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2017

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The Longevity Of Ceramic Veneers: Clinical Evaluation Of Mechanical, Biological, And Esthetic Performances Of Ceramic Veneers Up To 7-Years Retrospective Study, Rapeepan Monaraks Jan 2017

The Longevity Of Ceramic Veneers: Clinical Evaluation Of Mechanical, Biological, And Esthetic Performances Of Ceramic Veneers Up To 7-Years Retrospective Study, Rapeepan Monaraks

Chulalongkorn University Theses and Dissertations (Chula ETD)

Purpose: To evaluate the longevity and mechanical, biological and aesthetic performance of ceramic veneers placed after 5 to 7 years in service. Materials and Methods: Ceramic veneer restorations were clinically examined following modified from the United States Public Health Service (USPHS) and World Dental Federation (FDI) criteria. Clinical evaluation was performed by two clinicians regarding mechanical, biological and aesthetic performances during maintenance appointments between September 2016 and August 2017. Intra-examiner and inter-examiner reliability were evaluated by calculating the intraclass correlation coefficient and inter-examiner calibration. The results were analysed by Kaplan-Meier survival estimation method and log-rank test at a 95% confidence …

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Host Responses In Peri Implant Tissue In Comparison To Periodontal Tissue, Raviporn Madarasmi Jan 2017

Host Responses In Peri Implant Tissue In Comparison To Periodontal Tissue, Raviporn Madarasmi

Chulalongkorn University Theses and Dissertations (Chula ETD)

The host response in peri-implant tissue may differ from that in periodontal tissue in a healthy individual. The purpose of this study is to investigate the expression of inflammatory cytokines in peri-implant crevicular fluid (PICF)from single implant with two different abutment types in comparison to healthy periodontal tissue. Moreover, the effect of these inflammatory cytokines on the expression of FAK and RANKL were also studied. Nineteen participants with healthy implants and teeth were recruited according to the inclusion and exclusion criteria. PICF and gingival crevicular fluid (GCF) was collected using sterile paper points. The expression level of inflammatory cytokines including …

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Evaluation Of Voids In Class Ii Restorations Restored With Bulk-Fill And Conventional Nanohybrid Resin Composite, Saiisara Chaidarun Jan 2017

Evaluation Of Voids In Class Ii Restorations Restored With Bulk-Fill And Conventional Nanohybrid Resin Composite, Saiisara Chaidarun

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objectives: The aim of the study was to evaluate the influence of four resin composites on voids in small and large Class II cavities. Furthermore, the thickness of the first increment of the restorations was studied. Methods: Eighty artificial lower second premolars were divided into two preparation designs with 40 standardized Class II cavities in each, and then restored with four resin composites (three bulk-fill types: SonicFill 2, Filtek Bulk Fill (capsule), Filtek Bulk Fill (syringe) and a conventional nanohybrid resin composite: Premise). Restorations were sectioned for microscopic evaluation and a Kruskal-Wallis analysis was performed to evaluate the number of …

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Immunohistochemical Assessment Of The Peri-Implant Soft Tissues Around Different Abutment Materials : An Experimental Study In Human, Sirikarn Thongmeearkom Jan 2017

Immunohistochemical Assessment Of The Peri-Implant Soft Tissues Around Different Abutment Materials : An Experimental Study In Human, Sirikarn Thongmeearkom

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objective To evaluate the effect of 4 different types of abutment material, which are titanium, zirconium oxide, gold alloy, and zirconia-coping cemented on titanium-base, on the surrounding soft tissues. Material and Methods Twenty dental implants in posterior edentulous area were randomly divided into 4 groups and inserted 4 types of abutment materials; Titanium, zirconia, gold-alloy, and titanium-base, on the implant installation surgery day. Eight weeks after implant surgery, peri-implant soft tissues around experimental abutments were harvested and split according to implant side; buccal, lingual, mesial, and distal. The specimens were processed through immunohistochemical preparation and stained with CD3, CD20, CD68, …

