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Articles 631 - 657 of 657
Full-Text Articles in Engineering
Effects Of Hofmeister Ions On Solubility And Swelling On Gelatin Hydrogels, Hannah Eldridge
Effects Of Hofmeister Ions On Solubility And Swelling On Gelatin Hydrogels, Hannah Eldridge
Williams Honors College, Honors Research Projects
Hydrogels are known to be weak and brittle, due to the amounts of water that they hold. Gelatin-based hydrogels specifically are inexpensive and easily accessible, but often have poor physical properties. The goal of my project was to strengthen gelatin-based hydrogels and improve their mechanical properties by forming these hydrogels in different aqueous solutions containing kosmotropic Hofmeister's ions. Prior research has shown that these ions are able to take water away from gelatin-based gels, which forms a tougher hydrogel. The success of this project will be measured by studying the solubility and swelling effects that different Hofmeister ions have on …
Optimization Of E-Textiles For Lactic Acid Detection, Andrew Laboy, Mallory David
Optimization Of E-Textiles For Lactic Acid Detection, Andrew Laboy, Mallory David
Williams Honors College, Honors Research Projects
The overall goal of the project is to develop an e-textile that will be able to determine different characteristics of an athlete's health through multiple sensors. The goal of these sensors is to monitor physiological parameters for health and fitness uses in real time. Building from the existing sodium concentration sensor, these new sensors will detect lactate levels within sweat to monitor instantaneous health which allows customization of workout and overall health regimen.
Testing The Effectiveness Of Reflective "Cool" Pigments, Ashleigh Carpenter
Testing The Effectiveness Of Reflective "Cool" Pigments, Ashleigh Carpenter
Williams Honors College, Honors Research Projects
This project is an exploration of reflective "cooling" pigments used in coatings for the exterior of a structure in order to control the temperature inside. The pigments reflect sunlight to reduce the heating effect inside a structure. While the project will include the synthesis and testing of these pigments, the focus will be on the design and construction of an apparatus to test the effectiveness of these pigments. An apparatus will be constructed with a heat source and two structures of identical dimensions. The set-up will allow for the temperature of the inside of the structures to be recorded at …
Chloride Effect In Fly Ash Geopolymer Cement, Evan Dimmick
Chloride Effect In Fly Ash Geopolymer Cement, Evan Dimmick
Williams Honors College, Honors Research Projects
The production of ordinary portland cement (OPC) poses a significant impact on the world's carbon dioxide emissions through the wide global use of concrete. Geopolymer cements (GPC) made from alkali activated fly ash can serve as a replacement to OPCs, reducing the carbon dioxide emissions by as much as 80%. GPCs exhibit adequate or superior mechanical performance to OPCs. The corrosion of carbon steel rebar in concrete occurs largely from chloride ion attack. The focus of this project will be to experimentally determine the coefficient of diffusion for chloride ions in GPCs and OPCs and compare to the corrosion performance …
Methods For Film Coating Electrospun Fibers, Kristopher Dejean
Methods For Film Coating Electrospun Fibers, Kristopher Dejean
Williams Honors College, Honors Research Projects
Electrospinning uses high voltages to form polymer nanofiber membranes. These membranes have potential for use in filtration, tissue engineering, drug delivery, and catalysis. The nonwoven fiber mat is malleable but has a low tensile strength compared to a solid film of the same polymer. Joining the fibers with a thin film is desired to balance the strength and flexibility. Three methods of producing a film on fiber membrane were tested. The techniques are spraying then melting, spin coating, and dip coating. Electrospinning setup conditions, solvent ratios, damage to fibers, and spin coating speeds were determined. Research was abruptly stopped and …
Utilizing Virtual High-Throughput Screens To Identify Promising Inhibitors Of Complement Factor C1s, Lyndsey Schmucker
Utilizing Virtual High-Throughput Screens To Identify Promising Inhibitors Of Complement Factor C1s, Lyndsey Schmucker
Williams Honors College, Honors Research Projects
A large study was conducted to identify possible drug candidates to treat various diseases using computer algorithms, virtual high-throughput screens, and experimental validation of activity. Since the algorithm has the capability to screen millions of compounds, it is beneficial to pharmaceutical development as it allows a larger pool of compounds to be considered that would have otherwise been overlooked. As part of this larger study, this project attempts to identify drug candidates to treat human complement factor C1, a protein which causes tissue damage when underregulated1. A series of designed experiments validate candidates and confirm the performance of …
