Engineering Commons^™

Local Delivery Of Interleukin 4 By Retrovirus-Transduced T Lymphocytes Ameliorates Experimental Autoimmune Encephalomyelitis., Michael K. Shaw, James B. Lorens, Archana Dhawan, Richard Dalcanto, Harley Y. Tse, Alyssa B. Tran, Colleen Bonpane, Shanti L. Eswaran, Stefan Brocke, Nora Sarvetnick, Lawrence Steinman, Garry P. Nolan, C. Garrison Fathman

Journal Articles: Regenerative Medicine

Experimental autoimmune encephalomyelitis (EAE) is an inflammatory autoimmune disease of the central nervous system which serves as a model for the human disease multiple sclerosis. We demonstrate here that encephalitogenic T cells, transduced with a retroviral gene, construct to express interleukin 4, and can delay the onset and reduce the severity of EAE when adoptively transferred to myelin basic protein-immunized mice. Thus, T lymphocytes transduced with retroviral vectors can deliver "regulatory cytokines" in a site-specific manner and may represent a viable therapeutic strategy for the treatment of autoimmune disease.

Santa Clara Magazine, Volume 39 Number 1, Spring 1997, Santa Clara University

Santa Clara Magazine

6 - BLUE SKY INVASION Searching for the American Dream, aerospace workers transform the Santa Clara Valley. By David Beers '79, Illustrations by Dug Waggoner

15 - SEEING IS BELIEVING Professor Sally Wood develops software to help students visualize basic engineering concepts. By Laura Trujillo '92

18 - CONFRONTING THE SCARS OF CENTURIES A legal challenge to California's Proposition 209 is the latest round in a long- running debate over affirmative action. By Margaret M. Russell

26 - SHADOWY ALLIANCE A recent expose alleging CIA links to the crack cocaine epidemic in California's inner cities raises questions about responsibility and …

Ifn-Gamma, Igif, And Iddm., Nora Sarvetnick

Journal Articles: Regenerative Medicine

No abstract provided.

The Influence Of The Wastewater Drainage From The Las Vegas Valley On The Limnology Of Boulder Basin, Lake Mead, Nevada-Arizona, James F. Labounty, Michael J. Horn, Bureau Of Reclamation

Publications (WR)

Lake Mead, Colorado River, Arizona-Nevada, is one of the most heavily used reservoirs in the western United States, providing abundant recreational opportunities as well as downstream domestic and agricultural water for over 22 million users. Based on average nutrient levels and productivity, Lake Mead is classified as mildly mesotrophic. The interflow of the Colorado River dominates the limnology of much of the 106 km-long reservoir, and may still be identified at Hoover Dam under certain conditions. The lower basin of Lake Mead ending at Hoover Dam is known as Boulder Basin and is near the Las Vegas metropolitan area. Las …

Complexity Theory And Systems Theory, Martin Zwick

Complex Systems Faculty Publications and Presentations

I use the label, “complexity theory,” for the research program which studies nonlinear dynamics, “complexity,” “complex adaptive systems,” “artificial life,” etc., and whose intellectual Mecca in the United States is the Santa Fe Institute. I use the label, “systems theory,” for the research program which crystallized after World War II under the names of “general systems theory” and “cybernetics,” and which subsumed such postwar scientific developments as information theory, game theory, feedback control theory, and the beginnings of computer science and artificial intelligence. The central thesis of this paper is that complexity theory is a continuation and revitalization of systems …

Indicator Bacteria Concentrations Of Two Northwest Arkansas Streams In Relation To Flow And Season, Dwayne R. Edwards, Mark S. Coyne, Tommy C. Daniel, P. F. Vendrell, J. F. Murdoch, P. A. Moore Jr.

