Digital Commons Network^™

L-Ergothioneine Treatment In Old Cba/Caj Male Mice Slows The Progression Of Age-Related Hearing Loss, Mark A. Bauer

USF Tampa Graduate Theses and Dissertations

The naturally occurring amino acid, L-Ergothioneine (EGT), has immense potential as a therapeutic, having shown promise in the treatment of other disease models, including neurological disorders. EGT is naturally uptaken into cells via its specific receptor, OCTN1, suggesting that it is highly conserved, to be utilized by cells as an antioxidant and anti-inflammatory, particularly under stressed conditions. In our current study, EGT was administered over a period of 6 months to 25-26 month old CBA/CaJ mice as a possible treatment for age-related hearing loss (ARHL), since presbycusis has been linked to higher levels of cochlear oxidative stress, apoptosis and chronic …

Reproduction In Relation To Heavy-Metal Contamination Along An Urbanization Gradient In Aninvasive Florida Lizard Species (Anolis Sagrei), Elizabeth Hauck

USF Tampa Graduate Theses and Dissertations

Environmental contamination is accumulating rapidly worldwide due to increasing urbanization rates. Heavy metals are known to be particularly toxic to organisms, to accumulate in biological systems, and to be found in higher concentrations in animals located in areas of high urban levels. However, the physiological impacts of these toxic heavy metals in wildlife remain largely unknown. Lizards are excellent bioindicator species for environmental contaminants due to their trophic level as mesopredators and their susceptibility of exposure via air, water, diet, and soil through egg deposition. To assess the impacts heavy-metal contamination has on reproductive parameters in lizards and how these …

Historical Inquiry: Who Has The Power? Using Film To Introduce Students To Medieval Social Class Structures, Megan Todd, Janie Hubbard

The Councilor: A National Journal of the Social Studies

Using film in the classroom to teach history has long been endorsed as an effective pedagogical method when the lessons’ purposes and goals are clearly supported with facts. This article, which includes a National Council for the Social Studies C3 inquiry-based lesson plan, is targeted for educators who aspire to help students understand basic European Medieval history and engage in critical thinking. Medieval history is listed in many U.S. state curriculum standards and international teaching benchmarks; thus, this lesson contributes a teaching-ready source, particularly to introduce students to historical concepts, geographies, and politics (i.e., power structures). Clips from A Knight’s …

The Effectiveness Of Planned And Incidental Focus On Form In Learning Grammatical Concepts In Two Spanish As L 2 Classrooms, Rebeca Monasterio

Theses and Dissertations

The present research study examines the effectiveness of two types of in two Spanish classrooms for beginner students: planned focus on form and incidental focus on form. Focus on form is understood as an instructional practice that creates a real-life context to let students practice some aspects of the language in a communicative environment based on both meaning and form. In this study, planned focus on form is operationalized as input enhancement in classroom materials and teacher talk. On the other hand, incidental focus on form involves teacher´s spontaneous attention to form in teacher talk. Language learning was measured through …

A Relational Approach To Property, Jennifer Nedelsky

Articles & Book Chapters

No abstract provided.

Algae And Cyanobacteria In The Aphotic Habitats Of Veternica Cave (Medvednica Mt., Croatia) And Selected Caves Of The Dinaric Karst (South-Eastern Europe), Najla Baković, Tanja Pipan, Robert Baković, Roman Ozimec, Josip Rubinić, Renata Matoničkin Kepčija

International Journal of Speleology

Microphototrophs (algae and cyanobacteria) in karst environments have been intensively studied in aquatic epigean habitats. In recent decades knowledge about the communities inhabiting cave entrances and lampenflora has grown substantially, but the data about the communities in aphotic cave zone are scarce. This study aimed to investigate spatio-temporal presence of microphototrophs in the aphotic zone of Veternica Cave (Mt. Medvednica karst) and to present additional preliminary data from 22 caves of the Dinaric karst. The data were collected over ten years, in parallel with research on cave phagotrophic protists. In addition to the remains of microphototrophs, living algae and cyanobacteria …

