Digital Commons Network^™

Risk Factors Of Leptospirosis Among Agricultural Workers In Southeast Asia: Literature Review, Ronggo Adi Wibowo, Wawa Najwa Nurzakia, Meirany Sasitha Kirana, Yulia Arthemisia Wijaya, Jasmine Ayumaharani Sekaryudha, Dwi Sarwani Sri Rejeki, Rosita Dwi Jayanti

Jurnal Epidemiologi Kesehatan Indonesia

The agricultural sector is the primary source of livelihood for communities in Southeast Asia; however, these activities increase the risk of exposure to zoonotic diseases, particularly leptospirosis. Southeast Asia is one of the regions with the highest incidence of leptospirosis in the world. This literature review aims to identify risk factors for leptospirosis among agricultural workers in Southeast Asia. The search for research articles utilized three databases (Google Scholar, PubMed, and ScienceDirect) using a descriptive approach based on literature review and the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. A total of 9,800 articles were screened for …

Unlocking Knowledge: Designing An Infectious Diseases-Themed Escape Room For Medical Student And Resident Education, Mackenzie R. Keintz, Catherine Cichon, Evangeline Green, Jasmine R. Marcelin, Benjamin K. Arbeiter

Interprofessional Academy of Educators Spotlight on Scholarship

Background Serious games like escape rooms (ER) offer immersive, interactive, and effective teaching through cooperative problem-solving and goal-oriented challenges. ER have primarily been described in context of medical conferences, their integration into routine medical education serves as a novel strategy to foster early interest in infectious diseases (ID) and enhance long-term retention of medical knowledge. Methods We designed an ID–themed ER for trainees on the ID service, guided by Kern’s six-step approach to curriculum development. General needs assessment was obtained via discussion with key stakeholders and literature review. A targeted needs assessment identified high yield board review exam topics and …

Outcomes Of A Learning Needs Assessment Survey In The Development Of The Extension For Community Health Outcomes Model For Hiv Training In Midwestern Non-Metropolitan Areas, Duncan Works, Daniel Cramer, Elizabeth Lyden, Yue Zhan, Emmanuel Nazaire Essam Nkodo, Renae Furl, Jennifer O'Neill, Maureen Kubat, Heather Saarela, Nada A. Fadul, Jennifer Davis

Interprofessional Academy of Educators Spotlight on Scholarship

Background: In 2020, Nebraska’s HIV prevalence was 146 per 100,000 individuals, with 107 new diagnoses in 2021. Of the 2,497 people living with HIV (PWH) statewide, 23% resided in rural areas. Rural diagnoses nearly doubled in 2021, accounting for 35% of new cases. At presentation, rural PWH had significantly lower mean CD4 counts compared to their urban counterparts (378 vs. 953 cells/mm³), suggesting delays in diagnosis and care. In response, the University of Nebraska Medical Center (UNMC) Specialty Care Clinic implemented the Extension for Community Healthcare Outcomes (ECHO) model to enhance rural provider support through virtual lectures and case-based learning. …

Dynamical Analysis And Optimal Control Of The Mpox Transmission Model With Stratified Susceptibility, Tuhfatul Janan, Fatmawati Fatmawati, Cicik Alfiniyah, Santi Martini, Dipo Aldila, Agus Hasan

Mathematical Modelling and Numerical Simulation with Applications

This study develops a mathematical model of Mpox transmission that combines stratified susceptibility (low-risk and high-risk groups) with vaccinated and asymptomatically infected compartments. The analysis of the model begins with examining the well-posedness, boundedness, and nonnegativity conditions for the solutions. The local stabilities of the equilibria are examined through the Jacobian matrix and phase plane analysis, while the global stabilities are provided through Lyapunov functions. The estimated parameters are verified using epidemiological data on Mpox cases in the United States, with an MAPE of 2.20% and R_0 > 1, indicating that Mpox remains endemic. Sensitivity analysis indicates that the contact rate …

