Digital Commons Network^™

Va Dent J July, August And September 2018

Virginia Dental Journal

No abstract provided.

Airborne Fungal Monitoring In Healthcare Environments: A Systematic Review, Dana L. Surwill, Patricia Cruz, Mark P. Buttner, Jennifer R. Pharr, Nancy Lough, Theresa T. Roehr

Environmental & Global Health Faculty Research

Background: Fungal infections pose a significant threat to public health, with over 6.55 million cases and 2.55 million deaths annually. Exposure to fungal spores in indoor environments primarily occurs through inhalation or direct contact with surfaces. Monitoring is critical for early detection and prevention of outbreaks, yet routine airborne fungal testing is not universally mandated across healthcare settings. Methods: A systematic review of peer-reviewed articles from four databases was conducted to identify current airborne fungal monitoring guidelines and best practices for sample collection, culture media, incubation conditions, and results interpretation. Results: Eighteen articles met the inclusion criteria, and four studies …

Eastern Kentucky Drowning: Floods And Relief Efforts, Lynsey Joseph

Honors Theses

This thesis examines the impacts of repeated flash floods in Eastern Kentucky, focusing on the flood events of 2022 and 2025, to understand how environmental conditions, disaster policy, and socioeconomic factors have shaped the community vulnerability and recovery in the region. This research is relevant due to the increased frequency of extreme weather events that have had disproportionate effects on rural and low-income regions. The objective of this thesis is to evaluate the effectiveness of federal disaster response programs like the Federal Emergency Management Agency and to analyze these systems compared to community-based recovery efforts. This was done using a …

Connected Pastors: The Importance Of Having Safe Support Systems In Ministry, Karin A. Hines

Senior Honors Theses

Pastors minister to broken people, but sometimes they need help themselves. Many pastors do not seek help or do not have anyone safe to go to, often for fear of losing their influence or job. This thesis argues that sharing one’s life with safe people is essential, especially for those who are in high-stress professions. It explores pastoral support systems, examines comparable stigmas against seeking help in other fields, analyzes the science of sharing and isolation and their effects on the brain and body, and considers the Bible’s instructions on living in community for one’s personal well-being. Pastors require intentional, …

Randomised Controlled Trial Comparing Antibiotic Cement Bead Pouch Versus Negative Pressure Wound Therapy For The Management Of Severe Open Tibia Fracture Wounds: Beads Versus Vac (Bvv) Protocol, Lucas S Marchand, Gerard Slobogean, Nathan N O'Hara, Anthony D Harris, David W Grainger, Lehana Thabane, Mohit Bhandari, Gregory J Della Rocca, Patrick J Kellam, Robert D Zura, Debra Marvel, Jeffrey L Wells, I Leah Gitajn, Kyle J Jeray, Robert V O'Toole, Zachary M Working, Roman M Natoli, Patrick F Bergin, Jennifer E Hagen, Ashley E Levack, Ernesto Guerra-Farfan, Gregory M Schrank, Joan N Hebden, Franca Mossuto, Cassandra Tsoutsounakis, David Pogorzelski, Hailey Pineda, Sofia Bzovsky, Sheila Sprague, Bvv Investigators

Faculty, Staff and Student Publications

Introduction: Early open fracture management aims to minimise the risk of complications. For the most severe open fracture wounds, multiple irrigation and debridement surgeries are required to overcome severe wound contamination, to reassess the evolving tissue injury or to temporise and plan further surgery. When multiple irrigation and debridement surgeries are needed, uncertainty remains about how the open fracture wound should be managed to best minimise complications. The primary aim of this trial is to compare the antibiotic cement bead pouch vs negative pressure wound therapy in the management of patients with severe open tibia fracture wounds.

Methods and analysis: …

Recommendations Made And Accepted By A Telehealth-Enabled Antimicrobial Stewardship Program Implemented At Rural Veterans Affairs Medical Centers, Taissa A Bej, Jason P Burnham, Joshua D. Nordman, Et Al.

2020-Current year OA Pubs

BACKGROUND: To support Antimicrobial Stewardship programs (ASPs) as well as the clinical care of patients with infections, we disseminated and implemented a Videoconference Antimicrobial Stewardship Team (VAST) to connect multidisciplinary teams from rural Veterans Affairs (VA) medical centers with geographically distant ID experts. Here, we describe the clinical syndromes discussed and the response to recommendations made during VAST sessions.