Stochastic Models Of Zoonotic Avian Influenza With Multiple Hosts, Environmental Transmission, And Migration In The Natural Reservoir, Kaia Smith

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Perceived School Fairness And Willingness To Report Bias-Based Bullying Among Youth During Covid-19 Pandemic, Isak Kim, Deanna L. Burgess, Seriashia J. Chatters

Counseling Faculty Publications

BACKGROUND

As COVID-19 has let many students into remote learning environments and exacerbated inequality among marginalized individuals, there is a growing concern about Bias-Based Bullying (BBB) in online spaces among school-aged youths. Learning modality and perceived school fairness may affect youth's likelihood of reporting BBB.

METHODS

Data were collected as part of “No Place For Hate” (NPFH) project, which was conducted by an equity office of a school district. A sample of middle and high school students (N = 1117) in the school district was used as an analytic sample. We conducted a series of independent samples t tests and …

Effects Of Chronic Cirrhosis Induced By Intraperitoneal Thioacetamide Injection On The Protein Content And Michaelis–Menten Kinetics Of Cytochrome P450 Enzymes In The Rat Liver Microsomes, Devaraj Venkatapura Chandrashekar, Barent N. Dubois, Mamunur Rashid, Reza Mehvar

Pharmacy Faculty Articles and Research

Chronic intraperitoneal injection of thioacetamide (TAA) in rats has been used as an animal model of human cirrhosis to study the effects of the disease on drug metabolism. However, TAA inhibits P450 enzymes directly and independently of cirrhosis. We investigated the effects of chronic cirrhosis in rats, induced by 10 weeks of intraperitoneal TAA, on the P450 enzymes after a 10-day washout period to eliminate TAA. Liver histology and serum biomarkers of hepatic function confirmed cirrhosis in all animals. Microsomal total P450 content, P450 reductase activity and ethoxycoumarin O-deethylase activity, a general marker of P450 activity, were significantly reduced by …

The Impact Of Flipped Learning On The Language Performance And Attitudes Of Beginning Spanish As A Second Language Learners, Susana Dimas

Theses and Dissertations

The present study evaluated student academic performance on grammar focused tasks in a Spanish L2 flipped classroom compared to a non-flipped classroom as well as examined learners’ attitudes towards the implementation of the flipped model in the Spanish L2 instruction. This research included a between-group design, which involved a control group being instructed via a flipped approach and a comparison group learning the same material under a non-flipped model; and a within-group design with a group of learners combining these two different methodologies during one semester. Results in grammar-focused pre and post-tests indicated that Spanish L2 learners did not improve …

Detectives And The Legal System: A Paradigm To Support Scholarly Inquiry And Mixed Methods Research In The Social Sciences, James A. Bernauer, Frank Hartle

The Qualitative Report

It is argued in this article that the legal system, from initial investigation by detectives to final resolution in court by lawyers, judges, and juries, offers a basis for investigating phenomena in the social sciences using mixed methods. We think that this new paradigm combines the components of both the qualitative and quantitative paradigms and provides a practical model for conceptualizing and conducting mixed methods research. The implication of this new paradigm is that it may help us better understand underlying phenomena in scholarly inquiry and thus offers a potential contribution for using a mixed-methods approach in both education and …

Senior Recital: Briana Morin, Saxophone; Lu Witzig, Piano; November 12, 2022, Briana Morin, Lu Witzig

School of Music Programs

Kemp Recital Hall
November 12, 2022
Saturday Afternoon
2:30 p.m.