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Bioactive Clitoria Ternatea L. Flower Extract For The Glycemic Control To Carbohydrate Foods And Sugary Beverages, Charoonsri Chusak Jan 2017

Bioactive Clitoria Ternatea L. Flower Extract For The Glycemic Control To Carbohydrate Foods And Sugary Beverages, Charoonsri Chusak

Chulalongkorn University Theses and Dissertations (Chula ETD)

Clitoria ternatea L. flower, an edible plant containing anthocyanins, has been currently used as the source of natural colorant in foods, beverages and desserts worldwide. The previous report demonstrated its biological properties including antioxidant and antihyperglycemic activity. However, the various concentrations of Clitoria ternatea were used in food and beverages but the effective concentration of Clitoria ternatea on the digestibility of starch and glycemic response remains unknown. In this study, the effects of foods and beverage containing Clitoria ternatea L. flower extract (CTE) on starch digestibility in vitro, postprandial glycemic response and antioxidant capacity in human as well as sensory …

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The Effect Of Nutrition Education Intervention On The Amount Of School Lunch Consumption In Children Aged 3-5 Years: Case Study In Bangkok, Thailand, Hathaichanok Tirapongporn Jan 2017

The Effect Of Nutrition Education Intervention On The Amount Of School Lunch Consumption In Children Aged 3-5 Years: Case Study In Bangkok, Thailand, Hathaichanok Tirapongporn

Chulalongkorn University Theses and Dissertations (Chula ETD)

Low vegetable and fruit intake and micronutrient deficiency has been reported for Thai children aged three to five years. Many nutrition education programs have been recommended to solve these problems, especially for preschool children. This study aims to investigate the effect of the novel nutrition education program on the amount of vegetables, fruit, energy and nutrients consumption in school lunches of children aged three to five years. United for Healthier Kids is a nutrition education program that desires to motivate healthy eating via a set of nutrition education tools by encouraging variety in the types of food consumed, increase vegetables …

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Effect Of Different Cooking Methods On The Bioaccessibility Of Polyphenols And Antioxidant Capacities Of Pakwan Ban (Sauropus Androgynus), Imas Arumsari Jan 2017

Effect Of Different Cooking Methods On The Bioaccessibility Of Polyphenols And Antioxidant Capacities Of Pakwan Ban (Sauropus Androgynus), Imas Arumsari

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study was aimed to assess the effect of different cooking methods on the amounts of phytochemical compounds and antioxidant capacities of sweet leaf (Sauropus androgynus) before and during in vitro simulated gastrointestinal digestion. The optimum cooking time of each cooking method was prior selected according to the total phenolic compounds, the ferric-reductase antioxidant power (FRAP) activity, the color characteristics, the hardness, and the texture preference of cooked sweet leaf samples. Consequently, the sweet leaf samples cooked by boiling for 5 mins or microwaving at 800 watts for 90 sec were compared with raw sweet leaf. The results showed that …

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The Inhibitory Effect Of Anthocyanins-Rich Thai Berries Extracts On Lipid Digestion And Absorption, Netima Chamnansilpa Jan 2017

The Inhibitory Effect Of Anthocyanins-Rich Thai Berries Extracts On Lipid Digestion And Absorption, Netima Chamnansilpa

Chulalongkorn University Theses and Dissertations (Chula ETD)

Dyslipidemia is one of the major risk factor that contributes to chronic diseases such as cardiovascular disease and diabetic mellitus. Anthocyanin-rich Thai berries have been documented to have hypolipidemic activity. However, no scientific data is available regarding the mechanism of lipid lowering property. Thus, the objective of this study was to elucidate the mechanism of action of Thai berries including Prunus domestica L., Antidesma bunius (L.) Spreng, Syzygium cumini (L.) Skeels, Syzygium nervosum A. Cunn. Ex DC, and Muntingia calabura L. on a reduction of lipid digestion and absorption in vitro. Phytochemical compounds of Thai berries, including total phenolic (TP), …

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Preparation And Antimicrobial Activity Of Olive Oil Nanoemulsions, Kusuma Jaemsak Jan 2017