METHODS: Between September 2021 to February 2024, eight ID consultants established VASTs with ten rural VAMCs, holding regularly scheduled videoconference sessions to discuss clinical cases and provide recommendations. Data were collected on patient demographics, clinical syndromes, and recommendations. Acceptance of recommendations …

Hlafreq: Download And Combine Hla Allele Frequency Data, David A. Wells, Michael Mcauley

Research Outputs: 2025-Present

Human leukocyte antigen (HLA) genes encode cell-surface proteins which play an important role in immunity. Since different HLA alleles enable different immune responses, the population frequency of HLA alleles is often considered when designing vaccines (Gulukota & DeLisi, 1996). Specific HLA alleles have been linked to autoimmune disease (Simmonds & Gough, 2007) and associated with adverse drug reactions (Fan et al., 2017). Further, the success of solid organ and stem cell transplants is related to HLA matching between donor and recipient (Fürst et al., 2019; Morishima et al., 2002). We present HLAfreq, a Python package which can be used to …

Annona Muricata (Soursop) And Hematopoiesis: Ethnomedicinal Insights, Immunomodulatory Mechanisms, And Translational Challenges, Fatma Matano, Amiya Patra

Peninsula Medical School

Annona muricata (soursop) is a tropical medicinal plant widely used in traditional medicine across Africa, the Caribbean, and parts of South America. While its ethnomedicinal applications span a range of conditions, including infections, inflammation, and anemia-related symptoms, its potential relevance to hematopoiesis has not been systematically examined. This narrative review synthesizes ethnomedicinal knowledge, phytochemical composition, and experimental evidence to explore the biological plausibility by which A. muricata may indirectly influence hematopoietic processes. Bioactive constituents of A. muricata, including flavonoids, polyphenols, and acetogenins, have demonstrated antioxidant, anti-inflammatory, and immunomodulatory properties in preclinical models. These effects are particularly relevant given the established …

The Bonds Of Family: A Case Study On Interconnectedness In The Prison-Industrial Complex, Cameron Stone

Binghamton University Undergraduate Journal

Beginning in the 1960s, a rightward shift in politics and “War on Drugs” policies propelled the United States toward mass incarceration. The result was a prison population of around 2 million people, in which minority groups have been disproportionately imprisoned. While historians and legal scholars have examined the policies and legal structures behind mass incarceration, oral historians working in the tradition of social history emphasize the importance of narratives of those most impacted yet traditionally neglected. This paper specifically examines the relatively unstudied Columbia University's 2019 Mass Incarceration oral history collection, which explores the interconnected perspectives of one family’s experience …

Investigating The Effects Of Stress On The Passive Transfer Of Antibodies From Colostrum To The Newborn Calf, Audrey F. Dykes

Animal Science Undergraduate Honors Theses

The objective of the current study was to examine passive transfer of immunoglobulins A (IgA) and G (IgG) to the calf in relation to dam’s fecal cortisol and lactoferrin. In July 2024, late-gestation, Angus crossbred heifers pregnant by artificial insemination (n = 30) were moved to the University of Arkansas Division of Agriculture Stocker Unit and housed in 0.42-ha grass paddocks for each heifer. Calving began in mid-August. Heifers were observed routinely throughout the workday and then at 8 p.m., 12 a.m., and 6 a.m. After calving, the calf was allowed to stand and suckle once then dam sample collection …

Late Hepatitis B Reactivation After Hsct And B-Cell Depleting Therapy: Case Vignettes Challenging Fixed-Duration Prophylaxis, Ariana Cho, Harrison Moses, Muaz Alchirazi, Vishakh Keri, Lea Monday

Conference Presentation Abstracts

Hepatitis B virus (HBV) reactivation remains a critical concern in immunosuppressed oncology and hematopoietic stem cell transplant (HSCT) patients, yet the optimal duration of antiviral prophylaxis is unresolved. Current guidelines recommend 12–18 months of prophylaxis after HSCT or B-cell depleting therapy for patients who are isolated anti-HBc positive, based on documented cases of late reactivation beyond the traditional 12-month threshold. However, these recommendations largely derive from studies in HBsAg-positive patients or those receiving rituximab-containing regimens, with limited data addressing the broader range of high-risk scenarios encountered in practice. We present two vignettes highlighting this gap. Patient 1 is a 60-year-old …

Mycobacterium Chimaera In A Young Patient Without Underlying Cardiac Surgery History, Kate A. Szczesniak, Rakesh Shah, Malitha Hettiarachchi

