.5(6) Å3, and is composed of UO6 octahedra linked by [BSi4 O12 ]5− chains to …

Space Exploration: Nasa Investment Into The Private Space Sector And Public Opinion, Brooke Ziegenhagen

Senior Theses

The space exploration industry has entered a new era with companies such as SpaceX and Blue Origin leading the way to the privatization of space. This paper examines public opinion regarding the source of space exploration funding and proposes possible motivations for these sentiments. This is followed by an assessment on NASA’s investment trends into the commercial space industry. Both probes review the past decade, to reveal the public-private relationship in this new era and finally, conclude whether or not public opinion plays a role in the degree of NASA investment and what that role may be.

Experimental Evaluation Of Drying Spent Nuclear Fuel For Dry Cask Storage Through Vacuum And Forced Helium Dehydration, Jonathan Ellis Perry

Theses and Dissertations

Currently approximately 80,000 tons of spent nuclear fuel (SNF) are in either dry or wet storage at nuclear power plants or designated spent fuel storage facilities. Over 2,000 tons are added to that sum each year. All SNF must be dried to an accepted Nuclear Regulatory Commission (NRC) drying criteria before being placed in dry storage. Inadequately drying SNF increases the risk of detrimental effects to the fuel while in dry storage. Two commonly used drying operations in the nuclear industry are vacuum drying and forced helium dehydration (FHD). Although these drying processes have been used for many years, there …

Instrumentation And Experimentation Development For Robotic Systems, Tristan Kyzer

Theses and Dissertations

Localization of robotic systems is a necessity for control of robotic systems and often requires the use of costly sensors and equipment onboard the robot or installed within a facility. GPS or GNSS sensors are effective for localizing robots in GPSaccessible environments, but do not work as well in dense urban areas or inside fully enclosed buildings, such as factories or warehouses. Sensors such as LiDAR can be costly and require substantial experience and knowledge to utilize as well as potential changes to infrastructure for use. Computer vision-based localization systems offer potential as a localization solution for various applications. A …

Age And Sex Dependency Of Thoracic Aortic Aneurysm Progression In A Mouse Model Of Marfan Syndrome, Nazli Gharraee

Theses and Dissertations

Aneurysm of the ascending aorta is the most common type of thoracic aortic aneurysm, and it is a life-threatening manifestation of Marfan syndrome (MFS), a connective tissue disorder caused by mutation of the FBN1 gene. Incidence of Marfan syndrome is similar for men and women; however, men suffer from more severe aortic events compared to women.

This study aims to provide a better understanding of age and sex dependency of cell and extracellular matrix alterations of the aortic wall during the progression of the aneurysm caused by Marfan syndrome. To achieve this goal, the C1041G/+ mouse model of Marfan syndrome …

Nondestructive Evaluation And Structural Health Monitoring Of Manufacturing Flaws And Operational Damage In Composite Structures, Robin James

Theses and Dissertations

Advanced composite materials have begun to be used extensively in the manufacturing of aerospace structures. Composite aerospace structures can develop complex types of damages during the manufacturing stages and operational lifetime. This creates an indispensable demand for appropriate nondestructive evaluation (NDE) and structural health monitoring (SHM) methods that are tailored to specific types of damage. This dissertation addresses innovative methods for NDE and SHM of manufacturing flaws and operational damage in composite structures.

For the NDE of manufacturing flaws in carbon fiber reinforced polymer (CFRP) composites, an eddy current testing (ECT) NDE method has been developed by conducting multiphysics modeling …

Removal Of Heavy Metals Using Novel Adsorbent Materials, Lesley Joseph

Theses and Dissertations

Heavy metal contamination is a growing concern throughout the world, particularly as industrial and urban activities have increased. Inadequate water and wastewater treatment, coupled with increased industrial activity, have led to increased heavy metal contamination in rivers, lakes, and other water sources in developing countries. To address these concerns, a significant amount of research has been conducted on various novel adsorbents to evaluate their ability to remove heavy metals. Thus, in this study, MIL-100(Fe) and MIL-101(Cr) are fabricated and investigated to determine their ability to remove copper (Cu2+), cadmium (Cd2+), and lead (Pb2+) from aqueous solution. The experimental data fit …

Fate Of Nitrogen And Effectiveness Of Evaporation On Managing Leachate In Collection And Storage Ponds: A Case Study At The Three Rivers Solid Waste Authority Regional Landfill, Kaitlen Rose Drafts