A Comparison Of Fiber Mat Thickness Measurement Techniques Using Laser Interferometry And Water Displacement, Ryan Seabeck
A Comparison Of Fiber Mat Thickness Measurement Techniques Using Laser Interferometry And Water Displacement, Ryan Seabeck
Williams Honors College, Honors Research Projects
Polymer fiber mats may often be very thin which leads to complications in measuring thickness. The thickness of fiber mats, however, is crucial in understanding their behavior. Thickness affects how well the mat works as a filter as well as the pressure drop across the mat, and herein lies the need for accurate measurement techniques. Currently two of the available techniques for measuring mat thickness are by laser interferometry[1] and by buoyancy force when submerged in water[2]. Instead of measuring the buoyancy force in this experiment, an enclosure intended to measure the thickness via water displacement was …
Continuous Viral Vaccine Manufacturing And Viral Detection Strategies, Dylan G. Turpeinen
Continuous Viral Vaccine Manufacturing And Viral Detection Strategies, Dylan G. Turpeinen
Dissertations, Master's Theses and Master's Reports
Viruses are responsible for many human diseases that lead to suffering and death. Acquired immunodeficiency syndrome (AIDS), influenza, and coronavirus disease 2019 (COVID-19) have claimed the lives of millions of people. Two methods have been created to reduce the suffering caused by these diseases. The first is the manufacturing of vaccines that prevent disease and the second is the development of virus detection tests that lead to treatment. The work summarized in this dissertation discusses the development of a continuous virus purification process using an aqueous two-phase system for use in vaccine manufacturing. Additionally, two novel virus detection methods were …
Role Of Flocculation And Dispersion In Pelletization Of Iron Ore, Victor J. Claremboux
Role Of Flocculation And Dispersion In Pelletization Of Iron Ore, Victor J. Claremboux
Dissertations, Master's Theses and Master's Reports
Traditional modeling of iron ore pellet strength utilizes micromechanical models such as Rumpf’s equation, which correlate attractive forces and pellet properties into an average expected pellet strength. These models combine with repulsive forces within pellets to predict that pellet strength decreases with the introduction of these forces. However, naïvely applying Rumpf’s equation readily leads to incorrect predictions about the resulting behavior. Pellets created with strong repulsive forces arising from dispersion conditions are observed to be significantly stronger overall than pellets formed in the absence of dispersants. A new model is required to understand and predict the effects of these additives …
Virus-Like Particle Vaccine Manufacturing From Yeast, Ananya Ananya
Virus-Like Particle Vaccine Manufacturing From Yeast, Ananya Ananya
Dissertations, Master's Theses and Master's Reports
Influenza virus has an intrinsic nature to undergo mutations. Hence, there have been struggles to combat this disease since the time when the worst influenza pandemic first hit in 1918. Vaccines have proved to be effective in controlling the spread of the influenza A virus by providing herd immunity. However, the contemporary design of influenza A virus based on egg and cell-culture is not efficient in tackling influenza A virus transformation. Virus-like particles (VLPs) have established themselves as a potental platform for future vaccine candidates. VLPs have all the credentials to supplant contemporary vaccine designs without compromising on immunogenicity. For …
Radio Frequency Studies Of Soot Loading And Ammonia Storage On A Diesel Particulate Filter With A Scr Catalyst Coating, Shreyans Sethia
Radio Frequency Studies Of Soot Loading And Ammonia Storage On A Diesel Particulate Filter With A Scr Catalyst Coating, Shreyans Sethia
Dissertations, Master's Theses and Master's Reports
The radio frequency (RF) measurement technique has been shown to be a viable method for measurement of the amount of soot loaded onto DPF’s [1] and the amount of NH3 stored on SCR catalysts [2]. In one of the configurations, a microwave resonant cavity is formed by the metal can encasing the enclosed catalyst. Two metal probes acting as antennas are placed on either side of the catalyst. Power transmitted between the antennas is monitored as the frequency of the signal is swept. At certain frequencies, resonance is achieved. Measurements of the resonance frequencies, amplitude at resonance, and …
Mechanisms Of Pathogen Inactivation In Wastewater And Pharmaceutical Applications, Christa L. Meingast
Mechanisms Of Pathogen Inactivation In Wastewater And Pharmaceutical Applications, Christa L. Meingast
Dissertations, Master's Theses and Master's Reports
Infectious diseases are a significant threat to public health. Though society enacts practices to prevent the spread of these dangerous diseases, challenges remain. Therefore, continual advancements in treatment and prevention are required. Wastewater treatment and viral clearance in pharmaceutical applications are two key health measures that prevent the spread of infections.
