Engineering Commons^™

Artificial Synthetic Scaffolds For Tissue Engineering Application Emphasizing The Role Of Biophysical Cues, Samerender Nagam Hanumantharao

Dissertations, Master's Theses and Master's Reports

The mechanotransduction of cells is the intrinsic ability of cells to convert the mechanical signals provided by the surrounding matrix and other cells into biochemical signals that affect several distinct processes such as tumorigenesis, wound healing, and organ formation. The use of biomaterials as an artificial scaffold for cell attachment, differentiation and proliferation provides a tool to modulate and understand the mechanotransduction pathways, develop better in vitro models and clinical remedies. The effect of topographical cues and stiffness was investigated in fibroblasts using polycaprolactone (PCL)- Polyaniline (PANI) based scaffolds that were fabricated using a self-assembly method and electrospinning. Through this …

Using Transfer Path Analysis And Frequency Based Substructuring To Develop A Robust Vibration Laboratory Dynamic Test Fixture Design Process, Cora Taylor

Dissertations, Master's Theses and Master's Reports

The objective of this research is to determine a robust method for designing shock and vibration laboratory test fixtures that accurately reproduce the field environment for the component of interest. The methods presented in this research examine the boundary conditions presented unto the component of interest through transfer path analysis with the intent of reproducing the next-structure attachment impedance with a laboratory test fixture of one and two attachments. The first method includes only using the next-structure relative motion and stiffness to design a test fixture, while the second method uses an optimization algorithm to develop a lumped parameter model …

Lipemia Levels Analysis From Human Blood Samples, Zainab Ibrahim Alshoug

Dissertations, Master's Theses and Master's Reports

Worldwide, an estimated 31% of people who die each year have a cardiovascular disease (CVD), an all-encompassing group of diseases and conditions of the heart or blood vasculature. Access to portable, user-friendly tools to test lipid levels accurately and efficiently, without requiring large volume blood draws, will help improve access to wellness management by reducing costs and facilitating early screening and monitoring of CVD thus improving outcomes. Point of care micro or millifluidic chips to test biofluids that are integrated into detection units are an attractive measurement tool because of their potential for ease of use by patients at home …

Influence Of Rapid Solidification And Wrought Processing On Precipitation Strengthening And Deformation Mechanisms In Al-Sc-Zr Alloys, Yang Yang

Dissertations, Master's Theses and Master's Reports

Al-Sc-Zr alloys have drawn increasing attention in the last several decades due to their strengthening and coarsening resistance. In this study, solute concentrations of Sc and Zr were increased beyond their equilibrium solubilities without primary precipitate formation using melt-spinning. The melt-spun ribbon was metallurgically bonded into bulk shape using extrusion. With the proper aging treatment, the mechanical properties of the supersaturated melt-spun ribbon and extruded rod were found to be significantly higher than a baseline dilute alloy. Increased mechanical properties include microhardness, tensile strength at ambient-temperature, and compressive strength and threshold stress at and elevated-temperature. These increases were related to …

Establishment Of Cyber-Physical Correlation And Verification Based On Attack Scenarios In Power Substations, Koji Yamashita

Dissertations, Master's Theses and Master's Reports

Insurance businesses for the cyberworld are an evolving opportunity. However, a quantitative model in today's security technologies may not be established. Besides, a generalized methodology to assess the systematic risks remains underdeveloped. There has been a technical challenge to capture intrusion risks of the cyber-physical system, including estimating the impact of the potential cascaded events initiated by the hacker's malicious actions.

This dissertation attempts to integrate both modeling aspects: 1) steady-state probabilities for the Internet protocol-based substation switching attack events based on hypothetical cyberattacks, 2) potential electricity losses. The phenomenon of sequential attacks can be characterized using a time-domain simulation …

The Study Of Chemical Induced Polyolefin-Based Ion Exchange Membrane For Electrodialysis Application, Di Huang

Dissertations, Master's Theses and Master's Reports

High-performance ion exchange membranes with high ion exchange capacity (IEC), excellent mechanical properties, lower membrane resistance and superior ions conductivity were developed with chemical-induced polymerization in this work. Through a series of synthesizing experiments, structure characterization and properties testing for polyolefin-based cation exchange membrane (CEM) and anion exchange membrane (AEM), LDPE proved to be an optimized backbone material. The CEM with 57.5% styrene, 38.4% LDPE, 3% crosslinking degree and 1% initiator addition yield the highest IEC value (1.72 mol/g) and moderate burst strength. The 10% addition of styrene was found to enhance IEC of 57% to AEM. However, continually increase …