Relationship Between Immune Profile And Respiratory Parameters In Down Syndrome Children With Acute Pneumonia: Pre-Intervention Analysis, Shehab M. Abd El-Kader, Tamer M. El-Saeed, Marwa M. I. Ismaeel, Mohamed F. El-Banna, Ahmed M. Aboeleneen, Amany G. Atiaa, Fatma A Hegazy, Mona M. Abdelkhalek

Journal of Medical Rehabilitation Science

Background: Children with Down Syndrome (DS) exhibit immune dysregulation and increased susceptibility to severe pneumonia. While associations between immune status and infection risk are known, the relationship between specific baseline immune markers and respiratory parameters at the initial presentation of acute pneumonia in this population is unclear. Objective: To investigate the correlation between baseline serum immunoglobulin levels, white blood cell count (WBCs), and baseline respiratory parameters (respiratory rate and arterial oxygen saturation) in children with DS presenting with acute pneumonia. Material and methods: This descriptive, cross-sectional study analyzed baseline data from 40 children with DS and acute pneumonia enrolled prior …

Literary Works On Turkish Captives On Nargin Island, Arş. Gör. Dr. Orhan Baldane

Khazar Journal of Humanities and Social Sciences

In this study, firstly basic information about Nargin Island was given and then literary works that took the subject of captivity on Nargin Island were evaluated. As a result of our survey, 26 works in 5 different literary genres were identified in which the events on Nargin Island were the main subject or an important sub-theme within the plot. These works written in the genres of novel, poetry, theater, memoirs and diary, were published 12 in Azerbaijan and 14 in Türkiye. The fact that novels and the play were written after the 2000s is related to the inadequacy of relations …

Ventilator Weaning Through Spontaneous Breathing Trials In Children With Tetralogy Of Fallot In The Picu: A Case Report, Megah Fitrian, Kadek Ayu Erika, Muhammad Yunus

Jurnal Keperawatan Indonesia

Tetralogy of Fallot (TOF) is a congenital heart defect that causes chronic low oxygen levels, increased right ventricular workload, and a higher risk of complications. Weaning mechanical ventilation in patients with TOF is particularly challenging due to right ventricular dysfunction, muscle weakness, and the risk of heart failure. This study evaluates the use of a spontaneous breathing trial (SBT) strategy with pressure support ventilation (PSV) mode for mechanical ventilation weaning in pediatric patients with TOF. An observational study was conducted on a six-year-old pediatric patient with TOF and a cerebral abscess who underwent mechanical ventilation weaning using the SBT technique …

When The Tail Wags The Dog: The Game Of Justice And The Elusive Quest For Due Process In The Middle East, Mohamed Arafa

Southern Illinois University Law Journal

Due process guarantees lie at the heart of any legitimate legal system, serving as a critical safeguard against arbitrary state power and as a foundation for the rule of law. Yet their meaning and implementation vary significantly across legal traditions and political contexts.

This article examines the scope and limitations of due process guarantees in the Middle East, focusing on Egypt and Saudi Arabia as illustrative case studies. While both jurisdictions formally recognize procedural protections within their constitutional and legal frameworks, the practical application of these guarantees often diverges from international standards.

The article analyzes core due process principles—such as …

Impact Of Tropical Cyclones On Food And Nutrition Security: A Global Scoping Review And Thematic Analysis, Patience M. Chiotha, Budi Haryanto

Jurnal Epidemiologi Kesehatan Indonesia

The increasing frequency and intensity of tropical cyclones driven by climate change pose growing threats to food and nutrition security. Globally, an estimated 80–90 tropical cyclones occur annually, affecting approximately 119 million people. Evidence regarding their impact on food systems, dietary patterns, and nutritional status remains fragmented. This scoping review aimed to map global evidence on the impacts of tropical cyclones on food and nutrition security, identify key pathways of impact, and examine affected indicators at household and individual levels. The review followed Joanna Briggs Institute guidelines and PRISMA-ScR. Searches were conducted in PubMed/MEDLINE, Web of Science, Scopus, and Google …

