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The 24th Annual Research Conference Abstract Booklet, Nikki Lynn Rogers

University of Gondar Research Conferences

Staff members, postgraduate and senior undergraduate students of the University, invited guests and speakers participated in the conference. The annual conference of the University is meant to share experiences in research activities among juniors and seniors, staff and students, and invited guests. It is also meant to motivate students and young faculty to engage in research and also to initiate and strengthen interdisciplinary collaborations. The findings of the studies and the resulting recommendations are expected to be used in solving the diverse societal problems we have been facing.

Research activities at the University of Gondar are primarily aimed at solving …

A Review Of The Institute Of Medicine’S Analysis Of Using Chimpanzees In Biomedical Research, Robert C. Jones, Ray Greek

Biomedicine and Animal Models in Research Collection

We argue that the recommendations made by the Institute of Medicine’s 2011 report, Chimpanzees in Biomedical and Behavioral Research: Assessing the Necessity, are methodologically and ethically confused. We argue that a proper understanding of evolution and complexity theory in terms of the science and ethics of using chimpanzees in biomedical research would have had led the committee to recommend not merely limiting but eliminating the use of chimpanzees in biomedical research. Specifically, we argue that a proper understanding of the difference between the gross level of examination of species and examinations on finer levels can shed light on important methodological …

Simulating Influenza Transmission With Network Data, Henry V. Bongiovi

Statistics

Simulating Influenza Transmission with Real Network Data

Henry Bongiovi BS Statistics, California Polytechnic State University, San Luis Obispo

[email protected]

Keywords: Network Data, Simulation, Education, Influenza, Epidemic

Disease has been humanities arch rival since the dawn of our existence. As such, we have been trying our best to understand its spread and proliferation. One of the most common diseases, Influenza, is also one of the most complex. To understand the complexities of its spread would greatly improve our ability to combat it and other diseases like it. Using R in conjunction with the package statnet, I have created a simulation of …

Neuronostatin Inhibits Glucose-Stimulated Insulin Secretion Via Direct Action On The Pancreatic Α-Cell, Alison S. Salvatori, Mollisa M. Elrick, Willis K. Samson, John A. Corbett, Gina L.C. Yosten

Biological Sciences Faculty Research & Creative Works

Neuronostatin is a recently described peptide hormone encoded by the somatostatin gene. We previously showed that intraperitoneal injection of neuronostatin into mice resulted in c-Jun accumulation in pancreatic islets in a pattern consistent with the activation of glucagon-producing α-cells. We therefore hypothesized that neuronostatin could influence glucose homeostasis via a direct effect on the α-cell. Neuronostatin enhanced low-glucose-induced glucagon release in isolated rat islets and in the immortalized α-cell line αTC1-9. Furthermore, incubation with neuronostatin led to an increase in transcription of glucagon mRNA, as determined by RT-PCR. Neuronostatin also inhibited glucose-stimulated insulin secretion from isolated islets. However, neuronostatin did …

Sex-Biased Gene Flow Among Elk In The Greater Yellowstone Ecosystem, Brian K. Hand, Shanyuan Chen, Neil Anderson, Albano Beja-Pereira, Paul C. Cross, Michael Ebinger, Hank Edwards, Robert A. Garrott, Marty D. Kardos, Matt Kauffman, Erin L. Landguth, Arthur Middleton, Brandon Scurlock, P.J. White, Pete Zager, Michael K. Schwartz, Gordon Luikart

United States Geological Survey: Staff Publications

We quantified patterns of population genetic structure to help understand gene flow among elk populations across the Greater Yellowstone Ecosystem. We sequenced 596 base pairs of the mitochondrial control region of 380 elk from eight populations. Analysis revealed high mitochondrial DNA variation within populations, averaging 13.0 haplotypes with high mean gene diversity (0.85). The genetic differentiation among populations for mitochondrial DNA was relatively high (FST = 0.161; P = 0.001) compared to genetic differentiation for nuclear microsatellite data (FST = 0.002; P = 0.332), which suggested relatively low female gene flow among populations. The estimated ratio of male to female …

Spatial Transmission Of 2009 Pandemic Influenza In The Us, Julia R. Gog, Sebastien Ballesteros, Cecile G. Viboud, Lone Simonsen, Ottar N. Bjornstad, Jeffrey Shaman, Dennis L. Chao, Farid Khan, Bryan T. Grenfell