A low-cost, low-technology biosolids treatment process was developed to improve wastewater treatment by collecting key information on storage temperature, ammonia, volatile solids, moisture content, pH, and pathogen inactivation in biosolids over long-term storage at two wastewater treatment plants located in northern climates of the United States. Inactivation of pathogens …
Towards Efficient Water Treatment: Mechanism Of Colloidal Fouling Of Ultrafiltration Membranes, Ikenna Henry Ozofor
Towards Efficient Water Treatment: Mechanism Of Colloidal Fouling Of Ultrafiltration Membranes, Ikenna Henry Ozofor
Dissertations, Master's Theses and Master's Reports
This research study first reviewed challenges of conventional and membrane separation systems for water treatment. Though membrane separation systems appeared superior to the conventional counterparts for water and wastewater treatment, wider applications of membrane systems have been limited by some factors, most notably is membrane fouling. Experimental studies were therefore conducted to achieve the goal of this research, which is to investigate how feed properties affect fouling of ultrafiltration (UF) membranes by colloids.
Feed salinity, pH, and nanoparticle concentration were the variables studied to unravel how different UF membranes are fouled by model silica colloids (with average diameter of 25nm). …
Investigation Of The Stability Of Liquid And Air Films By Synchronized Tri-Wavelength Reflection Interferometry Microscope, Yuesheng Gao
Investigation Of The Stability Of Liquid And Air Films By Synchronized Tri-Wavelength Reflection Interferometry Microscope, Yuesheng Gao
Dissertations, Master's Theses and Master's Reports
Liquid films are widely involved in many processes, such as froth flotation, oil extraction, foam/bubble stabilization, etc. In the meantime, air films are commonly seen in diverse fields like dust control, ink print, coating industry, and so on. Stabilities of these liquid/air films are of great importance to improve the processes. As more and more researchers are paying increasing attention to liquid/air films, tremendous efforts have been made to explore the properties of the films. On the one hand, some theoretical models have also been well developed in recent decades. State-of-the-art technologies, such as AFM, SFA, and RICM, have also …
Systems Analysis For Sustainability Assessment Of Biogas And Bio-Ch4 Production From Food Waste And Dairy Manure Mixtures In The Us, Sharath Kumar Ankathi
Systems Analysis For Sustainability Assessment Of Biogas And Bio-Ch4 Production From Food Waste And Dairy Manure Mixtures In The Us, Sharath Kumar Ankathi
Dissertations, Master's Theses and Master's Reports
The purpose of the dissertation is to relate systems analysis for bioenergy to identify optimum configurations for improved scenarios and to make better decisions in a systems perspective.
Chapter 1 is a review of the literature to identify the state of the knowledge in terms of systems analysis for anaerobic digestion (AD) bioenergy systems. The key outcomes from this review showed that anaerobic digestion of mixtures of food waste and animal manure has great potential to achieve economic and environmental benefits compared to other treatments of organic waste materials, such as landfilling or conventional manure management.
Chapter 2 focuses on …
Energy Conservation And Heat Transfer Enhancement For Mixed Convection On The Vertical Galvanizing Furnace, Dan Mei, Yuzheng Zhu, Xuemei Xu, Futang Xing
Energy Conservation And Heat Transfer Enhancement For Mixed Convection On The Vertical Galvanizing Furnace, Dan Mei, Yuzheng Zhu, Xuemei Xu, Futang Xing
Mechanical & Aerospace Engineering Faculty Publications
The alloying temperature is an important parameter that affects the properties of galvanized products. The objective of this study is to explore the mechanism of conjugate mixed convection in the vertical galvanizing furnace and propose a novel energy conservation method to improve the soaking zone temperature based on the flow pattern and heat transfer characteristics. Herein, the present study applied the k-ε two-equation turbulence model to enclose the Navier-Stokes fluid dynamic and energy conservation equations, and the temperature distributions of the steel plate and air-flow field in the furnace were obtained for six Richardson numbers between 1.91 ⋅ 105 …
Chemical And Thermal Sintering Of Supported Metals With Emphasis On Cobalt Catalysts During Fischer−Tropsch Synthesis, Mahmood Rahmati, Mohammad-Saeed Safdari, Thomas H. Fletcher, Morris D. Argyle, Calvin H. Bartholomew
Chemical And Thermal Sintering Of Supported Metals With Emphasis On Cobalt Catalysts During Fischer−Tropsch Synthesis, Mahmood Rahmati, Mohammad-Saeed Safdari, Thomas H. Fletcher, Morris D. Argyle, Calvin H. Bartholomew
Faculty Publications
This comprehensive critical review combines, for the first time, recent advances in nanoscale surface chemistry, surface science, DFT, adsorption calorimetry, and in situ XRD and TEM to provide new insights into catalyst sintering. This work provides qualitative and quantitative estimates of the extent and rate of sintering as functions of nanocrystal (NC) size, temperature, and atmosphere. This review is unique in that besides summarizing important, useful data from previous studies, it also advances the field through addition of (i) improved or new models, (ii) new data summarized in original tables and figures, and (iii) new fundamental perspectives into sintering of …
Modeling Of Rotary Packed Beds For Reactive And Non-Reactive Systems, Chinyere Evangeline Ezeobinwune
Modeling Of Rotary Packed Beds For Reactive And Non-Reactive Systems, Chinyere Evangeline Ezeobinwune
Graduate Theses, Dissertations, and Problem Reports
Rotary packed beds (RPBs) are used in a wide range of reactive and non-reactive applications. In this research, a 2-d, first-principles, dynamic model of a non-reactive RPB that is used for heat exchange between the outgoing flue gas from a power plant and the incoming air to the boiler/pulverizer of the power plant is developed. A 2-d, first-principles model of a reactive RPB is developed where a functionalized metal-organic framework (MOF) is used for CO2 capture.