Conference Presentation Abstracts

Introduction/Objective Mycobacterium chimaera (M. chimaera), within the Mycobacterium Avium Complex (MAC), is a slow-growing nontuberculous mycobacterium (NTM) species that is most often characterized by nonspecific symptoms of night sweats, fever, and fatigue. Due to the nonspecific symptoms of M. chimaera and the rarity of this infection, delayed or misdiagnosis occurs in these patients. Risk factors of contaminated heater-cooler units used in cardiac surgery have been reported; however, cases without this exposure, such as this case, have been cited less commonly. This case of M. chimaera will present a young patient initially presenting with dyspnea who was found to have a …

An Investigation Of Entamoeba Histolytica Chitin Synthases And Other Encystation Factors In Early Encystation, John N. Talledo

All Theses

Entamoeba histolytica is a food-and-water-borne human protozoan pathogen that relies on a two-stage life cycle for successful proliferation outside of the host. E. histolytica exists in its dormant cyst form while outside of its host and converts to the motile trophozoite (amoeba) form in the small intestine. The trophozoites colonize the large intestine to cause symptomatic disease in ~10% of infections, resulting in ~100 million cases of amoebic dysentery each year. Trophozoites can convert back to the cyst form, which is shed in feces to continue the infection cycle.

Currently, there is a lack of understanding of the exact molecular …

Prognostic Predictors Of Developmental And Functional Outcomes In Children With Global Developmental Delay: A Retrospecive Chart Review, Rachel Lynne Kuechle, Sadie Elizabeth Olson, Eliana Hazel Parks, Hailee Lynn Schauer, Mara Marie Vannyhuis, Audrey Elizabeth Whitman

Physical Therapy Scholarly Projects

Background and Purpose: Global developmental delay (GDD) is a broad, global disorder in which children do not reach the appropriate gross and fine motor milestones as expected for their age. GDD’s impact can extend beyond motor skills to include speech and language development, cognitive abilities, social and personal skills, and ADL’s. This study aims to investigate the prognostic predictors of developmental and functional improvement of children with GDD. Our study also examines how the prognosis of children diagnosed with GDD will be affected based on therapeutic intervention in order to offer evidence-based recommendations to support children with GDD and their …

Testing The In Vitro Effectiveness Of Protease Inhibitors Against Histomonas Meleagridis, Evy Belle Hafer

Animal Science Undergraduate Honors Theses

Histomonas meleagridis is a protozoal parasite able to exist in a flagellated or amoeboid form that infects gallinaceous birds, particularly turkeys, and causes significant mortality. There is currently no effective treatment for this disease. The purpose of this study was to assess the anti-histomonal activity of commercially available protease inhibitors, leupeptin, bestatin, and antipain, using an established in vitro model. Three protease inhibitors, leupeptin, bestatin, and antipain, were evaluated across five assays. Treatment groups included: 1) non-treated control, 2) leupeptin 100 µM, 3) bestatin hydrochloride 100 µM, and 4) antipain dihydrochloride 100 µM. Histomonads were enumerated using a hemocytometer after …

The Effects Of Avian Influenza On Consumer Egg Prices In The United States, Jacob B. Franklin

Agricultural Economics and Agribusiness Undergraduate Honors Theses

Outbreaks of highly pathogenic avian influenza (HPAI) create major challenges to poultry supply chains due to the high mortality rates in flocks, leading to disruptions in production and higher costs for producers. Using quantitative data from Federal Reserve Bank of St. Louis, USDA, and National Agricultural Statistics Service, this research analyzes changes in egg production, retail prices, and regional variations throughout the United States for the 2022-2025 HPAI event. A time-series regression model was used to control for production costs, seasonal patterns, and regional differences. All of these measures come together to quantify the impact of HPAI outbreaks on consumer …

Structure Of The Spoiie Protein In Clostridioides Difficile, Robert B. Bauer

Biological Sciences Undergraduate Honors Theses

Clostridioides difficile is an opportunistic pathogen responsible for severe gastrointestinal infection. C. difficile-related infection is extremely prevalent in healthcare facilities, causing roughly 30,000 deaths annually in the United States alone. Its main mechanism of virulence is sporulation, which is directed by the SpoIIE protein. This makes SpoIIE an attractive target for the remedy and prevention of infections. The objective of this study was to analyze its structure using both lab techniques and artificial intelligence modeling. A truncated version of this protein, SpoII∆TM, was expressed and analyzed using optimal conditions previously determined in the lab. SDS-PAGE results and analyses confirmed …

