Digital Commons Network^™

Identification And Characterization Of An Operon, Msaabcr, That Controls Virulence And Biofilm Development In Staphlococcus Aureus, Gyan S. Sahukhal, Mohamed O. Elasri

Faculty Publications

Background

Community-acquired, methicillin-resistant Staphylococcus aureus strains often cause localized infections in immunocompromised hosts, but some strains show enhanced virulence leading to severe infections even among healthy individuals with no predisposing risk factors. The genetic basis for this enhanced virulence has yet to be determined. S. aureus possesses a wide variety of virulence factors, the expression of which is carefully coordinated by a variety of regulators. Several virulence regulators have been well characterized, but others have yet to be thoroughly investigated. Previously, we identified the msa gene as a regulator of several virulence genes, biofilm development, and antibiotic resistance. We also …

Arthropod Communities And Red-Headed Woodpecker (Melanerpes Erythrocephalus) Habitat Selection, Michael C. Lordon

DePaul Discoveries

Red-headed woodpecker populations are near-threatened. Their habitat selection and reproductive success may be related to the availability of arthropods. We sampled the arthropod community within 0.04 ha plots surrounding known nests and compared these findings to plots without nests in the same fragments of forest or park in Cook County, IL. After 14 days, the traps were recovered, yielding close to 45,000 arthropods across 10 orders. Nest and control site differences were not statistically significant. Differences between park and forest diversity were not statistically significant either, but the greater diversity values in forests were consistent with expectations. We conclude that …

Investigating The Viability Of Two Stenotrophomonas Maltophilia Isolates After Air-Drying, Samantha Lane, Joanna Brooke

DePaul Discoveries

Abstract

Stenotrophomonas maltophilia is a water-borne infectious bacterium that is found in both clinical (hospitals) and non-clinical environments. This human pathogen is commonly recovered from respiratory tract infections. A recent study at a hospital in Taiwan suggested that dry patient charts can serve as a vehicle of transmission of this bacterium⁷. As S. maltophilia is not commonly isolated from dry surfaces, this current study tested the hypothesis that this pathogen can remain viable for some time on a dry surface. This study was designed to determine how long S. maltophilia could remain viable after air-drying by observing …

Disparities Of Sexually Transmitted Infections And Vaccinations Among Young Men Who Have Sex With Men, Aimee Fata

DePaul Discoveries

This study looks at the socio-demographic factors that are associated with vaccination and infection prevalence in a sample of young men who have sex with men (YMSM). Data were collected through a cross sectional questionnaire that surveyed 200 men between the ages of 16 and 24. Results indicated that there was a clustering of sexually transmitted infections (STIs) in the sample, with STIs significantly associated with one another. Also, the demographics of homelessness during the past 12 months and African American showed significant positive associations between STIs and negative associations between vaccinations. Results suggest the need for better access to …

Online Harassment, Defamation, And Hateful Speech: A Primer Of The Legal Landscape, Alice E. Marwick, Ross Miller

Center on Law and Information Policy

This interdisciplinary project focused on online speech directed at women and seeks to provide a primer on (i) what legal remedies, if any, are available for victims of sexist, misogynist, or harassing online speech, and (ii) if such legal remedies and procedures exist, whether practical hurdles stand in the way of victims’ abilities to stop harassing or defamatory behavior and to obtain legal relief. The study concluded that while online harassment and hateful speech is a significant problem, there are few legal remedies for victims. This is partly due to issues of jurisdiction and anonymity, partly due to the protection …

Learning From Networks: Care Transitions, Market Competition, & Community Interventions, Glen P. Mays

Health Management and Policy Presentations

Social network analysis methods offer many avenues of inquiry for studying new developments in health policy and health care delivery. The expanding availability of large linkable electronic clinical and administrative data sources allows for novel SNA applications with dependent data structures. Opportunities include the study of delivery patterns within accountable care organizations (ACOs), and other multi-provider networks, price and quality competition within new health insurance exchanges, and population health effects attributable to complex community-level interventions.

