Engineering Commons^™

การวิเคราะห์ผลกระทบทางชีวกลศาสตร์ของการใช้เครื่องมือผูกในการผ่าตัดเชื่อมข้อกระดูกสันหลังแบบสั้นด้วยวิธีการทางไฟไนต์เอลิเมนต์, ณัฐภัทร วิริยะ

Chulalongkorn University Theses and Dissertations (Chula ETD)

งานวิจัยนี้มุ่งเน้นการทดสอบผลกระทบของการใช้อุปกรณ์ผูกมัดที่มีการปรับแต่งแต่ละรูปแบบต่อการผ่าตัดเชื่อมข้อแบบสั้นบริเวณกระดูกสันหลังส่วนเอวด้วยวิธีการทางไฟไนต์เอลิเมนต์ โดยจำลองลักษณะของกระดูกสันหลังส่วนเอวตั้งข้อ L1-L5 ของมนุษย์ และจำลองลักษณะการผ่าตัดด้วยวิธีการเชื่อมข้อผ่านลักษณะการผ่าตัดแบบ Posterior lumbar interbody fusion หรือ PLIF และ Posterolateral lumbar fusion หรือ PLF ซึ่งเป็นเทคนิคการผ่าตัดที่ได้รับความนิยมในการรักษาในปัจจุบัน ซึ่งจะเปรียบผ่านการใส่และไม่ใส่อุปกรณ์ผูกมัดรูปแบบใหม่นี้ ผลการวิจัยนำเสนอผ่านปัจจัยทางชีวกลศาสตร์ที่สำคัญได้แก่ ความสามารถในการเคลื่อนไหว (Range of motion, ROM), ความดันภายในหมอนรองกระดูกสันหลัง (Intradiscal pressure, IDP) และ แรงที่กระทำบนข้อต่อ Facet (Facet joints force, FJF) ซึ่งสูงขึ้นเมื่อผ่านการผ่าตัดด้วยวิธีการดังกล่าว ผ่านการปรับแต่งของตำแหน่งการตรึง, แรงตรึงตั้งต้น และ ลักษณะการตรึง จากผลการวิจัยพบว่าการใช้อุปกรณ์ผูกมัดดังกล่าวประกอบกับการผ่าตัดทั้ง 2 รูปแบบสามารถลดผลกระทบทางชีวกลศาสตร์ได้มากกว่าการผ่าตัดแบบไม่ใช้อุปกรณ์ควบคู่ ซึ่งให้ผลที่แตกต่างกันตามแต่ลักษณะการปรับแต่งของอุปกรณ์ดังกล่าว ซึ่งการค้นพบดังกล่าวสามารถต่อยอดและสร้างความเข้าใจมากขึ้นถึงปัจจัยหรือผลกระทบการใช้อุปกรณ์ผูกมัดประกอบกับการผ่าตัดเชื่อมข้อของกระดูกสันหลังเพื่อประโยชน์สูงสุดของการผ่าตัดและการรักษาให้มีประสิทธิภาพ

การพัฒนาท่อถ่างขยายทางเดินอาหารชนิดย่อยสลายได้ที่เคลือบผิวด้วยโปรตีนไฟโบรอินไหม, ธันยพร ฉันทโรจน์ศิริ

Chulalongkorn University Theses and Dissertations (Chula ETD)

