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Articles 21301 - 21330 of 24316
Full-Text Articles in Entire DC Network
Memory Activism And Mexico’S War On Drugs: Countermonuments, Resistance, And The Politics Of Time, Alexandra Délano Alonso, Benjamin Nienass
Memory Activism And Mexico’S War On Drugs: Countermonuments, Resistance, And The Politics Of Time, Alexandra Délano Alonso, Benjamin Nienass
Department of Political Science and Law Faculty Scholarship and Creative Works
The widespread violence in Mexico by state and nonstate actors since the government launched a military strategy against drug cartels in 2006 has generated demands for justice, including spaces of mourning and commemoration that recognize hundreds of thousands of Mexican nationals and migrants from other countries who have been killed or disappeared. Creating memorial spaces for ongoing forms of violence whose perpetrators and victims are hard to define has proven difficult from a bureaucratic, political, and aesthetic perspective. This article examines and contrasts three commemorative and transformative memorial interventions to show that in a context that lacks a clear transition …
Dickens’S Changing Perspective Towards Capitalism And The Bourgeoisie, Christina Oliveira
Dickens’S Changing Perspective Towards Capitalism And The Bourgeoisie, Christina Oliveira
Honors Program Theses
Most scholars agree that author and social activist Charles Dickens (1812-1870) made keen observations on human behavior and societal problems through his works. However, scholars are divided over whether to categorize Dickens and his work as radically reformist or pro-bourgeoisie. Through an analysis of three of Dickens’s texts, A Christmas Carol (1843), Bleak House (1852), and Great Expectations (1861), this thesis demonstrates that Dickens’s works carry contradictory ideologies. As time passes, Dickens becomes disillusioned with capitalism but continues to promote capitalist and bourgeois values and ideologies. The trajectory of Dickens’s views shows the difficulties in imagining different realities outside of …
Essential Role Of Systemic Iron Mobilization And Redistribution For Adaptive Thermogenesis Through Hif2-Α/Hepcidin Axis, Jin-Seon Yook, Mikyoung You, Jiyoung Kim, University Of Nebraska-Lincoln, Rong Fan, Bhanwar Lal Puniya, Tomáš Helikar, Sophie Vaulont, Jean-Christophe Deschemin, Meshail Oklar, Liwei Xie, Manik C. Ghosh, Tracey A. Rouault, Jaekwon Lee, Soonkyu Chung
Essential Role Of Systemic Iron Mobilization And Redistribution For Adaptive Thermogenesis Through Hif2-Α/Hepcidin Axis, Jin-Seon Yook, Mikyoung You, Jiyoung Kim, University Of Nebraska-Lincoln, Rong Fan, Bhanwar Lal Puniya, Tomáš Helikar, Sophie Vaulont, Jean-Christophe Deschemin, Meshail Oklar, Liwei Xie, Manik C. Ghosh, Tracey A. Rouault, Jaekwon Lee, Soonkyu Chung
Department of Nutrition and Health Sciences: Faculty Publications
Iron is an essential biometal, but is toxic if it exists in excess. Therefore, iron content is tightly regulated at cellular and systemic levels to meet metabolic demands but to avoid toxicity. We have recently reported that adaptive thermogenesis, a critical metabolic pathway to maintain whole-body energy homeostasis, is an irondemanding process for rapid biogenesis of mitochondria. However, little information is available on iron mobilization from storage sites to thermogenic fat. This study aimed to determine the iron-regulatory network that underlies beige adipogenesis. We hypothesized that thermogenic stimulus initiates the signaling interplay between adipocyte iron demands and systemic iron liberation, …
Effect Of Human-Animal Interactions On Retail Employees’ Job Satisfaction And Job Performance, Michelle Elizabeth Davis
Effect Of Human-Animal Interactions On Retail Employees’ Job Satisfaction And Job Performance, Michelle Elizabeth Davis
Walden Dissertations and Doctoral Studies
Research has shown that companion animals can have a positive effect on people who suffer from mental and physical illnesses; however, few studies have considered the impact of human-animal interactions (HAIs) on employees in the work environment. This quantitative study investigated the effect of HAIs on 146 employees’ job satisfaction and job performance in three retail environments with a range of potential animal interactions: retail store with no animal presence (none), retail store with occasional animal presence (occasional), and retail store with persistent animal presence (constant). Retail employees’ job satisfaction and performance in each retail setting were assessed using the …
Embracing Dynamic Models For Gene Drive Management, Andrew J. Golnar, Emily W. Ruell, Alun L. Lloyd, Kim M. Pepin
Embracing Dynamic Models For Gene Drive Management, Andrew J. Golnar, Emily W. Ruell, Alun L. Lloyd, Kim M. Pepin
United States Department of Agriculture Wildlife Services: Staff Publications
Robust methods of predicting how gene drive systems will interact with ecosystems is essential for safe deployment of gene drive technology. We describe how quantitative tools can reduce risk uncertainty, streamline empirical research, guide risk management, and promote cross-sector collaboration throughout the process of gene drive technology development and implementation.