Recurrent Urinary Tract Infections In An Elite Level Diver: A Disablement Model Case Study, Matt O'Sullivan, Dominique M. Stevens, Lindsey E. Eberman

Clinical Practice in Athletic Training

This article presents a case of complicated and recurrent pyelonephritis, an infection of 1 or both kidneys, in an elitelevel diver. Urinary tract infections (UTIs) are among the most common outpatient infections in the United States; most are uncomplicated and resolve without significant mortality or morbidity. However, UTIs have the potential to present significant clinical challenges if the UTI becomes complicated or recurrent. Additionally, recurrent UTIs can carry a significant burden to both the individual patients and the larger healthcare system. The current paper reviews the epidemiological literature surrounding UTIs, the significant impact they have on a patient’s health-related quality …

Pseudomonas Aeruginosa: A Rare Cause Of Necrotizing Fasciitis, Carrine S. Kogulan, Oluwafemi Ajibola

Student Publications

Necrotizing fasciitis (NF) is a rare but life-threatening soft tissue infection characterized by rapid progression, systemic toxicity, and high mortality. While Group A Streptococcus is the most common pathogen, Pseudomonas aeruginosa is an uncommon cause, typically reported in immunocompromised patients.

We present the case of a 77-year-old male with chronic lymphocytic leukemia (CLL), chronic kidney disease, and other comorbidities who initially presented to an outside facility with three days of fever and left lower extremity pain. He was admitted with presumed cellulitis, and blood cultures grew Pseudomonas aeruginosa. Despite appropriate antibiotic therapy with vancomycin and ceftriaxone, the patient developed …

Numerical Simulations And Hyers-Ulam Stability Of A Novel Nonlocal Anthropogenic Cutaneous Leishmaniasis Mathematical Model, Khalid Fanoukh Al Oweidi, Zakirullah -, Kamal Shah, Thabet Abdeljawad

Mathematical Modelling and Numerical Simulation with Applications

In this work, the fractal-fractional Atangana-Baleanu derivative with the Mittag-Leffler kernel is employed to capture the memory and hereditary effects inherent to anthropogenic cutaneous leishmaniasis transmission dynamics. The Banach fixed-point theorem and contraction mapping principle are used to prove the existence and uniqueness of solutions, while Hyers-Ulam stability of the system is analyzed to demonstrate the robustness of solutions with respect to small perturbations. Using a nonlinear least-squares approach, model parameters and fractional order are estimated using epidemiological data from the World Health Organization. The basic reproduction number $R_0 = 0.53$ indicates that the disease is under control after adding …

Optimal Control And Bifurcation Analysis Of A Predator–Prey Model With Self-Limiting Growth And Predator Disease, Dipo Aldila, Muhammad Akmal Fasya, Bevina D. Handari, Chidozie Williams Chukwu, Olumuyiwa James Peter

Mathematical Modelling and Numerical Simulation with Applications

We propose and analyze an eco-epidemiological predator–prey model that incorporates self-limitation and disease transmission within the predator population. The model is formulated as a system of ordinary differential equations describing logistic prey growth under the interspecific interaction with the predator. On the other hand, the predator population is divided into susceptible and infected classes, whose growth is constrained by prey availability. Three biologically relevant equilibria are identified: predator extinction, disease-free coexistence, and coexistence with endemic disease. The existence and stability of these equilibria are determined by key ecological and epidemiological thresholds, including the basic reproduction number. Using numerical continuation methods, …

Therepairer_Vol11no12_Dec1906

The Repairer

No abstract provided.