Efficacy Of Tick Sampling Methods In Urban Parks., Emma Staples

College of Arts & Sciences Senior Theses

Amblyomma americanum (Lone star ticks) are parasites and vectors of diseases, including Ehrlichiosis. Questions remain about how an urban environment affects the host-seeking behavior of A. americanum across different life stages and thus the efficacy of different sampling methods. We sought to compare the efficacy of different sampling methods on A. americanum ticks in urban parks during the fall season and explore how the urban heat island (UHI) effect may impact each method’s efficacy. We hypothesized that, where the UHI effect is weaker near the city’s periphery, the CO₂ trapping method would collect more A. americanum adults and nymphs …

Understanding Barriers To Breast Cancer Screening Among Rural Women In South Carolina: A Qualitative Study Using The Idea Model, Israt Jahan

All Theses

Breast cancer screening rates remain low among rural women in South Carolina, leading to higher incidences of late-stage cancer diagnosis. This qualitative study used semi-structured interviews to investigate reasons why many women delay or avoid screenings, even when free screening programs such as the Best Chance Network are available in South Carolina. Guided by the IDEA model, the study explored how women interpret cancer risk, how they seek and trust cancer information, how they understand screening explanations, and what barriers affect their ability to take action. Participants described fear of pain, fear of diagnosis, personal relevance, confusion about the screening …

Ai×Life 2026: Advances In Computational Biology Across Scales For Life & Health Sciences, Suma Mohan S., Devika N. T., Pranavathiyani G.

Conference Proceedings

Book of Abstracts of the International Conference, AIxLife 2026: Advances in Computational Biology Across Scales for Life & Health Sciences, held on 17–18 April 2026, SASTRA Deemed to be University, Thanjavur, Tamil Nadu, INDIA 

About the Conference

Conventional computational biology laid the foundation for biological data analysis through statistical models, algorithms, and curated databases, enabling insights into genes, proteins, and pathways. Today, the integration of artificial intelligence, spanning machine learning, deep learning, and large language models (LLMs) is driving a transformative shift across biological scales, from atomic and molecular interactions to pathways, cellular systems, organisms, and populations.

AI-powered approaches …

Group B Streptococcus In Pregnant Women: Universal Guidelines And Protocols, Dania Presteguin

Undergraduate Honors Thesis Collection

Background: Group B Streptococcus (GBS) is a leading cause of maternal sepsis and neonatal mortality globally. Variability in screening and treatment guidelines influences global disease burden.

Objective: This study uses a cross-national analysis to compare screening and treatment guidelines and their impact on prevalence, screening, intrapartum antibiotic prophylaxis (IAP), and maternal-neonatal clinical manifestations Methodology: A systematic review of secondary literature was conducted using PubMed, Scopus, and CINAHL (2010-2025). Inclusion criteria include maternal GBS colonization and one or more measures of interventions and neonatal infection rates. No geographic or demographic restrictions were applied. A total of 67 studies were screened, and …

Shark Immunology And Its Biomedical Potential: Evolution, Innovation, And The Imperative Of Conservation, Reesha Bhagat

Undergraduate Honors Thesis Collection

This review aims to shed light on a significant ecological deficit and its implications for the future of science and medicine. Sharks possess a uniquely adaptive, cancer-resistant, and evolutionarily refined immune system with transformative biomedical potential, making their conservation a scientific and medical imperative. We are losing something medically irreplaceable, and we don’t even fully understand it yet. Shark conservation is a pressing scientific imperative because sharks are ecologically essential and represent an irreplaceable biomedical resource.

The Effects Of Heat Stress On White Blood Cell Profiles And Antibody Concentrations In Broilers Genetically Selected For Low Water Conversion Ratio Compared To The Modern Random Bred Broiler, Luke B. Janski

Poultry Science Undergraduate Honors Theses

Heat stress (HS) is one of the most significant environmental stressors impacting poultry production worldwide, reducing growth, feed efficiency, welfare, and immune competence. With global temperatures rising, understanding physiological and immunological adaptations to HS is essential for sustainable production. Broiler chickens selectively bred for low water conversion ratio (LWCR) have shown potential for reduced water consumption under environmental challenges; however, their immune resilience under HS conditions compared with modern random-bred (MRB) broilers remains unclear. This study investigated the effects of cyclic HS on red- (RBC) and white- (WBC) blood cells and humoral immunity in LWCR and MRB broilers. Birds were …