Gene drive technologies, although diverse in design and mode of action, are molecular architectures that promote the transmission of genetic information between generations. In theory, the release of one gene-drive-modified organism (GDMO) has the potential to irreversibly alter species, ecosystems, and environmental processes at a global scale (although in practice …
Economic Effects Of Predation By Scaup On Baitfish And Sportfish Farms, Carole R. Engle, Stephen Clements, Brian S. Dorr, J. Brian Davis, Luke A. Roy, Anita M. Kelly
Economic Effects Of Predation By Scaup On Baitfish And Sportfish Farms, Carole R. Engle, Stephen Clements, Brian S. Dorr, J. Brian Davis, Luke A. Roy, Anita M. Kelly
United States Department of Agriculture Wildlife Services: Staff Publications
Fish-eating birds have been found to consume baitfish and sportfish raised on farms in the United States. Understanding the on-farm economic effects of such wildlife conflicts is essential for wildlife management agencies to make informed decisions. Lesser scaup, while not widely considered a fisheating bird, will consume farmed fish. Baitfish and sportfish farms in Arkansas (the major baitfish and sportfish producingstate in the U.S.) were surveyed to gather data on the cost of protecting farm crops from scaup. The values of lost sales revenue from the various species of baitfish and sportfish consumed by scaup were estimated based on a …
Evidence On The Effectiveness Of Small Unmanned Aircraft Systems (Suas) As A Survey Tool For North American Terrestrial, Vertebrate Animals: A Systematic Map Protocol, Jared A. Elmore, Michael F. Curran, Kristine O. Evans, Sathishkumar Samiappan, Meilun Zhou, Morgan B. Pfeiffer, Bradley F. Blackwell, Raymond B. Iglay
Evidence On The Effectiveness Of Small Unmanned Aircraft Systems (Suas) As A Survey Tool For North American Terrestrial, Vertebrate Animals: A Systematic Map Protocol, Jared A. Elmore, Michael F. Curran, Kristine O. Evans, Sathishkumar Samiappan, Meilun Zhou, Morgan B. Pfeiffer, Bradley F. Blackwell, Raymond B. Iglay
United States Department of Agriculture Wildlife Services: Staff Publications
Background: Small unmanned aircraft systems (sUAS) are replacing or supplementing manned aircraft and groundbased surveys in many animal monitoring situations due to better coverage at finer spatial and temporal resolutions, access, cost, bias, impacts, safety, efficiency, and logistical benefits. Various sUAS models and sensors are available with varying features and usefulness depending on survey goals. However, justification for selection of sUAS and sensors are not typically offered in published literature and existing reviews do not adequately cover past and current sUAS applications for animal monitoring nor their associated sUAS model and sensor technologies, taxonomic and geographic scope, flight conditions and …
Rabies Post-Exposure Healthcare-Seeking Behaviors And Perceptions: Results From A Knowledge, Attitudes, And Practices Survey, Uganda, 2013, Sarah C. Bonaparte, Laura Adams, Barnabas Bakamutumaho, Galileu Barbosa Costa, Julie M. Cleaton, Amy Gilbert, Modupe Osinubi, Emily G. Pieracci, Sergio Recuenco, Victor Tugumizemu, Joseph Wamala, Ryan M. Wallace
Rabies Post-Exposure Healthcare-Seeking Behaviors And Perceptions: Results From A Knowledge, Attitudes, And Practices Survey, Uganda, 2013, Sarah C. Bonaparte, Laura Adams, Barnabas Bakamutumaho, Galileu Barbosa Costa, Julie M. Cleaton, Amy Gilbert, Modupe Osinubi, Emily G. Pieracci, Sergio Recuenco, Victor Tugumizemu, Joseph Wamala, Ryan M. Wallace
United States Department of Agriculture Wildlife Services: Staff Publications
Background Rabies is a viral disease of animals and people causing fatal encephalomyelitis if left untreated. Although effective pre- and post-exposure vaccines exist, they are not widely available in many endemic countries within Africa. Since many individuals in these countries remain at risk of infection, post-exposure healthcare-seeking behaviors are crucial in preventing infection and warrant examination.