2025 Novel Drug Approvals, Katherine Ghattas Pharmd, Amanda Rawa Pharmd

Transformative Medicine

The year 2025 marked another strong chapter in pharmaceutical innovation, with multiple novel therapies gaining approval from the U.S. Food and Drug Administration (FDA). These approvals reflect continued progress in addressing unmet medical needs across a wide range of disease states. This article reviews the FDA’s 2025 novel drug approvals, spotlighting a few therapeutic advancements and emerging trends. A comprehensive table of all approved agents is provided, along with a focused discussion of four particularly impactful therapies: donidalorsen (Dawnzera), taletrectinib (Ibtrozi), delgocitinib (Anzupgo), gepotidacin (Blujepa), etripamil (Cardamyst). Each of these agents represents a step forward in its respective field and …

The Experiences Of Faith-Based Non-Profit Human Services Professionals In The Implementation Of Parental Resources For Homeless Mothers, Latasha Sublett

Walden Dissertations and Doctoral Studies

Homelessness is a worldwide, complex social problem that has impacted groups like women and children. In recent studies, researchers have demonstrated that homeless mothers can face mental health challenges and stressors related to parenting, while homeless children can experience emotional and physical difficulties. Parental resources have been cited as a tool to help homeless families address stress and development in distinct settings in current research; however, there was limited research on how faith-based non-profits utilize parental resources to help homeless mothers. The purpose of the generic qualitative study was to learn the perceptions and experiences of faith-based non-profit human services …

Determinants Of Stunting Among Under-Five Children (0–59 Months) In Central Sulawesi Province, Marchell Bamba, Mondastri Korib Sudaryo, Ratna Djuwita, Helwiah Umniyati

Jurnal Epidemiologi Kesehatan Indonesia

Stunting is caused by chronic malnutrition which can be caused by various factors including poverty, poor nutritional intake and maternal health, and inappropriate infant feeding. This study was conducted to determine what factors cause stunting in Central Sulawesi Province. This study was conducted using a cross-sectional observational analysis method using secondary data from the Survei Kesehatan Indonesia (SKI) 2023. The analysis was carried out using logistic regression. The sample used was 2179 respondents. The dependent variable is stunting while the independent variables are age, gender, area of residence, gestational age, provision of PMT, exclusive breastfeeding, maternal occupation, maternal education, and …

U.S. Pharmacists’ Perceptions Of Getting The Covid-19 Vaccine And How That Affects Their Interactions With The Public, Megan Boals

Walden Dissertations and Doctoral Studies

Pharmacists play a pivotal role in public health, particularly in promoting vaccination. However, vaccine hesitancy among pharmacists significantly undermines their willingness to provide effective patient counseling and to advocate for vaccination, potentially eroding public trust in vaccines. This descriptive-phenomenological study sought to understand the factors contributing to pharmacists’ COVID-19 vaccine hesitancy and how this hesitancy affected their willingness to recommend vaccines to patients. Twenty practicing pharmacists were interviewed via Zoom between September 23 and October 14, 2025. The health belief model helped interpret the study findings. Thematic analysis, as described by Braun and Clarke, was conducted to identify and interpret …

Il-10, Il-17 And Vegf As Biomarkers For Differentiating Tuberculosis In North-Western Nigeria, Ibrahim Aminu

Muthanna Medical Journal

Background: Cytokines mediate resistance to tuberculosis infection and play a significant role in host susceptibility and the progression of the infection. Aim: This study aimed to determine whether plasma levels of IL-17, IL-10, and VEGF can discriminate between non-resistant TB, monoresistant TB, Multidrug-resistant TB, and TB-negative subjects. Methods: Three hundred and twenty-five presumptive TB patients were recruited from 2020 to 2023 in the North-western region of Nigeria as study participants from whom sputum and blood samples were collected. The sputum samples were processed accordingly to detect drug-susceptible, monoresistant, and multidrug-resistant Mycobacterium tuberculosis (MDR-TB) using the Ziehl-Neelsen staining technique, GeneXpert, and …

Barriers And Facilitators To Accessing Addiction Treatment Services For Sexual Minority (Lgbq+) People: Systematic Review, Miriam Hillyard, Beatrice Cockbain, Colin Drummond, Katharine Rimes, Emmert Roberts

