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The Search, The Jackson Laboratory

Search Magazine

No abstract provided.

Overcoming The “Dual-Delivery” Stigma: A Review Of Patient-Centeredness In The Costa Rica Medical Tourism Industry, Alicia Mason

Faculty Submissions

Due to the growing globalization of health care and an increase in access to technology many consumers are utilizing the World Wide Web for securing medical services abroad, a phenomenon commonly known as medical tourism. The current investigation employs an emic cultural approach for analyzing the Western concept of patient-centeredness within several public and private medical facilities within Costa Rica. Through a detailed field investigation and personal interviews with directors of Costa Rica’s largest accrediting institutions (AAAAF and ProMed), hospital organizations, and private health clinics an interpretative framework for evaluating patient-centeredness and quality of care is offered. Discussion, implications, and …

Septic Arthritis Of The Shoulder In A Dental Patient - A Case Report And Review, Elana Dolin Dmd, Leigh D. Perlmutter Dmd, Stuart L. Segelnick Dds, Mea A. Weinberg Dmd, Robert Schoor Dds

Individual Scholarship

Septic arthritis of the glenohumoral joint is rare following dental procedures, comprising approximately 3% of all joint infections. Septic arthritis following bacteremia from dental procedures is uncommon and generally occurs in prosthetic joints. Predisposing causes may include immunocompromising diseases such as diabetes, HIV infection, renal failure and intravenous drug abuse. We report a rare case of unilateral glenohumoral joint septic arthritis in a 60-year-old male patient (without a prosthetic joint) secondary to a dental procedure. The insidious nature of the presentation is highlighted. Septic arthritis infections, though rare, require a high level of clinical suspicion. Vague symptoms of shoulder pain …

Prevalence And Phenology Of White-Nose Syndrome Fungus Pseudogymnoascus Destructans In Bats From Poland, Konrad Sachanowicz, Arkadiusz Stępień, Mateusz Ciechanowski

KIP Articles

Pseudogymnoascus destructans (Pd), a parasitic fungus (being responsible for a disease known as white-nose syndrome, WNS) that caused mass mortality of cave-dwelling, hibernating bats in North America, appears to be native of Europe, where it also occurs on wintering bats, but no similar outbreaks of WNS have been recorded. Herein, we provide the first account on prevalence and phenology of P. destructans in Poland. Bats were counted once per month, from October or January to May (2010-2013), in an abandoned ore mine in southern Poland. Presence of P. destructans in two samples was confirmed by sequencing of isolated fungal DNA. …

Presumed Imminence: Judicial Risk Assessment In The Post-9/11 World, Avidan Y. Cover

Cardozo Law Review

Court opinions in the terrorism context are often distinguished by fact-finding that relates to risk assessment. These risk assessments - inherently policy decisions - are influenced by cultural cognition and by cognitive errors common to probability determinations, particularly those made regarding highly dangerous and emotional events. In a post-9/11 world, in which prevention and intelligence are prioritized over prosecution, courts are more likely to overstate the potential harm, neglect the probability, and presume the imminence of terrorist attacks. As a result, courts are apt to defer to the government and require less evidence in support of measures that curtail civil …

Comparative Analysis Of Gingival Tissue Antigen Presentation Pathways In Ageing And Periodontitis, Octavio A. Gonzalez, Michael John Novak, Sreenatha S. Kirakodu, Luis Orraca, Kuey-Chu Chen, Arnold J. Stromberg, Janis Gonzalez-Martinez, Jeffrey L. Ebersole

Center for Oral Health Research Faculty Publications

AIM: Gingival tissues of periodontitis lesions contribute to local elevations in mediators, including both specific T cell and antibody immune responses to oral bacterial antigens. Thus, antigen processing and presentation activities must exist in these tissues to link antigen-presenting cells with adaptive immunity. We hypothesized that alterations in the transcriptome of antigen processing and presentation genes occur in ageing gingival tissues and that periodontitis enhances these differences reflecting tissues less capable of immune resistance to oral pathogens.

MATERIALS AND METHODS: Rhesus monkeys (n = 34) from 3 to 23 years of age were examined. A buccal gingival sample from healthy …

The Accelerator, Volume 7 Issue 13, Spring 2014, Christa Santos

The Accelerator

No abstract provided.