Preparation And Antimicrobial Activity Of Olive Oil Nanoemulsions, Kusuma Jaemsak

Chulalongkorn University Theses and Dissertations (Chula ETD)

Due to their health benefits including antioxidant, anti-inflammatory and also antimicrobial activities, extra virgin olive oil (EVOO) has received much attention in food, cosmetics, and pharmaceutical industries. Nanoemulsions (NEs) solubilize and increase absorption and bioavailability of lipophilic substances (i.e. olive oil). However, there is insufficient data in the formation of olive oil NEs. This study aimed to investigate the formation of oil-in-water NEs containing EVOO using low-energy approach and high-energy approach. NEs were characterized for size, polydispersity and zeta potential after storage at different conditions for up to 180 days. They were determined for antimicrobial susceptibility. From the result, NEs …

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Relationship Between Depression And Metabolic Syndrome In Working Age Population In Bangkok, Matthawan Sujinnapram Jan 2017

Relationship Between Depression And Metabolic Syndrome In Working Age Population In Bangkok, Matthawan Sujinnapram

Chulalongkorn University Theses and Dissertations (Chula ETD)

The objectives of this observational descriptive cross-sectional study were to determine the prevalences of depression and metabolic syndrome and to examine the relationship between depression and metabolic syndrome and dietary pattern in working age people in Bangkok. The samples were 446 participants (123 males and 323 females) aged 20 and over who received an annual health examination 2017. The metabolic syndrome was defined by NCEP ATP III criteria. The data on waist circumference, fasting blood glucose, triglycerides, high-density lipoprotein cholesterol, blood pressure, depression score, and dietary pattern were collected. The relationship between depression and metabolic syndrome and dietary patterns were …

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Microencapsulation Instant Coffee By Spray Drying Using Hydrolysed Konjac Glucomannan, Desi Sakawulan Jan 2017

Microencapsulation Instant Coffee By Spray Drying Using Hydrolysed Konjac Glucomannan, Desi Sakawulan

Chulalongkorn University Theses and Dissertations (Chula ETD)

This research is aimed at finding a suitable wall material from konjac glucomannan to shield antioxidant compounds in coffee extract along with appropriate condition of spray drying to produce microencapsulated instant coffee. There are two steps of study. In the first step, two types of konjac powder (A. muelleri and A. bulbifer) and different concentrations of mannanase enzyme were used to investigate the viscosity reduction of konjac glucomannan hydrolysate (KGMH). It is found that mannanase at 38,000 units per gram substrate was able to lower the viscosity of A. muelleri solution to less than 100 m.Pa.s, while A. bulbifer remained …

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Halophilic Bacteria From Salty Fermented Foods And Its Bacteriocin Encoding Gene Expression To Use As Biocontrol Agent Against Staphylococcus Aureus In Salt Added Foods, Vishal Chhetri Jan 2017

Halophilic Bacteria From Salty Fermented Foods And Its Bacteriocin Encoding Gene Expression To Use As Biocontrol Agent Against Staphylococcus Aureus In Salt Added Foods, Vishal Chhetri

Chulalongkorn University Theses and Dissertations (Chula ETD)

This research was aimed to isolate, select and apply bacteriocin producing halophilic bacteria from salty fermented foods, Plara (Thai traditional salty fermented fish) and soya sauce as bio-control agent in foods. The isolates having inhibitory activity against different strains of Staphylococcus aureus were selected, identified and characterized prior to application as protective starter in food models. Bacterial communities of Plara and soya sauce samples were studied by two methods, a cultural dependent and cultural independent method (Reverse Transcriptase PCR DGGE (Rev-T PCR-DGGE)), and subsequently sequenced by 16s rDNA analysis. Halanaerobium spp. in Plara and Staphylococcus gallinarum in soya sauce were …

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Rapid Quality Determination Of Mulberry Leaf Tea During Storage Using Electronic Nose And Electronic Tongue, Anchalee Ruengdech Jan 2017

Rapid Quality Determination Of Mulberry Leaf Tea During Storage Using Electronic Nose And Electronic Tongue, Anchalee Ruengdech