Implementation Of A Channel-Aware Routing Protocol In The Network Simulator For Underwater Acoustic Communication Networking, Adesoji Bello

Dissertations, Master's Theses and Master's Reports

Over two-thirds of the earth surface are occupied by water, however the level of research in the field of Underwater Wireless Sensor Networking (UWSN) does not necessarily commensurate with the size and potentials. Importantly, the underwater acoustic channel is susceptible to signal degradation as a result of the dynamic and harsh state of the environment such as high propagation delay and limited channel bandwidth.

The above challenges are the motivation behind the Implementation of The Channel-aware Routing Protocol (CARP) for the routing performance optimization in UWSN. CARP [1] is a cross-layer routing paradigm which collaboratively leverages the link quality estimation …

Investigation Of The Stability Of Liquid And Air Films By Synchronized Tri-Wavelength Reflection Interferometry Microscope, Yuesheng Gao

Dissertations, Master's Theses and Master's Reports

Liquid films are widely involved in many processes, such as froth flotation, oil extraction, foam/bubble stabilization, etc. In the meantime, air films are commonly seen in diverse fields like dust control, ink print, coating industry, and so on. Stabilities of these liquid/air films are of great importance to improve the processes. As more and more researchers are paying increasing attention to liquid/air films, tremendous efforts have been made to explore the properties of the films. On the one hand, some theoretical models have also been well developed in recent decades. State-of-the-art technologies, such as AFM, SFA, and RICM, have also …

Systems Analysis For Sustainability Assessment Of Biogas And Bio-Ch4 Production From Food Waste And Dairy Manure Mixtures In The Us, Sharath Kumar Ankathi

Dissertations, Master's Theses and Master's Reports

The purpose of the dissertation is to relate systems analysis for bioenergy to identify optimum configurations for improved scenarios and to make better decisions in a systems perspective.

Chapter 1 is a review of the literature to identify the state of the knowledge in terms of systems analysis for anaerobic digestion (AD) bioenergy systems. The key outcomes from this review showed that anaerobic digestion of mixtures of food waste and animal manure has great potential to achieve economic and environmental benefits compared to other treatments of organic waste materials, such as landfilling or conventional manure management.

Chapter 2 focuses on …

Life Cycle Information Models With Parameter Uncertainty Analysis To Facilitate The Use Of Life-Cycle Assessment Outcomes In Pavement Design Decision-Making, Chaitanya Ganesh Bhat

Dissertations, Master's Theses and Master's Reports

The objective of this dissertation is to develop Life Cycle Information Models (LCIMs) to promote consistent and credible communication of potential environmental impacts quantified through Life-Cycle Assessment (LCA) methodology. The introduction of Life Cycle Information Models (LCIMs) will shift the focus of pavement LCA stakeholders to collect reliable foreground data and adapt to consistent background data present within LCIMs. LCA methodology requires significant Life Cycle Inventory (LCI) data to model real world systems and quantify potential environmental impacts. The lack of guidance in ISO standards on consistently compiling LCI data and defining protocols for modeling lowers the reliability of LCA …

Hybrid Electric Vehicle Energy Management Strategy With Consideration Of Battery Aging, Bin Zhou

Dissertations, Master's Theses and Master's Reports

The equivalent consumption minimization strategy (ECMS) is a well-known energy management strategy for Hybrid Electric Vehicles (HEV). ECMS is very computationally efficient since it yields an instantaneous optimal control. ECMS has been shown to minimize fuel consumption under certain conditions. But, minimizing the fuel consumption often leads to excessive battery damage. The objective of this dissertation is to develop a real-time implementable optimal energy management strategy which improves both the fuel economy and battery aging for Hybrid Electric Vehicles by using ECMS. This work introduces a new optimal control problem where the cost function includes terms for both fuel consumption …

Experimental Evaluation Of An Rwd Vehicle With Parameter Extraction For Analytical Modeling And Evaluation, Jon Furlich