Biosystems and Agricultural Engineering Faculty Publications

Concentrations of indicator bacteria such as fecal coliform (FC) and fecal streptococcus (FS) are often used to assess the suitability of waters for their intended use(s) and to allocate resources for water quality improvement measures. There is evidence, however, that concentrations of FC and FS can be influenced by variables such as season and flow rate during sampling, which could lead to biased results. The objective of this study was to assess the impacts of season and flow rate on concentrations of FC and FS. Fecal indicator bacteria concentrations were measured for approximately three years at five sites on two …

Vegetative Filter Strip Removal Of Metals In Runoff From Poultry Litter-Amended Fescuegrass Plots, Dwayne R. Edwards, P. A. Moore Jr., Tommy C. Daniel, Puneet Srivastava, D. J. Nichols

Biosystems and Agricultural Engineering Faculty Publications

Runoff from land areas amended with poultry (Gallus gallus domesticus) manure can contain elevated concentrations of metals such as Cu, Fe, and Zn. Vegetative filter strips (VFS) can reduce runoff concentrations of animal manure components, but reported studies have typically focused on nutrients and solids rather than metals. This experiment assessed the impact of VFS length (0 to 12 m) on concentrations and mass losses of Cu, Fe, K, Na, Ni, and Zn in runoff from fescuegrass (Festuca arundinacea Schreb.) plots (1.5 m wide × 6 and 12 m long) treated with poultry litter. The runoff was produced from simulated …

Miniaturized Isfet Glucose Sensor Including A New Structure Actuation System, Chang-Soo Kim, Hwa-Il Seo, Chae-Hyang Lee, Byung-Ki Sohn

Electrical and Computer Engineering Faculty Research & Creative Works

A new principle of an amperometric actuation technique was incorporated in the ISFET glucose sensor. The ISFET is fabricated by the CMOS process and the platinum working electrode is deposited by the lift-off process. A sensor with a specially designed ladder type working electrode exhibits improved operation in response time, response magnitude and detection range. An expectation concerning the reduction of sensor size is also discussed.

Effect Of Cl Incorporation On The Performance Of Amorphous Silicon Thin Film Transistor, Jong Hyuni Choi, Chang-Soo Kim, Sung Ki Kim, Jin Jang

Electrical and Computer Engineering Faculty Research & Creative Works

No abstract provided.

Teasing Apart The Threads Of Staple Strength, Andrew Peterson

Journal of the Department of Agriculture, Western Australia, Series 4

A successful partnership between two local inventors and Agriculture WA's Wool Program has created a new instrument which, just like the growth rings of trees, can show seasonal changes in the fibre diameter of wool. This will have considerable value to the wool industry as Andrew Peterson explains.

Mechanisms Of Cytokine-Mediated Localized Immunoprotection., Nora Sarvetnick

Journal Articles: Regenerative Medicine

No abstract provided.

Santa Clara Magazine, Volume 38 Number 4, Fall 1996, Santa Clara University

Santa Clara Magazine

4 - ENTER THE CLASS OF 2000 They're committed, they're ambitious, they're adventurous-and they're here! By Christine Courard '97 Photographs by Charles Barry

10 - A COMMUNITY OF SCHOLARS FOR THE COMMON GOOD Unique gifts of students, facu lty, staff, and alumni advance University efforts to integrate learning and living. By Paul Locatelli, S.J, '60

13 - HEADY DAYS, MYLANTA NIGHTS Riding the roller coaster of high tech investing. Coming out on top. By Therese Poletti '81

18 - THE TAO OF PERSONAL LEADERSHIP New book by English Department chair describes how ancient Chinese philosophy can help leaders bring a …

Pancreatic Expression Of Interleukin-4 Abrogates Insulitis And Autoimmune Diabetes In Nonobese Diabetic (Nod) Mice., Regula Mueller, Troy Krahl, Nora Sarvetnick

Journal Articles: Regenerative Medicine

Diabetes in nonobese diabetic (NOD) mice is a T cell-dependent autoimmune disease. The destructive activities of autoreactive T cells have been shown to be tightly regulated by effector molecules. In particular, T helper (Th) 1 cytokines have been linked to diabetes pathogenesis, whereas Th2 cytokines and the cells that release them have been postulated to be protective from disease. To test this hypothesis, we generated transgenic NOD mice that express interleukin (IL) 4 in their pancreatic beta cells under the control of the human insulin promoter. We found that transgenic NOD-IL-4 mice, both females and males, were completely protected from …