School of Psychology

Background Sexual minority (lesbian, gay, bisexual, queer and other non-heterosexual) people experience significant disparities in addiction problems compared with heterosexual people.  Aims We aimed to answer the question, what are the barriers and facilitators to accessing drug/alcohol addiction treatment services for sexual minority adults?’.  Method A systematic review was conducted by searching Medline, PsycINFO, CINAHL, Web of Science, and Sociological Abstracts for any English-language primary research article (qualitative, quantitative or mixed methods) relevant to the study aims, from inception up to 18 April 2025. Quality of included studies was assessed using the Mixed-Methods Appraisal Tool (MMAT-2018). Barriers and facilitators were …

The Experiences Of Faith-Based Non-Profit Human Services Professionals In The Implementation Of Parental Resources For Homeless Mothers, Latasha Sublett

Walden Dissertations and Doctoral Studies

No abstract provided.

Enterotoxaemia In Goats: Prevalence, Etiology, Risk Factors, And Therapeutic Approaches: A Comprehensive Review, Muhammad Mohsen, Jam Kashif Zaman, Amjad Hussain Mirani, Nazeer Hussain Kalhoro, Benazir Sahito

Journal of Bioresource Management

Enterotoxaemia remains one of the most severe and rapidly fatal diseases affecting goats, mainly caused by Clostridium perfringens types C and D. Despite widespread vaccination practices, the disease continues to produce significant health and economic losses, particularly in intensive and semi-intensive goat production systems. This review summarizes the current understanding of enterotoxaemia, focusing on its etiology, pathogenesis, epidemiology, risk factors, diagnostic approaches, and updated therapeutic and preventive strategies. C. perfringens overgrows in the intestinal lumen under favorable conditions such as sudden dietary changes, high-energy feeding, or stress-related microbial imbalance. The toxins produced especially epsilon and beta induce intestinal necrosis, vascular …

Indonesia’S Archipelagic Healthcare: Lessons From Sumenep Regency In Promotion, Prevention, And Overcoming Disparity, Restu Karlina Rahayu, Tia Subekti, Andi Setiawan

Asia-Pacific Social Science Review

This study examines healthcare in Indonesia’s archipelagic region, using semi-structured qualitative interviews with 20 informants, including island residents, medical professionals, and government officials. Findings reveal inadequate medical facilities on the islands, particularly for emergencies. For instance, there is only one hospital on Arajasa Island, established in 2023, while smaller, less populated islands rely solely on public health centers staffed by general practitioners, lacking specialists. Patients requiring specialized care must be referred to an off-island hospital, but transportation is limited and weather-dependent, leading to high personal costs if ships or boats are unavailable. In response, the Sumenep government has implemented initiatives, …

Phytochemistry And Pharmacological Activities Of Sphagneticola Trilobata: A Systematic Review With Perspectives For Drug Discovery, Sonali Dnyaneshwar Labhade, Suraj Kamadi, Pawan Nandkishor Karwa, Ritesh Prakash Bhole, Harshad Sunil Kapare, Sohan Satyanarayan Chitlange

Makara Journal of Science

Sphagneticola trilobata (L.) Pruski is a medicinal plant widely used in traditional medicine for its anti-inflammatory, antimicrobial, antioxidant, hepatoprotective, wound healing, and CNS depressant effects. Despite its broad pharmacolo-gical potential, clinical application is limited due to a lack of mechanistic understanding, standardization, and clinical validation. This review aims to provide a comprehensive overview of the phytochemical composition, pharmacological activities, and therapeutic potential of S. trilobata, while highlighting research gaps and suggesting future directions for clinical translation. A systematic review of scientific literature, ethnobotanical sources, and pharmacological studies was conducted, focusing on phytochemical analysis, biological activity, toxicity, and potential applications …

Patterns Of Multimorbidity Among Low-Income Adults Who Smoke With Implications For Tailored Interventions: A Cluster Analysis Using A Mixture Of Bernoulli Model, Monique T. Cano, Michael R. Lindstrom, Oscar F. Rojas Perez, Ricardo F. Muñoz

School of Mathematical & Statistical Sciences Faculty Publications

Introduction: Smoking cigarettes remains a leading modifiable risk factor for preventable health conditions. In the United States, the health burden of smoking disproportionately impacts low-income individuals. Multimorbidity is common in this group, complicating treatment and worsening outcomes. Identifying multimorbidity clusters can support targeted, individualized interventions. This study aimed to identify multimorbidity clusters among individuals who smoke and experience economic hardship and provide clinical recommendations to enhance health outcomes.