Methodology A rabies knowledge, attitudes, and practices survey was conducted at 24 geographically diverse sites in Uganda during 2013 to capture information on knowledge concerning the disease, response to potential exposure events, and vaccination practices. Characteristics of the surveyed population and of the canine-bite …
Differing Alterations Of Odor Volatiles Among Pathogenic Stimuli, Patrick Millet, Talia Martin, Maryanne Opiekun, Gary K. Beauchamp, Bruce A. Kimball
Differing Alterations Of Odor Volatiles Among Pathogenic Stimuli, Patrick Millet, Talia Martin, Maryanne Opiekun, Gary K. Beauchamp, Bruce A. Kimball
United States Department of Agriculture Wildlife Services: Staff Publications
Alterations of the volatile metabolome (the collection of volatiles present in secretions and other emanations) that occur in response to inflammation can be detected by conspecifics and chemometric analyses. Using a model system where mouse urinary metabolites are altered by treatment with lipopolysaccharide (found in the outer cell membrane of gram-negative bacteria), we hypothesized that alteration of body odor volatiles will vary according to the pathogen responsible for inducing the inflammation. We tested this hypothesis by treating mice with different immunogens that engage different immune signaling pathways. Results suggest that alterations of body odor volatiles resulting from inflammation do contain …
Using Object-Based Image Analysis To Detect Laughing Gull Nests, Benjamin F. Martini, Douglas A. Miller
Using Object-Based Image Analysis To Detect Laughing Gull Nests, Benjamin F. Martini, Douglas A. Miller
United States Department of Agriculture Wildlife Services: Staff Publications
Remote sensing has long been used to study wildlife; however, manual methods of detecting wildlife in aerial imagery are often time-consuming and prone to human error, and newer computer vision techniques have not yet been extensively applied to wildlife surveys. We used the object-based image analysis (OBIA) software eCognition to detect laughing gull (Leucophaeus atricilla) nests in Jamaica Bay as part of an ongoing monitoring effort at the John F. Kennedy International Airport. Our technique uses a combination of high resolution 4-band aerial imagery captured via manned aircraft with a multispectral UltraCam Falcon M2 camera, LiDAR point cloud data, and …
Impact Of The Histidine‐Containing Phosphocarrier Protein Hpr On Carbon Metabolism And Virulence In Staphylococcus Aureus, Linda Pätzold, Anne-Christine Brausch, Evelyn-Laura Bielefeld, Lisa Zimmer, Greg A. Somerville, Markus Bischoff, Rosmarie Gaupp
Impact Of The Histidine‐Containing Phosphocarrier Protein Hpr On Carbon Metabolism And Virulence In Staphylococcus Aureus, Linda Pätzold, Anne-Christine Brausch, Evelyn-Laura Bielefeld, Lisa Zimmer, Greg A. Somerville, Markus Bischoff, Rosmarie Gaupp
School of Veterinary and Biomedical Sciences: Faculty Publications
Carbon catabolite repression (CCR) is a common mechanism pathogenic bacteria use to link central metabolism with virulence factor synthesis. In gram‐positive bacteria, catabolite control protein A (CcpA) and the histidine‐containing phosphocarrier protein HPr (encoded by ptsH) are the predominant mediators of CCR. In addition to modulating CcpA activity, HPr is essential for glucose import via the phosphotransferase system. While the regulatory functions of CcpA in Staphylococcus aureus are largely known, little is known about the function of HPr in CCR and infectivity. To address this knowledge gap, ptsH mutants were created in S. aureus that either lack the open reading …
Occluded World, Mark Anthony Cayanan
Occluded World, Mark Anthony Cayanan
English Faculty Publications
The poem is part of a manuscript in progress loosely tethered to the Agoo apparitions during the early 1990s.
Search Strategies For “A Meta-Analysis Of The Influence Of Temperature On West Nile Virus Disease Cases”, Hunter Jones, Cynthia M. Schmidt
Search Strategies For “A Meta-Analysis Of The Influence Of Temperature On West Nile Virus Disease Cases”, Hunter Jones, Cynthia M. Schmidt
Search Strategies: Leon S. McGoogan Health Sciences Library
No abstract provided.
