Digital Commons Network^™

Cerebral Blood Flow And Cardiovascular Risk Effects On Resting Brain Regional Homogeneity, Bhim M Adhikari, L Elliot Hong, Zhiwei Zhao, Danny J J Wang, Paul M Thompson, Neda Jahanshad, Alyssa H Zhu, Stefan Holiga, Jessica A Turner, Theo G M Van Erp, Vince D Calhoun, Kathryn S Hatch, Heather Bruce, Stephanie M Hare, Joshua Chiappelli, Eric L Goldwaser, Mark D Kvarta, Yizhou Ma, Xiaoming Du, Thomas E Nichols, Alan R Shuldiner, Braxton D Mitchell, Juergen Dukart, Shuo Chen, Peter Kochunov

Faculty, Staff and Student Publications

Regional homogeneity (ReHo) is a measure of local functional brain connectivity that has been reported to be altered in a wide range of neuropsychiatric disorders. Computed from brain resting-state functional MRI time series, ReHo is also sensitive to fluctuations in cerebral blood flow (CBF) that in turn may be influenced by cerebrovascular health. We accessed cerebrovascular health with Framingham cardiovascular risk score (FCVRS). We hypothesize that ReHo signal may be influenced by regional CBF; and that these associations can be summarized as FCVRS→CBF→ReHo. We used three independent samples to test this hypothesis. A test-retest sample of N = 30 healthy …

Anti-Diabetic Effects Of Glp1 Analogs Are Mediated By Thermogenic Interleukin-6 Signaling In Adipocytes, Absalon D Gutierrez, Zhanguo Gao, Vala Hamidi, Liang Zhu, Karla Bermudez Saint Andre, Kayla Riggs, Monika Ruscheinsky, Hongyu Wang, Yongmei Yu, Charles Miller, Hernan Vasquez, Heinrich Taegtmeyer, Mikhail G Kolonin

Faculty, Staff and Student Publications

Mechanisms underlying anti-diabetic effects of GLP1 analogs remain incompletely understood. We observed that in prediabetic humans exenatide treatment acutely induces interleukin-6 (IL-6) secretion by monocytes and IL-6 in systemic circulation. We hypothesized that GLP1 analogs signal through IL-6 in adipose tissue (AT) and used the mouse model to test if IL-6 receptor (IL-6R) signaling underlies the effects of the GLP1-IL-6 axis. We show that liraglutide transiently increases IL-6 in mouse circulation and IL-6R signaling in AT. Metronomic liraglutide treatment resulted in AT browning and thermogenesis linked with STAT3 activation. IL-6-blocking antibody treatment inhibited STAT3 activation in AT and suppressed liraglutide-induced …

The Role Of Metformin In Treatment Of Weight Gain Associated With Atypical Antipsychotic Treatment In Children And Adolescents: A Systematic Review And Meta-Analysis Of Randomized Controlled Trials, Zeeshan Mansuri, Ramkrishna Makani, Chintan Trivedi, Mahwish Adnan, Ramu Vadukapuram, John Rafael, Ashutosh Lodhi, Abhishek Reddy

School of Medicine Publications

Introduction: Second-generation antipsychotics are associated with significant weight gain. The aim of this systematic review and meta-analysis was to determine the efficacy and safety of metformin for the treatment of weight gain in children and young adults treated with second-generation antipsychotics.

Methods: We followed PRISMA guidelines to evaluated studies published before March 2020 in Medline, Google Scholar, PubMed, Cochrane library database, annual scientific sessions of the American Psychiatric Association, American Academy of Child and Adolescent, Psychiatry, and American Society of Clinical Psychopharmacology. Studies included compared metformin with the placebo for management of weight gain in children and adolescents taking atypical …

Alteration In Tyrosine Phosphorylation Of Cardiac Proteome And Egfr Pathway Contribute To Hypertrophic Cardiomyopathy, Mingguo Xu, Kevin C. Bermea, Marzieh Ayati, Han Byeol Yang, Xiaomei Yang, Andres Medina, Zongming Fu, Amir Heravi, Xinyu Zhang, Genaro A. Ramirez-Correa

School of Medicine Publications

Alterations of serine/threonine phosphorylation of the cardiac proteome are a hallmark of heart failure. However, the contribution of tyrosine phosphorylation (pTyr) to the pathogenesis of cardiac hypertrophy remains unclear. We use global mapping to discover and quantify site-specific pTyr in two cardiac hypertrophic mouse models, i.e., cardiac overexpression of ErbB2 (TgErbB2) and α myosin heavy chain R403Q (R403Q-αMyHC Tg), compared to control hearts. From this, there are significant phosphoproteomic alterations in TgErbB2 mice in right ventricular cardiomyopathy, hypertrophic cardiomyopathy (HCM), and dilated cardiomyopathy (DCM) pathways. On the other hand, R403Q-αMyHC Tg mice indicated that the EGFR1 pathway is central for …