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study was aimed to develop rapid methods based on electronic nose (e-nose) and electronic tongue (e-tongue) to determine the quality attributes and phytochemicals of mulberry leaf tea. This study was divided into three parts: (1) to determine the effect of cultivar on the quality attributes and phytochemicals of mulberry leaf tea, (2) to evaluate the effect of packaging and storage time on quality attributes and phytochemicals of mulberry leaf tea, and (3) to employ e-tongue combined with chemometrics for prediction of phytochemicals and antioxidant activity of mulberry leaf tea. Mulberry leaf tea prepared from three different mulberry cultivars including …

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Assessment Of Cadmium Migration Into Groundwater In Mae Sot District, Tak Province Using Monte Carlo Technique, Pongsathorn Thunyawatcharakul Jan 2017

Assessment Of Cadmium Migration Into Groundwater In Mae Sot District, Tak Province Using Monte Carlo Technique, Pongsathorn Thunyawatcharakul

Chulalongkorn University Theses and Dissertations (Chula ETD)

Mae Sot is a district in Tak province that confronts Cd contamination within the area. The target organs for Cd exposure was kidneys and skeletal system which could lead to severe health effects such as renal dysfunction, osteoporosis, bone softening, Itai-Itai disease, and lung cancer. The intention of this study was to examine the sorption behavior of nine soil samples in the study area and applied Monte Carlo technique that would increase model efficiency for Cd migration in to the soil profile. Batch adsorption experiments were performed and fitted with the adsorption isotherms as follows: Linear, Langmuir, and Freundlich isotherms. …

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The Effect Of Edta-Application To Heavy Metals Phytoremediation By Vetiver, Ramida Wasino Jan 2017

The Effect Of Edta-Application To Heavy Metals Phytoremediation By Vetiver, Ramida Wasino

Chulalongkorn University Theses and Dissertations (Chula ETD)

Contaminated soil with heavy metals includes Pb, Zn, and Cd were remediated by phytoremediation with vetiver to solved the problem in Thailand. This study compared the ability of two species of vetiver (i.e., Songkhla 3 and Prachuap Khiri Khan) in absorbing Pb, Zn, and Cd in contaminated soils and study the effect of EDTA application. After the experiment, Toxicity Characteristic Leaching Procedure (TCLP) test, Allium test, and seed germination were used to determined the toxicity of remediated soil. In this study, 5 mmol of ethylenediaminetetraacetic acid (EDTA) was used to improve the solubility of heavy metals in soil which leads …

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Pretreatment Prognostic Factors To Predict Survival Outcome In Advanced Non-Small Cell Lung Cancer With First Line Treatment In Thailand: A Retrospective Cohort Study, Sureerat Jaruhathai Jan 2017

Pretreatment Prognostic Factors To Predict Survival Outcome In Advanced Non-Small Cell Lung Cancer With First Line Treatment In Thailand: A Retrospective Cohort Study, Sureerat Jaruhathai

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Tumor genetic information and biologic markers are often used as prognostic factors. However, these have limited applicable in real daily practice due to their high cost . Objective: To evaluate which inexpensive, convenient simple prognostic factors are associated with survival outcome with first line treatment among patients with advanced non-small cell lung cancer (NSCLC). Methods: Retrospectively reviewed the charts of patients diagnosed with having advanced NSCLC with no previous treatment seen at King Chulalongkorn Memorial Hospital and Police General Hospital during 1 January 2008-31 Dec 2013. Results: A total of 301 patients were included in the study; 68.1% males. …

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Coal Combustion Products Utilization For Soil Amendment, Tran Thi Anh Tuyet Jan 2017

Coal Combustion Products Utilization For Soil Amendment, Tran Thi Anh Tuyet

Chulalongkorn University Theses and Dissertations (Chula ETD)