Vitamin D Status And Demographic And Lifestyle Determinants Among Adults In The United States (Nhanes 2001-2006), Yan Cao, Katie L. Callahan, Sreenivas P. Veeranki, Yang Chen, Ying Liu, Shimin Zheng

ETSU Faculty Works

This study looked at risk factors associated with vitamin D levels in the body among a representative sample of adults in the U.S., NHANES III (2001-2006) data were used to assess the relationship between several demographic and health risk factors and vitamin D levels in the body. The Baseline-Category Logit Model was used to test the association between vitamin D level and the potential risk factors age, education, ethnicity, poverty status, physical activity, smoking, alcohol, obesity, diabetes and total cholesterol with both genders. Vitamin D insufficiency and deficiency were significantly associated with age, race, education, physical activity, obesity, diabetes and …

Commodification Of The Female Egg: Stem Cell Technology And The Future, Rachel Ostander

North Carolina Central University Science & Intellectual Property Law Review

No abstract provided.

Bjc Today

BJC Today

No abstract provided.

The Adolescent Female's Lived-Experience Of Obesity, Jamie L. Randall-Arell, Rose Utley

The Qualitative Report

For adolescent girls, negative messages about obesity and body image from society, media, school, family, and peers are plentiful. Yet the lived-experience of obese adolescent girls has rarely been reported in scientific literature. The purpose of this study was to explore the lived-experience of the obese adolescent female and understand the impact of the messages received. A descriptive phenomenological approach was used to conduct face-to-face interviews with eight adolescent girls, age 11-18. Participants were recruited through network sampling and had a body mass index of 30 or more. Merleau-Ponty’s philosophy of embodied perception guided interpretation and data analysis. Seven themes …

Characterizing The Response Of Multidrug-Resistant Klebsiella Pneumoniae Species To The Application Of A Phage Cocktail, Steven Liu

Symposium

Project Summary: The application of bacteriophages to treat bacterial infections is known as phage therapy, which takes advantage of bacteriophage’s natural ability to infect and lyse bacterial hosts. Phages have been shaped by billions of years of evolution to be highly specialized deliverers of bactericidal agents to the cytoplasm of their target bacteria. Ever since discovery of bacteriophages in 1915, phage therapy was recognized as a potentially powerful tool for eliminating bacterial infections. The effectiveness of phage therapy can be increased by creating a mixture of multiple phages to target a wider variety of bacterial strains. Furthermore, phage therapy has …

Nursing Students' Attitude And Knowledge Of Alzheimer's Disease, Michelle Kimzey

Nursing Theses and Dissertations

As the population ages, nurses must be prepared to provide care for the large number of people with Alzheimer's disease (PWAD). Research is limited on nursing students and people with AD, whether nursing education prepares students to care for this population, or the best methods to educate students in an insightful and collaborative environment. The aim of this mixed methods design study was to determine the effects of educational experiences on nursing students' knowledge and attitudes towards people with AD. The qualitative piece identified factors that influenced and explained differences in nursing students' knowledge and attitudes surrounding the care of …

Vaccination Perceptions Of School Employees In A Rural School District, Janelle L. B. Macintosh

Faculty Publications

Background: There continues to be a need for increases in adult vaccination rates, especially among those working in environments which may easily become communicable disease outbreak centers, such as school employees in the school environment. The purpose of this study was to evaluate why rural Utah school employees were non-compliant with the influenza and measles, mumps, and rubella (MMR) vaccines, as well as to identify their view on mandatory vaccination policies.