Global Health Faculty Publications

The 2009 H1N1 influenza pandemic provides a unique opportunity for detailed examination of the spatial dynamics of an emerging pathogen. In the US, the pandemic was characterized by substantial geographical heterogeneity: the 2009 spring wave was limited mainly to northeastern cities while the larger fall wave affected the whole country. Here we use finely resolved spatial and temporal influenza disease data based on electronic medical claims to explore the spread of the fall pandemic wave across 271 US cities and associated suburban areas. We document a clear spatial pattern in the timing of onset of the fall wave, starting in …

Beef Export Price Response To Sanitary Status And Traceability Systems: Implications For Paraguay, Silvana Careaga

Master's Theses

Global beef markets are highly influenced by sanitary issues, mainly related to animal health and food safety, which have been determining levels and trends in global beef trade. Food safety issues affecting human health such as bovine spongiform encephalopathy (BSE) associated with Creutzfeldt-Jacob Disease (vCJD) in humans, and other diseases affecting production such as foot and mouth disease (FMD) has encouraged putting these issues to beef trade attention. A way to address these concerns and comply with international standards is the use of traceability systems in order to quickly identify hazard sources and assure beef quality and safety. The goal …

Benchmarks 2014, June 13, The Rockefeller University

BenchMarks 2014

BenchMarks. Friday, June 13, 2014

The community newsletter of The Rockefeller University

BenchMarks is published monthly and is distributed on the campus of The Rockefeller University. It produced by the Office of Communications and Public Affairs

A Metapopulation Model For Sylvatic T. Cruzi Transmission With Vector Migration, Christopher Kribs, Britnee Crawford

Mathematics Faculty Publications - Archive

This study presents a metapopulation model for the sylvatic transmission of Trypanosoma cruzi, the etiological agent of Chagas' disease, across multiple geographical regions and multiple overlapping host-vector transmission cycles. Classical qualitative analysis of the model and several submodels focuses on the parasite's basic reproductive number, illustrating how vector migration across patches and multiple transmission routes to hosts (including vertical transmission) determine the infection's persistence in each cycle. Numerical results focus on trends in endemic [equilibrium] persistence levels as functions of vector migration rates, and highlight the significance of the different epidemiological characteristics of transmission in each of the three regions.

Oligomask: A Framework For Assessing And Removing The Effect Of Genetic Variants On Microarray Probes, Daniel Bottomly, Beth Wilmot, Shannon K. Mcweeney

The R Journal

As expression microarrays are typically designed relative to a reference genome, any individual genetic variant that overlaps a probe’s genomic position can possibly cause a reduction in hybridization due to the probe no longer being a perfect match to a given sample’s mRNA at that locus. If the samples or groups used in a microarray study differ in terms of genetic variants, the results of the microarray experiment can be negatively impacted. The oligoMask package is an R/SQLite framework which can utilize publicly available genetic variants and works in conjunction with the oligo package to read in the expression data …

Who's Your Expert? Use Of An Expert Opinion Survey To Inform Development Of American Psychiatric Association Practice Guidelines., Joel Yager, Robert Kunkle, Laura J. Fochtmann, Sara M. Reid, Robert Plovnick, James E. Nininger, Joel J. Silverman, Michael J. Vergare

Department of Psychiatry and Human Behavior Faculty Papers

OBJECTIVE: For many clinical questions in psychiatry, high-quality evidence is lacking. Credible practice guidelines for such questions depend on transparent, reproducible, and valid methods for assessing expert opinion. The objective of this study was to develop and demonstrate the feasibility of a method for assessing expert opinion to aid in the development of practice guidelines by the American Psychiatric Association (APA).