งานวิจัยนี้มีจุดมุ่งหมายในการพัฒนาท่อขยายหลอดอาหารชนิดย่อยสลายได้จากวัสดุ polydioxanone (PDO) ให้มีการย่อยสลายช้าลง โดยทำการขึ้นรูปด้วยเทคนิคการถักทอแบบ Hook cross เพื่อให้ได้ท่อถ่างขยายที่มีสมบัติเชิงกลเหมาะสมสำหรับการใช้ในทางเดินอาหาร ทำการศึกษาการบำบัดด้วยพลาสม่าเพื่อเปลี่ยนแปลงโครงสร้างพื้นผิว ทดสอบสมบัติเชิงกลของท่อถ่างขยายที่ขึ้นรูปด้วยโครงสร้างที่ต่างกัน การเคลือบโปรตีนไฟโบรอินลงบนเส้นไหม PDO และทดสอบอัตราการย่อยสลายของท่อถ่างขยายทางเดินอาหารที่เคลือบผิวด้วยโปรตีนไฟโบรอิน การศึกษานี้พบว่า มีการเพิ่มขึ้นของแรงขยายออกด้านข้างของท่อถ่างขยายเมื่อมีการเพิ่มความหนาแน่นของการถัก แต่เมื่อเพิ่มความหนาแน่นของการถักมากขึ้นจะทำให้แรงขยายลดลง และการขึ้นรูปแบบ Hook cross จะสามารถปรับรูปร่างของท่อถ่างขยายขึ้นกับรอยตีบได้ดีกว่าวิธีถักแบบ braided การบำบัดด้วยพลาสมานั้นถึงแม้จะช่วยเปลี่ยนแปลงสมบัติพื้นผิวของเส้นไหม PDO แต่ไม่ได้ช่วยเรื่องการเคลือบโปรตีนไฟโบรอิน การที่จะเคลือบโปรตีนไฟโบรอินลงบนท่อถ่างขยาย PDO ต้องใช้วิธีการเคลือบโดยใช้ไนโตรเจนเหลวและเอธานอล เมื่อผ่านการเคลือบด้วยโปรตีนไฟโบรอินแล้ว เส้นไหม PDO มีการเปลี่ยนแปลงสมบัติพื้นผิวทั้งในด้านโมเลกุลพื้นผิวและความชอบน้ำ และท่อถ่างขยายทางเดินอาหาร PDO ที่ผ่านการเคลือบด้วยโปรตีนไฟโบรอินมีการย่อยสลายช้ากว่าท่อถ่างขยายทางเดินอาหารที่ไม่ได้เคลือบด้วยโปรตีนไฟโบรอิน 4 สัปดาห์ และมีการละลายของโปรตีนไฟโบรอินออกมาอย่างรวดเร็วใน 4-8 สัปดาห์แรก และได้ทดสอบการใส่ท่อถ่างขยายทางเดินอาหาร PDO ในลำไส้สุกร ซึ่งพบว่าการเคลือบโปรตีนไฟโบรอินอาจทำให้การกางของท่อถ่างขยายนั้นน้อยกว่าแบบที่ไม่ได้ผ่านการเคลือบ ซึ่งจะสามารถนำไปพัฒนาใช้ในทางคลินิกได้ต่อไป

Plasma Protein Signatures Of Adult Asthma, Gordon J. Smilnak, Yura Lee, Abhijnan Chattopadhyay, Annah B. Wyss, Julie D. White, Sinjini Sikdar, Jianping Jin, Andrew J. Grant, Alison A. Motsinger-Reif, Jian-Liang Li, Mikyeong Lee, Bing Yu, Stephanie J. London

Mathematics & Statistics Faculty Publications

Background: Adult asthma is complex and incompletely understood. Plasma proteomics is an evolving technique that can both generate biomarkers and provide insights into disease mechanisms. We aimed to identify plasma proteomic signatures of adult asthma.

Methods: Protein abundance in plasma was measured in individuals from the Agricultural Lung Health Study (ALHS) (761 asthma, 1095 non-case) and the Atherosclerosis Risk in Communities study (470 asthma, 10,669 non-case) using the SOMAScan 5K array. Associations with asthma were estimated using covariate adjusted logistic regression and meta-analyzed using inverse-variance weighting. Additionally, in ALHS, we examined phenotypes based on both asthma and seroatopy (asthma with …

Integrative Machine Learning Approaches For Enhanced Classification Of Genomic Sequences: A Next-Generation Sequencing Perspective, Sujatha Alla, Nagesh Bheesetty, Sai Gireesh Komaragiri, Prasanthi Chidipudi, Joshit Mohanty, Sathish Kumar Chintala, Jubin Thomas, Jayapal Vummadi, Hemanth Volikatla, Navin Kamuni