Extirpation Risk Of The Endangered Golden Langur (Trachypithecus Geei) Inside And Outside Biological Corridors, Langthel Sub-District, Trongsa, Central District Bhutan, Kuenzang Dorji
All Master's Theses
I assessed extirpation risks of the golden langur (Trachypithecus geei) in two landscapes (inside and outside the biological corridor). Working with a team of trained scientists, I collected data on group size, feeding range, sleeping sites, and predation on golden langurs from Langthel sub-districts, Trongsa district, central Bhutan. I used scan sampling to follow 24 groups of golden langurs (15 groups outside and 9 groups inside the biological corridor) to estimate average group sizes in the two landscapes. I confirmed their sleeping sites and recorded the physiognomies of sleep sites and dimensions of the trees used as sleeping …
Pore Space Property, Joseph Schremmer
Pore Space Property, Joseph Schremmer
Faculty Articles
Through modern technology, we can use the void pore space of underground rock formations for a growing number of socially beneficial purposes. These run the gamut from unconventional oil and gas production to climate change mitigation. The common law of property and tort, however, has struggled to keep up. Significant questions remain about the nature of property rights in pore space. Of particular interest are the limits, if any, on an owner’s right to use pore space for beneficial purposes when it extends beneath the land of another. For example, may A hydraulically fracture an oil well on her property …
The Rediscovered Stages Of Agency Adjudication, Emily S. Bremer
The Rediscovered Stages Of Agency Adjudication, Emily S. Bremer
Journal Articles
Modern administrative law understands the Administrative Procedure Act (APA) to establish an informal and a formal procedural mode of two types of agency action: rulemaking and adjudication. This Article argues that this understanding, which is sound as applied to rulemaking, is wrong as applied to adjudication.
Revisiting the voluminous and long-neglected research that informed the APA, this Article argues the statute codified informal and formal stages—not modes—of adjudication. In this staged process, informal procedures such as investigations, examinations, inspections, and conferences are used in the initial stages of the process and are sufficient to finally dispose of the vast majority …
Quiebres En California, Lilianet Brintrup Hertling
Quiebres En California, Lilianet Brintrup Hertling
Fiction and Poetry
"To write in order to understand” is the motto that propelled the writing of this volume. The four parts of the book portray nature, cities and their inhabitants, in a constant journey between Northern California and Southern Chile. This poetic discourse collects fragments of a life dedicated to travel and to the observation of the natural and cultural environment from the point of view of a traveler who is “just passing by” the Californian territory.
Escribir para entender, fue el moto que impulsó la escritura de este volumen. Las cuatro partes del libro tematizan la naturaleza, las ciudades y sus …
Jack Weatherford. Genghis Khan And The Making Of The Modern World, Ashok Kumar Malhotra
Jack Weatherford. Genghis Khan And The Making Of The Modern World, Ashok Kumar Malhotra
Comparative Civilizations Review
Jack Weatherford’s book Genghis Khan and the Making of the Modern World is divided into three segments. Part one tells the story of Genghis Khan’s birth in 1162, his rise to power on the steppe, and the influence of the steppe in shaping his mindset. Growing up in this wilderness helped fashion the personality which led him to consolidate many warring tribes into a single Mongolian country by 1206. Furthermore, unifying these diverse ethnic groups into a Mongolian nation provided Genghis Khan an excellent model which he replicated in the rest of the world. Part two is devoted to the …
Sustainable Civilization: Informatization Strategy, Andrew Targowski
Sustainable Civilization: Informatization Strategy, Andrew Targowski
Comparative Civilizations Review
The article proposes strategic aspirations for the development of sustainable civilization, which are based on organizing the Geoinformatics Steering System, which will monitor civilizations based on established indexes measuring the state of civilization. This monitoring must have a uniform system on many levels of human organization, from the enterprise (company) to regions, countries, continents and the world. The condition for this organization is the creation of the World Civilization Organization because the current efforts of people and countries are chaotic.
The Human Search For A Sense Of Wholeness, Ross R. Maxwell
The Human Search For A Sense Of Wholeness, Ross R. Maxwell
Comparative Civilizations Review
How can we characterize a civilization? From an economic point of view, a civilization consists of a system of interacting fulltime interdependent specialized occupations. From a cultural point of view, on the other hand, a civilization consists of what Ben Nelson, the late president of the International Society for the Comparative Study of Civilizations (1971-1977), called a civilizational complex, a structure that developed from the blending of multiple cultures.