Theses and Dissertations

Treatment of leachate from municipal solid waste (MSW) landfills can be complex and difficult, due to the variety of contaminants present. The purpose of this work was to evaluate the fate of nitrogen and effectiveness of leachate evaporation in a leachate storage and collection pond at the Three Rivers Solid Waste Authority (TRSWA) MSW landfill in Jackson, South Carolina. This was accomplished by determining the fate of nitrogen species in the pond, exploring effect of the site’s Lilypad droplet sprayer system on ammonia-nitrogen, and exploring potential to reduce overall quantity of leachate to be treated through evaporation from the pond. …

Temperature Dependence Of Electroluminescence And Current-Voltage Characteristics Of Arrays Of Deep Ultraviolet Algan Micropixel Led, Dhruvinkumar Prakashchandra Patel

Theses and Dissertations

III-Nitride based deep ultraviolet (DUV) light emitting diodes are non-toxic light sources that are highly desirable to replace current mercury lamp-based technology for air and water purification, surface and object disinfection, and sterilization. In the present. By freezing out defect related conduction pathways at temperatures less than 50K, the external quantum efficiency (EQE) of an interconnected array of 1,296 AlGaN DUV micropixels is improved by 4 times, underscoring the importance of defect management. Assuming a current injection efficiency (CIE) of 100% and considering that the light extraction efficiency (LEE) is constant with temperature, the 4-fold increase in the EL signal …

Deep Learning Based Sound Event Detection And Classification, Alireza Nasiri

Theses and Dissertations

Hearing sense has an important role in our daily lives. During the recent years, there has been many studies to transfer this capability to the computers. In this dissertation, we design and implement deep learning based algorithms to improve the ability of the computers in recognizing the different sound events.

In the first topic, we investigate sound event detection, which identifies the time boundaries of the sound events in addition to the type of the events. For sound event detection, we propose a new method, AudioMask, to benefit from the object-detection techniques in computer vision. In this method, we convert …

Removal Of Selected Organic Contaminants By Various (Nano) Adsorbent-Ultrafiltration Hybrid Systems, Sewoon Kim

Theses and Dissertations

Organic contaminants, which result from overuse and discharge of dyes, pharmaceutically active compounds, personal care products, and endocrine-disrupting compounds, have been received attention as contemporary water issues. However, conventional water and/or wastewater treatment system cannot sufficiently control for these contaminants for their stability and complexity. In this study, combined novel adsorbent with ultrafiltration (UF) hybrid system (termed ‘adsorbent-UF’) was applied to removal selected organic contaminants. UF with upstream adsorption has positive effects on performance in terms of the removal of selected organic contaminants, separating used adsorbents and reducing foulants. Activated biochar, metal organic frameworks, and Ti3C2TX MXene were used as …

Discovery And Investigation Of Ammonia Decomposition Catalysts, Katherine Mccullough

Theses and Dissertations

Liquid ammonia can be used as a hydrogen transportation and generation source for use in PEM fuel cells. Current Ru catalysts for ammonia decomposition contain high loadings of Ru and require reaction temperatures at or above 550°C to attain equilibrium conversion. For on-site hydrogen generation, it is of interest to combine hydrogen generation from ammonia decomposition directly with PEM fuel cells. For this occur, operating temperatures need to be considerably lowered and effluent concentrations of ammonia need to be minimized to avoid poisoning of the membrane. Therefore, it is of interest to develop a low-cost catalyst that exhibits high activity …

Experimental Investigation Of Single And Two-Phase Heat Transfer Performance In Microchannels With Surface Modifications And Multiple Inlet Restrictors, Saad Kadham Oudah

Theses and Dissertations

Due to shrinking component sizes and faster switching speeds, the volumetric heat generation rates and surface heat flux in many advanced power electronic devices have increased exponentially, creating an urgent need for efficient cooling technologies. It has become particularly challenging to maintain an optimal temperature at the device level. Among advanced cooling techniques, single-phase and two-phase microchannel heat sinks show considerable promise in removing a significant amount of heat from a small surface area. Considered one of the most efficient heat dissipaters, the two-phase microchannel heat sink can handle very high heat flux at a small footprint and requires relatively …

Multimodal Robotic Health In Future Factories Through Iiot, Data Analytics, And Virtual Commissioning, Clint Saidy

Theses and Dissertations

The manufacturing sector is continuously reinventing itself by embracing opportunities offered by the industrial internet of things and big data, among other advances. Modern manufacturing platforms are defined by the quest for ever increasing automation along all aspects of the production cycle. Furthermore, in the next decades, research and industry are expected to develop a large variety of autonomous robots for a large variety of tasks and environments enabling future factories. This continuing pressure towards automation dictates that emergent technologies are leveraged in a manner that suits this purpose. These challenges can be addressed through the advanced methods such as …