Engineering Management & Systems Engineering Faculty Publications

The advent of Next-Generation Sequencing (NGS) techniques has revolutionized genomic research by enabling the rapid sequencing of DNA and RNA. This data can be used for various applications, including genome sequencing, transcriptome profiling, metagenomics, and epigenetics studies. For this study, DNA classifier dataset was extracted from UCI repository of machine learning databases. This vast amount of genomic data necessitates the development of sophisticated machine learning (ML) models for effective classification and analysis. This study presents a comprehensive comparison of various ML models, including Support Vector Machines (SVM), Random Forests (RF), and Neural Networks (NNs), approaches, in classifying genomic data. We …

Developing An Immunomodulatory Strategy Using Biophysical Cues To Modulate Macrophage Phenotype For Fracture Healing And Bone Regeneration, Harshini Suresh Kumar

Theses and Dissertations--Biomedical Engineering

Chronic inflammation is a major cause of the pathogenesis of musculoskeletal diseases such as fragility, fracture, and nonunion. Studies have shown that modulating the immune phenotype of macrophages from proinflammatory to pro-healing can heal recalcitrant bone defects. Current therapeutic strategies predominantly apply biochemical cues, which often lack target specificity, and controlling their release kinetics in vivo is challenging spatially and temporally. We have developed a magnetic iron-oxide nanocomplexes (MNC)-based therapy for resolving chronic inflammation in the context of promoting fracture healing. Here, we show that MNC internalized macrophages, when coupled with an external magnetic field, can exert an intracellular magnetic …

Relating Temperature, Sleep, And Pathology In Mouse Models Of Alzheimer's Disease, Jun Wang

Theses and Dissertations--Biomedical Engineering

It is well established that sleep plays an important role in Alzheimer’s disease (AD) pathology. There is growing evidence that sleep issues may accelerate AD pathology by interrupting the physiological clearance of amyloid‐β (Aβ) from the brain, which mainly occurs in normal sleep. As the over-accumulation of amyloid‐β (Aβ) is believed to lead the cascade effect that eventually causes neurodegeneration in AD patients, development of therapeutic strategies for improving sleep quality may help slow disease progression. It is well documented that the composition and dynamics of sleep are sensitive to changes in ambient temperature. We therefore developed a sleep enhancement …

Development Of Iron Oxide Nanozyme For Cancer Therapy, Zhongchao Yi

Theses and Dissertations--Biomedical Engineering

Cancer therapies that leverage reactive oxygen species (ROS) have shown potential for cancer inhibition due to their ability to induce oxidative stress in tumor cells. Iron oxide nanoparticles (IONPs) have garnered significant attention as a promising platform for ROS-dependent disease treatment, owing to their remarkable biocompatibility and Fenton catalytic activity. However, the low catalytic activity of IONPs has been a major hurdle in their clinical translation. To overcome this challenge, IONPs of different compositions are examined for their Fenton reaction under pharmacologically relevant conditions in this work. The results show that wüstite (Fe_1-xO) nanoparticles exhibit higher catalytic activity …

Cellular Level Changes Induced In Cancer Cells Due To Microgravity, Sai Deepika Reddy Yaram

Graduate Theses, Dissertations, and Problem Reports (ETD)

The increase in human activity in space has revealed several kinds of physiological challenges brought on by the absence of Earth's gravitational pull. NASA observed that during spaceflight, astronauts experience a 1-1.5% monthly loss in the mineral density of weight-bearing bones, with rehabilitation efforts on Earth often proving ineffective. This issue extends to muscles, the neuro vestibular system, the cardiovascular system, and vision. Cancer has emerged as a significant cause of mortality among astronauts, with studies up to 2017 showing that 41.3% of natural cause deaths among U.S. astronauts were due to cancer, primarily due to space radiation exposure. Cancer …

Implementing Unmanned Aerial Vehicles To Collect Human Gait Data At Distance And Altitude For Identification And Re-Identification, Donn E. Bartram

Graduate Theses, Dissertations, and Problem Reports (ETD)