METHODS: A "snowball" process initially soliciting nominees from three sets of professional leaders was used to identify experts on a guideline topic (psychiatric evaluation). In a Web-based survey, the experts were asked to rate their level of agreement that …

Cayucos Community Health Plan, Jennifer Joyce Franich

Master's Theses

Recent, mounting research shows that chronic disease, the leading causes of death and primary driver of health care costs, cannot be effectively addressed through education or preventative health alone. A physical environment that promotes health—through access to healthy food, opportunities for physical activity, quality housing, transportation options, and safe schools—is an integral part of making our communities healthier. This research and accompanying Healthy Community Plans will serve as a way for the County to begin looking in-depth at the ways the built environment (our streets, parks, and neighborhoods) contribute or detract from the health of the community. Though the creation …

Multipolarity, Intellectual Property, And The Internationalization Of Public Health Law, Sam F. Halabi

Michigan Journal of International Law

The cause of global health today is arguably the most influential human rights movement ever seen, mobilizing vast flows of direct and indirect aid to the developing world to fight disease and build health care infrastructure; prompting the establishment of international organizations like UNAIDS and the Global Fund to fight AIDS, Tuberculosis and Malaria (Global Fund); including global health as a priority in major diplomatic summits; and driving the formation and implementation of international agreements to address global health threats. Champions of this movement claim that the diverse and influential state and non-state actors participating in the development of the …

The Prevalence, Causes, And Relativity Of Dental Anxiety In Adult Patients To Irregular Dental Visits, Balgis O. Gaffar, Adel S. Alagl, Asim A. Al-Ansari

Saudi Medical Journal

OBJECTIVE: To assess the frequency and causes of dental anxiety and their relation to irregular dental visits among adult dental patients. METHODS: The Dental Anxiety Question (DAQ) included within a self-administered questionnaire was distributed to 1025 patients attending the Interns9 Dental Clinics in the Department of Preventive Dental Sciences, College of Dentistry, University of Dammam, Dammam, Kingdom of Saudi Arabia from March 2012 to February 2013. A cross-sectional study design was used. The questionnaire consisted of 22 closed-ended questions divided into 4 sections; 1) demographics, 2) regularity of dental visits, and related causes, 3) DAQ, cancellation of dental appointments, history …

Secretory Iga Is Concentrated In The Outer Layer Of Colonic Mucus Along With Gut Bacteria, Eric W. Rogier, Aubrey L. Frantz, Maria E. C. Bruno, Charlotte S. Kaetzel

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Antibodies of the secretory IgA (SIgA) class comprise the first line of antigen-specific immune defense, preventing access of commensal and pathogenic microorganisms and their secreted products into the body proper. In addition to preventing infection, SIgA shapes the composition of the gut microbiome. SIgA is transported across intestinal epithelial cells into gut secretions by the polymeric immunoglobulin receptor (pIgR). The epithelial surface is protected by a thick network of mucus, which is composed of a dense, sterile inner layer and a loose outer layer that is colonized by commensal bacteria. Immunofluorescence microscopy of mouse and human colon tissues demonstrated that …

From Sea To Shining Sea: Force Health Management Of Infectious Diseases In A Cross-Global Deployment Flux Toward Tropical Environments, Joanna M. Nelms

Master of Public Health Program Student Publications

Infectious diseases in fighting armies are a pestilence as old as war itself. The history of the United States military is rich in successes of innovation and lessons learned in failure in the prevention and treatment of infectious diseases. Over the nearly two and a half centuries of American warfare, military research and development have contributed greatly to advancements in vaccines, medical treatments, and other control and prevention strategies for tropical and other infectious diseases. Current deployments in desert environments have provided continued research and progress in infectious disease control, treatment, and prevention, despite a relative decrease in civilian medical …

Association Between Symptomatic Vulvovaginal Candidiasis And Hiv Rna Levels In Plasma And Genital Secretions Among Women On Haart, Teke Apalata, William H. Carr, Benjamin Longo-Mbenza, Willem A. Sturm, P. Moodley

Publications and Research

Background. Genital tract (GT) inflammation plays a major role in HIV transmission. We aimed to determine the association between symptomatic vulvovaginal candidiasis (VVC) and HIV RNA levels in plasma and GTs of HIV-infected women on highly active antiretroviral therapy (HAART).

Method. Women with VVC on HAART were recruited from a primary healthcare clinic in KwaZulu-Natal Province, South Africa, between June 2011 and December 2011. VVC was diagnosed clinically, supported by Gram staining and culture of genital secretions. HIV RNA load was determined by reverse transcription polymerase chain reaction. CD4+ counts were obtained from patients’ medical records.

