Digital Commons Network^™

In Silico Analysis Of Tetrodotoxin Binding In Voltage-Gated Sodium Ion Channels From Toxin-Resistant Animal Lineages, Shana L. Geffeney, Jennie Ann Cordingley, Kenyon Mitchell, Charles T. Hanifin

Biology Faculty Publications

Multiple animal species have evolved resistance to the neurotoxin tetrodotoxin (TTX) through changes in voltage-gated sodium ion channels (VGSCs). Amino acid substitutions in TTX-resistant lineages appear to be positionally convergent with changes in homologous residues associated with reductions in TTX block. We used homology modeling coupled with docking simulations to test whether positionally convergent substitutions generate functional convergence at the level of TTX–channel interactions. We found little evidence that amino acids at convergent positions generated similar patterns among TTX-resistant animal lineages across several metrics, including number of polar contacts, polar contact position, and estimates of binding energy. Though binding energy …

November 17, 2022, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Malignant Potential Of Breast Cancer Stem Cells Is Associated With Environment-Dependent Upregulation Of The Oct3/4 Network, Robin Rajan

All Publications

The pioneer transcriptional factors (PTFs) of the Oct3/4 network including Oct3/4, Nanog, Sox2, Sall4 (ONSS), have been associated with breast cancer. Regulation of ONSS and other factors in this network were assessed for their role in malignancy. M ethods Triple negative breast cancer cell line (MDA-MB-231) transfected with human Oct3/4-GFP promoter was sorted using FACS. Differentially expressed genes (DEGs) were identified using qPCR and microarray. 3D mammospheres (CSC) from Oct3/4(+) cells were assessed for stable Oct3/4 expression. Tumor seeding and lung metastatic potential of Oct3/4(+) cells were assessed in immunocompromised mice. DEGs in the tumors were assessed with respect to …

Epigenetic And Genetic Associations And Gene Expression For The Risk Of Eczema In Two Consecutive Generations, Rumana Siddique

Electronic Theses and Dissertations Archive

Studies demonstrated genetic and epigenetic associations with eczema. However, not many studies investigated the interaction of epigenetic and genetic associations with eczema. Additionally, few studies examined gene expression (GE) levels along with epigenetic and genetic associations with eczema. Using the multigenerational epigenetic, genetic, and GE data of Isle of Wight (IOW) birth cohort, I investigated the interplay between DNA methylation (DNAm) and a genetic variant (SNP) with eczema and GE. First, I evaluated epigenome-wide associations of eczema using the DNAm data of two generations of the IOW (namely, the F1 and F2 generations) and examined the overlap of genes of …

Whole Genome Duplication Analysis Of The Invasive Lonicera Maackii (Amur Honeysuckle), Gaochan Wang

Theses

Invasive Lonicera maackii (L. maackii) is one of the highly successful and problematic bush honeysuckles found in the central and eastern of United States of America, which has been reported to pose a threat to native ecosystems by decreasing biodiversity. The mechanism by which L. maackii negatively impact environments is typically through either the direct effect of increased dominance or the indirect effect of territory modification. Numerous studies have documented the negative effects of L. maackii on native biota and the key traits such as seed dispersal, phenology, resistance to herbivory, rapid growth and environmental plasticity that contribute to invasion …

Core Values: A Phenomenological Study Of Spiritual Formation Through The Longevity Of Values Gained From Women's Ministry, Belinda Copeland

Doctoral Dissertations and Projects

While many churches today have moved away from the practice of church-based women’s ministries, other churches still see their value and continue their dedication to providing specifically tailored programs to address the spiritual formation in women. The Bible reminds us in Hebrews 10:25 that we are not to forsake “the assembling of ourselves together, as the manner of some…” (King James Bible, 1769/2017, Heb. 10:25). However, some churches desire to assemble specific ministries separately, women from men. This study attempted to identify values in the spiritual formation of women and explored whether those values are still helpful in the spiritual …

Early Childhood Education: A Hermeneutic Phenomenology Study Of Male Staff Retention, Justine Louise Flint

Doctoral Dissertations and Projects

The purpose of this qualitative hermeneutic phenomenology study was to describe the lived experiences of male early childhood teachers in the northeast region of the United States (US). The theory guiding this study was Victor Vroom’s expectancy theory of motivation. Vroom’s theory explains the behavioral process of why individuals choose one behavior over another or one career over another. The central research question in this study addressed the male early childhood teachers’ experiences working in the early childhood education (ECE) career field and motivation to remain in the ECE career field. This study highlighted ECE challenges and goals from the …

Domain Knowledge As Motion-Aware Inductive Bias For Deep Video Synthesis: Two Case Studies, Long Mai