Gait patterns are a class of biometric information pertaining to the way a person moves and poses. Gait information is unique to each person and can be used to identify and reidentify people. Historically, this task has been achieved through the use of multiple ground-based imaging sensors. However, as Unmanned Aerial Vehicles (UAVs) advance, they present the opportunity to evolve the process of persons identification and re-identification. Collecting human gait data using UAVs at distances ranging from 20m to 500m and altitudes ranging from 0m to 120m is a challenging task. The current biometric data collection methods, primarily designed for …

Matrix Stiffness Sensing By Nascent Adhesions And The Role Of Riam In Adhesion Assembly, Nikhil Mittal

Dissertations, Master's Theses and Master's Reports

Mechanical stiffness of the extracellular matrix (ECM) impacts many cellular functions such as proliferation, migration, and differentiation. ECM stiffness is sensed by a cell via integrin-based focal adhesions (FAs) by changing conformation and biochemical activities of molecules within FAs by the exchange of the force between the ECM and filamentous actin (F-actin). Cells in turn respond to this stiffness by generating traction force that plays an important role in many biological events such as tissue morphogenesis, stem cell differentiation, wound healing, and cancer cell metastasis. The stiffness of the extracellular matrix induces differential tension within integrin-based adhesions. Understanding stiffness sensing …

Multi-Functional Gelatin-Dithiolane Hydrogels For Tissue Engineering, Saad Asim

Dissertations, Master's Theses and Master's Reports

Biomaterials that integrate multiple functionalities, mimic the extracellular matrix (ECM) microenvironment to support cellular growth, and adhere robustly to damaged tissues are highly needed to advance tissue engineering. Protein-based biomaterials are promising due to their inherent biocompatibility, biomimicry, biodegradation, and cell-supportive properties. Herein, by leveraging the unique ability of dithiolanes to generate on-demand in-situ thiols, we developed a new class of dithiolane-modified, protein-based biomaterial that combines unique, seemingly opposing functions for tissue engineering. Dithiolane-modified gelatin, a model protein used herein, enabled photoinitiator-free photo-crosslinking to form multi-functional gelatin-dithiolane (GelDT) hydrogels, which displayed exceptional long-term stability in cell culture media (>28 …

Computational Analysis Of Vascular Aneurysms, Seyedmostafa Rezaeitaleshmahalleh

Dissertations, Master's Theses and Master's Reports

Vascular aneurysms, such as intracranial aneurysms (IAs) and abdominal aortic aneurysms (AAAs), pose significant health risks, particularly upon rupture. Disturbed hemodynamics, characterized by swirling flow patterns, can lead to cellular and structural changes that disrupt normal physiological processes and contribute to destructive vascular remodeling. Integrating hemodynamic analysis into clinical assessments of aneurysms has become crucial, especially through patient-specific computational fluid dynamics (CFD) simulations based on medical imaging. However, the complexity of CFD tools presents challenges in model creation and post-simulation analysis, limiting their accessibility to clinicians.
This project aimed to advance aneurysm management by exploring the role of intraluminal thrombus …

An Fpga-Based Eit System For Deep Space Medical Imaging, Kendall R. Farnham

Dartmouth College Ph.D Dissertations

Dangers associated with high radiation and microgravity exposure in space are critical challenges inhibiting us from exploring deep space and pursuing long-duration missions, as current medical systems are unable to monitor, diagnose, or treat tissue injury within physical spacecraft constraints and communication limits. Ultrasound (US) is the current imaging system used on the International Space Station, but this technology relies on telemedical support (or onboard artificial intelligence/autonomous capabilities) for both operation and diagnosis, posing challenges for crews isolated in deep space. Electrical impedance tomography (EIT) is a non-invasive, non-ionizing technology that produces images of the electrical properties of tissues and …

Mobile Robot Adhesion Methodology And Development Of An Automatous Robot Module, Lauren Baird, Zachariah Stone, Madison Lemons, Jonathon Moody