Time-Domain Measurement Of Magnetization Dynamics In Ferrofluids, Brian Egenriether

Theses and Dissertations

Time-domain measurements are made on a magnetite-based (Fe3O4) ferrofluid using an inductive technique. The constituent particles are 5.8% by volume, polydisperse, and have a nominal diameter of 10nm with a ~1nm-thick anionic hydrophobic coating. The ferrofluid is placed in a sealed channel on a coplanar waveguide (CPW) situated in an adjustable external magnetic bias field. A fast-rising step current in the CPW quickly reorients the local magnetic field above the signal trace causing the particles’ moments to align in the new field configuration. This changing magnetization induces a voltage in the CPW that is detected by a sampling oscilloscope. Precessional …

Enhanced Flow Boiling And Bubble Dynamics With Hfe7100 & Di Water In Interconnected Microchannels, Jiaxuan Ma

Theses and Dissertations

Flow boiling in microchannels using dielectric fluids is one of the most desirable cooling solutions for high power electronics. Primary two-flow patterns, including bubbly flow, slug flow, and annular flow, have been well established in microchannels. However, it is challenging to promote flow boiling performance, particularly critical heat flux (CHF), due to their unfavorable thermophysical properties. Considering these situations, flow boiling in parallel and isolated microchannels have been extensively studied. In this dissertation, a novel concept that has five parallel microchannels (W=200 µm, H=250 µm, L=10 mm) are interconnected by micro-slots (20 µm wide and 250 µm deep) starting from …

Modeling Human-Structure Interaction Using Control System When Bouncing On Flexible Structure, Ahmed Tamween Baeewi Al-Zubaidi

Theses and Dissertations

High performance materials have enabled engineers to design civil structures with lower dead loads. However, lower dead loads result in a higher live-to-dead load ratio and the possibility of excessive vibrations due to human loading. Classical methods that have been used to study this human-structure interaction (HSI) model the person as a mass-spring-damper (MSD) system. While these models are often able to represent the dynamics of the system, the human body is a more complex, dynamic system. For example, MSD systems cannot add energy to the overall human-structure system; therefore, they do not allow for the incorporation of excitation that …

Vascular Endothelial Dysfunction And Effects On Arterial Wall Microstructure, Jeffrey Thomas Rodgers

Theses and Dissertations

Vascular endothelial cell dysfunction (ECD) is a disease characterized by the inability of the vascular endothelial cells to transmit signaling molecules, namely nitric oxide (NO), in response to changes in blood flow rate. This disease is shown to be incident in the onset of more severe vascular disease such as hypertension, atherosclerosis, and heart failure. Long-term ECD is shown to cause long-term remodeling such as decreased flow-mediated dilation, increased pulse-wave velocity, intimal-medial thickening, and increased wall stiffness due to collagen deposition. We used second harmonic generation (SHG) microscopy to analyze this change in the collagen microstructure of the arterial extracellular …

Grafting Based Thermoplastic-Thermoset Bonding For Aerospace Structures, Saurabh Vaidya

Theses and Dissertations

The use of carbon fiber composites is rapidly increasing in the aerospace industry. Fiber reinforced plastic composites can primarily be classified as thermoplastic and thermoset, both offer unique advantages over one another. Thermosets cure at relatively low temperature and in general, are lower priced than thermoplastic composites. However, the cost of autoclave for the curing of thermosets is a major drawback. On the other hand, thermoplastics are showing higher damage tolerance. They can be re-melted and re-consolidated and have the potential to be re-used / recycled. The repair of TP composites is not developed yet. Therefore, both the types attract …

Real-Time Probabilistic Solvers For Digital Twins Of Power Electronic Systems, Matthew Aaron Milton

Theses and Dissertations

In recent years, switching power electronic systems for use in power conversion, generation, and distribution have become increasingly larger and complex in their design. With the increase in complexity comes the increase in difficulty in performing analysis, experiments, and health management on such systems in physical space. Part of this difficulty comes from challenge of access to and understanding of the internal interplay of the numerous components, safety and cost of system operation, and the inherent uncertainty of physical characteristics of systems and their environment.

A recent approach for testing and diagnostics/prognostics of power electronic systems is the application of …

Rehabilitation Of Timber Piles Using Fiber Reinforced Polymers Analyzed With Acoustic Emission, Rebekah Marie Krol

Theses and Dissertations

Assessing the current state of infrastructure and implementing strengthening or rehabilitation methods on old or damaged members is important to ensure safety and longevity of structures. Non-destructive testing is an important tool for localizing and characterizing damage in structures, especially structures that are more susceptible to damage because of age or environment. In addition to locating inadequate members, it is essential to have a repair technique in place so that the structure can continue to be used in a safe manner.