Methods: A questionnaire was distributed to all school employees in a rural Utah school district. Data analysis included frequencies and measures of central tendency and dispersion for quantitative items …

Environmental Data Analysis And Remote Sensing For Early Detection Of Dengue And Malaria, Md Zahidur Rahman, Leonid Roytman, Abdelhamid Kadik, Dilara A. Rosy

Publications and Research

Malaria and dengue fever are the two most common mosquito-transmitted diseases, leading to millions of serious illnesses and deaths each year. Because the mosquito vectors are sensitive to environmental conditions such as temperature, precipitation, and humidity, it is possible to map areas currently or imminently at high risk for disease outbreaks using satellite remote sensing. In this paper we propose the development of an operational geospatial system for malaria and dengue fever early warning; this can be done by bringing together geographic information system (GIS) tools, artificial neural networks (ANN) for efficient pattern recognition, the best available ground-based epidemiological and …

Refugee Health In Montgomery County: A Retrospective Descriptive Study Of Refugee Health Screening Results From April 2007 - April 2008, Marjan Lyons

Master of Public Health Program Student Publications

Introduction: The top refugee health concerns characteristically are associated with parasitic infections, infectious diseases such as malaria, tuberculosis, and parasites, as well as nutritional deficiencies such as anemia, and malnourishment. Understanding the specific health needs of the refugee population will not only improve the transition of the refugees within the United States healthcare systems, but also improve public health within the community.

Methods: Health records from Public Health - Dayton & Montgomery Country were used to obtain the prevalence of both acute and chronic health conditions within the newly resettled refugee population. There were a total of 193 refugees included …

Newborn Cord Care Is Clean Cord Care As Effective As Antiseptic Agents In Preventing Infection And Decreasing Cord Separation Time?, Jaclynn Carl Bsn, Rn, Amy Hess Bsn, Rn, Felicia Mazzoni Bsn, Rn

Patient Care Services / Nursing

No abstract provided.

Bladder Cancer Versus Hemorrhagic Cystitis: A Case Of Mistaken Identity In A 34-Year-Old Male Undergoing Therapy For Granulomatosis With Polyangiitis, Jonathan Amatruda, Kevin D. Dieckhaus, Poornima Hegde, John A. Taylor Iii

Articles - Patient Care

A 34-year-old male was referred for management of bladder cancer noted on workup for gross hematuria and new-onset irritative voiding symptoms. The patient's history was significant for recently diagnosed granulomatosis with polyangiitis for which he was undergoing treatment with oral cyclophosphamide and corticosteroids. Cystoscopy revealed lesions suspicious for malignancy, but the patient was diagnosed with hemorrhagic cystitis secondary to BK virus infection upon cytology review, and immunostaining confirmed a polyomavirus infection of the urothelium. The patient's symptoms resolved after a modification of his immunosuppressive regimen, and antiviral therapy was ultimately unnecessary. Though symptomatic BK virus infection of the genitourinary tract …

Genome-Wide Analysis Of Regulatory Proteases Sequences Identified Through Bioinformatics Data Mining In Taenia Solium, Hong-Bin Yan, Zhong-Zi Lou, Li Li, Paul J. Brindley, Yadong Zheng, Xuenong Luo, Junling Hou, Aijiang Guo, Wan-Zhong Jia, Xuepeng Cai

Microbiology, Immunology, and Tropical Medicine Faculty Publications

Background

Cysticercosis remains a major neglected tropical disease of humanity in many regions, especially in sub-Saharan Africa, Central America and elsewhere. Owing to the emerging drug resistance and the inability of current drugs to prevent re-infection, identification of novel vaccines and chemotherapeutic agents against Taenia solium and related helminth pathogens is a public health priority. The T. solium genome and the predicted proteome were reported recently, providing a wealth of information from which new interventional targets might be identified. In order to characterize and classify the entire repertoire of protease-encoding genes of T. solium, which act fundamental biological roles in …

Host Species Restriction Of Middle East Respiratory Syndrome Coronavirus Through Its Receptor, Dipeptidyl Peptidase 4, Neeltje Van Doremalen, Kerri L. Miazgowicz, Shauna Milne-Price, Trenton Bushmaker, Shelly Robertson, Dana Scott, Joerg Kinne, Jason S. Mclellan