Williams Honors College, Honors Research Projects

Due to the increasing availability of space travel as not only a scientific exploration but a commercial exploration, there is a need for an onsite repair station that can be deployed in the event of aircraft maintenance, damage, or failure. We have been tasked with researching and creating a prototype of an automatous robot that can be attached to a spacecraft body, move along the surface while avoiding obstacles, scan for damage, 3D print a repair piece, and then make the repair, all without the need of direct human input. Our team, as will be discussed throughout, was tasked with …

An In-Vitro Model For Visualizing Intraocular Lens And Lens Capsule Interaction In Posterior Capsule Opacification, Amjad Chatila

Bioengineering Dissertations - Archive

Posterior Capsule Opacification (PCO) is a common complication post cataract surgery. It is believed that Intraocular Lens (IOL) physical and chemical properties would affect their PCO potential. The tight binding between IOL and posterior lens capsule (PLC) is believed to have a negative impact on PCO formation, as suggested in the “No space, no cell, no PCO” hypothesis. To test the hypothesis, we have recently developed an in vitro 3D system to simulate IOL and PLC physical interaction. To expand the function and capability of this system, one objective of my work was to develop the next generation adhesion force …

Novel Engineering Approaches For Orthopedic Injury Treatment And Infection Diagnosis, Cynthia Co

Bioengineering Dissertations - Archive

Bioengineering has made significant contributions to the treatment of orthopedic injury through interdisciplinary approaches. Central to these advancements are many orthopedic implants, including anchors and joint replacements, which have been designed to restore mobility. Despite their functional efficacy, these products have limited lifespan and are associated with many complications, such as implant-associated infection. The success of implant design and function, both in the short and long term, is paramount for enhancing patient outcomes and overall well-being. Therefore, my thesis work is dedicated to addressing these critical challenges, aiming to maximize their treatment effect while minimizing the implant-associated complications.

Long-term patient …

Dental Students’ Psychological Stress: A Comprehensive Investigation Of Stress Inducing Factors At Mohammed Vi University Of Sciences And Health, Latifa El Mouden, Elmehdi Fettach

Health Sciences

Dental students are significantly confronted with mental health problems. We conducted a prospective recruitment of students at the Faculty of Dentistry of the Mohammed VI University of Sciences and Health to investigate the determinants of stress specific to this population in order to find solutions to improve their quality of life. In our study, 410 students responded to the survey, the average age of the students was 21.51 ± 2.102 years, 70% were female, 30% were in their 6th year, and 60% of the students were from Casablanca. The average MSP-25B score was 101.94 ± 33.035. In our study, there …

Instantaneous Generation Of Subject-Specific Finite Element Models Of The Hip Capsule, Ahilan Anantha-Krishnan, Casey A. Myers, Clare K. Fitzpatrick, Chadd W. Clary

Mechanical and Biomedical Engineering Faculty Publications and Presentations

Subject-specific hip capsule models could offer insights into impingement and dislocation risk when coupled with computer-aided surgery, but model calibration is time-consuming using traditional techniques. This study developed a framework for instantaneously generating subject-specific finite element (FE) capsule representations from regression models trained with a probabilistic approach. A validated FE model of the implanted hip capsule was evaluated probabilistically to generate a training dataset relating capsule geometry and material properties to hip laxity. Multivariate regression models were trained using 90% of trials to predict capsule properties based on hip laxity and attachment site information. The regression models were validated using …

Transparent And Conductive Gallium Oxide Electrode For Simultaneous Recording And Optogenetic Stimulation, Christopher Patrick Carey

Graduate Theses, Dissertations, and Problem Reports (ETD)

Neural electrode technology has been around for centuries since the times of Galvani. In early electrophysiology experiments metal wires were used to induce contractions in dissected animals. The metal wire electrode has since been a standard tool to both stimulate and record neural activity. In the past two decades, a new strategy for neural stimulation has been formulated based on the emergent field of optogenetics. Optogenetics refers to the use of light-sensitive proteins genetically imbedded in the membrane of a neuron to elicit neural activity. This technique offers more selectivity in the stimulation of neurons. Typical optogenetic neural electrodes, or …