Results. Plasma HIV RNA …

The Children Of Spring Street: The Remains Of Childhood In A Nineteenth Century Abolitionist Congregation, Meredith Alyson Berman Ellis

Dissertations - ALL

This dissertation examines the skeletal remains of 75 children interred the burial vaults (1820-1846) of the 19th century Spring Street Presbyterian Church in lower Manhattan. New York City and the 8th Ward neighborhood of the church were rapidly urbanizing and diversifying in the early 19th century. These changes affected how children lived and grew. Family life, institutional involvement, and the city itself are considered as structuring forces that helped shape the skeletal remains of the children that did not survive. This dissertation combines historical data, theoretical models of embodiment and agency, and skeletal data to reconstruct their experiences of growing …

Written Examination Of Geriatric Medicine For Medical Students And Residents: Evaluation On Content Validity, Chih-Hsueh Lin, Yi-Chun Li, Chia-Ing Li, Tsai-Chung Li, Chih-Yi Hsiao, Fang-Mien Tsai, Cheng-Chieh Lin, Ching-Yu Chen

Journal of Medical Education

Objective: The study aimed to construct content-valid item banks of geriatric medicine examination for medical students and residents to assist the development of the computerized geriatric examination system. Methods: In 2011-2013, totally 800 items used in the Taiwan Association of Gerontology and Geriatrics (TAGG) board examinations from 2002 to 2009 were collected. Thirty experts were invited to assess the appropriateness of test items for medical students and residents, while content validity of the items was computed by Lawshe's Content Validity Ratio (CVR) approach. Results: 140 items (mean CVR value = 0.49; ranged from 0.33 to 0.87) for medical students and …

Effect Of Monophasic Pulsed Current On The Treatment Of Plantar Fasciitis, Abdullah Alotaibi

Loma Linda University Electronic Theses, Dissertations & Projects

Background: Plantar fasciitis (PF) is one of the most common soft tissue disorders that causes inferior heel and rear foot pain. Monophasic pulsed current (MPC) is a method of electrical stimulation (ES) clinically used to promote and accelerate wound healing processes. The aim of this prospective clinical trial was to investigate the effect of MPC and MPC coupled with plantar fascia specific stretching exercises (SE) in the treatment of PF. Methods: Forty four participants (twenty- two subjects were women; 22 were men with a mean age of 49 ± 10.6 years) diagnosed with PF were randomly allocated to receive MPC …

Characterization Of Corynebacterium Pseudotuberculosis Biovar Equi Isolates Obtained From Cal Poly Horses And Review Of Application Of Transposons To Better Prevent Pigeon Fever In Horses, Irene Hasen

Animal Science

No abstract provided.

Modeling The Transmission Dynamics Of Typhoid In Malaria Endemic Settings, Steady Mushayabasa, Claver P. Bhunu, Ngoni A. Mhlanga

Applications and Applied Mathematics: An International Journal (AAM)

Typhoid and malaria co-infection is a major public health problem in many developing countries. In this paper, a deterministic model for malaria and typhoid co-infection is proposed and analyzed. It has been established that the model exhibits a backward bifurcation phenomenon. Overall, the study reveals that a typhoid outbreak in malaria endemic settings may lead to higher cumulative cases of dually-infected individuals displaying clinical symptoms of both infections than singly-infected individuals displaying clinical symptoms of either malaria or typhoid.

Therapeutic Effect Of Mercurius Solubilis On Immune Status Of A Borderline Leprosy Case, Dhruba Chakraborty, Amit Dinda, Utpal Sengupta, Pradeep Das, Tuhin Chakraborty, Jogneshwar Sengupta

Indian Journal of Research in Homoeopathy

A Borderline Lepromatous (BL) leprosy case was treated with Mercurius solubilis, a homoeopathic medicine for two years. The clinical, immunological and histological assessment of the patient before and after treatment was recorded. The patient showed appreciable improvement in clinical signs and symptoms. Lesions on the skin almost disappeared; no swelling of hand and feet was noted along with disappearance of infiltration on eye brows. Nodular lesions on both the ear lobes diminished remarkably. Regain of sensation to touch, pain and pressure were noted and their test responses were normal. Slit skin smears were negative from all sites with 0 Bacteriological …

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Against the Grain

No abstract provided.