Nowadays, coal has a crucial role in generating energy all over the world. As a result, the consumption of coal creates a huge amount of coal combustion products, including bottom ash and fly ash. The coal ash has the potential characteristics to become a resource material in agriculture such as its texture, water holding capacity, bulk density, pH etc., and contains almost all the essential plant nutrients. However, most of the coal ash created is dumped into the landfill, which is a contributing factor in the environmental degradation. This study wants to use coal ash in agriculture as a way …

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Cost-Effectiveness Analysis Of Aripiprazole Compare With Risperidone In Patient With Autism Spectrum Disorders, Kridsadadanudej Wongwejwiwat Jan 2017

Cost-Effectiveness Analysis Of Aripiprazole Compare With Risperidone In Patient With Autism Spectrum Disorders, Kridsadadanudej Wongwejwiwat

Chulalongkorn University Theses and Dissertations (Chula ETD)

Autism spectrum disorders (ASD) are a group of deficits in social interaction and social communication (American Psychiatric Association, 2013). The result of a study in Thailand found that ASD patients with less self-reliance increased the number of caregivers, indirect costs and total costs (Naruemol Junsamut, 2014). Risperidone and aripiprazole showed the effectiveness for treating irritability/disruptive behavior in ASD (LeClerc & Easley, 2015). The objective of this research was to estimate the cost-effectiveness of aripiprazole compared with risperidone for treating ASD patient. Seven studies were selected to analyze the outcomes of effectiveness utilizing network meta-analysis. The number of improving symptoms that …

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Human Health Risk Assessment Of Cadmium Exposure Through Rice Consumption In Mae Tao, Mae Sot District, Tak Province, Parin Suwatvitayakorn Jan 2017

Human Health Risk Assessment Of Cadmium Exposure Through Rice Consumption In Mae Tao, Mae Sot District, Tak Province, Parin Suwatvitayakorn

Chulalongkorn University Theses and Dissertations (Chula ETD)

Mae Tao sub-district is located in the Mae Tao watershed, an important Cd contaminated area in Thailand. This study was conducted to i) investigate total Cd concentration in rice from households in the Mae Tao sub-district and ii) estimate health risks from Cd exposure through rice consumption. A total number of 159 rice samples were collected from households in all 6 villages of the Mae Tao sub-district. These rice samples were digested with concentrated nitric acid and analyzed by the inductively coupled plasma mass spectrometry (ICP-MS). Biodata information and rice consumption behavior were surveyed from the local residents at the …

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Factors Associated With Infant And Under-Five Mortality In Myanmar, Lal Hrin Mawi Jan 2017

Factors Associated With Infant And Under-Five Mortality In Myanmar, Lal Hrin Mawi

Chulalongkorn University Theses and Dissertations (Chula ETD)

Myanmar is committed to achieve unfinished agenda for reducing child mortality, fourth indicator of Millennium Development Goals (MDGs) and global target to achieve under-five mortality rate 25 per 1000 live births in 2030. Moreover, under-five mortality varies across states and regions within the country and the study aims to explore determinants of mortality across different health care planning zones. The results showed that infants who were breastfed had lower risk of death by 11.7 percent comparison with children who were not, and twin or multiple births were more likely to die by 8.1%. Moreover, short preceding birth interval, mothers with …

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Private Stakeholders’ Perception On Leveraging Provider Payment Methods For Both Public And Private Sectors To Help Meet National Health Goals In Myanmar, Nay Nyi Nyi Lwin Jan 2017

Private Stakeholders’ Perception On Leveraging Provider Payment Methods For Both Public And Private Sectors To Help Meet National Health Goals In Myanmar, Nay Nyi Nyi Lwin

Chulalongkorn University Theses and Dissertations (Chula ETD)

Myanmar has committed to achieving universal health coverage (UHC) by 2030. With a poor economy and scarce resource, the government alone cannot achieve UHC without the collaboration of private stakeholders which has an increasing role in the health sector with evolving political and administrative circumstances. To uplift equitable access to essential quality health care services with financial risk protection and efficiency, the country is eager to know a suitable mix of provider payment methods which can be used as key levers to support achieving UHC goals. This study is designed to explore the private stakeholders' perception on leveraging provider payment …