Dartmouth Scholarship

Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in 2012. Recently, the MERS-CoV receptor dipeptidyl peptidase 4 (DPP4) was identified and the specific interaction of the receptor-binding domain (RBD) of MERS-CoV spike protein and DPP4 was determined by crystallography. Animal studies identified rhesus macaques but not hamsters, ferrets, or mice to be susceptible for MERS-CoV. Here, we investigated the role of DPP4 in this observed species tropism. Cell lines of human and nonhuman primate origin were permissive of MERS-CoV, whereas hamster, ferret, or mouse cell lines were not, despite the presence of DPP4. Expression of human DPP4 in nonsusceptible BHK and …

Research Briefs, Unlv Innovation Staff Writer

UNLV Innovation

• UNLV Leads $20 Million Project on Solar Energy-Water Nexus
• UNLV to Receive $20.3 Million NIH Grant to Support Clinical and Bench-to-Bedside Research
• Fossilized Remains of Extinct Wolf Species Discovered In Nevada
• Physicist Seeks to Build a Safer, More Efficient Lithium-ion Battery
• Study: Elevated Levels of Lead Found in Mexican Hot Sauces
• Extreme Climate Change Linked to Early Animal Evolution

(Remember) The Future: The Preemptive Governance Of Memory In The Age Of Mass Catastrophe, Kimberly J. Cunningham

Dissertations, Theses, and Capstone Projects

This study is a critical engagement with the preemptive turn in post-biopolitical governance in psychotherapies to treat traumatic memory and its related clinical diagnosis, post traumatic stress disorder (PTSD), in the wake of the mass disasters of the 21st century. Emerging in the post-911 era of increased anticipatory action in the governance of populations and also, increasingly ubiquitous and large scale threat such as global recession, climate change, and terrorism/war, traumatic memory of these events is framed increasingly as a population-level contagion to be addressed by anticipatory action. A study of trends in emerging and favored psychotherapies for trauma post-911 …

The Revolving Door Pattern Of Jail Incarceration And Homelessness And Its Influence On Mortality And Morbidity Among New York City Adults, Sungwoo Lim

Dissertations, Theses, and Capstone Projects

Objectives

The purpose of this dissertation study was to identify timing and sequencing of jail incarceration and homelessness by utilizing sequence analysis and to test whether a particular trajectory contributes to mortality risk and discontinuity of HIV care.

Methods

The main data source was an existing matched dataset, constructed using administrative data from the New York City (NYC) Departments of Health and Mental Hygiene, Correction, and Homeless Services. The study cohort consisted of 15,620 NYC adults with recent histories of both jail incarceration and homelessness. Monthly experiences of jail incarceration, homelessness, and community-dwelling in 2001-03 were summarized into trajectory groups …

An Asian Origin Of Virulent Aeromonas Hydrophila Responsible For Disease Epidemics In United States-Farmed Catfish, Mohammad J. Hossain, Dawei Sun, Donald J. Mcgarey, Shannon Wrenn

Faculty Articles

Unlabelled: Since 2009, catfish farming in the southeastern United States has been severely impacted by a highly virulent and clonal population of Aeromonas hydrophila causing motile Aeromonas septicemia (MAS) in catfish. The possible origin of this newly emerged highly virulent A. hydrophila strain is unknown. In this study, we show using whole-genome sequencing and comparative genomics that A. hydrophila isolates from diseased grass carp in China and catfish in the United States have highly similar genomes. Our phylogenomic analyses suggest that U.S. catfish isolates emerged from A. hydrophila populations of Asian origin. Furthermore, we identified an A. hydrophila strain isolated …

From The Bx To A Ba: Latino Male Students And The Transition From High School To College, Alejandro Eduardo Carrion

Dissertations, Theses, and Capstone Projects

This study aims to provide a counter narrative to the deficit filled discourse surrounding Latino males by informing teachers, policymakers and researchers of the barriers and resources encountered by this population as they make the transition from high school to college. A qualitative research design was utilized for this study, which focused on 10 Latino males who mainly identified as Puerto Rican and Dominican, from the Bronx. Bourdieu's Theory of Practice, and his theoretical tools of field (structures), habitus (dispositions) and capital (social, cultural and economic), was used as the theoretical framework guiding this study. Participants shared the nuances of …