Gsbs News, Spring 2014, Graduate School Of Biomedical Sciences, University Of Texas Health Science Center At Houston/M.D. Anderson Cancer Center

GSBS News

Cover image by artist Syd Moen; Benefactor News: Smithville fundraiser supports GSBS fellow; New endowment to support MD/PhD Program; Coming full circle: developing and promoting a Core Curriculum; Celebrating 50 Years of Excellence: GSBS Alumni All-Stars shine at Super Panel and 2013 Reunion; Faculty Membership Report; Faculty News: Dr. Vicki Knutson retires; GSBS Outreach Council hosts community Science Night; Student News; 2013-2014 Student Awards; Alumni News; Message to Alumni

The Research Express

Research Express Newsletter

• Research Symposium Success!
• The National Institute of Health Announces Major Change in Policy on Resubmission of Unsuccessful Grant Applications
• The National Institute of Allergy and Infectious Diseases (NIAID) – Ten Steps to a Winning R01 Application
• 2014 NOSORH Grant Writing Institute: Beyond the Basics – Online Course – Registration open now through July 3rd.

Direct V. Indirect Exposure To Trauma: An Insight To Officer Coping Mechanisms, Marybel Cortez

McNair Scholars Research Journal

Police officers serve a vital role in our communities and face particularly acute trauma and stress in the execution of their jobs. Therefore, it is critical to fully understand how police officers react in these situations. Studies have shown that officers endure a distinctive source of stress and are presented with the risk of exposure to traumatic events. Chopko & Schwartz (2012) surveyed 183 officers and found that more than 30% displayed symptoms of PTSD; however, this study focused on direct exposure to trauma. The current study expands this previous research to study the effects of indirect experiences of trauma. …

Ursinus Magazine, Spring / Summer 2014, Wendy Greenberg, Kathryn Campbell, Ellen Labrecque, Jennifer Meininger Wolfe, Bobby Fong, Olivia Frymark, Joshua C. Walsh, Erika Compton, Sara Sherr, Matt Kozusko

Ursinus Magazine, 1995–Present

Letter from the President • Start-ups compete for prize money • Preventing a pandemic • The Richard T. Schellhase Essay Prize in Ethics • It's official: Peace Corps preparatory program begins • Ursinus welcomes four new members to Board of Trustees • Greetings from Ursinus: Hollywood comes to campus • Athletics: Deep in talent, men's lacrosse just miss conference playoffs; Hill is standout on men's golf team; Rebuilding year for women's golf team; Baseball, a comeback for the ages • The arts • "Ursinus gave us a sense of community" • Watson winner hopes for global connection of black male …

The Osprey, Spring 2014, The Osprey Staff

Osprey

The student magazine of Cal Poly Humboldt.

A Genetic Basis For Differential Survival Of Escherichia Coli In The Environment, Chelsea Kliebert

Honors Capstones

No abstract provided.

Protecting Human Health And Stewarding The Environment: An Essay Exploring Values In U.S. Environmental Protection Law, Tracy Bach

Michigan Journal of Environmental & Administrative Law

The purpose of this conference is to explore “the relationship between environmental protection and public health and how it should inform our efforts to become better stewards of the environment.” No one would disagree with the assertion that during the last forty years of federal environmental protection, air and water quality have improved and led to concomitant improvements in human health. Exploring the contours of this “relationship,” Environmental Protection Agency (EPA) Administrator Gina McCarthy said in her keynote speech that “[t]he thing is, the word ‘relationship’ is too neutral. The link between the health of our planet and the health …

Voices Raised, Issue 44, University Of Dayton. Women's Center

Women’s Center Newsletter

Included in this issue: The 2014 Miryam Award; Campus to Career 2014; I Hate Bullies; Have you made your graduation “bucket list?”; Sinus Infections; Inspiration Station; Female Flyers – Consistent Leaders On and Off the Court; UD alumnae among 2014’s Top 25 Women to Watch.

Cd8Α Dendritic Cells Drive Establishment Of Hsv-1 Latency, Kevin R. Mott, Sariah J. Allen, Mandana Zandian, Bindu Konda, Behrooz G. Sharifi, Clinton Jones, Steven L. Wechsler, Terrence Town, Homayon Ghiasi

School of Veterinary and Biomedical Sciences: Faculty Publications

It is generally accepted that CD8 T cells play the key role to maintain HSV-1 latency in trigeminal ganglia of ocularly infected mice. Yet, comparably little is known about the role of innate immunity in establishment of viral latency. In the current study, we investigated whether CD8α DCs impact HSV-1 latency by examining latency in the trigeminal ganglia (TG) of wildtype (WT) C57BL/6 versus CD8α^‒/‒ (lack functional CD8 T cells and CD8α⁺ DCs), CD8β^‒/‒ (have functional CD8α⁺ T cells and CD8α⁺ DCs), and β2m^‒/‒ (lack functional CD8 T cells but have CD8α^{+ …}

Effects Of Antibiotics & Antifungals On Isolated Porcine Vasculature, Kathryn Young

Honors Projects

No abstract provided.