Structural Basis For Mechanotransduction In A Potassium-Dependent Mechanosensitive Ion Channel, Jonathan Mount, Grigory Maksaev, Brock T Summers, James A J Fitzpatrick, Peng Yuan

2020-Current year OA Pubs

Mechanosensitive channels of small conductance, found in many living organisms, open under elevated membrane tension and thus play crucial roles in biological response to mechanical stress. Amongst these channels, MscK is unique in that its activation also requires external potassium ions. To better understand this dual gating mechanism by force and ligand, we elucidate distinct structures of MscK along the gating cycle using cryo-electron microscopy. The heptameric channel comprises three layers: a cytoplasmic domain, a periplasmic gating ring, and a markedly curved transmembrane domain that flattens and expands upon channel opening, which is accompanied by dilation of the periplasmic ring. …

Enterotoxigenic Escherichia Coli Heat-Labile Toxin Drives Enteropathic Changes In Small Intestinal Epithelia, Alaullah Sheikh, Brunda Tumala, Tim J Vickers, John C Martin, Bruce A Rosa, Subrata Sabui, Supratim Basu, Rita D Simoes, Makedonka Mitreva, Chad Storer, Erik Tyksen, Richard D Head, Wandy Beatty, Hamid M Said, James M Fleckenstein

2020-Current year OA Pubs

Enterotoxigenic E. coli (ETEC) produce heat-labile (LT) and/or heat-stable (ST) enterotoxins, and commonly cause diarrhea in resource-poor regions. ETEC have been linked repeatedly to sequelae in children including enteropathy, malnutrition, and growth impairment. Although cellular actions of ETEC enterotoxins leading to diarrhea are well-established, their contributions to sequelae remain unclear. LT increases cellular cAMP to activate protein kinase A (PKA) that phosphorylates ion channels driving intestinal export of salt and water resulting in diarrhea. As PKA also modulates transcription of many genes, we interrogated transcriptional profiles of LT-treated intestinal epithelia. Here we show that LT significantly alters intestinal epithelial gene …

Effects Of Sowing Date And Phosphorus Fertiliser Application On Winter Survival Of Lucerne Cv. Aohan In The Northern Semi-Arid Region Of China, Z. L. Wang, Q. Zh. Sun, Y. W. Wang, Zh. Y. Li, Sh. F. Zhao

IGC Proceedings (1977-2023)

In the northern semi-arid region of China, winter survival is always a limiting factor for lucerne production, because low temperatures and a dry climate in winter (Zhou et al., 1993; Ma, 2000; Sun & Gui, 2001; Sun et al., 2003). An experiment was conducted to find an appropriate sowing date and P application rate in order to improve lucerne winter survival.

Reasons For The Premature Decline In Astragalus Adsurgens Stands In Kerqin Sandy Land, Q. Zh. Sun, Z. L. Wang, J. G. Han, Y. W. Wang, G. R. Liu

IGC Proceedings (1977-2023)

Diseases partly account for reductions in Astragalus adsurgens, stand longevity. The effect of some cultural practices on the control of pests and diseases have been reported (Hou, 1986; Nan, 1996), but few reports have detailed the relationship among soil fertiliser status, diseases and premature stand decline. This study was conducted to investigate these relationships in order to extend the longevity of Astragalus adsurgens stands.

The Influence Of Fertiliser Application To Strip-Sown Grasslands On Herbage Production And Quality, A. Kohoutek, P. Komárek, V. Odstrčilová, P. Nerušil

IGC Proceedings (1977-2023)

To increase the productivity of dairy cattle in the Czech Republic requires an improvement in herbage quality and an increase in the net energy of herbage. The decrease in cattle numbers by 50 % and the expansion of the grassland area both result in a surplus of feedstuffs of low quality. Introduction of strip-seeding of legumes and grasses into grasslands in interaction with fertilisation provides a possible solution to this problem.