Review Of: Science Advice To The President (William T. Golden, Ed. Aaas Press 2d Ed. 1993)., Timothy Van Dyke

RISK: Health, Safety & Environment (1990-2002)

Review of: Science Advice to the President (William T. Golden, ed. AAAS Press 2d Ed. 1993). Acknowledgments, index of names, introductions, notes, tables. ISBN 0-87168-509-4 [340 pp. $29.95 paper. American Association for the Advancement of Science, 1333 H St. NW, Washington DC 20701.]

Santa Clara Magazine, Volume 38 Number 3, Summer 1996, Santa Clara University

Santa Clara Magazine

6 - THE BEATEN TRACK SCU Psychologist Stephanie Etukudo and Senior Lecturer in English Jeffrey Zorn debate whether ability groupings serve students' best interests.

12 - WHAT WOULD SOLOMON SAY? Adoptions gone awry trigger controversy over how to safeguard the rights of parents while protecting the welfare of the child. By Elizabeth Fernandez '79

18 - A THIRST FOR HEALING A pilgrim to Lourdes finds that the cures offered by the blessed waters can be mostly invisible. By Dee Danna '68 (MBA '72)

24 - THE FLOWERING OF SANTA CLARA UNIVERSITY For more than a century, the Mission Gardens have …

Il-10 Is Necessary And Sufficient For Autoimmune Diabetes In Conjunction With Nod Mhc Homozygosity., Myung-Shik Lee, Regula Mueller, Linda S. Wicker, Laurence B. Peterson, Nora Sarvetnick

Journal Articles: Regenerative Medicine

Contrary to expectations based on in vitro experiments, we previously found that pancreatic IL-10 did not inhibit autoimmune diabetes but accelerated it in an MHC-dependent manner. Therefore, the ability of IL-10 to overcome the absence of all non-MHC diabetes susceptibility (Idd) alleles was studied in transgenic mice expressing pancreatic IL-10 backcrossed to B10.H2g7 congenic mice, which have no Idd alleles other than NOD MHC (H2g7). IL-10 transgenic backcross 1 (BC1) mice with H2g7/g7 haplotype developed clear-cut insulitis and diabetes, but neither transgenic mice with the H2g/b haplotype nor nontransgenic BC1 mice did so. Further implicating IL-10 in autoimmune diabetes, anti-IL-10 …

Anion Induced Blue To Purple Transition In Bacteriorhodopsin, Mrunalini Pattarkine, Anil K. Singh

Faculty Works

Purple membrane (PM, λ" role="presentation">λmax" role="presentation">max 570 nm) of H. halobium on treatment with sulphuric acid changes its colour to blue (λ" role="presentation">λmax" role="presentation">max 608 nm). The purple chromophore can be regenerated from the blue chromophore by exogeneous addition of anions such as CI−" role="presentation">− and HPO42−" role="presentation">2−4. Chloride ion is found to be more effective than the dibasic phosphate ion in regenerating the purple chromophore. Nevertheless, one thing common to the anion regeneration is that both CI−" role="presentation">− and HPO42−" role="presentation">2−4 show marked pH effect. At pH 1.0 the efficiency of …

Santa Clara Magazine, Volume 38 Number 2, Spring 1996, Santa Clara University

Santa Clara Magazine

10 - IT CHANGED MY LIFE Reflecting on 30 years of the Santa Clara Communiry Action Program, former SCCAP directors recount what participating in the organization meant to them.

14 - ATTICUS An excerpt from the recent novel by SCU's new Gerard Manley Hopkins, S.)., Professor in Arts and Humanities. By Ron Hansen M.A. '95

22 - LOST IN CYBERSPACE Universities debate Internet addiction among students: Should we stop them before rhey surf again? By Jeff Brazil '85

28 - THE GRAPES OF WRATH: PART II Professor of Modern Languages Francisco Jimenez '66 remembers his childhood as a migrant laborer, …

The Effect Of Wet End Operations On Sizing Loss In Alkaline Papers, Suresh B. Cherukuri

Masters Theses

Changes in wet end of alkaline papermaking affect the size development as well as sizing loss. These changes include pH, alkalinity and type of filler used. Precipitated and ground varieties of carbonate fillers and the alkalinity associated with · them are believed to be the causes for the gradual sizing loss in alkaline papers due the accelerated hydrolysis reaction of sizing chemicals at higher alkalinity.