Urban Nesting Biology, Population Viability And Ecology Of The Willow Flycatcher, Empidonax Traillii, Stephanie Alexandra Byrne Doorly

Dissertations and Theses

Reproductive success, in any species, relies both on the habitat utilized to reproduce and on the successful reproductive output of individual animals within a population. Populations in turn rely on the reproductive fitness of the individual. Whether populations remain stable, grow, or decline ultimately relies on the combined reproductive output of the individuals within that population.

We studied the Willow Flycatcher (Empidonax traillii; henceforth WIFL), a well-studied Neartic-Neotropical migrant passerine whose breeding range extends from the east to west coast of North America. Across much of their range, and in particular in the western regions, breeding population are …

Human Dectin-1 Deficiency Impairs Macrophage-Mediated Defense Against Phaeohyphomycosis, Rebecca A. Drummond, Jigar V. Desai, Amy P. Hsu, Vasileios Oikonomou, Donald C. Vinh, Joshua A. Acklin, Michael S. Abers, Magdalena A. Walkiewicz, Sarah L. Anzick, Muthulekha Swamydas, Simon Vautier, Mukil Natarajan, Andrew J. Oler, Daisuke Yamanaka, Katrin D. Mayer-Barber, Yoichiro Iwakura, David Bianchi, Brian Driscoll, Ken Hauck, Ahnika Kline, Nicholas S.P. Viall, Christa S. Zerbe, Elise M.N. Ferré, Monica M. Schmitt, Tom Dimaggio, Stefania Pittaluga, John A. Butman, Adrian M. Zelazny, Yvonne R. Shea, Cesar A. Arias, Cameron Ashbaugh, Maryam Mahmood, Zelalem Temesgen, Alexander G. Theofiles, Masayuki Nigo, Varsha Moudgal, Karen C. Bloch, Sean G. Kelly, M. Suzanne Whitworth, Ganesh Rao, Cindy J. Whitener, Neema Mafi, Juan Gea-Banacloche, Lawrence C. Kenyon, William R. Miller, Katia Boggian, Andrea Gilbert, Matthew Sincock, Alexandra F. Freeman, John E. Bennett, Rodrigo Hasbun, Constantinos M. Mikelis, Kyung J. Kwon-Chung, Yasmine Belkaid, Gordon D. Brown, Jean K. Lim, Douglas B. Kuhns, Steven M. Holland, Michail S. Lionakis

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Subcutaneous phaeohyphomycosis typically affects immunocompetent individuals following traumatic inoculation. Severe or disseminated infection can occur in CARD9 deficiency or after transplantation, but the mechanisms protecting against phaeohyphomycosis remain unclear. We evaluated a patient with progressive, refractory Corynespora cassiicola phaeohyphomycosis and found that he carried biallelic deleterious mutations in CLEC7A encoding the CARD9-coupled, β-glucan-binding receptor, Dectin-1. The patient's PBMCs failed to produce TNF-α and IL-1β in response to β-glucan and/or C. cassiicola. To confirm the cellular and molecular requirements for immunity against C. cassiicola, we developed a mouse model of this infection. Mouse macrophages required Dectin-1 and CARD9 for IL-1β and …

The Quality Of Energy- And Macronutrient-Balanced Diets Regulates Host Susceptibility To Influenza In Mice, Taylor A Cootes, Nayan D Bhattacharyya, Susie S Y Huang, Lina Daniel, Kim S Bell-Anderson, Sebastian A Stifter, Tracy Chew, Samantha M Solon-Biet, Luis R Saraiva, Yi Cai, Xinchun Chen, Stephen J Simpson, Carl G Feng

2020-Current year OA Pubs

Modulation of individual macronutrients or caloric density is known to regulate host resistance to infection in mice. However, the impact of diet composition, independent of macronutrient and energy content, on infection susceptibility is unclear. We show that two laboratory rodent diets, widely used as standard animal feeds and experimental controls, display distinct abilities in supporting mice during influenza infection. Mice placed on the highly processed AIN93G showed increased mortality to infection compared with those on a grain-based chow diet, suggesting a detrimental role for highly processed food in host defense. We further demonstrate that the heightened susceptibility of AIN93G-fed mice …

Gene Therapy Knockdown Of Hippo Signaling Resolves Arrhythmic Events In Pigs After Myocardial Infarction, Sui Zhang, Shijie Liu, John P Leach, Ke Li, Emerson C Perin, James F Martin

Faculty, Staff and Students Publications

No abstract provided.