Range-Based Livestock Production In Turkmenistan, R. H. Behnke, G. Davidson

IGC Proceedings (1977-2023)

Turkmenistan retains a centralized system of livestock production in which many critical assets are owned by the state. Though technically in the temperate zone, the country's climate is harsh and unstable. Groundwater resources are unevenly distributed, leaving many potential grazing areas seasonally inaccessible due to lack of drinking water for livestock. This paper summarizes the results of a three-year study of rangelands, livestock production, flock economics and land tenure at two study sites, one in central and the other in eastern Turkmenistan. The results of this study suggest that pastoral communities in Turkmenistan have coped remarkably well with the institutional …

Interactive Virtualisation In Java Script Of Electromagnetism When Changing The Dynamic, Static Parameters Of Ferromagnetics, Adambek Tatenov, Nauan Shambulov, Umirbek Baitukayev, Aidana Ospanova, Nurgul Shinykulova

Karbala International Journal of Modern Science

Laboratory-based work is necessary for developing the skills of measuring physical quantities, performing physics experiments, and drawing correct conclusions from their observations. Training programs that simulate physics processes and phenomena that cannot always be shown “live”, can significantly help students. The authors developed and implemented the processes of the phenomenon of the physics course “Electromagnetism” – “Study of dynamic hysteresis of ferromagnets” and interactively virtualised using the Java Script computer software environment. The originality of this approach is that it provides a convenient tool for creating a simulation environment for any physics problem. This interactive virtual laboratory development will be …

Potential Use Of Proteolytic Bacteria Paenibacillus Dendritiformis (Bt7) Isolated From Batu Tannery Effluents For The Detergent Industry, Chandran Masi, Degafneh Tadesse, Abate Ayele

Karbala International Journal of Modern Science

This research was aimed at identifying a bacterium that can produce alkaline proteases. As a result, bacteria that produce proteases were isolated from Batu tannery effluents, tested for protease synthesis on skim milk agar plates, and validated with a protease assay. Microscopic and molecular phylogenetic analyses identified Paenibacillus dendritiformis (BT7) as the bacterial isolate with the highest alkaline protease production. The isolate's maximum enzyme production was obtained by 2% inoculum size, 40°C temperature, 9.0 pH, and a 48-hour incubation time with production media components such as glucose, casein, MgCl2, and 2% NaCl. The maximal enzyme activity was 270 U/mL under …

Rising From The Dead: A Jurisprudential Review Of Recent Cemetary And Human Rights Cases, Mary Catherine Joiner, Ryan M. Seidemann

Ohio Northern University Law Review

No abstract provided.

The Use Of Knowledge And Moral Imagination In The Common Law, Allen Mendenhall

Ohio Northern University Law Review

No abstract provided.

Human Rights In The Era Of Artificial Intelligence “Figures, Opinions And Solutions”, Dr. Heidi Issa Hassan

مجلة جامعة الإمارات للبحوث القانونية UAEU LAW JOURNAL

Technology has cast its shadow on us in most aspects of our lives and nothing has escaped its grip even human intelligence. Human intelligence now has a major rival known as "artificial intelligence" (AI). The main question is can machines think like humans?!

Since AI involves, in part, the dispensation with humans, then it is a matter that affects human rights, regardless of the manifestations, consequences or even scope of this dispensation.

Accordingly, this study has several problems to tackle: 1) the absence of adequate binding national and international provisions governing AI, 2) AI systems involve changing the way businesses …

Pippin, Department Of Theatre And Dance

Fall 2022

What are you willing to give to make your life extraordinary? What if you could have fame and glory handed to you? PIPPIN explores the journey of one young man who knows he’s meant to be great but knows not what it will cost. This multi-Tony Award-winning musical dazzles with exciting choreography and show-stopping songs by the writer/composer of Wicked, Stephen Schwartz.

A Relational Account Of Resolutions: Resolution As Reacquaintance, Daniel Grasso

Theses

A Relational Account of Self-Constraint: Resolution as Reacquaintance

Resolutions and self-promises are two much discussed tools of self-constraint in the face of weakness of will. However, the discussions often begin from a negative and alienated direction, emphasizing self-compulsion, fear of irrationality, or binding ourselves through self-obligation. Jorah Dannenberg has suggested a more optimistic agent-centered account of how to bind ourselves through self-promises. His account has much kinship with the influential Sartrean approach from Berislav Marusic. These more positive agent-centered accounts are appealing as they appear to answer three of the major puzzles of self-constraint: 1. How is self-restraint supposed to …

