Digital Commons Network^™

Drug-Resistant Bacterial Infections: We Need Urgent Action And Investment That Focus On The Weakest Link, Christiane Dolecek, Sadia Shakoor, Buddha Basnyat, Tochi Okwor, Benn Sartorius

Department of Pathology and Laboratory Medicine

Despite high mortality and morbidity, drug-resistant bacterial infections remain the forgotten pandemic. We argue for strengthening of diagnostics, WASH (water, sanitation, and hygiene) and infection prevention and control to reduce drug-resistant infections, as an integral part of sustainable high-quality health services, particularly in low- and middle-income countries.

Christ In The Covenant Curses? Deuteronomy 28 And The Gospel, A. Rahel Wells

Faculty Publications

No abstract provided.

The Effects Of Environmental Instability On Egyptian & South African Treasures, Rileigh Hanley, Keelie Hanley

Student Research Symposium (SRS)

Both Egypt and South Africa are known around the world for their one-of-a-kind tourist attractions dependent on the natural environment for sustainability. As food and water become more limited in South Africa, the natural ecosystems and animal population dwindle, which in turn becomes detrimental to the country's local culture and economy; struggling to advance. By traveling to South Africa, the questions of “What implications have food and water insecurity had on South Africa and how has the culture and economy of South Africa adapted to a decrease in food and water accessibility?” were explored. Egypt is home to ancient treasures, …

Hacia La Preservación De Los Relatos De Las Comunidades Digitales De Los Mmorpg Mediante Etnografías Digitales: Una Mirada Desde Los Estudios Visuales Al Caso Futur0 Server [2005-2012] De Ragnarok Online, Romano Ponce Díaz

Journal of Roleplaying Studies and STEAM

Resumen: La ponderación planteada en los siguientes párrafos centra su interés en las plataformas digitales de narrativa audiovisual donde los participantes pueden alterar y determinar el relato por medio de la interacción social sucedida en el mismo, concretamente, los videojuegos multijugador masivos de rol en línea en servidores emulados. Además, se abordan las implicaciones de la desaparición potencial y real de la información, datos, testimonios y vestigios de estas comunidades digitales participativas a causa de la naturaleza falible de los dispositivos de almacenaje electrónico. De esa forma, se busca plantear un breve panorama general de los antecedentes históricos de las …

Imaginar La Historia: El Juego De Rol Leyenda Como Punto De Contacto Entre El Análisis Historiográfico Y El Narratológico En La Conquista Del Imperio Azteca, Marcos O. Cabobianco, Martín Van Houtte

Journal of Roleplaying Studies and STEAM

ESPAÑOL

Los juegos de rol se pensaron ya como una herramienta educativa. Generalmente, se adaptaron sus idiosincrasias al contexto didáctico-pedagógico, como simulación de situaciones relevantes para el tema a enseñar. Pocas veces fue aprovechado su potencial para servir de puente entre la historiografía (escritura de la historia), la narratología (estudio de las narraciones), la metahistoria (estudio de cómo se escribe e interpreta la historiografía en tanto narración). En esta ponencia proponemos estudiar cómo las herramientas de un juego de rol particular colaboran con el estudio metahistórico de la conquista del imperio azteca, teniendo en cuenta la polisemia de la expresión: …

Toni Morrison's Trans-Subjective And Trans-Generational Phenomenology, Dr. Michael Sawyer

Duquesne Studies in Phenomenology

No abstract provided.

The Legacy And Representation Of Blacks In Spain, Dr. Nicholas Jones

Duquesne Studies in Phenomenology

No abstract provided.

Editor's Introduction, Dr. James Haile Iii

Duquesne Studies in Phenomenology

No abstract provided.

The Power Of Connection And Wellness: Building A Foundation For A Successful Law Career, Reid D. Murtaugh

Ohio Northern University Law Review

No abstract provided.

The Old Man And The Sea As A Thematic And Critical Study, Assistant Instructor: Liwaa Ahmed Abdullah

Midad AL-Adab Refereed Quarterly Journal

الرجل العجوز والبحر ، هي رواية فريدة من نوعها والأكثر مبيعا لروايات هيمنجواي التي تحاول تعزيز العلاقة بين الرجل والطبيعة. حيث في هذه الد بدراسة تحليليه ونقديه لرواية الرجل العجوز والبحر وكذلك المواضيع الرئيسية المتمثلة بالرجل والطبيعة وكذلك موضوع السؤال عن البقاء في رواية الرجل العجوز والبحر وتعتمد هذه الرواية بشكل رئيسي على شخصية سانتياغو

Animation As An Early Source For Metaphor Acquisition By Younger Children, Dr. Mahmoud Arif Edan