Detection Of Tooth Position By Yolov4 And Various Dental Problems Based On Cnn With Bitewing Radiograph, Kuo Chen Li, Yi-Cheng Mao, Mu-Feng Lin, Yi-Qian Li, Chiung-An Chen, Tsung-Yi Chen, Patricia Angela R. Abu

Department of Information Systems & Computer Science Faculty Publications

Periodontitis is a high prevalence dental disease caused by bacterial infection of the bone that surrounds the tooth. Early detection and precision treatment can prevent more severe symptoms such as tooth loss. Traditionally, periodontal disease is identified and labeled manually by dental professionals. The task requires expertise and extensive experience, and it is highly repetitive and time-consuming. The aim of this study is to explore the application of AI in the field of dental medicine. With the inherent learning capabilities, AI exhibits remarkable proficiency in processing extensive datasets and effectively managing repetitive tasks. This is particularly advantageous in professions demanding …

Polarizable Amoeba Force Field Predicts Thin And Dense Hydration Layer Around Monosaccharides, Luke A. Newman, Mackenzie G. Patton, Breyanna A. Rodriguez, Ethan W. Summer, Valerie Vaissier Welbourn

Chemistry & Biochemistry Faculty Publications

Polarizable force fields crucially enhance the modeling of macromolecules in polar media. Here, we present new parameters to model six common monosaccharides with the polarizable AMOEBA force field. These parameters yield a thinner, but denser, hydration layer than that previously reported. This denser hydration layer results in eliminating non-physical aggregation of glucose in water-an issue that has plagued molecular dynamics simulations of carbohydrates for decades.

Nano-Pulse Treatment Overcomes The Immunosuppressive Tumor Microenvironment To Elicit In Situ Vaccination Protection Against Breast Cancer, Anthony Nanajian, Megan Scott, Niculina I. Burcus, Brittney L. Ruedlinger, Edwin A. Oshin, Stephen J. Beebe, Siqi Guo

Bioelectrics Publications

We previously reported that nano-pulse treatment (NPT), a pulsed power technology, resulted in 4T1-luc mammary tumor elimination and a strong in situ vaccination, thereby completely protecting tumor-free animals against a second live tumor challenge. The mechanism whereby NPT mounts effective antitumor immune responses in the 4T1 breast cancer predominantly immunosuppressive tumor microenvironment (TME) remains unanswered. In this study, orthotopic 4T1 mouse breast tumors were treated with NPT (100 ns, 50 kV/cm, 1000 pulses, 3 Hz). Blood, spleen, draining lymph nodes, and tumors were harvested at 4-h, 8-h, 1-day, 3-day, 7-day, and 3-month post-treatment intervals for the analysis of frequencies, death, …

Modernizing And Harmonizing Regulatory Data Requirements For Genetically Modified Crops-Perspectives From A Workshop, Nicholas P Storer, Abigail R Simmons, Jordan Sottosanto, Jennifer A Anderson, Ming Hua Huang, Debbie Mahadeo, Carey A Mathesius, Mitscheli Sanches Da Rocha, Shuang Song, Ewa Urbanczyk-Wochniak

Faculty, Staff and Student Publications

Genetically modified (GM) crops that have been engineered to express transgenes have been in commercial use since 1995 and are annually grown on 200 million hectares globally. These crops have provided documented benefits to food security, rural economies, and the environment, with no substantiated case of food, feed, or environmental harm attributable to cultivation or consumption. Despite this extensive history of advantages and safety, the level of regulatory scrutiny has continually increased, placing undue burdens on regulators, developers, and society, while reinforcing consumer distrust of the technology. CropLife International held a workshop at the 16th International Society of Biosafety Research …

Infant Molds For Cleft Deformities, Hannah Brunow, Drew Reinbolt, Rhonda Troyer, Christian Miller

Williams Honors College, Honors Research Projects

Cleft lip and palate are very common birth defects where the roof of a baby's mouth and lip do not form properly while in the womb. Babies born with cleft lip or palate can undergo surgery after going through a process to make the initial gap smaller through incrementally smaller, retainer-like appliances. We will be trying to find a way to improve the pre-surgery process by implementing 3D printing. We will be performing this research for a craniofacial orthodontist at Akron Children's Hospital. We hope that our success will lead to a decrease in the amount of time spent making …