A, B, C'S Of Trk Receptors And Their Ligands In Ocular Repair, Akash Gupta, Jeremias G Galletti, Zhiyuan Yu, Kevin Burgess, Cintia S De Paiva

Faculty, Staff and Students Publications

Neurotrophins are a family of closely related secreted proteins that promote differentiation, development, and survival of neurons, which include nerve growth factor (NGF), brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4. All neurotrophins signal through tropomyosin receptor kinases (TrkA, TrkB, and TrkC) which are more selective to NGF, brain-derived neurotrophic factor, and neurotrophin-3, respectively. NGF is the most studied neurotrophin in the ocular surface and a human recombinant NGF has reached clinics, having been approved to treat neurotrophic keratitis. Brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4 are less studied neurotrophins in the ocular surface, even though brain-derived neurotrophic factor is well characterized in …

The Effects Of Tillage And Cover Crops On Crop Yield And Soil Properties In Wheat Double-Cropping Systems, Peters E. Egbedi

LSU Doctoral Dissertations

This three-year study was conducted on a commerce silt loam soil at the Northeast Research and Experiment Station near St. Joseph, Louisiana to evaluate the following objectives: 1) evaluate crop yield response to tillage, winter, and summer cover crops in wheat double-cropping systems. 2) evaluate the effects of tillage, winter and summer cover crops on soil properties under different cropping systems. 3) quantify the economic benefits of double-cropping, cover cropping and monoculture systems under conventional and no tillage practices. A winter cover crop (WCC) mix (winter wheat (Triticum aestivum and Austrian winter pea (Pisum sativum) and summer …

Los Juegos De Rol Como Apoyo Para El Desarrollo De Narrativas Literarias De Fantasía Y Ciencia Ficción, Ricardo Victoria-Uribe, Nazario Robles-Bastida

Journal of Roleplaying Studies and STEAM

ESPAÑOL

El ‘storytelling’ o la narrativa, al igual que el juego, han formado parte de la civilización humana desde tiempos inmemoriales. Ambos han tenido como función ayudar al desarrollo psicológico y cultural de los participantes, así como al desarrollo de historias que transmiten una serie de creencias, valores, conocimientos y filosofías. A finales del Siglo XX, se dio origen a una transversalidad entre juegos y narrativa, cuando obras como las del afamado Tolkien, Conan el Bárbaro de Robert E. Howard y ‎Fafhrd & the Gray Mouser de Frietz Leiber, entre otras, inspiran la creación de los primeros juegos de …

Secure Cloud-Based Iot Water Quality Gathering For Analysis And Visualization, Soin Abdoul Kassif Baba M Traore, Maria Valero, Amy Gruss

KSU Proceedings on Cybersecurity Education, Research and Practice

Water quality refers to measurable water characteristics, including chemical, biological, physical, and radiological characteristics usually relative to human needs. Dumping waste and untreated sewage is the reason for water pollution and several diseases to the living hood. The quality of water can also have a significant impact on animals and plant ecosystems. Therefore, keeping track of water quality is a substantial national interest. Much research has been done for measuring water quality using sensors to prevent water pollution. In summary, those systems are built based on online and reagent-free water monitoring SCADA systems in wired networks. However, centralized servers, transmission …

Competing Visions Of Fundamental Global Change: Comparative Book Review Of Rethinking Humanity By Seba & Arbib, Cristian Ziliberberg

Markets, Globalization & Development Review

No abstract provided.

Turning Red: Tradition, Repression, Mommy Issues, And A Millennial Way Of Growing Up, Hazal Bayar

Markets, Globalization & Development Review

No abstract provided.

A Global Palette Of Insightful Reviews, Nikhilesh Dholakia, Deniz Atik

Markets, Globalization & Development Review

No abstract provided.

The Conquest Of Milk: The Rise Of Lactase Persistence And The Fall Of Scandinavian Hunter-Gatherers, Nicholas Mays

James Madison Undergraduate Research Journal (JMURJ)

Over half of the global human population suffers from lactase nonpersistence, a condition marked by losing the ability to digest lactose after infancy. However, a minority of the global population, primarily located in Central and Northern Europe, has a genetic mutation that results in lactase persistence, which is the continued ability to process lactose after infancy. This interdisciplinary analysis blends archaeology, cultural anthropology, evolutionary biology, and archaeogenetics to explore the origin and rise of lactase persistence in Europe and its contribution to the end of hunter-gatherer societies in Scandinavia. Furthermore, the paper uses gene-culture coevolutionary theory to argue that lactase …

The Echo: November 14, 2022, Taylor University

2022-2023 (Volume 110)

No abstract provided.