Dissertations, Master's Theses and Master's Reports

This study was conducted to perform experimental vibration testing on a light duty rear wheel drive vehicle. The vehicle is known to have excessive longitudinal acceleration response perceived after step changes in the driver torque command. The excessive response includes shuffle and clunk transients. Experimental testing was performed to understand the coupling between driver torque commands and peak shuffle oscillations. Data was also targeted to understand the coupling between driveline torsional oscillations and longitudinal vehicle vibrations. This data was also used to establish vehicle parameters for use in an analytical CAE model of the driveline and coupling. Driver applied tip-in …

Measurement Of Current Distribution In The Land Channel Direction Of A Proton Exchange Membrane Fuel Cell, Chinmay Kulkarni

Dissertations, Master's Theses and Master's Reports

A fully functional proton exchange membrane fuel cell with single land channel geometry on the cathode and segmented anode current collector with 9 mm² active area with a 350μm spatial resolution was utilized to measure the local current distribution in the land channel direction. A distinguished printed circuit board approach was used for the data acquisition to adapt to any flow field design.

Performance of this segmented cell was examined at dry, wet and moderate humidity settings to study the water transport phenomenon in the PEMFC. In the dry condition at 60 ͦ C with 0% relative humidity, the …

Mechanisms Of Pathogen Inactivation In Wastewater And Pharmaceutical Applications, Christa L. Meingast

Dissertations, Master's Theses and Master's Reports

Infectious diseases are a significant threat to public health. Though society enacts practices to prevent the spread of these dangerous diseases, challenges remain. Therefore, continual advancements in treatment and prevention are required. Wastewater treatment and viral clearance in pharmaceutical applications are two key health measures that prevent the spread of infections.

A low-cost, low-technology biosolids treatment process was developed to improve wastewater treatment by collecting key information on storage temperature, ammonia, volatile solids, moisture content, pH, and pathogen inactivation in biosolids over long-term storage at two wastewater treatment plants located in northern climates of the United States. Inactivation of pathogens …

High-Performance Zero Liquid Discharge (Zld) Treatment Of High-Salinity Brines Using A Multiple-Effect Absorption Distillation Concept, Sunil Pinnu

Dissertations, Master's Theses and Master's Reports

State-of-the-art zero liquid discharge (ZLD) technologies are currently bound with either intensive use of high-grade electrical energy such as mechanical vacuum vapor compressors utilized in brine crystallizers or high capital cost with environmental concerns such as evaporation ponds. The present study aims to address these issues by an innovative desiccant-based ZLD system in which a multiple-effect distillation (MED) unit is uniquely embedded at the heart of an absorption-desorption system. Here, the MED and absorption systems are inherently coupled enabling both heat and mass transfer processes between a high-salinity water and a desiccant solution. The proposed technology employs an absorption-based thermally-driven …

Development Of A Software-Defined Underwater Acoustic Communication System, Zijian Zhu

Dissertations, Master's Theses and Master's Reports

This report started with a brief history and recent development of underwater acoustic communication systems as well as software-defined radio technologies. Then, some challenges from underwater acoustic channels and available underwater acoustic communication modems are discussed. After finished introducing the basics of SDR and GNU Radio, a detailed description of implementing a software-defined acoustic communication system in GNU Radio are presented, along with some key concepts of the system.

Then, some hardware specifications are presented, following by detailed documentation on a software-defined acoustic communication system experiment with a host computer, a USRP, an acoustic hydrophone, and a hydrophone. At the …

Demand-Driven Execution Using Future Gated Single Assignment Form, Omkar Javeri

Dissertations, Master's Theses and Master's Reports

This dissertation discusses a novel, previously unexplored execution model called Demand-Driven Execution (DDE), which executes programs starting from the outputs of the program, progressing towards the inputs of the program. This approach is significantly different from prior demand-driven reduction machines as it can execute a program written in an imperative language using the demand-driven paradigm while extracting both instruction and data level parallelism. The execution model relies on an executable Single Assignment Form which serves both as the internal representation of the compiler as well as the Instruction Set Architecture (ISA) of the machine. This work develops the instruction set …

Nanofiber Scaffolds As 3d Culture Platforms, Stephanie Bule

Dissertations, Master's Theses and Master's Reports

Cell culture has become the basis for understanding the fundamental mechanisms of cell, tissue and organ function. Although major advancements in uncovering the underlying processes and mechanisms of normal and diseased cell biology have been made by using two-dimensional (2D) cell culture, there is a recent shift in moving towards three-dimensional (3D) culture platforms. The motivation is to better recapitulate the microenvironment of cells in vivo to obtain results that are more indicative to actual cellular processes. In this study, electrospun nano-fibrous scaffolds made of polycaprolactone were used as a 3D culture tool to investigate difference in cell behavior and …