For the non-reactive system, a Ljungstrom-type air preheater (APH) is considered. Existing models for these rotating heat exchangers are typically 1-d. There are …
Review Of Established And Emergent Methods For The Production Of C4 Olefins, James Matthew Koval
Review Of Established And Emergent Methods For The Production Of C4 Olefins, James Matthew Koval
Graduate Theses, Dissertations, and Problem Reports
Current production of C4 olefins is dominated by naphtha cracking and butane dehydrogenation, but significant research interest is developing in alternate feedstocks due to an abundance of inexpensive natural gas and bioethanol. The current C4 olefin production methods are costly, make use of already-depleted petroleum resources, and are often hazardous to workers, which forms the impetus for investigation into alternative methods and assessment of their viability as a future means of olefin production. Methods of natural gas conversion to higher order hydrocarbons are discussed, including Fischer-Tropsch synthesis and oxidative methane coupling, each of which could form the first …
Process Development Of Shale Gas Assisted Lignin And Biomass Reforming Through Novel Reaction Pathway And Catalyst Design To Produce Hydrogen Rich Syngas For Fuels And Value Added Chemicals, Amoolya D. Lalsare
Graduate Theses, Dissertations, and Problem Reports
Novel biomass reforming strategy through synergistic co-processing with flare gas (methane and carbon dioxide) was developed at West Virginia University. Hardwood biomass comprised of lignin, hemicellulose, and cellulose is abundant in the US and potentially a sustainable source of hydrogen through extensive reforming and gasification. Ever-increasing shale gas production in the US occasionally leads to flaring owing to stranded production across the US. Achieving biomass co-processing with natural gas about to be flared in such stranded shale plays is the underlying motivation here. A novel reaction pathway was discovered wherein methane and carbon dioxide assisted reforming of biomass could be …
Process Modeling And Techno-Economic Analysis Of Thermo-Catalytic Dimethyl Ether Synthesis And Microwave-Based Aromatics Production Technologies From Shale Gas, Chirag Mevawala
Graduate Theses, Dissertations, and Problem Reports
Production of dimethyl ether (DME) and direct non-oxidative methane dehydroaromatization (DHA) to aromatics via conventional and microwave (MW)-assisted processes are investigated in this research. Plant-wide models of the shale gas to DME process with integrated CO2 capture via direct and indirect synthesis routes have been developed. Optimal parameter estimation, and model validation are undertaken for various sections of the process including the pre-reforming reactor, auto-thermal reforming reactor, DME synthesis reactors, CO2 capture units and separation sections. A novel DME separation process has been developed for efficient separation of DME, syngas, and CO2. Plant-wide techno-economic optimization is …
Application Of Immobilized Palladium Monolithic Catalysts In Suzuki-Miyaura And Tsuji-Wacker Redox Reactions, Sajjad Ghobadi
Application Of Immobilized Palladium Monolithic Catalysts In Suzuki-Miyaura And Tsuji-Wacker Redox Reactions, Sajjad Ghobadi
Theses and Dissertations
Herein, a wholistic analysis of the viability of monolithic catalysts for redox reactions is presented. The interdisciplinary approach taken in this systematic study included preparation and investigation on Pd-on-carbon monoliths as catalysts in a flow and electrochemical settings.