Food Security: At What Cost? Dietary And Behavioural Coping Strategies Of Low-Income Households In Cairo And Implications On Children’S Food Security, Radwa Saad

Theses and Dissertations

This study explores the dietary and behavioural coping strategies employed by low-income households in urban poverty pockets of Greater Cairo in response to food price fluctuations. It investigates the impact of nutrition-related coping behaviours on the food security of households, focusing namely on children and youth. The study uses qualitative research in the form of in-depth interviews, focus group discussions and key informant interviews with mothers residing in one of the largest informal settlements of Cairo, to arrive at an in-depth analysis of the problem. The research reveals that low-income households employ poor coping strategies in response to high food …

Evaluation Of The Organic-Pollution Based On The Determination Of Some Polycyclic Aromatic Hydrocarbons(Pahs) In Tigris River Water In 2012 At Baghdad City , Iraq, Kamal H. Al-Rubaie, Abdel-Amir M. Fenjan, Wasan A. Mahmood

Baghdad Science Journal

This study aims to predict the organic pollution produced from the presence of some polycyclic aromatic hydrocarbons (PAHs) and determination it's concentrations (µg/L , ppb) in Tigris river water by a collection twenty-seven water samples from a selected three stations with nine sampling sites and three depths of water (5 cm , 2 m and 4 m) each site for 4.6 km distance of a geographic studied area which is located between the ( Al-Senak and AL-Sarrafiah bridges ) at Baghdad city – Iraq on May, 2012. The geographic location was determined with a Global Positioning System (GPS) and Geographic …

Identification Pseudomonas Aeruginosa By 16s Rrna Gene For Differentiation From Other Pseudomonas Species That Isolated From Patients And Environment, Mohammed E. Altaai, Ismail H Aziz, Abeer A. Marhoon

Baghdad Science Journal

Pseudomonas aeruginosa is a common and major opportunistic human pathogen, its causes many and dangersinfectious diseases due to death in some timesex: cystic fibrosis , wounds inflammation , burns inflammation , urinary tract infection , other many infections otitis external , Endocarditis , nosocomial infection and also causes other blood infections (Bacteremia). thereforebecomes founding fast and exact identification of P. aeruginosafrom samples culture very important.However, identification of this species may be problematic due to the marked phenotypic variabilitydemonstrated by samples isolates and the presence of other closely related species. To facilitate species identification, we used 16S ribosomal DNA(rRNA) sequence data …

Hiding The Statute In Plain View: University Of Texas Southwestern Medical Center V. Nassar, Michael J. Zimmer

Nevada Law Journal

No abstract provided.

Cystic Echinococcoses In Mongolia: Molecular Identification, Serology And Risk Factors, Akira Ito, Temuulen Dorjsuren, Anu Davaasuren, Tetsuya Yanagida, Yasuhito Sako, Kazuhiro Nakaya, Minoru Nakao, Oyun-Erdene Bat-Ochir, Tsendjav Ayushkhuu, Narantuya Bazarragchaa, Nyamkhuu Gonchigsengee, Tiaoying Li, Gurbadam Agvaandaram, Abmed Davaajav, Chinchuluun Boldbaatar, Gantigmaa Chuluunbaatar

Harold W. Manter Laboratory of Parasitology: Library Materials

Abstract

Background

Cystic echinococcosis (CE) is a globally distributed cestode zoonosis that causes hepatic cysts. Although Echinococcus granulosus sensu stricto (s.s.) is the major causative agent of CE worldwide, recent molecular epidemiological studies have revealed that E. canadensis is common in countries where camels are present. One such country is Mongolia.

Methodology/Principal Findings

Forty-three human hepatic CE cases that were confirmed histopathologically at the National Center of Pathology (NCP) in Ulaanbaatar (UB) were identified by analysis of mitochondrial cox1 gene as being caused by either E. canadensis (n = 31, 72.1%) or E. granulosus s.s. ( …

Dermatological Manifestations Of Hepatitis C Virus Infection In Saudi Arabia, Mona R. Halawani

Saudi Medical Journal

The Saudi Ministry of Health data indicates that almost 32% of viral hepatitis cases were caused by hepatitis C virus (HCV). It has been widely reported that chronic HCV infection is associated with and may trigger or exacerbate many skin manifestations in 20-40% of patients visiting dermatologists. The most commonly encountered dermatological manifestations of HCV infection globally include mixed cryoglobulinemia, porphyria cutanea tarda, cutaneous and/or oral lichen planus, urticaria, pruritus, thrombocytopenic purpura, and psoriasis. The current article indicates that HCV infection is increasing in Saudi Arabia and approximately 12% of the reported dermatological manifestations are caused by HCV infection. We …