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Technical Efficiency Of Private Clinics Under Universal Coverage Scheme In Bangkok, Thailand, Pimpitcha Kangyang Jan 2017

Technical Efficiency Of Private Clinics Under Universal Coverage Scheme In Bangkok, Thailand, Pimpitcha Kangyang

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study aimed to measure technical efficiency of 88 private clinics under Universal Coverage Scheme (UC) in Bangkok in fiscal year 2017 and to identify the factors affecting their technical efficiency. The study was divided to two parts. The first part was measuring of technical efficiency with data envelopment analysis (DEA) and the second part was identifying the factors affecting efficiency with regression analysis using Tobit model. The result of DEA under a variable return to scale assumption showed that 84 private clinics under UC (95.45 percent of the target of study) were operating on pure technical efficiency frontier (VRSTE), …

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Cost-Effectiveness Analysis Of Laparoscopic Cholecystectomy Compared With Open Cholecystectomy At A Private Hospital In Myanmar, Pye Paing Heing Jan 2017

Cost-Effectiveness Analysis Of Laparoscopic Cholecystectomy Compared With Open Cholecystectomy At A Private Hospital In Myanmar, Pye Paing Heing

Chulalongkorn University Theses and Dissertations (Chula ETD)

Laparoscopic cholecystectomy (LC) has become the main treatment of uncomplicated gallstone diseases in developed countries due to shorter hospital stay, faster recovery time and other benefits. However, it is still controversial for developing countries. This study aims to evaluate whether laparoscopic cholecystectomy is more cost-effective than open cholecystectomy (OC) in the treatment of gallstone diseases in Myanmar. A cost-effectiveness analysis was evaluated from the provider perspective. The required cost and outcome data were obtained from a private hospital which is located in Yangon, Myanmar. Two outcomes are used as effectiveness in this study, namely cases of complications avoided and cases …

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Factors Influencing Health Care Utilization Among Middle Aged And Elderly People In China, Qilimuge - Jan 2017

Factors Influencing Health Care Utilization Among Middle Aged And Elderly People In China, Qilimuge -

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: China's one-child policy, significant advancement in health care, increase in life expectancy and decrease in birth rate all contribute to rapidly aging society. Proportion of elderly will continue to grow, which will put more burden on an already troubled health care system. This study tries to assess factors influencing health care utilization among middle-aged and elderly people in China. Objective: To analyze factors influencing health care utilization among middle-aged and elderly people in China. Methods: The study used secondary data from the China Health and Retirement Longitudinal Study (CHARLS) 2013 wave survey. The outcomes of interest include outpatient and …

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Technical Efficiency Of Public District Hospitals In Vietnam, Thi Binh Lam Jan 2017

Technical Efficiency Of Public District Hospitals In Vietnam, Thi Binh Lam

Chulalongkorn University Theses and Dissertations (Chula ETD)

The objectives of this study aimed to evaluate the Technical Efficiency of public district hospitals in Vietnam and to determine factors affecting the hospitals' efficiency. Input-Oriented Data Envelopment Analysis (DEA) model was applied to estimate the technical efficiency scores among 52 public district hospitals in 6 provinces of Vietnam in 2014. Then, Tobit regression model was employed to explore the determinant factors. Results of the DEA indicated that there were considerable variations of efficiency scores in terms of return to scale assumptions. The average variable return to scale technical efficiency (VRSTE) and constant return to scale technical efficiency (CRSTE) were …

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Factors Affecting Health Seeking Behavior Of People In Ejin Horo County, China, Yuan Yuan Jan 2017

Factors Affecting Health Seeking Behavior Of People In Ejin Horo County, China, Yuan Yuan

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study aims to explore health seeking behavior in Ejin Horo county, China, specifically it tries to assess how socioeconomic-demographic factors and health literacy affect the decision to use formal outpatient care and conditioning on use the choice among the three-tiered health care facilities visited by people in Ejin Horo county, China during the period of 2016. Our attention is placed on the demand side because Ejin Horo county is the most powerful county in Inner Mongolia and the supply of health services in this county is quite comprehensive. In essence, the study on health seeking behavior will be able …