Debaryomyces Hansenii: A Foodborne Yeast That Produces Anti- Candida Killer Toxin, Nabaraj Banjara

Department of Food Science and Technology: Dissertations, Theses, and Student Research

Candida yeasts are commensal members of the gastrointestinal, mucosal, oral and vaginal microbiota. Candida albicans and C. tropicalis can be found as a part of the normal human commensal flora, especially in all sections of the gastrointestinal tract. However, when the host defense system and microbiota are disturbed, Candida can become pathogenic and cause severe infection or candidiasis. Antifungal drugs used to treat candidiasis have been shown to result in treatment failures due to drug toxicity and/or development of resistance during long term antifungal therapy and, in recent years, the incidence of Candida infections has increased dramatically due to the …

Are Mass Screenings An Effective Diagnostic Tool For Chlamydia?, Shari Forschen

Theses and Dissertations

Chlamydia Trachomatis infection has historically been a focus of primary health of adolescents and young adults in the age group between 15-24 years of age. Satterwhite et al. (2013) report sexually transmitted infections (ST!) are disproportionately larger amongst adolescent groups than adults. STI's are growing in a day and age where health promotion and disease prevention are at the forefronts of the minds of many providers. Chlamydia infections within the United States have increased nationally. Most recent statistics from the Centers for Disease Control and Prevention (CDC, 2013) indicate that in 2001 the chlamydia rates for women were 429.6/100,000 population …

Premedical Programs Newsletter, April 2014, University Of Dayton

Pre-Health Resource Center Campus Communications

Newsletter for students, staff, and faculty in the premedical and predental programs.

2014 (Spring), University Of Dayton. Department Of Mathematics

Colloquia

Abstracts of the talks given at the 2014 Spring Colloquium.

Commonly Prescribed Β-Lactam Antibiotics Induce C.Trachomatis Persistence/Stress In Culture At Physiologically Relevant Concentrations, Jennifer Kintner, Dawn Lajoie, Jennifer Hall, Judy Whittimore, Robert V. Schoborg

ETSU Faculty Works

Chlamydia trachomatis, the most common bacterial sexually transmitted disease agent worldwide, enters a viable, non-dividing and non-infectious state (historically termed persistence and more recently referred to as the chlamydial stress response) when exposed to penicillin G in culture. Notably, penicillin G-exposed chlamydiae can reenter the normal developmental cycle upon drug removal and are resistant to azithromycin-mediated killing. Because penicillin G is less frequently prescribed than other ß-lactams, the clinical relevance of penicillin G-induced chlamydial persistence/stress has been questioned. The goal of this study was to determine whether more commonly used penicillins also induce C. trachomatis serovar E persistence/stress. All penicillins …

Dipl 4277 Aa Global Health, Bioterrorism, And International Security, Yanzhong Huang Phd

Diplomacy Syllabi

Health issues, especially infectious diseases, have affected world history more extensively than most of us can imagine. In today's world, international trade and travel threaten pandemics by transporting and spreading diseases globally at jet speed. The growing risk of exposure to infectious disease, coupled with the looming threat of bioterrorism, creates a situation in which health and security are interacting with greater frequency and intensity. This development parallels post-Cold War efforts to redefine the concept of security to encompass new global challenges. How did epidemics function as causal agents of historical change? What are the major linkages between health and …

A Stochastic Agent-Based Model Of Pathogen Propagation In Dynamic Multi-Relational Social Networks, Bilal Khan, Kirk Dombrowski, Mohamed Saad

Department of Sociology: Faculty Publications

We describe a general framework for modeling and stochastic simulation of epidemics in realistic dynamic social networks, which incorporates heterogeneity in the types of individuals, types of interconnecting risk-bearing relationships, and types of pathogens transmitted across them. Dynamism is supported through arrival and departure processes, continuous restructuring of risk relationships, and changes to pathogen infectiousness, as mandated by natural history; dynamism is regulated through constraints on the local agency of individual nodes and their risk behaviors, while simulation trajectories are validated using system-wide metrics. To illustrate its utility, we present a case study that applies the proposed framework towards a …

Ct Scan In Children With Acute Bacterial Meningitis: Experience From Emergency Department Of A Tertiary-Care Hospital In Karachi, Pakistan, Jabeen Fayyaz, Arshalooz Rehman, Akhter Hamid, Munawar Khursheed, Nukhba Zia, Asher Feroze, Uzma R. Khan

Department of Emergency Medicine

Objective: To determine the role of computed tomography scan in children presenting to emergency department with symptoms and signs of suspected acute bacterial meningitis.