Editor's Note, Joseph Drew, Editor-In-Chief
Editor's Note, Joseph Drew, Editor-In-Chief
Comparative Civilizations Review
It has always seemed somewhat ironic that the International Society for the Comparative Study of Civilizations has never agreed on the exact definition of the single word arguably most central to its mission: “civilization”.
Virginal Apprehensions Within The Liminal Monastic Space Of The Nun Of Watton, Aimee Alicia Melicher
Virginal Apprehensions Within The Liminal Monastic Space Of The Nun Of Watton, Aimee Alicia Melicher
Theses and Dissertations
The Nun of Watton is a treatise by Ælred of Rievaulx focusing on the scandalous affair of a nun becoming pregnant by a lay brother, and through a series of events is miraculously transformed back into a virgin like state. In my thesis, I will be examining the properties of the space that the nuns of Watton inhabit and how the functions of the space affected the events that occurred by applying Henri Lefebvre’s spatial theory. Additionally, I will be arguing that the Nun received a miraculous abortive churching. Those actions protected the purity of the monastery and the people …
Moving Beyond Thoughts And Prayers: A New And Improved Federal Assault Weapons Ban, Esther Ness
Moving Beyond Thoughts And Prayers: A New And Improved Federal Assault Weapons Ban, Esther Ness
Fordham International Law Journal
No abstract provided.
Tactical Nuclear Weapons Cannot Comply With The Law Of Armed Conflict, Evan Richardson
Tactical Nuclear Weapons Cannot Comply With The Law Of Armed Conflict, Evan Richardson
Fordham International Law Journal
No abstract provided.
Effect Of Mutation And Vaccination On Spread, Severity, And Mortality Of Covid-19 Disease, Dr Hossam Zawbaa, Hasnaa Osama, Ahmed El‐Gendy, Haitham Saeed, Hadeer S. Harb, Yasmin M. Madney, Mona Abdelrahman, Marwa Mohsen, Ahmed M.A. Ali, Mina Nicola, Marwa O. Elgendy, Ihab A. Ibrahim, Mohamed E.A. Abdelrahim
Effect Of Mutation And Vaccination On Spread, Severity, And Mortality Of Covid-19 Disease, Dr Hossam Zawbaa, Hasnaa Osama, Ahmed El‐Gendy, Haitham Saeed, Hadeer S. Harb, Yasmin M. Madney, Mona Abdelrahman, Marwa Mohsen, Ahmed M.A. Ali, Mina Nicola, Marwa O. Elgendy, Ihab A. Ibrahim, Mohamed E.A. Abdelrahim
Articles
Coronavirus disease 2019 (COVID-19) has had different waves within the same country. The spread rate and severity showed different properties within the COVID-19 different waves. The present work aims to compare the spread and the severity of the different waves using the available data of confirmed COVID-19 cases and death cases. Real-data sets collected from the Johns Hopkins University Center for Systems Science were used to perform a comparative study between COVID-19 different waves in 12 countries with the highest total performed tests for severe acute respiratory syndrome coronavirus 2 detection in the world (Italy, Brazil, Japan, Germany, Spain, India, …
Socioeconomic Challenges Of California Strawberry Production And Disease Resistant Cultivars, Julie Guthman, Estelí Jiménez-Soto
Socioeconomic Challenges Of California Strawberry Production And Disease Resistant Cultivars, Julie Guthman, Estelí Jiménez-Soto
School of Geosciences Faculty and Staff Publications
Strawberries are the 4th highest grossing crop in California and supply 90% of US strawberries. But the industry's long reliance on the use of chemical fumigants to control soil disease, nematodes and weeds is being threatened by increased regulation of these fumigants, leading to urgent efforts to develop and test non-chemical alternatives to fumigation, such as disease resistant cultivars. Many of these technologies are promising ecologically, but making them economically viable for growers is more challenging, especially in light of the socioeconomic context of strawberry production in California that has created a state of lock-in for a sustainability transition. This …
Gender In Eastern Mesolithic Europe As Seen Through Grave Clusters, Danielle Norris
Gender In Eastern Mesolithic Europe As Seen Through Grave Clusters, Danielle Norris
Student Scholarship
No abstract provided.