Precipitated and ground calcium carbonate fillers are used as fillers and compared to non carbonate filler such as kaolin clay for their response to size development and sizing loss at lower and higher alkalinity ranges …

Proceedings: Seventeenth Vertebrate Pest Conference, Rohnert Park, California, March 5-7, 1996 (Complete Work), Robert M. Timm , Editor, A. Charles Crabb , Editor

Vertebrate Pest Conference Proceedings: 17th (1996)

340 registered attendees
58 papers
273 pages
52 Mb

You have come from throughout California, from across the United States, and from many corners of the world to gather here for the purpose of sharing information, expertise, and wisdom in dealing with vertebrate pest problems. Our common purpose is to find yet better methods for preventing and resolving situations in which wildlife comes into conflict with humans. The Conference's mission remains one of education. We learn from each other, and we strive to find better ways of applying our knowledge to real-world problems.

Disaccharide Intolerance Of European Starlings, Leonard R. Askham

Vertebrate Pest Conference Proceedings: 17th (1996)

The use of disaccharides to discourage bird depredation to agricultural crops has elicited some interest during the last few years. Data developed in these trials indicate that several avian species are intolerant to sucrose because of the lack of sucrase enzymes in their digestive systems. Based on this research it is hypothesized that progressively increasing rates and volumes of solutions would elicit consistent adverse stress reactions. Furthermore, that if birds were intolerant to sucrose, because of their co-evolutionary development with plants, then they should lack the ability to digest lactose. The data developed in these trials does not support either …

Closing Remarks—Seventeenth Vertebrate Pest Conference, Rex O. Baker

Vertebrate Pest Conference Proceedings: 17th (1996)

As chair-elect of the council, I would like to thank all of those who participated in this 17th Vertebrate Pest Conference.

We had a total attendance of 340 from 27 states in the U.S., including 27 attendees from 8 countries outside the U.S. The contributions and sacrifices made by foreign speakers is genuinely appreciated and has, as always, added greatly to the diversity of the conference.

As most of you know, the council's primary goal is fostering education and advancement in the field of vertebrate pest management. We have always tried to draw noted experts to present a broad range …

Field Efficacy Of Diphacinone Grain Baits Used To Control The California Ground Squirrel, J. A. Baroch

Vertebrate Pest Conference Proceedings: 17th (1996)

Diphacinone treated oat groats were effective in reducing populations of California ground squirrels (Spermophilus beecheyi) by more than 84%. Two concentrations of active ingredient (0.005% and 0.01%) were compared, as well as two application methods: spot baiting and bait stations. Squirrel activity on test plots was assessed before and after bait applications using visual counts and active burrow counts. There was good correspondence between results of the two activity indices. There was no significant improvement in efficacy provided by the higher concentration of diphacinone. Bait consumption was much lower on bait station plots. Squirrel carcasses were found on …

Overhead Wires Reduce Roof-Nesting By Ring-Billed Gulls And Herring Gulls, Jerrold L. Belant, Sheri K. Ickes

Vertebrate Pest Conference Proceedings: 17th (1996)

The authors evaluated the effectiveness of overhead wires in reducing roof-nesting by ring-billed gulls (Larus delawarensis) and herring gulls (L. argentatus) at a 7.2 ha food warehouse in Bedford Heights, Ohio during 1994-1995. In 1994, stainless steel wires (0.8 mm diameter) were attached generally in spoke-like configurations between 2.4 m upright metal poles spaced at 33.7 m intervals over the main portion of roof. The 6 to 14 wires radiating from each pole created a mean maximum spacing between wires of about 16 m. Nesting by ring-billed and herring gulls was reduced by 76% and 100% …