Permit Management Guide For Sanitation Projects In Rural Alaska, Cooper Arend

Student Projects for Graduate Degrees

This project examines the permitting management process currently used for rural sanitation infrastructure projects executed by the Alaska Native Tribal Health Consortium (ANTHC) Division of Environmental Health and Engineering (DEHE). These projects are large-scale, federally funded projects requiring numerous permits from federal, state and local agencies with varying requirements and timelines. Despite this complexity, the permitting process relies heavily on informal, experience-based knowledge rather than any formal documentation. A qualitative research approach was used to examine the existing ANTHC workflows, review past project documentation, analyze regulatory materials, and incorporate staff interviews and feedback. Findings from this project indicated that while …

Exploring Google Trends In Assessing Personal Finance Needs For Cooperative Extension Service Programming, Megan Wells

Graduate Theses and Dissertations

The Cooperative Extension Service (CES) relies on systematic needs assessments to guide program development; yet, traditional approaches often depend heavily on stakeholder input and professional judgment, offering limited insight into consumer level needs. This mixed methods study explored Google Trends as a complementary, consumer driven data source for assessing Family Resource Management (FRM) needs within the Arkansas CES. Grounded in Witkin and Altschuld’s three level needs assessment framework and Uses and Gratifications Theory, the study integrated three data sources representing stakeholders, service providers, and consumers: (1) Family and Consumer Sciences (FCS) advisory committee reports, (2) survey of Family Consumer Science …

Is Design A Form Of Caregiving?, Sidney Jordan

Interior Design Capstones

This thesis challenges the traditional hierarchy of clinical architecture, which historically prioritizes patient outcomes while overlooking the practitioner’s human experience. By investigating whether environmental design can act as a form of caregiving, this research addresses the critical gap between the physiological demands of healthcare labor and the holistic needs of the people performing it. The project argues that burnout is not just a result of high-stakes medicine, but is actively produced by physical layouts and a workplace culture that treats providers as parts of a machine rather than valued individuals. The methodological framework utilizes a tri-layered approach to bridge the …

Through The Lens Of Zoology, Madalyn Haun

Interior Design Capstones

Current zoo and sanctuary models often fail to meet the complex psychological, behavioral, and spatial needs of endangered and rehabilitated wildlife, resulting in chronic stress and welfare compromises. Beyond the Cage presents a transformation approach to zoological design, shifting the paradigm from entertainment-based displays to a “welfare-first” philosophy. This book argues that effective captive care requires expansive, species-appropriate habitats that facilitate natural behaviors, rather than merely simulating natural aesthetics. Through the lens of modern zoology, this work explores the implementation of groundbreaking exhibit re-creation, focusing on habitat enlargement, precise climate change control, and innovative environmental enrichment. A central pillar of …

Promoting Influenza Vaccination Among College Students, Wajeeha Khan Valley

Electronic Theses, Projects, and Dissertations

Influenza remains a significant public health concern on college campuses, where high population density, shared living environments, and frequent social interaction increase the risk of viral transmission. Despite the availability of safe and effective influenza vaccines, vaccination rates among college-aged students remain consistently low. Many students underestimate their personal risk for influenza and hold persistent misconceptions regarding vaccine safety, effectiveness, and side effects. The widespread use of social media further influences these attitudes, as misinformation can rapidly spread while credible health messaging often struggles to gain visibility. It is important to eliminate vaccine hesitancy among college students through innovative, behavior-focused …

Determinants Of Hypertension Awareness And Control In Kenya: A Secondary Analysis Of National Survey Data, Alexander K. Davis

Honors Theses

In low- and middle-income countries (LMICs), cardiovascular diseases (CVDs) are prevalent and pose a major concern as the current healthcare systems are oriented primarily towards communicable diseases. The largest contributor to CVDs, hypertension, is a significant issue in Kenya, a model LMIC. Based on previous studies in this lab, high rates of hypertension are present in the region of Kasigau, Kenya. Kasigau is a small region within Taita-Taveta County, Kenya. Traditional risk factors are not necessarily predictive of hypertension in all regions of Kenya. This study aims to address the lack of tested risk factors for hypertension in Kenya and …

Enhancing Food Security In Stann Creek. Belize Using Meat Rabbits, Lindsey Garretson

Crop, Soil and Environmental Sciences Undergraduate Honors Theses

In recent years, food insecurity and the prevalence of hunger have rapidly grown throughout the world, but especially within Latin America and the Caribbean. Along with growing rates of food insecurity and hunger there are increases in medical conditions including negative impacts the functioning of every major organ system, increased rates of mental illness, both overweight and underweight children, wasting in both children and adults, and anemia. Availability and access to healthy, nutritional food options can help lower the risk of these conditions. With these considerations, the goal of this project was to create an all-encompassing manual and construction guide …