State Changes: Insights From The U.S. Long Term Ecological Research Network, Julie C. Zinnert, Jesse B. Nippert, Jennifer A. Rudgers, Steven C. Pennings, Grizelle González, Merryl Alber, Sara G. Baer, John M. Blair, Adrian Burd, Scott L. Collins, Christopher Craft, Daniela Di Iorio, Walter K. Dodds, Peter M. Groffman, Ellen Herbert, Christine Hladik, Fan Li, Marcy E. Litvak, Seth Newsome, John O’Donnell, William T. Pockman, John Schalles, Donald R. Young
State Changes: Insights From The U.S. Long Term Ecological Research Network, Julie C. Zinnert, Jesse B. Nippert, Jennifer A. Rudgers, Steven C. Pennings, Grizelle González, Merryl Alber, Sara G. Baer, John M. Blair, Adrian Burd, Scott L. Collins, Christopher Craft, Daniela Di Iorio, Walter K. Dodds, Peter M. Groffman, Ellen Herbert, Christine Hladik, Fan Li, Marcy E. Litvak, Seth Newsome, John O’Donnell, William T. Pockman, John Schalles, Donald R. Young
Advanced Science Research Center
Understanding the complex and unpredictable ways ecosystems are changing and predicting the state of ecosystems and the services they will provide in the future requires coordinated, long-term research. This paper is a product of a U.S. National Science Foundation funded Long Term Ecological Research (LTER) network synthesis effort that addressed anticipated changes in future populations and communities. Each LTER site described what their site would look like in 50 or 100 yr based on long-term patterns and responses to global change drivers in each ecosystem. Common themes emerged and predictions were grouped into state change, connectivity, resilience, time lags, and …
Ifn-Β Acts On Monocytes To Ameliorate Cns Autoimmunity By Inhibiting Proinflammatory Cross-Talk Between Monocytes And Th Cells., Javad Rasouli, Giacomo Casella, Larissa Ishikawa, Rodolfo Thome, Alexandra Boehm, Adam Ertel, Carolina R Melo-Silva, Elisabeth R. Mari, Patrizia Porazzi, Weifeng Zhang, Dan Xiao, Luis J. Sigal, Paolo Fortina, Guang-Xian Zhang, A M Rostami, Bogoljub Ciric
Ifn-Β Acts On Monocytes To Ameliorate Cns Autoimmunity By Inhibiting Proinflammatory Cross-Talk Between Monocytes And Th Cells., Javad Rasouli, Giacomo Casella, Larissa Ishikawa, Rodolfo Thome, Alexandra Boehm, Adam Ertel, Carolina R Melo-Silva, Elisabeth R. Mari, Patrizia Porazzi, Weifeng Zhang, Dan Xiao, Luis J. Sigal, Paolo Fortina, Guang-Xian Zhang, A M Rostami, Bogoljub Ciric
Department of Neurology Faculty Papers
IFN-β has been the treatment for multiple sclerosis (MS) for almost three decades, but understanding the mechanisms underlying its beneficial effects remains incomplete. We have shown that MS patients have increased numbers of GM-CSF+ Th cells in circulation, and that IFN-β therapy reduces their numbers. GM-CSF expression by myelin-specific Th cells is essential for the development of experimental autoimmune encephalomyelitis (EAE), an animal model of MS. These findings suggested that IFN-β therapy may function via suppression of GM-CSF production by Th cells. In the current study, we elucidated a feedback loop between monocytes and Th cells that amplifies autoimmune neuroinflammation, …
Collagen Structure-Function Mapping Informs Applications For Regenerative Medicine., James D San Antonio, Olena Jacenko, Andrzej Fertala, Joseph P R O Orgel
Collagen Structure-Function Mapping Informs Applications For Regenerative Medicine., James D San Antonio, Olena Jacenko, Andrzej Fertala, Joseph P R O Orgel
Department of Orthopaedic Surgery Faculty Papers
Type I collagen, the predominant protein of vertebrates, assembles into fibrils that orchestrate the form and function of bone, tendon, skin, and other tissues. Collagen plays roles in hemostasis, wound healing, angiogenesis, and biomineralization, and its dysfunction contributes to fibrosis, atherosclerosis, cancer metastasis, and brittle bone disease. To elucidate the type I collagen structure-function relationship, we constructed a type I collagen fibril interactome, including its functional sites and disease-associated mutations. When projected onto an X-ray diffraction model of the native collagen microfibril, data revealed a matrix interaction domain that assumes structural roles including collagen assembly, crosslinking, proteoglycan (PG) binding, and …