Celebrating Gifts, Katy Kelly

University Libraries Blog Archive

One Day, One Dayton gifts support student experiential learning in conjunction with the Marian Library's new Christmas exhibit – which correspondingly celebrates vocation and gifts.

Microbiome Insights Into Pediatric Familial Adenomatous Polyposis., Thomas M. Attard, Seth Septer, Caitlin E. Lawson, Mark I. Attard, Sonny T M Lee, Shahid Umar

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Individuals with familial adenomatous polyposis (FAP) harbor numerous polyps with inevitable early progression to colon cancer. Complex microbiotic-tumor microenvironment perturbations suggest a dysbiotic relationship between polyp and microbiome. In this study, we performed comprehensive analyses of stool and tissue microbiome of pediatric FAP subjects and compared with unaffected cohabiting relatives through 16S V4 region amplicon sequencing and machine learning platforms.

RESULTS: Within our FAP and control patient population, Firmicutes and Bacteroidetes were the predominant phyla in the tissue and stool samples, while Proteobacteria dominated the polyp/non-polyp mucosa. A decline in Faecalibacterium in polyps contrasted with a decline in Bacteroides …

Thanatechnology: Designing For Death, Samantha Grace Bruner

Theses and Dissertations

Thanatechnology, or the study of death technology, is based within the human need to “figure out” death. Through the ages, humans have used technology to further our understanding of what it means to die and what it means to mourn as a way of figuring out what it means to live. Digital data is a huge part of recent digital technology and includes social media data which is a part of many peoples’ daily lives. This leads to many questions including what happens to social media pages when someone dies. These “digital graveyards” leave a lasting impact on many social …

The Free Press Vol. 54, November 11-14-2022, Kelly Ledsworth

Free Press, The

Osher School of Music produces "Nine: the Musical"--Walking on the Left--Walking on the Right--October 31st student Senate Meeting--The Peer Career Guide Program--Mr. Burns Takes the Stage

Now It’S Personal: From Me To Mine To Property Rights, David Shoemaker, Bas Van Der Vossen

Philosophy Faculty Articles and Research

Philosophical theories of property rights struggle to adequately explain the moral significance of ownership. We propose that the moral significance of property rights is due to the intersection of what we call "the extended self” and conventionally protected rights claims. The latter, drawing on conventionalist accounts of property rights, explains the social nature and flexibility of property. The former, drawing on naturalist theories, explains their personal nature. The upshot is that we find at this intersection the full moral significance of property.

Tumor-Intrinsic Sirpa Promotes Sensitivity To Checkpoint Inhibition Immunotherapy In Melanoma, Zhicheng Zhou, Mei-Ju May Chen, Yikai Luo, Kamalika Mojumdar, Xin Peng, Hu Chen, Shweta V Kumar, Rehan Akbani, Yiling Lu, Han Liang

Faculty, Staff and Student Publications

Checkpoint inhibition immunotherapy has revolutionized cancer treatment, but many patients show resistance. Here we perform integrative transcriptomic and proteomic analyses on emerging immuno-oncology targets across multiple clinical cohorts of melanoma under anti-PD-1 treatment, on both bulk and single-cell levels. We reveal a surprising role of tumor-intrinsic SIRPA in enhancing antitumor immunity, in contrast to its well-established role as a major inhibitory immune modulator in macrophages. The loss of SIRPA expression is a marker of melanoma dedifferentiation, a key phenotype linked to immunotherapy efficacy. Inhibition of SIRPA in melanoma cells abrogates tumor killing by activated CD8+ T cells in a co-culture …

Puppy Yoga, Cardozo Wellness Society, Cardozo Student Animal Legal Defense Fund

2022–2023 Flyers

No abstract provided.