Method: Individuals who smoke and experience economic hardship (N = 60) were recruited from the San Francisco Health Network (SFHN) and were assessed for physical and mental conditions. Cluster analysis was …

A Challenging Presentation Of Mycoplasma Pneumoniae: Mild Hepatic Dysfunction With Persistent Leukocytosis In A Pediatric Patient, Robert J. Heins, Sierra Scott, Stephen Mock

Student Publications

Mycoplasma pneumoniae (MP) is a common pediatric respiratory pathogen that can rarely present with extrapulmonary manifestations such as hepatic involvement. Recognition of hepatic dysfunction in this context is important for accurate diagnosis and timely therapy. A five-year-old female with asthma presented with fever, cough, fatigue, pruritus, and scleral icterus. Laboratory evaluation revealed leukocytosis, elevated C-reactive protein, mild transaminitis, direct hyperbilirubinemia, elevated PT/PTT, and normocytic anemia. Infectious and hepatic workups were initially unrevealing. The patient showed gradual clinical improvement while receiving empiric ceftriaxone but had persistent leukocytosis. On hospital Day 7, a positive MP IgM prompted azithromycin initiation, which corresponded to …

Letter To The Editor: Evidence For A Two-Step Species-Level Pulmonary Nocardiosis Diagnostic Approach, John Halphen, Mohadese Ahmadzade, Babith Mankidy, Ashkan Berenji, Mohammad Ghasemi-Rad

Faculty, Staff and Students Publications

Pulmonary nocardiosis, a rare and diagnostically challenging infection, usually presents with heterogeneous radiographic findings, compounded by the low sensitivity of traditional confirmatory cultures. In their most recent work, Wang et al analyzed 102 patients with pulmonary nocardiosis to address these concerns, investigating species-characteristic imaging patterns, pathological associations, and the role of metagenomic next-generation sequencing (mNGS) in the diagnostic approach. High-resolution computed tomography (CT) in adult patients with pulmonary infections caused by Nocardia wallacei was demonstrated to have a sensitive (85.71%) and specific (83.34%) presentation of bronchopneumonia in relation to the five Nocardia species in the sample with CT data. The …

Structural Barriers And Clinical Outcomes: A Literature Review On The Role Of Social Determinants In Hiv Care Engagement And Viral Suppression, Vonda M. Mckeithan

Knowledge and Creativity Expo

This project explores how social and structural challenges, including unstable housing, poverty, and stigma, impact the ability of people living with HIV to stay in care and achieve viral suppression. It reviews recent research and argues that health interventions must go beyond the clinic and address broader social barriers to improve equity in HIV outcomes.

Competing In Collegiate Championships During Covid: Caveat Or Calamity, Samuel K. Pappert

Denver Sports & Entertainment Law Journal

No abstract provided.

Associations Between Caregiver-Provider Communication Quality And Unmet Care Needs Among Older Adults, Jiaming Liang, Rafael Samper-Ternent, Brian Downer, Zhigang Xie

Faculty, Staff and Student Publications

BACKGROUND: Unmet care needs (lack of assistance with daily activities) among older adults are common and linked to adverse health outcomes, greater healthcare utilization, and caregiver burden. While effective patient-provider communication is known to improve care quality, less is understood about the role of caregiver-provider communication, particularly across sociodemographic, health, and caregiving contexts. METHODS: We conducted a cross-sectional secondary analysis of pooled 2021–2023 National Health and Aging Trends Study (NHATS) and National Study of Caregiving (NSOC) data, restricted to community-dwelling older adults (65 + years) who received assistance from caregivers due to difficulty with daily activities, and had at least …