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Threshold Of Luminance Contrast And Chromaticity Contrast For Subjects Wearing Simulated Low Vision Glasses, Mintra Manavutt Jan 2017

Threshold Of Luminance Contrast And Chromaticity Contrast For Subjects Wearing Simulated Low Vision Glasses, Mintra Manavutt

Chulalongkorn University Theses and Dissertations (Chula ETD)

As reported by WHO in 2010, there are 246 million people with low vision (total population in the world is 6,737 million). The proper environment is important for doing their daily activities not only to be safe and convenient but also to improve the quality of life. This research investigated the threshold of luminance contrast and chromaticity contrast for subjects wearing simulated low vision glasses. The subjests are color normal vision wearing simulated low vision glasses with visual acuity (VA) ranging between 0.05 and 0.3: narrow vision (NV), blur vision (BL), occlusion vision (OLS) and combination of blur and occlusion …

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Effect Of Degradation Of Peg 600 On Color Fading And Crosslinking In Soft Gelatin Capsule Shell, Weena Nittayasoot Jan 2017

Effect Of Degradation Of Peg 600 On Color Fading And Crosslinking In Soft Gelatin Capsule Shell, Weena Nittayasoot

Chulalongkorn University Theses and Dissertations (Chula ETD)

Autoxidation of polyethylene glycol (PEG) 600, which is a hydrophilic liquid commonly filled in soft gelatin capsules, results in formaldehyde which is an oxidizing agent. The objectives of the present study were to study the effect of formaldehyde on fading of brilliant blue dye and crosslinking in the soft gelatin capsules; also to investigate possibility of inhibition of PEG 600 autoxidation by a selected antioxidant. Nine PEG 600 based fill formulations were prepared according to a full factorial design with 2 factors and 3 levels of water (0, 5, 10 %w/w) and an antioxidant, i.e. d-α-tocopherol (0, 0.001, 0.05 %w/w). …

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Application Of Radio Frequency Identification (Rfid) Technology For Tracking The Manufacture Of Narcotic Drugs And Psychotropic Substances: A Case Study Of Phenobarbital Tablets Production, Jesdaporn Rachivong Jan 2017

Application Of Radio Frequency Identification (Rfid) Technology For Tracking The Manufacture Of Narcotic Drugs And Psychotropic Substances: A Case Study Of Phenobarbital Tablets Production, Jesdaporn Rachivong

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study applied RFID tracking of the manufacturing process and tracing back of product for preventing API loss with phenobarbital tablets as a case study. GPO has produced narcotic drugs, and psychotropic substances complied with GMP, Narcotics Act, and Psychotropic Substances Act. It included designing RFID implementation, determining user requirement and functional specification, selecting suitable devices, evaluating significant parameters and verifying the designed system. The verified software was continuously tested in stages of site testing and was assessed the risk with FMEA tool, user's satisfaction and the impact on the manufacturing process. The risk priority class of a plant which …

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Preparation And Stabilization Of X-Ray Amorphous Solid State Structure Of Salbutamol Sulfate Adsorbed On Mesoporous Silica, Treeruk Prasertsri Jan 2017

Preparation And Stabilization Of X-Ray Amorphous Solid State Structure Of Salbutamol Sulfate Adsorbed On Mesoporous Silica, Treeruk Prasertsri

Chulalongkorn University Theses and Dissertations (Chula ETD)

The main objective of this study was to focus on the preparation of X-ray amorphous salbutamol sulfate (SS) with mesoporous silica (S244 silica) carrier by using incipient wetness impregnation approach and further investigated on the utilization of poly (vinylpyrrolidone) (PVP) K12 for the stabilization of amorphous produced. Initially, SS was prepared in solution state and later loaded on S244 silica. The output product showed the non-ordered arrangement of SS with the longer interconversion time to crystalline when comparing with ground amorphous SS. It should be explained that SS was located on the silica surface randomly with no molecular packing according …

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