Midad AL-Adab Refereed Quarterly Journal

The purpose of this study is to highlight evidence the animations the primary source for younger children to acquire metaphors. They can make use of those cartoons to recognise and activate their conceptual maps. The study applied the Conceptual Metaphor Theory (CMT) by Lakoff, & Johnson (1980) to be the theoretical framework of this study. The data collection is one-on-one method interviews (or face to face) which is the major and commonest type of the data collection methods in research whose nature is qualitative, yet this research applies the mixed method that combines the prose of the quantitative and qualitative …

Virginia Woolf: The Search For Identity As A Woman, م.د. محمود حسن زغير

Midad AL-Adab Refereed Quarterly Journal

تحاو ل الدراس ة الحالية جعل القراءة لفيرجيني ا وول ف محورا للبحث عن هوي ة المرأ ة وعلاقتها بكتابته ا. ي ق د م القرن العشرو ن سيناريو قويًا للانعكاسا ت الجمالي ة والنقدي ة من خلا ل تعزي ز العلاقا ت بي ن المؤلفي ن عل ى م ر السنين السابق ة أكث ر م ن أ ي وق ت مضى والتي لم يت م تقديمها فقط ف ي النصو ص الأدبي ة ولكنه ا تظهر أيضً ا هد ف ا للتحلي ل النظري في العدي د من المقالا ت في ذل ك الوق ت. قد يكون هذا …

A Genomically And Clinically Annotated Patient-Derived Xenograft Resource For Preclinical Research In Non-Small Cell Lung Cancer., Xing Yi Woo, Anuj Srivastava, Philip C Mack, Joel H. Graber, Brian J Sanderson, Michael W Lloyd, Mandy Chen, Sergii Domanskyi, Regina Gandour-Edwards, Rebekah A Tsai, James G. Keck, Mingshan Cheng, Margaret Bundy, Emily L Jocoy, Jonathan W Riess, William Holland, Stephen C. Grubb, James G Peterson, Grace Stafford, Carolyn Paisie, Steven Neuhauser, Radha Krishna Murthy Karuturi, Joshy George, Allen K. Simons, Margaret Chavaree, Clifford G Tepper, Neal Goodwin, Susan Airhart, Primo N Lara, Thomas H Openshaw, Edison Liu, David R Gandara, Carol J Bult

Faculty Research 2022

UNLABELLED: Patient-derived xenograft (PDX) models are an effective preclinical in vivo platform for testing the efficacy of novel drugs and drug combinations for cancer therapeutics. Here we describe a repository of 79 genomically and clinically annotated lung cancer PDXs available from The Jackson Laboratory that have been extensively characterized for histopathologic features, mutational profiles, gene expression, and copy-number aberrations. Most of the PDXs are models of non-small cell lung cancer (NSCLC), including 37 lung adenocarcinoma (LUAD) and 33 lung squamous cell carcinoma (LUSC) models. Other lung cancer models in the repository include four small cell carcinomas, two large cell neuroendocrine …

A Ruff Day On The Road: How Relocation Affects Children Pre-K Through Third Grade And How A Picture Book Can Help, Bryant Miller

Honors Projects

Moving their home from across town, a couple of states away, or overseas is something most will experience at least once in their lifetime. For all, moving is a big change, but for children, it can have lasting effects. Presumably, social skills, academic development, and family dynamics are all impacted when children move. But how and to what length are these factors influenced? This led to the original research question, how does relocation affect children and how can this transition during relocation be eased? After the first portion of the research was done to answer these questions, the research then …

Smart Biomaterials For Enhancing Cancer Therapy By Overcoming Tumor Hypoxia: A Review, Samar A. Salim, Taher A. Salaheldin, Mohamed M. Elmazar, A F. Abdel-Aziz, Elbadawy A. Kamoun

Nanotechnology Research Centre

No abstract provided.

Cultivating Community, Convening, And Collaboration Through Rit’S Makerspace, Michael Buffalin Iv, Anna Pasquantonio, Scott Nost, Juilee Decker

Presentations and other scholarship

Makerspaces are places of community, convening, and collaboration. They are spaces where anyone can “teach, learn, and practice creative skills”[1]. As such, this article charts our journey as students, staff, and faculty who collaborated within and beyond our academic makerspace to produce an exhibition in winter 2022 at the University Gallery at Rochester Institute of Technology (RIT) in Rochester, NY. This project was a five-week-long undertaking in an interdisciplinary museum studies course in collaboration with The Construct (our university makerspace), the Museum Studies program in the College of Liberal Arts, and the Vignelli Center for Design Studies. We reproduced items …

Combining Isotopic And Genetic Analyses To Quantify Microbial Facilitation Of Recalcitrant Resource Use By Terrestrial And Aquatic Consumers, Alexi Christina Besser