Methods: The retrospective analysis was done on children who were admitted through the Emergency Department at Aga Khan University Hospital, Karachi, from September 2009 to September 2011 with the diagnosis of acute bacterial meningitis. Information related to age, gender, presenting complaints, clinical signs and symptoms, computed tomography scan findings and final outcome of patients was gathered from the medical records. SPSS 19 was used for statistical analysis.

Results: A total of 192 patients were admitted with …

Media-Centered: Docs To Watch, Winifred Fordham Metz

Against the Grain

No abstract provided.

Analyzing Cholera Dynamics In Homogeneous And Heterogeneous Environments, Drew Posny

Mathematics & Statistics Theses & Dissertations

Cholera continues to be a serious public health concern in developing countries and the global increase in the number of reported outbreaks suggests that activities to control the diseases and surveillance programs to identify or predict the occurrence of the next outbreaks are not adequate. Mathematical models play a critical role in predicting and understanding disease mechanisms, and have long provided basic insights in the possible ways to control infectious diseases. This dissertation is concerned with mathematical modeling and analysis of cholera dynamics. First, we study an autonomous model in a homogeneous environment with added controls that involves both direct …

Relating The Metatranscriptome And Metagenome Of The Human Gut, Eric A. Franzosa, Xochitl C. Morgan, Nicola Segata, Levi Waldron, Joshua Reyes, Ashlee M. Earl, Georgia Giannoukos, Matthew R. Boylan, Dawn Ciulla, Dirk Gevers, Jacques Izard, Wendy S. Garrett, Andrew T. Chan, Curtis Huttenhower

Department of Food Science and Technology: Faculty Publications

Although the composition of the human microbiome is now well-studied, the microbiota’s > 8 million genes and their regulation remain largely uncharacterized. This knowledge gap is in part because of the difficulty of acquiring large numbers of samples amenable to functional studies of the microbiota. We conducted what is, to our knowledge, one of the first human microbiome studies in a well-phenotyped prospective cohort incorporating taxonomic, metagenomic, and metatranscriptomic profiling at multiple body sites using self-collected samples. Stool and saliva were provided by eight healthy subjects, with the former preserved by three different methods (freezing, ethanol, and RNAlater) to validate self-collection. …

Histopathologic Aspects In Plagioscion Squamosissimus (Heckel, 1940) Induced By Neoechinorhynchus Veropesoi, Metacestodes And Anisakidae Juveniles = Aspectos Histopatólogicos Em Plagioscion Squamosissimus Induzidos Por Neoechinorhynchus Veropesoi, Metacestódeos E Juvenis Da Família Anisakidae, Francisco Tiago De Vasconcelos Melo, Rogério Antonio Ribeiro Rodrigues, Elane Guerreiro Giese, Scott Lyell Gardner, Jeannie Nascimento Dos Santos

Scott L. Gardner Publications

Abstract

Plagioscion squamosissimus (Heckel 1840), a fish endemic to the Amazon Basin and commonly known as the “silver croaker,” plays an important role in the ecology and economy of Pará State, Brazil. Knowledge of host-parasite relationships is important to understanding the role of parasites in the control of natural host populations. This work describes histopathological aspects caused by several common intestinal parasites found during a helminthological survey of fish in northern Brazil. We observed a high prevalence of helminth infection, especially by J₃ nematode juveniles of the family Anisakidae and metacestodes of the family Protocephalidae (both with 100% prevalence). …

Overexpression Of Thioredoxin Binding Protein (Tbp-2) Increases Oxidation Sensitivity And Apoptosis In Human Lens Epithelial Cells, Yibo Yu, Kuiyi Xing, Rilwan Badamas, Charles A. Kuszynski, Hongli Wuand, Marjorie F. Lou

School of Veterinary and Biomedical Sciences: Faculty Publications

Thioredoxin (Trx) is an important redox regulator with cytosolic Trx1 and mitochondrial Trx2 isozymes. Trx has multi-physiological functions in cells and its bioavailability is negatively controlled through active site binding to a specific thioredoxin binding protein (TBP-2). This paper describes the delicate balance between TBP-2 and Trx, and the effect of overexpression of TBP-2 in the human lens epithelial cells. Cells overexpressing TBP-2 (TBP-2 OE) showed a 7- fold increase of TBP-2, and a nearly 40% suppression of Trx activity but no change in Trx expression. The TBP-2 OE cells grew slower and their population decreased to 30% by day …