Dissertations and Theses

Deep neural networks have been part of many breakthroughs in computer graphics and vision research. In the context of visual content synthesis, deep learning models have achieved impressive performance in the image domain. However, adapting the successes of image synthesis models to the video domain has been difficult, arguably due to the lack of sufficiently strong inductive biases that encourage the models to capture the temporal-dynamic nature of video data. Inductive bias refers to the prior knowledge incorporated into the learning models to explicitly drive the learning process toward the solutions that capture meaningful structures from data, which is critical …

The Effects Of Traumatic Stress & Role Of The Neuropeptide Y System As A Therapeutic In Females, Roxanna J. Nahvi

NYMC Student Theses and Dissertations

The incidence of many stress-elicited disorders is markedly influenced by sex. Women are twice as likely as men to develop posttraumatic stress disorder (PTSD), depression, anxiety disorders, and social impairments following exposure to traumatic stress. However, most of the studies in animal models examining putative therapeutics for stress-triggered impairments, including single prolonged stress (SPS), were performed predominantly with males. Previous studies in males demonstrated that intranasal neuropeptide Y (NPY) can provide therapeutic relief of many SPS-triggered symptoms. Nevertheless, the overwhelming majority of studies found that NPY levels in females in many brain regions are lower than in male rodents. NPY …

Vulnerability As A Launching State: Why The United States Should Adopt Explicit Indemnification Procedures In Response To The Growth Of The Commercial Space Industry, Mollie Carney

St. John's Law Review

(Excerpt)

This Note argues that the current United States launch license requirements should be amended to include explicit indemnification procedures, should the United States be held liable for damages as a Launching State under the Liability Convention. Part I of this Note examines the evolution of the space industry from a field marked by Cold War tensions to one that is dominated by private industry, and the risks that are associated with the rapid growth of the commercial space industry. Part II will explain the current legal regime by (1) setting a framework of liability generally, (2) examining the Liability …

Effects Of Oxidative Damage During Ruesi Dadton Exercise In Mild Cognitive Impairment: A Randomized Controlled Trial, Phaksachiphon Khanthong, Ananya Dechakhamphu, Kusuma Sriyakul, Aungkana Krajarng, Chuntida Kamalashiran, Parunkul Tungsukruthai

International Journal of Exercise Science

International Journal of Exercise Science 15(3): 1528-1537, 2022. This study aimed to investigate the effect of biomarkers of oxidative stress (OS) in 8-isoprostane (8-iso) and 8-hydroxy-2'–deoxyguanosine (8-OH-dG) on mild cognitive impairment (MCI) during a 12-week Ruesi Dadton (RD) exercise. A total of 274 enrolled participants were classified into blocks based on age and formal educational years, and randomly assigned into two groups: RD and control (CON). The participants’ cognitive functions were tested using Mini-Mental State Examination and Montreal Cognitive Assessment (MoCA) scores to screen for MCI. Urine samples of approximately 30 mL were collected from both groups pre- and post-intervention. …

Mixed Emotions: How Lower Courts Misconstrue Transunion And Have Since Created A New Judicially Cognizable Injury For Stand-Alone Emotional Distress, Varun Elangovan

Nebraska Law Bulletin (Selected Issues)

In TransUnion, LLC v. Ramirez, the United States Supreme Court held that “in a suit for damages, mere risk of future harm, standing alone, cannot qualify as a concrete harm—at least unless the exposure to the risk of future harm itself causes a separate concrete harm.” Notably, the Court failed to take a position on what common law analog would suffice as a “separate concrete harm,” and instead, affirmed that an emotional distress injury caused by the risk of future harm may be a sufficient concrete injury. Resultingly, lower courts have construed TransUnion to stand for the proposition that an …

We Are ... Marshall, November 16, 2022, Office Of Marshall University Communications

We Are ... Marshall: the Newsletter for Marshall University 1999-2023

No abstract provided.

Cubesat Power Module Snap-Fit Mechanism, Thomas Nguyen

Honors Capstone Projects and Theses

No abstract provided.

Piety And Politics: The Relationship Between Holiness, Spiritual Formation, And Socio-Political Engagement, Evan Howard

Essays

No abstract provided.

Suffolk Journal, Vol.86, No. 7, 11/16/2022, Suffolk Journal

Suffolk Journal

No abstract provided.

Shiyong Wu Lab Showcases Student Alumna Researchers At American Society For Photobiology Meeting, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Cardiogenic Shock Due To Atrial Arrhythmia As The Initial Presentation Of Transthyretin Cardiac Amyloidosis, Svenja M. Schneider, Kirpal Kochar, Max Ruge, Stefanie Marek-Iannucci, Tanuka Datta, Alexander Hajduczok, Waqas Ullah, Indranee Rajapreyar, Yevgeniy Brailovsky

Jefferson Hospital Staff Papers and Presentations

Atrial arrhythmias are common in transthyretin cardiac amyloidosis (ATTR-CA), with a prevalence of ≤80%. They are often not well tolerated. We describe 3 patients with decompensated heart failure and cardiogenic shock precipitated by atrial arrhythmias who ultimately received diagnoses of ATTR-CA. (Level of Difficulty: Intermediate.)