This study aims to review the use of acoustic emission for evaluating damage obtained in timber piles subjected to …

Role Of Ahr Ligands In Immune Modulation To Suppress Inflammation Through The Regulation Of Microrna And Gut Microbiome, Osama Azeldeen Abdulla

Theses and Dissertations

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor and an environmental sensor that is highly conserved evolutionarily. It was first discovered in the early 1970s for its ability to bind with high affinity to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), an environmental pollutant and induce a xenobiotic-metabolizing enzyme known as aryl hydrocarbon hydroxylase (AHH). AhR was shown to regulate TCDD-mediated toxicity against a variety of tissues including the immune system. More recently, AhR has been characterized as key regulator of the immune system, specifically the differentiation of T cells. Also, several AhR ligands have been characterized in addition to TCDD such as …

An Acoustic Emission And Artificial Intelligence Approach To Structural Health Monitoring For Aerospace Application, Joseph Chandler Garrett

Theses and Dissertations

In the area of aerospace and other applications, structural health monitoring (SHM) has been a significant and growing area of research in recent years. Throughout the operational life of aerospace structures, various damage scenarios may manifest, and it is of great concern to the aerospace community to develop methodologies for detecting and assessing these damage scenarios. In this paper, fundamental research on the use of the acoustic emission (AE) approach to SHM for fatigue crack growth is presented. In general, the AE approach to SHM and non-destructive evaluation (NDE) involves the sensing of ultrasonic Lamb waves propagating through a structure. …

Mitigating Corrosion And Enhancing Energy Density Of Zinc-Based Anodes In Primary And Secondary Aqueous Batteries, Ehsan Faegh

Theses and Dissertations

Today Lithium-ion (Li-ion) batteries are the most-emphasized battery technology among the many different battery systems in the market. However, due to their high cost (especially for electric vehicle applications), flammability and toxicity, the development of inexpensive and safer alternative battery chemistries has been the focus of a significant amount of recent research. Among various battery chemistries, Aluminum-based (Al-based) and Zinc-based (Zn-based) batteries have been touted as promising options to compete with Li-ion batteries. However, the practical realization of Al battery chemistries has been difficult over a long period of time (170 years) due to a number of fundamental and intrinsic …

Separate Effects Tests For Studying Thermal Gradient Driven Cracking In Uo2 Pellets Undergoing Resistive Heating, Sobhan Patnaik

Theses and Dissertations

A variety of normal operation and accident scenarios can generate thermal stresses large enough to cause cracking in light-water reactor (LWR) fuel pellets. Cracking of fuel pellets can lead to reduced heat removal, larger centerline temperatures, and localized stress in cladding, all of which impact fuel performance. It is important to understand the temperature profile on the pellet before and after cracking to improve cracking models in fuel performance codes such as BISON. However, in reactor observation and measurement of cracking is very challenging owing to the harsh environment and design of fuel rods.

Recently, a state-of-the-art experimental pellet cracking …

Physical Modeling Of Backward Erosion Piping Phenomenon In A Geotechnical Centrifuge, William Fernando Ovalle Villamil

Theses and Dissertations

Backward erosion piping is a mechanism of internal erosion that has been widely recognized as a potential hazard for water-retaining structures, such as dams and levees, that are founded on granular materials. Backward erosion piping initiates toward the downstream zone of the structure by the concentration of flow at an exit point acting as drainage, which leads to a localized loosening of the soil and eventually to a continuous migration of grains from the foundation following a piping path pattern. Such piping path extends backward toward the impoundment once a certain critical hydraulic condition is met, resulting in the loss …

Experimental Investigation Of Spray Cooling Integrated With A Modified Vapor Compression Refrigeration System Using Several Refrigerants, Nabeel Mukhlif Abdulrazzaq

Theses and Dissertations

Spray cooling has gained increasing interest over the last three decades due to its high thermal performance as a direct cooling technique. Researchers are investigating spray cooling in thermal management systems for electronic applications, particularly focusing on the use of dielectric fluids including FC-72, FC-87, ammonia, and refrigerants such as R113 and R134a. Their studies indicate that the usage of dielectric fluids as a working fluid in spray cooling systems is promising and has significant thermal performance enhancement, which is suitable for a wide range of electronic applications. However, several deficiencies have been identified with the working fluids studied thus …