The Lived Experiences Of Nurses Caring For Dying Pediatric Patients, Danna Leigh Curcio

Dissertations, Theses, and Capstone Projects

The purpose of this research study was to explore the lived experiences of nurses caring for dying pediatric patients. Nurses and health care professionals may at times have difficulty adjusting and processing when life ends and this may have the potential to interfere with patient care. Reflection on past events and actions enable critical discovery of strategies to benefit both nurses and patients. The method for conducting this research study was from a qualitative phenomenological perspective exploring the lived experiences of nurses caring for dying pediatric patients. The philosophical underpinning of Merleau-Ponty (2008), in combination with the research method of …

The Lived Experience Of Young Adult Burn Survivors' Use Of Social Media, Marie S. Giordano

Dissertations, Theses, and Capstone Projects

The purpose of this phenomenological study was to illuminate the meaning of social media use by young adult burn survivors. Five females and four males, aged 20-25, who sustained burns > 25%, were interviewed. Van Manen's (1999) phenomenological methodology provided the framework for this study. The meaning of the context of the lived experience is described in the five essential themes of identity, connectivity, social support, making meaning, and privacy. These young adult burn survivors, having experienced the traumatic effects of a burn during adolescence, use social media as a way of expressing their identity, while being cautious about privacy. Part …

Oxidation Of Cellular Amino Acid Pools Leads To Cytotoxic Mistranslation Of The Genetic Code, Tammy J. Bullwinkle, Noah M. Reynolds, Medha Raina, Adil Moghal, Eleftheria Matsa, Andrei Rajkovic, Huseyin Kayadibi, Farbod Fazlollahi, Christopher Ryan, Nathaniel Howitz, Kym F. Faull, Beth A. Lazazzera, Michael Ibba

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Aminoacyl-tRNA synthetases use a variety of mechanisms to ensure fidelity of the genetic code and ultimately select the correct amino acids to be used in protein synthesis. The physiological necessity of these quality control mechanisms in different environments remains unclear, as the cost vs benefit of accurate protein synthesis is difficult to predict. We show that in Escherichia coli, a non-coded amino acid produced through oxidative damage is a significant threat to the accuracy of protein synthesis and must be cleared by phenylalanine-tRNA synthetase in order to prevent cellular toxicity caused by mis-synthesized proteins. These findings demonstrate how stress …

Chronic Illness And Disasters: Development Of A Theoretical Framework, Jacqueline K. Owens, Donna S. Martsolf

The Qualitative Report

In a disaster, individuals with chronic illnesses risk poor outcomes. This grounded theory study sought to develop a framework that describes how these individuals manage health-related challenges during disasters. The five phases of disaster response (non-disaster, pre-disaster, impact, emergency, reconstruction) and the individual, local, state, and federal level model served as conceptual frameworks. Using purposive sampling, 30 individuals with chronic illnesses and 10 lay caregivers were recruited from Florida and New Orleans. Data sources included interviews and media data. Constant comparative analysis techniques were used to build the theoretical framework. Transcript analysis suggested that participants used four unique ways to …

Clinical Informatics: A New Paradigm For Advances In Biomedical Informatics, B.W. Trevor Rohm, C.E. Tapie Rohm

Communications of the IIMA

The medical informatics field is going through a rapid change. The current model used is one of patient to physician, with information technology as a value added segment. However, with rapid developments in hardware and software, innovations in the medical informatics field can take a quantum leap forward by changing its basic model of thinking. The evolving field of medical informatics is giving way to new developments in clinical informatics. With clinical informatics comes the natural progression to patient centered care, and patient access, to a plethora of online information. A new model is proposed of patient to information technology …

Progress Notes, Lehigh Valley Health Network

Progress Notes

No abstract provided.