Towards "Best Practice" Vertebrate Pest Management In Australia, Mike Braysher, Peter O'Brien, Mary Bomford

Vertebrate Pest Conference Proceedings: 17th (1996)

Australia has 26 species of introduced pest mammals that cause extensive damage to agriculture and the conservation of native wildlife. Past efforts tried to eradicate them. This focus on reducing pest numbers rather than the outcome, reduced damage, has had limited success. Under its Vertebrate Pest Program, the Bureau of Resource Sciences has developed principles and a strategic approach to managing pest damage. Close cooperation with land managers as co-researchers and co-learners is an essential element, as is a coordinated group approach to pest management. The approaches are illustrated with an example.

Effectiveness Of Vichos Non-Lethal Collars In Deterring Coyote Attacks On Sheep, J. Russell Mason, Richard J. Burns

Vertebrate Pest Conference Proceedings: 17th (1996)

Vichos non-lethal collars containing 45 to 105 ml of 3 % capsicum oleo resin were evaluated as deterrents to coyote attacks on sheep. Each of five coyotes tested made neck/throat attacks on one collared lamb; four punctured collars and one pulled the collar from a lamb without puncturing it. One coyote did not resume biting the lamb for 60 min; it was retested two and four days later. At two days, the coyote punctured a second collar and briefly halted its attack. At four days, the coyote attacked a third collared lamb but made no attempt to grasp the neck/throat …

An Overview Of Animal Damage Control (Adc) Assistance To The Vertebrate Pest Management Industry, William H. Clay

Vertebrate Pest Conference Proceedings: 17th (1996)

The Animal Damage Control (ADC) program has had a long history dating back to 1885. ADC was officially established in 1931 under the United States Department of Agriculture. In 1939, the program was moved to the United States Department of Interior's Fish and Wildlife Service. In 1996, ADC was transferred back to the USDA and placed under the Animal and Plant Health Inspection Service. The mission of the Animal Damage Control program is to provide federal leadership in managing problems caused by wildlife. Current program assistance includes: a) technical assistance in wildlife management; b) conducting research and development activities related …

Improved Sealants For M-44 Cyanide Capsules, Guy Connolly

Vertebrate Pest Conference Proceedings: 17th (1996)

The M-44 sodium cyanide ejector is one of the most important tools used by the Animal Damage Control (ADC) program to protect livestock from coyotes. Unacceptable performance of M-44 cyanide capsules due to inadequate seals stimulated research to develop a better capsule sealant. Comparative tests of crude beeswax, Scheel SC-100 wax, and other materials revealed that capsules sealed with SC-100 were most resistant to deterioration in adverse environments. Based on these results, SC-100 wax was selected as the sealant of choice. Beginning in April 1989, all M-44 capsules made for ADC program use have been sealed with SC-100 wax. Since …

Impacts Of A Daily Trap Check Law On The California Adc Program, Craig Coolahan

Vertebrate Pest Conference Proceedings: 17th (1996)

Effective January 1, 1990 California law required that all steel-jawed leghold traps be inspected at least daily and all animals in such traps be removed. The inspection and removal could be performed by the individual who set the traps, the landowner, or an agent of either. Prior to the passage of this law, California Animal Damage Control (ADC) personnel were exempt from Department of Fish and Game trap checking regulations. The data suggest that a decrease in trap use occurred after the implementation of the daily trap check. Where the program could effectively substitute other control tools or methods for …

Analysis Of Vertebrate Pest Research, Jim Hone

Vertebrate Pest Conference Proceedings: 17th (1996)

Research on vertebrate pest control is mostly empirical, focusing on control of species X in location Y using method Z. Such an approach is needed. The science of vertebrate pest research is developing some generalizations across species, locations, and methods. This paper further explores such generalizations by discussing six questions asked by Hone (1994), the answers to which are relevant to vertebrate pest research world-wide. Several case studies are examined, with emphasis on control of damage by small mammals and predation control. Suggestions are made for future research.