Sara Jurca, Oral History Interview, 2022, Aaron Hughes

COVID-19 Oral Histories

In October and November of 2022, You Li's Journalism 313 students conducted oral history interviews with one another to document the student experience of the COVID-19 pandemic. In this interview, EMU undergraduate Sara Jurca talks about switching careers, and schools during the pandemic.

Held At Bay: A Case Study Of A Lake Community’S Effort To Prevent A Zebra Mussel Invasion, Benjamin Breske

Department of Environmental Studies: Undergraduate Student Theses

This case study was completed in a lake community in the upper midwestern United States. It seeks to understand the social factors that allowed a lake community to establish an effort to protect against a zebra mussel invasion, as well as the perceptions of the different stakeholders and the steps they took to get the effort going. Rural community action is important for the sustainability of many of the world’s natural resources as these communities are often the first line of defense. Understanding how efforts like this one come together is vital for creating similar efforts elsewhere. I conducted a …

The Significance Of Cephalopod Beaks As A Research Tool: An Update, José C. Xavier, Alexey V. Golikov, José P. Queirós, Catalina Perales-Raya, Rigoberto Rosas-Luis, José Abreu, Giambattista Bello, Paco Bustamante, Juan C. Capaz, Valerie H. Dimkovikj, Angel F. González, Hugo Guímaro, Airam Guerra-Marrero, José N. Gomes-Pereira, Jorge Hernández-Urcera, Tsunemi Kubodera, Vladimir Laptikhovsky, Evgenia Lefkaditou, Fedor Lishchenko

Marine Science

The use of cephalopod beaks in ecological and population dynamics studies has allowed major advances of our knowledge on the role of cephalopods in marine ecosystems in the last 60 years. Since the 1960’s, with the pioneering research by Malcolm Clarke and colleagues, cephalopod beaks (also named jaws or mandibles) have been described to species level and their measurements have been shown to be related to cephalopod body size and mass, which permitted important information to be obtained on numerous biological and ecological aspects of cephalopods in marine ecosystems. In the last decade, a range of new techniques has been …

Office Of Research, Economic Engagement And Outreach Update, November 16, 2022, Office Of Research, Economic Engagement And Outreach

Office of Research, Economic Engagement and Outreach

No abstract provided.

Impact Of Alcohol On Bone Health In People Living With Hiv: Integrating Clinical Data From Serum Bone Markers With Morphometric Analysis In A Non-Human Primate Model, Alexandra Denys, Allison Norman, Daniel S. Perrien, Larry J. Suva, Liz Simon, Lee S. Mcdaniel, Tekeda Ferguson, Kim Pedersen, David Welsh, Patricia E. Molina, Martin J.J. Ronis

School of Medicine Faculty Publications

People living with HIV (PLWH) represent a vulnerable population to adverse musculoskeletal outcomes due to HIV infection, antiretroviral therapy (ART), and at-risk alcohol use. Developing measures to prevent skeletal degeneration in this group requires a grasp of the relationship between alcohol use and low bone mass in both the PLWH population and its constituents as defined by sex, age, and race. We examined the association of alcohol use with serum biochemical markers of bone health in a diverse cohort of PLWH enrolled in the New Orleans Alcohol Use in HIV (NOAH) study. To explore the effects of alcohol on bone …

Vaccinate: Posters From The Covid-19 Pandemic, Aaron Sutherlen, Judy Diamond, Meghan Leadabrand, Julia Mcquillan, St Patrick Reid

Zea E-Books Collection

In 2022 we are living through a global pandemic, and vaccines are one of the most effective strategies for slowing the spread of infectious disease, minimizing symptoms, and lowering healthcare demands. In short, vaccines save lives and can reduce the risk of contagion from social interaction.

In the United States in late 2021, after the vaccines had been broadly available for almost a year, one in five adults still chose not to get vaccinated against COVID-19.

Art can disrupt what is embedded in our minds and open us up to new perspectives and insights. We hope to offer access to …

Remote Sensing Evidence For Significant Variations In The Global Gross Domestic Product During The Covid-19 Epidemic, Bin Guo, Wencai Zhang, Lin Pei, Xiaowei Zhu, Pingping Luo, Weili Duan

Mechanical and Materials Engineering Faculty Publications and Presentations

Coronavirus disease 2019 (COVID-19) has been spreading rapidly and is still threatening human health currently. A series of measures for restraining epidemic spreading has been adopted throughout the world, which seriously impacted the gross domestic product (GDP) globally. However, details of the changes in the GDP and its spatial heterogeneity characteristics on a fine scale worldwide during the pandemic are still uncertain. We designed a novel scheme to simulate a 0.1° × 0.1° resolution grid global GDP map during the COVID-19 pandemic. Simulated nighttime-light remotely sensed data (SNTL) was forecasted via a GM(1, 1) model under the assumption that there …

Sixty Years Of Oceanography And Marine Biology: An Annual Review (Ombar) – A Brief Retrospective And Prospective, Sj Hawkins, A Oven, Ip Smith, Aj Lemasson

School of Biological and Marine Sciences

No abstract provided.