Biology ETDs

Quantifying the flow of energy and nutrients through food webs is foundational to understanding the structure and function of ecosystems. Here, I utilize the stable carbon and nitrogen isotope analysis of individual amino acids to trace the movement of essential amino acids through terrestrial and freshwater food webs in New Mexico, USA. I first explore isotopic patterns among co-occurring terrestrial plants and aquatic algae. I then combine this molecular isotopic approach with 16S and 18S rRNA sequencing to demonstrate the importance of gut microbiota as sources of essential amino acids to wild mammalian hosts. Next, I explore the roles of …

Hypertrophic And Fibrotic Human Pkd Hearts Are Associated With Macrophage Infiltration And Abnormal Tgf-Β1 Signaling, Farideh Amirrad, Gregory A. Fishbein, Robert A. Edwards, Surya M. Nauli

Pharmacy Faculty Articles and Research

Autosomal dominant polycystic kidney disease (PKD) is a hereditary kidney disorder which can affect cardiovascular system. Cardiac hypertrophy and cardiomyopathy in PKD have been reported by echocardiography analyses, but histopathology analyses of human PKD hearts have never been examined. The current studies evaluated human heart tissues from five subjects without PKD (non-PKD) and five subjects with PKD. Our histopathology data of human PKD hearts showed an increased extracellular matrix associated with cardiac hypertrophy and fibrosis. Hypertrophy- and fibrosis-associated pathways involving abnormal cardiac structure were next analyzed. We found that human PKD myocardium was infiltrated by inflammatory macrophage M1 and M2; …

Wind Beneath Their Wings, Eric F. Spina

President's Blog: From the Heart

During Sunday’s scholarship brunch, I marveled at Daisha Williams' poise, confidence — and ease in articulating why investing in students pays dividends.

Keeping An Eye On Circadian Time In Clinical Research And Medicine, Elizabeth B. Klerman, Allison Brager, Mary A. Carskadon, Christopher M. Depner, Russell Foster, Namni Goel, Mary Harrington, Et Al

Psychology: Faculty Publications

Background: Daily rhythms are observed in humans and almost all other organisms. Most of these observed rhythms reflect both underlying endogenous circadian rhythms and evoked responses from behaviours such as sleep/wake, eating/fasting, rest/activity, posture changes and exercise. For many research and clinical purposes, it is important to understand the contribution of the endogenous circadian component to these observed rhythms. Content: The goal of this manuscript is to provide guidance on best practices in measuring metrics of endogenous circadian rhythms in humans and promote the inclusion of circadian rhythms assessments in studies of health and disease. Circadian rhythms affect all aspects …

Student Senate Meeting Minutes November 15, 2022, Student Senate-Winona State University

Student Senate Meeting Minutes

This document is the official Winona State University Student Senate Minutes November 15, 2022.

Leveraging Smart-Phone Cameras And Image Processing Techniques To Classify Mosquito Genus And Species, Sriram Chellappan, Pratool Bharti, Mona Minakshi, Willie Mcclinton, Jamshidbek Mirzakhalov

USF Patents

Identifying insect species integrates image processing, feature selection, unsupervised clustering, and a support vector machine (SVM) learning algorithm for classification. Results with a total of 101 mosquito specimens spread across nine different vector carrying species demonstrate high accuracy in species identification. When implemented as a smart-phone application, the latency and energy consumption were minimal. The currently manual process of species identification and recording can be sped up, while also minimizing the ensuing cognitive workload of personnel. Citizens at large can use the system in their own homes for self-awareness and share insect identification data with public health agencies.

The Effects Of Whole-Body Hot Water Immersion After Exercise Induced Muscle Damage On Exercise Performance And Inflammatory Markers, Rogelio A. Realzola

Health, Exercise, and Sports Sciences ETDs

This study examined the effects of hot water immersion (HWI) on exercise performance and inflammatory markers after a resistance exercise-induced muscle damage protocol. Strength trained males (n = 5) and females (n = 5) completed two experimental trials separated by at least 2 weeks in a randomized crossover design; one trial involved HWI, the other temperate water immersion (TWI). For each trial, subjects performed a muscle damaging protocol followed by HWI or TWI for up to 50 minutes. The protocol consisted of 10 sets of 8 repetitions at 70% of 1-repetition maximum with 4s eccentric, 1s concentric lifting …

Independent - Nov. 15, 2022, Monty Stites

The Independent (1988-present)

No abstract provided.