Modeling The Effects Of Wastewater Infrastructure Options On Water Quality In Greater Cleveland, Ohio, Mike Foster

Dissertations, Master's Theses and Master's Reports

The city of Cleveland, OH, and the Northeast Ohio Regional Sewer District are in the process of an ambitious engineering project designed to reduce the amount of untreated wastewater that is discharged into Lake Erie and its tributaries. The project involves the construction of seven tunnels that will intercept combined sewer overflows for transport to wastewater treatment plants, along with upgrades to the treatment capacity of these plants. This report will examine the water quality impacts of this project, as well as the impact of six additional proposed management options, on the streams of Greater Cleveland and the Lake Erie …

Spatial Analysis Of The Infrastructural Demands Of Integrating 5g Technology: A Case Study In The City Of Detroit, Gregory Putman

Dissertations, Master's Theses and Master's Reports

The invention of 5G technology is expected to revolutionize wireless communication, technology, and capabilities. One major challenge in realizing this vision is the actual deployment of 5G nodes and the development of 5G network infrastructure. Higher frequency and shorter wavelengths that are characteristic of 5G technology is expected to decrease signal range radii of 5G nodes, which could have serious implications for the implementation of a 5G network. This study assessed cell signal density and cell signal coverage that could be achieved using existing 4G infrastructure in the city of Detroit. Results indicate that existing infrastructure is not capable of …

Optimal Mission Planning Of Autonomous Mobile Agents For Applications In Microgrids, Sensor Networks, And Military Reconnaissance, Casey D. Majhor

Dissertations, Master's Theses and Master's Reports

As technology advances, the use of collaborative autonomous mobile systems for various applications will become evermore prevalent. One interesting application of these multi-agent systems is for autonomous mobile microgrids. These systems will play an increasingly important role in applications such as military special operations for mobile ad-hoc power infrastructures and for intelligence, surveillance, and reconnaissance missions. In performing these operations with these autonomous energy assets, there is a crucial need to optimize their functionality according to their specific application and mission. Challenges arise in determining mission characteristics such as how each resource should operate, when, where, and for how long. …

3d Printing Of Iron Oxide Incorporated Polydimethylsiloxane Soft Magnetic Actuator, Rasoul Bayaniahangar

Dissertations, Master's Theses and Master's Reports

Soft actuators have grown to be a topic of great scientific interest recently. As the fabrication of soft actuators with conventional microfabrication methods are tedious, expensive, and time consuming, employment of 3-D printing fabrication methods appears promising as they can simplify fabrication and reduce the production cost. Complex structures can be fabricated with 3-D printing such as helical coils can achieve actuation performances that otherwise would not be possible with simpler geometries. In this thesis development of soft magnetic helical coil actuators of iron-oxide embedded polydimethylsiloxane (PDMS) was achieved with embedded 3-D printing techniques. Composites with three different weight ratios …

Detection And Thermal Stabilization Of Virus Based On Surface Properties, Xue Mi

Dissertations, Master's Theses and Master's Reports

Viral diseases take the lives of millions of people each year. The most effective methods to prevent viral disease outbreak are viral detection to reduce contact with viral pathogens and vaccines to prevent disease. To reduce the costs of the detection of viruses and improve vaccine formulation, we explored viral surface properties. The properties we have focused on are viral hydrophobicity and surface charge using chemical force microscopy (CFM). CFM is a single-particle technique that measures the adhesion force of a functionalized atomic force microscopy (AFM) probe, and in this study, a virus covalently bound to a surface. The non-enveloped …

The Effects Of Carbon Equivalent, Return Ratios, Mold Preparation, Riser Feed And Casting Temperature On The Microstructural And Mechanical Properties Of 100-70-03 Pearlitic Ductile Iron, Erin Vandusen

Dissertations, Master's Theses and Master's Reports

The most common and costly detriments to ductile iron foundries are casting defects, particularly in new and complex components. The ability to understand the factors and processes that create microstructures and the associated properties would allow accurate virtual predictions of casting outcomes. An experimental study of standard foundry variables, carbon equivalent, return ratio, mold preparation, riser feed, and casting temperature on a target of 100-70-03 pearlitic, hypereutectic ductile iron provided the groundwork for an ICME database. Density decreased when the fraction of graphite nodules was greater due to the low density of graphite. A greater percentage of return scrap and …