Degradable Staples And Delivery Device, Meha Elango, Jessica Cabrera, Makayla Scarpitti, Kareemat Melaiye

Williams Honors College, Honors Research Projects

The scope of this project is to design a method to secure skin grafts to healthy tissue. The ultimate goal for the proposed method is to be dissolvable in some form. Currently, skin grafts procedures utilize staples in most cases to hold a skin graft in place, but there are disadvantages that come with it. Staples are easy to place, but time consuming during the removal procedure. They also cause a lot of pain and discomfort for the patient. The goal of this project is to determine a way a secure skin grafts to healthy skin in order to reduce …

Custom Mobility Aid - Exoskeleton, Jenna Rentsch, Mackenzie Yu, Perry Antalek, Joseph Wisniewski

Williams Honors College, Honors Research Projects

Injuries to the spinal cord can cause major mobility deficits, paralysis, and even death. Our client is an adult male who has suffered fractures to the C4 and C5 vertebrae resulting in partial nerve damage and loss of mobility in the lower extremities, primarily on the left side. He complains of significant loss of function and frequent falls due to an inability to fully pick-up his left foot and hold his hip in flexion during swing phase of gait. He describes his walking as a "stuttered walk" and frequently complains that his left foot drags and drops during steps. The …

Aggregation-Induced Emission Probe For Alzheimer's Detection And Treatment Screening, Gemini Ramlo

Williams Honors College, Honors Research Projects

The proposed project is to research if ROF-2, an aggregation-induced emitter, can be used to screen medications for Alzheimer's Disease and to accurately detect this disease, along with its progression. This will be done through multiple incubation periods using different identifiers that have already been solidified within Alzheimer's research to prove its ability and accuracy within screening and detection regarding this disease.

Potential Role Of Ttt Complex In Regulating Dna Replication Checkpoint In The Fission Yeast Schizosaccharomyces Pombe, Sankhadip Bhadra

Browse all Theses and Dissertations

DNA replication can be perturbed by various agents that slow or stall the replication forks, causing replication stress. If undetected, stressed forks may collapse, causing mutagenic DNA damage or cell death. In response to replication stress and DNA damage, the eukaryotic cell activates the DNA replication checkpoint (DRC) and DNA damage checkpoint (DDC) pathways to promote DNA synthesis, repair, and cell survival. The two cell cycle checkpoint pathways are controlled by the protein sensor kinases Rad3 (hATR/scMec1) and Tel1 (hATM/scTel1) in fission yeast, although Tel1 plays a minimal role in checkpoint functions. Rad3 and Tel1 belong to a family of …

Tympanostomy Tube Efficiency Study, Reem Ghumrawi, Kristi Weir

Williams Honors College, Honors Research Projects

The ventilation of the middle ear, crucial for maintaining optimal ear health, is often impeded by factors such as swelling, inflammation, and mucus in the eustachian tubes, particularly during upper respiratory infections or allergies. This issue, prevalent in children due to their narrow and horizontal eustachian tubes, prompts the insertion of tympanostomy tubes by ENT surgeons to establish an alternative airway for pressure equalization and fluid drainage. Despite the common belief in the effectiveness of these tubes, there is a notable dearth of research validating their optimal functionality. This study aims to address this gap by systematically comparing the efficiency …

The Impact Of Modern Buildings On Traditional Urban Environments And Urban Identity, Ann S. Ibrahim

Al-Esraa University College Journal for Engineering Sciences

Contemporary cities face significant challenges in integrating modern buildings into traditional urban environments while preserving urban identity. This study focuses on the relationship between modern architecture and urban heritage. The research problem revolves around how modern buildings affect urban identity in traditional areas, and whether they can interact positively with the urban context without distorting its traditional character.

The study aims to analyze this impact by examining a range of global examples using architectural indicators such as visual integration, spatial integration, material harmony, urban scale, accessibility, and environmental impact. A three-point scale (weak, partial, excellent) was applied to assess each …