Using Stable Isotope Analyses To Assess The Trophic Ecology Of Scleractinian Corals, Michael P. Lesser, Marc Slattery, Keir J. Macartney

School of Earth, Environmental, & Marine Sciences Faculty Publications

Studies on the trophic ecology of scleractinian corals often include stable isotope analyses of tissue and symbiont carbon and nitrogen. These approaches have provided critical insights into the trophic sources and sinks that are essential to understanding larger-scale carbon and nitrogen budgets on coral reefs. While stable isotopes have identified most shallow water (<30 m) corals as mixotrophic, with variable dependencies on autotrophic versus heterotrophic resources, corals in the mesophotic zone (~30–150 m) transition to heterotrophy with increasing depth because of decreased photosynthetic productivity. Recently, these interpretations of the stable isotope data to distinguish between autotrophy and heterotrophy have been criticized because they are confounded by increased nutrients, reverse translocation of photosynthate, and changes in irradiance that do not influence photosynthate translocation. Here we critically examine the studies that support these criticisms and show that they are contextually not relevant to interpreting the transition to heterotrophy in corals from shallow to mesophotic depths. Additionally, new data and a re-analysis of previously published data show that additional information (e.g., skeletal isotopic analysis) improves the interpretation of bulk stable isotope data in determining when a transition from primary dependence on autotrophy to heterotrophy occurs in scleractinian corals.

Piglet Cardiopulmonary Bypass Induces Intestinal Dysbiosis And Barrier Dysfunction Associated With Systemic Inflammation, Jeffrey D. Salomon, Haowen Qiu, Dan Feng, Jacob Owens, Ludmila Khailova, Suzanne Osorio Lujan, John Iguidbashian, Yashpal S. Chhonker, Daryl J. Murry, Jean-Jack Riethoven, Merry L. Lindsey, Amar B. Singh, Jesse A. Davidson

Nebraska Center for Biotechnology: Faculty and Staff Publications

The intestinal microbiome is essential to human health and homeostasis, and is implicated in the pathophysiology of disease, including congenital heart disease and cardiac surgery. Improving the microbiome and reducing inflammatory metabolites may reduce systemic inflammation following cardiac surgery with cardiopulmonary bypass (CPB) to expedite recovery postoperatively. Limited research exists in this area and identifying animal models that can replicate changes in the human intestinal microbiome after CPB is necessary. We used a piglet model of CPB with two groups, CPB (n=5) and a control group with mechanical ventilation (n=7), to evaluate changes to the microbiome, …

Increased Circulating Cortisol After Vaginal Birth Is Associated With Increased Fgf19 Secretion In Neonatal Pigs, Caitlin Vonderohe, Gregory Guthrie, Barbara Stoll, Valeria Melendez Hebib, Harry Dawson, Douglas Burrin

Children’s Nutrition Research Center Staff Publications

The influence of birth modality (scheduled cesarean or spontaneous vaginal) on the development of the newborn has been a source of controversy in neonatology. The impact of cesarean vs vaginal birth on the development of bile acid and fibroblast growth factor 19 (FGF19) signaling is unknown. Our aim was to determine the effect of birth modality and gestational age (preterm vs term) on plasma hormone levels, bile acid pool distribution, expression of genes in the bile acid-FXR-FGF19 pathway, and plasma levels of FGF19 at birth and on day 3 of life in neonatal pigs. Four sows underwent cesarean delivery on …

The Rider (2022-11-14), Verilu Infante

The Rider Archives

Vol.8 No.12

Moral Foundations In Bunkerville And Malheur, David Keith Frey

Theses and Dissertations

The events of the Bunkerville standoff and the Malheur wildlife refuge occupation were both important confrontations with the government by the western land rights movement. Participants in and responders to the events engage in distinct moral judgments and rationales. Utilizing cultural schema analysis and moral foundations theory (MFT), I explored the differences in rationales and judgments made by participants and responders in their explicit, public moral discourses of both events. My analysis indicates that responders and participants defined and utilized the same moral foundations, but in distinct ways. Participants were more diverse in their invocation of moral foundations while responders …

Inhibiting Ack1-Mediated Phosphorylation Of C-Terminal Src Kinase Counteracts Prostate Cancer Immune Checkpoint Blockade Resistance, Dhivya Sridaran, Surbhi Chouhan, Kiran Mahajan, Arun Renganathan, Cody Weimholt, Shambhavi Bhagwat, Melissa Reimers, Eric H Kim, Manish K Thakur, Muhammad A Saeed, Russell K Pachynski, Markus A Seeliger, W Todd Miller, Felix Y Feng, Nupam P Mahajan

2020-Current year OA Pubs

Solid tumours are highly refractory to immune checkpoint blockade (ICB) therapies due to the functional impairment of effector T cells and their inefficient trafficking to tumours. T-cell activation is negatively regulated by C-terminal Src kinase (CSK); however, the exact mechanism remains unknown. Here we show that the conserved oncogenic tyrosine kinase Activated CDC42 kinase 1 (ACK1) is able to phosphorylate CSK at Tyrosine 18 (pY18), which enhances CSK function, constraining T-cell activation. Mice deficient in the Tnk2 gene encoding Ack1, are characterized by diminished CSK Y18-phosphorylation and spontaneous activation of CD8