Diet-Derived Metabolites And Mucus Link The Gut Microbiome To Fever After Cytotoxic Cancer Treatment, Zaker I Schwabkey, Diana H Wiesnoski, Chia-Chi Chang, Wen-Bin Tsai, Dung Pham, Saira S Ahmed, Tomo Hayase, Miriam R Ortega Turrubiates, Rawan K El-Himri, Christopher A Sanchez, Eiko Hayase, Annette C Frenk Oquendo, Takahiko Miyama, Taylor M Halsey, Brooke E Heckel, Alexandria N Brown, Yimei Jin, Mathilde Raybaud, Rishika Prasad, Ivonne Flores, Lauren Mcdaniel, Valerie Chapa, Philip L Lorenzi, Marc O Warmoes, Lin Tan, Alton G Swennes, Stephanie Fowler, Margaret Conner, Kevin Mchugh, Tyler Graf, Vanessa B Jensen, Christine B Peterson, Kim-Anh Do, Liangliang Zhang, Yushu Shi, Yinghong Wang, Jessica R Galloway-Pena, Pablo C Okhuysen, Carrie R Daniel-Macdougall, Yusuke Shono, Marina Burgos Da Silva, Jonathan U Peled, Marcel R M Van Den Brink, Nadim Ajami, Jennifer A Wargo, Pavan Reddy, Raphael H Valdivia, Lauren Davey, Gabriela Rondon, Samer A Srour, Rohtesh S Mehta, Amin M Alousi, Elizabeth J Shpall, Richard E Champlin, Samuel A Shelburne, Jeffrey J Molldrem, Mohamed A Jamal, Jennifer L Karmouch, Robert R Jenq

Faculty, Staff and Student Publications

Not all patients with cancer and severe neutropenia develop fever, and the fecal microbiome may play a role. In a single-center study of patients undergoing hematopoietic cell transplant (n = 119), the fecal microbiome was characterized at onset of severe neutropenia. A total of 63 patients (53%) developed a subsequent fever, and their fecal microbiome displayed increased relative abundances of Akkermansia muciniphila, a species of mucin-degrading bacteria (P = 0.006, corrected for multiple comparisons). Two therapies that induce neutropenia, irradiation and melphalan, similarly expanded A. muciniphila and additionally thinned the colonic mucus layer in mice. Caloric restriction …

Slc7a8 Is A Key Amino Acids Supplier For The Metabolic Programs That Sustain Homeostasis And Activation Of Type 2 Innate Lymphoid Cells, Santosh K Panda, Do-Hyun Kim, Pritesh Desai, Patrick F Rodrigues, Raki Sudan, Susan Gilfillan, Marina Cella, Steven J Van Dyken, Marco Colonna

2020-Current year OA Pubs

Group 2 innate lymphoid cells (ILC2) are innate counterparts of T helper 2 (Th2) cells that maintain tissue homeostasis and respond to injuries through rapid interleukin (IL)-5 and IL-13 secretion. ILC2s depend on availability of arginine and branched-chain amino acids for sustaining cellular fitness, proliferation, and cytokine secretion in both steady state and upon activation. However, the contribution of amino acid transporters to ILC2 functions is not known. Here, we found that ILC2s selectively express

University Band & Philharmonic Orchestra

Bailey School of Music Concert Programs

Program for the November University Band & Philharmonic Orchestra performance.

Environmental Drivers Of The First Major Animal Extinction Across The Ediacaran White Sea-Nama Transition, Scott D Evans, Chenyi Tu, Adriana Rizzo, Rachel L Surprenant, Phillip C Boan, Heather Mccandless, Nathan Marshall, Shuhai Xiao, Mary L Droser

Faculty, Staff and Student Publications

The Ediacara Biota-the oldest communities of complex, macroscopic fossils-consists of three temporally distinct assemblages: the Avalon (ca. 575-560 Ma), White Sea (ca. 560-550 Ma), and Nama (ca. 550-539 Ma). Generic diversity varies among assemblages, with a notable decline at the transition from White Sea to Nama. Preservation and sampling biases, biotic replacement, and environmental perturbation have been proposed as potential mechanisms for this drop in diversity. Here, we compile a global database of the Ediacara Biota, specifically targeting taphonomic and paleoecological characters, to test these hypotheses. Major ecological shifts in feeding mode, life habit, and tiering level accompany an increase …