A Review Of Radiation-Induced Alterations Of Multi-Omic Profiles, Radiation Injury Biomarkers, And Countermeasures, Sushil K. Shakyawar, Nitish K. Mishra, Neetha N. Vellichirammal, Lynnette Cary, Tomáš Helikar, Robert Powers, Rebecca E. Oberley-Deegan, David B. Berkowitz, Kenneth W. Bayles, Vijay K. Singh, Chittibabu Guda

Department of Biochemistry: Faculty Publications

Increasing utilization of nuclear power enhances the risks associated with industrial accidents, occupational hazards, and the threat of nuclear terrorism. Exposure to ionizing radiation interferes with genomic stability and gene expression resulting in the disruption of normal metabolic processes in cells and organs by inducing complex biological responses. Exposure to high-dose radiation causes acute radiation syndrome, which leads to hematopoietic, gastrointestinal, cerebrovascular, and many other organ-specific injuries. Altered genomic variations, gene expression, metabolite concentrations, and microbiota profiles in blood plasma or tissue samples reflect the whole-body radiation injuries. Hence, multi-omic profiles obtained from high-resolution omics platforms offer a holistic approach …

Unraveling The Complex Interactions Between Members Of The Schistosoma Haematobium Group And Bulinus Snails In And Around Lake Victoria In West Kenya, Caitlin Raiselle Babbitt

Biology ETDs

Schistosoma haematobium, the agent of urogenital schistosomiasis, and related schistosomes are transmitted by members of the genus Bulinus. Each of the 38 Bulinus species vary in their ability to vector schistosome species and non-schistosome trematodes resulting in a patchwork of snail-parasite compatibilities. Accurately identifying snail intermediate hosts and the disease-causing parasites they transmit is critical for snail control strategies and the management of human schistosomiasis. Towards these ends, this thesis identifies bulinid species and the parasites they transmit and implicates certain species in the transmission of S. haematobium. The thesis also includes a systematic review of methods …

November 11, 2022 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Caspase-8 Inactivation Drives Autophagy-Dependent Inflammasome Activation In Myeloid Cells., Yung-Hsuan Wu, Shu-Ting Mo, I-Ting Chen, Fu-Yi Hsieh, Shie-Liang Hsieh, Jianke Zhang, Ming-Zong Lai

Department of Microbiology and Immunology Faculty Papers

Caspase-8 activity controls the switch from cell death to pyroptosis when apoptosis and necroptosis are blocked, yet how caspase-8 inactivation induces inflammasome assembly remains unclear. We show that caspase-8 inhibition via IETD treatment in Toll-like receptor (TLR)-primed Fadd-/-Ripk3-/- myeloid cells promoted interleukin-1β (IL-1β) and IL-18 production through inflammasome activation. Caspase-8, caspase-1/11, and functional GSDMD, but not NLRP3 or RIPK1 activity, proved essential for IETD-triggered inflammasome activation. Autophagy became prominent in IETD-treated Fadd-/-Ripk3-/- macrophages, and inhibiting it attenuated IETD-induced cell death and IL-1β/IL-18 production. In contrast, inhibiting GSDMD or autophagy did not prevent IETD-induced septic …

"The Village That Learns": A Learning Journey Across Intraventions And Domains Over Two Decades In A Rural Thai Community, Deborah A. Fields, Luis Morales-Navarro, Paulo Blikstein

Instructional Technology and Learning Sciences Faculty Publications

What does it mean to become a village that learns? In this paper we document the transformative learning journey of a small Thai village over 24 years, becoming a community that identified, tackled, and iterated on problems, altering their everyday practices and lives. In that process the village shifted from a subsistence agricultural community staggeringly in debt to one known for its sustainable environmental, agricultural, and financial initiatives. To understand the village’s learning journey, we consider the village itself as the primary unit of analysis, applying an iterative case study approach, with chronological sequencing, thematic, and biographical narrative analysis …