The Suzuki-Miyaura reaction-focused study led to rational design, preparation, and successful application of Pd0-on-graphene oxide (GO) monolithic catalysts in flow conditions. In this study a combination of chemical reduction, freeze-casting, and vapor-phase reduction processes was applied to Pd-GO structures leading to the preparation of these monoliths. The Suzuki flow synthesis reactions revealed that the monolithic structure led to significantly improved …
Beneficiation Of Coal Using Supercritical Water And Carbon Dioxide Extraction, Matthew Decuir Virginia Commonwealth University Cl
Beneficiation Of Coal Using Supercritical Water And Carbon Dioxide Extraction, Matthew Decuir Virginia Commonwealth University Cl
Theses and Dissertations
This work explores the use of carbon dioxide, water, and their mixtures as solvent for the pre-combustion beneficiation of raw coal without using any toxic mineral acids in the temperature range of 200-400℃. The fluid polarity, ionic constant, and supercritical point can be adjusted by H2O/CO2 ratio and temperature. Adding carbon dioxide to hydrothermal fluid also increases the ionization by forming carbonic acid. Extractions with supercritical fluids have several benefits including enhanced mass transport, ease of separation and recycle, wide range of extractive capability and tunability, better inherent safety, and in the case of carbon dioxide and …
Self-Assembled Metal Nanoparticle/Polymer Nanocomposites As Nanoreactors For One-Pot Reactions, Andrew Harrison
Self-Assembled Metal Nanoparticle/Polymer Nanocomposites As Nanoreactors For One-Pot Reactions, Andrew Harrison
Theses and Dissertations
Polymer nanoreactors incorporating gold nanoparticle catalysts were self-assembled via Flash Nanoprecipitation. The incorporated gold nanoparticles maintained catalytic activity, which was evaluated using reduction of 4-nitrophenol with sodium borohydride as a model reaction. The diffusion coefficient for 4-nitrophenol was determined by NMR and used to calculate the second Damköhler number, which indicated that the systems were not diffusion limited. Despite similar diffusion coefficients, catalytic performance was strongly affected by the co-precipitant. For example, the apparent reaction rate per surface area using castor oil was over 8-fold greater than polystyrene. Thus, we measured the partition coefficient of 4-nitrophenol between water and castor …
Higher Tensile Forces Across Cellular Junctions And An Intact Nuclear Linc Complex Is Required For Epithelial Function And Stability, Fnu Vani Narayanan
Higher Tensile Forces Across Cellular Junctions And An Intact Nuclear Linc Complex Is Required For Epithelial Function And Stability, Fnu Vani Narayanan
Theses and Dissertations
Recent advances in three-dimensional (3D) cell culture systems have provided key insights into the understanding of biochemical and physiological states of native tissue. A significant progress in the field of mechanobiology involves measuring cellular traction forces in a more native 3D environment. However, the effects of mechanical forces exerted across cellular junctions and the nuclear LINC complex, in an organized 3D system has not been investigated thus far. Epithelial cells spontaneously form acini (also known as cysts or spheroids) with a single, fluid-filled central lumen, when grown in 3D matrices. The size of the lumen is dependent on apical secretion …
Formulation And Validation Of Nanoparticle Controlled Delivery For Chemotherapeutic Drug Products, Shani L. Levit
Formulation And Validation Of Nanoparticle Controlled Delivery For Chemotherapeutic Drug Products, Shani L. Levit
Theses and Dissertations
Taxol, a formulation of paclitaxel (PTX), is one of the most widely used anticancer drugs, particularly for treating recurring ovarian carcinomas following surgery. Clinically, PTX is used in combination with other drugs such as lapatinib (LAP) to increase treatment efficacy. Delivering drug combinations with nanoparticles has the potential to improve chemotherapy outcomes. In this study, we use Flash NanoPrecipitation, a rapid, scalable process to encapsulate weakly hydrophobic drugs (logP in vitro. Encapsulating either PTX or LAP into nanoparticles increases drug potency. When PTX and LAP are co-loaded in the same nanoparticle, they have a synergistic effect that is greater than …
Reaction Profiling Of Extracellular Protein Phosphorylation Through A Microfluidic Reactor Coupled With Raman Spectroscopy, Abigail Casey
Reaction Profiling Of Extracellular Protein Phosphorylation Through A Microfluidic Reactor Coupled With Raman Spectroscopy, Abigail Casey
Theses and Dissertations
Diseases and disorders in the human body are considered abnormalities of proper cellular function. Understanding the signal transduction mechanisms that cause these abnormalities is crucial to developing earlier detection methods, better treatment options and effective cures. While current diagnostic procedures are powerful tools in diagnosing diseases, they are ineffective in informing physicians on the real-time behavior of the signal transduction mechanisms associated with diseases and disorders. Currently, disease progression is monitored over time through routine patient visits and testing by one or more of the above techniques. By developing an approach that can monitor structural and conformational changes of proteins …