Transposon Mutagenesis Reveals Rbms3 Silencing As A Promoter Of Malignant Progression Of Brafv600e-Driven Lung Tumorigenesis, Aria Vaishnavi, Joseph Juan, Maebh Jacob, Christopher Stehn, Eric E Gardner, Michael T Scherzer, Sophia Schuman, J Edward Van Veen, Brandon Murphy, Christopher S Hackett, Adam J Dupuy, Steven A Chmura, Louise Van Der Weyden, Justin Y Newberg, Annie Liu, Karen Mann, Alistair G Rust, William A Weiss, Conan G Kinsey, David J Adams, Allie Grossmann, Michael B Mann, Martin Mcmahon

Faculty, Staff and Student Publications

Mutationally activated BRAF is detected in approximately 7% of human lung adenocarcinomas, with BRAFT1799A serving as a predictive biomarker for treatment of patients with FDA-approved inhibitors of BRAFV600E oncoprotein signaling. In genetically engineered mouse (GEM) models, expression of BRAFV600E in the lung epithelium initiates growth of benign lung tumors that, without additional genetic alterations, rarely progress to malignant lung adenocarcinoma. To identify genes that cooperate with BRAFV600E for malignant progression, we used Sleeping Beauty-mediated transposon mutagenesis, which dramatically accelerated the emergence of lethal lung cancers. Among the genes identified was Rbms3, which encodes an RNA-binding protein previously implicated as a …

Preclinical Evaluation Of Combination Nemtabrutinib And Venetoclax In Chronic Lymphocytic Leukemia, Elizabeth M Muhowski, Janani Ravikrishnan, Britten Gordon, Lianbo Yu, Shrilekha Misra, Brandi Walker, Sudharshan Eathiraj, Deepa Sampath, Kerry A Rogers, John C Byrd, Jennifer A Woyach

Faculty, Staff and Student Publications

Inhibitors of B cell receptor (BCR) signaling such as the Bruton's tyrosine kinase (BTK) inhibitors are effective therapeutics for chronic lymphocytic leukemia (CLL). The first-in-class covalent BTK inhibitor, ibrutinib, produces durable responses in most CLL patients; however, complete responses are only observed in a minority of patients. B cell lymphoma 2 (BCL2), an anti-apoptotic protein that contributes to CLL cell survival, has also been investigated as a therapeutic target. The BCL2 inhibitor venetoclax is effective in patients with CLL and can produce undetectable minimal residual disease, allowing discontinuation of therapy. In combination, ibrutinib and venetoclax have shown preclinical synergy and …

Maneuvering Mestizaje In Shakespeare's Tragicomedies, Andrea Phiana Borunda

English Language and Literature ETDs

This project explores and wades through the implications of mestizaje in the murky depths of Shakespeare’s oceans. Disguises and mistakes in identities and in gender and “race” draw on the hybridity and indeterminacy of the early modern stage and its fluidity and lack of order to reflect an unhomed and unmediated formation of nationhood, diaspora, and (trans)global identities. Drawing on ecocritical and critical race theories, I contend the tragicomic works of Shakespeare expose and dismantle ecoracial fantasies of white male supremacy to curate a space of mestizaje for a new generation of BIPOC scholars.

Taxonomic Revision And Morphometric Analysis Of Selected Anthurium (Araceae) Species From Bolivia And Peru, Daniel M. Tarazona Ocana

Theses

The genus Anthurium (Araceae) consists of around 1,200 species distributed in the Neotropics, particularly in Central and South America. The montane forests in the eastern flank of the Andes, ranging from northern Ecuador to central Bolivia; hereafter, the East Andes Gradient region, are particularly rich in terms of species diversity, and include an understudied group of Anthurium species endemic to the region. Within this group of species, some taxa are difficult to distinguish from each other mainly due to the lack of identification keys, incomplete species descriptions and unknown synonyms. In this study, a combination of traditional taxonomic techniques and …

Tell Virgil Write Brick On My Brick’: Doctoral Bashments, (Re)Visiting Hiphopography And The Digital Discursivity Of The Dj - A Mixed Down Methods Movement, Todd Craig

Publications and Research

No abstract provided.

Efficacy Of A One-Piece Aberration Neutral Hydrophobic Acrylic Toric Intraocular Lens, Phillip J. Buckhurst, George Lau, Jon I. Williams, Mark Packer

School of Health Professions

PURPOSE: To assess the refractive outcomes, intraocular centration and rotational stability of the enVista toric intraocular lens (IOL). PATIENTS AND METHODS: This study was a prospective, multi-centre, double-masked, partially randomized and partially controlled clinical trial. A total of 191 participants were implanted with toric IOL (1.25, 2.00, or 2.75D) or non-toric IOL (control). The lowest range of corneal astigmatic eyes were randomized to 1.25D toric or control. Higher astigmatic powers were allocated to the treatment arm. Subjects were assessed immediately postoperatively, 1-2 (V1), 7-14 (V2), 30-60 (V3) and 120-180 (V4) days postoperatively. Unaided (UDVA) and distance corrected visual acuity (CDVA), …