A Novel Pixel-Based Multiple-Point Geostatistical Simulation Method For Stochastic Modeling Of Earth Resources, Adel Asadi

Dissertations, Master's Theses and Master's Reports

Uncertainty is an integral part of modeling Earth's resources and environmental processes. Geostatistical simulation technique is a well-established tool for uncertainty quantification of earth systems modeling. Multiple-point statistical (MPS) algorithms are specifically advantageous when dealing with the complexity and heterogeneity of geological data. MPS algorithms take advantage of using training images to mimic physical reality. This research presents a novel and efficient pixel-based multiple-point geostatistical simulation method for mineral resource modeling. Pixel-based simulation implies the sequential modeling of individual points on the simulation grid by borrowing spatial information from the training image and honoring conditioning data points. The developed method …

Study Of Silica Nanoparticle Composite On Silica-Hydrogen Peroxide Complexations And Their Effects In Catechol Based Adhesives, Rattapol Pinnaratip

Dissertations, Master's Theses and Master's Reports

Mussel adhesive proteins contain catechol moiety, which allows the protein to crosslinked, solidify, and adhere to surrounding surfaces even under wet conditions. Incorporating the catechol moiety into polymeric adhesive resulted in bioadhesive, which still functions under wet conditions. However, the adhesive must be oxidized in order to crosslink and adhere to surfaces. The oxidation process of catechol adhesive was proven to produce singlet oxygen, superoxide, and hydrogen peroxide (H₂O₂). These reactive oxygen species, with lack of control, can wreak havoc to the biological system causing poor healing and undesired biological response.

Here, we studied the silica …

Continuous Viral Vaccine Manufacturing And Viral Detection Strategies, Dylan G. Turpeinen

Dissertations, Master's Theses and Master's Reports

Viruses are responsible for many human diseases that lead to suffering and death. Acquired immunodeficiency syndrome (AIDS), influenza, and coronavirus disease 2019 (COVID-19) have claimed the lives of millions of people. Two methods have been created to reduce the suffering caused by these diseases. The first is the manufacturing of vaccines that prevent disease and the second is the development of virus detection tests that lead to treatment. The work summarized in this dissertation discusses the development of a continuous virus purification process using an aqueous two-phase system for use in vaccine manufacturing. Additionally, two novel virus detection methods were …

The Laboratory Performance And Aging Characteristics Of Rubber Modified Asphalt Mixture Using A Dry Process, Dongdong Ge

Dissertations, Master's Theses and Master's Reports

The accumulation of waste tires generates severe environmental issues. Using crumb rubber processed from waste tires on the pavement could relieve the pressure of waste tire on the environment and improve the performance of the pavement as well. The application of crumb rubber on the pavement using the dry process was proved to be a cost-effective strategy in some projects, however, the interaction between the rubber and asphalt binder was unknown in the rubber modified asphalt mixture using the dry process, especially when reclaimed asphalt pavement was adopted. The performance improvement of the rubber particle to the asphalt mixture was …

Virus-Like Particle Vaccine Manufacturing From Yeast, Ananya Ananya

Dissertations, Master's Theses and Master's Reports

Influenza virus has an intrinsic nature to undergo mutations. Hence, there have been struggles to combat this disease since the time when the worst influenza pandemic first hit in 1918. Vaccines have proved to be effective in controlling the spread of the influenza A virus by providing herd immunity. However, the contemporary design of influenza A virus based on egg and cell-culture is not efficient in tackling influenza A virus transformation. Virus-like particles (VLPs) have established themselves as a potental platform for future vaccine candidates. VLPs have all the credentials to supplant contemporary vaccine designs without compromising on immunogenicity. For …

Vehicle Dynamics Modeling For Autonomous Drifting And Clothoid Based Waypoint Interpolation, Shubham Vatsa

Dissertations, Master's Theses and Master's Reports

The advent of autonomous vehicles necessitates a redefinition of road safety regulations, considering a controller can possess better driving skills than an average person. The work presented here partly focuses on a vehicle dynamics model development to help imitate and control vehicle drifting maneuvers. As we see, a professional driver drifting through the traffic while keeping the car safe, it can be utilized to avoid accidents at high speeds, if required. Although drifting can produce higher yaw rates than the regular driving regime, these control capabilities have not yet been exploited in the current automotive control systems. Therefore, this report …