Digital Commons Network^™

Guarding International Borders Against Hiv: A Comparative Study In Futility, Matthew J. Defazio

Pace International Law Review

Back in 1985, when knowledge of HIV began to spread, governments reacted by passing immigration laws to restrict the entry of HIV positive individuals. These laws required such individuals to either declare their HIV status or undergo mandatory HIV testing to secure entry. As justification for these initiatives, many countries claimed to be preserving the public health and their domestic economy. The United States, China, and Russia are three countries that have had, or still have, some form of HIV immigration restrictions. Initially, it may seem logical that preventing HIV positive individuals from entering a country will cut down on …

2013-November-26-Moorman Nih Grant, University Marketing And Communications, East Tennessee State University

ETSU News

No abstract provided.

Jak/Stat Inhibitors And Mapk/Erk Inhibitors For Rsv Infection, Shyam S. Mohapatra

USF Patents

The present invention concerns a method for treating or reducing the likelihood of developing a respiratory syncytial virus (RSV) infection in a subject by administering an effective amount of an inhibitor of the janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway or the mitogen-activated kinase (MAPK)/extracellular signal-regulated kinase (ERK1/2) signaling pathway to the subject. Another aspect of the invention concerns a pharmaceutical composition that includes an inhibitor of JAK/STAT or MAPK/ERK signaling to the subject; and a pharmaceutically acceptable carrier. Another aspect of the invention concerns a method for identifying agents useful for treating or reducing the …

Global Mortality Estimates For The 2009 Influenza Pandemic From The Glamor Project: A Modeling Study, Lone Simonsen, Peter Spreeuwenberg, Roger Lustig, Robert J. Taylor, Douglas M. Fleming, Madelon Kroneman, Maria D. Van Kerkhove, Anthony D. Mounts, W. John Paget

Global Health Faculty Publications

Background

Assessing the mortality impact of the 2009 influenza A H1N1 virus (H1N1pdm09) is essential for optimizing public health responses to future pandemics. The World Health Organization reported 18,631 laboratory-confirmed pandemic deaths, but the total pandemic mortality burden was substantially higher. We estimated the 2009 pandemic mortality burden through statistical modeling of mortality data from multiple countries.

Methods and Findings

We obtained weekly virology and underlying cause-of-death mortality time series for 2005–2009 for 20 countries covering ~35% of the world population. We applied a multivariate linear regression model to estimate pandemic respiratory mortality in each collaborating country. We then used …

The Eps Matrix As An Adaptive Bastion For Biofilms: Introduction To Special Issue, Alan W. Decho

Faculty Publications

No abstract provided.

The Archaeology Of 19th-Century Health And Hygiene At The Sullivan Street Site, New York City, Jean E. Howson

Northeast Historical Archaeology

The households represented by archaeological remains at the Sullivan Street site in Greenwich Village are used to explore issues related to health care in 19th-century New York City. Backyard features and domestic artifact assemblages are discussed in the context of institutional development and specific changes in medical practice. Consumer choices are seen as responses to differential access to sanitation, medical care, and information. Social class had a significant effect on both the infrastructure and material culture of health and hygiene for these households.

Capture Of Lipopolysaccharide (Endotoxin) By The Blood Clot: A Comparative Study, Margaret T. Armstrong, Frederick R. Rickles, Peter B. Armstrong

Medicine Faculty Publications

In vertebrates and arthropods, blood clotting involves the establishment of a plug of aggregated thrombocytes (the cellular clot) and an extracellular fibrillar clot formed by the polymerization of the structural protein of the clot, which is fibrin in mammals, plasma lipoprotein in crustaceans, and coagulin in the horseshoe crab, Limulus polyphemus. Both elements of the clot function to staunch bleeding. Additionally, the extracellular clot functions as an agent of the innate immune system by providing a passive anti-microbial barrier and microbial entrapment device, which functions directly at the site of wounds to the integument. Here we show that, in …

2013 November 25 - Graduate Council Minutes, College Of Graduate And Continuing Studies, East Tennessee State University

Graduate Council Agendas and Minutes

No abstract provided.

Lapatinib And Sorafenib Kill Gbm Tumor Cells In A Greater Than Additive Manner, Seyedmehrad Tavallai

Theses and Dissertations

Glioblastoma multiforme (GBM) is the most common and malignant brain tumor in adults, affecting thousands of people worldwide every year, with a life expectancy, post diagnosis of 12 months. Surgery, radiotherapy and chemotherapy together, result in an overall mean survival not exceeding 15 months. Targeted therapeutic agents sorafenib, an oral multi kinase inhibitor, and lapatinib, an epidermal growth factor receptor (EGFR) inhibitor, used in combination have been shown to kill GBM cells be through inhibition of major growth mediating signaling pathways that are frequently over expressed in gliomas, including mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase/ protein kinase B (PI3K/AKT). …

Knockdown Of Selenocysteine-Specific Elongation Factor In Amblyomma Maculatum Alters The Pathogen Burden Of Rickettsia Parkeri With Epigenetic Control By The Sin3 Histone Deacetylase Corepressor Complex, Steven W. Adamson, Rebecca E. Browning, Khemraj Budachetri, José M.C. Ribeiro, Shahid Karim

Faculty Publications

Selenocysteine is the 21st naturally-occurring amino acid. Selenoproteins have diverse functions and many remain uncharacterized, but they are typically associated with antioxidant activity. The incorporation of selenocysteine into the nascent polypeptide chain recodes the TGA stop codon and this process depends upon a number of essential factors including the selenocysteine elongation factor (SEF). The transcriptional expression of SEF did not change significantly in tick midguts throughout the blood meal, but decreased in salivary glands to 20% at the end of the fast feeding phase. Since selenoprotein translation requires this specialized elongation factor, we targeted this gene for knockdown by RNAi …

Factors Influencing Vaccination Decisions In African American Mothers Of Preschool Age Children, Chauntel Mckenzie Mcnair

USF Tampa Graduate Theses and Dissertations

Rates and coverage levels of immunizations of African-American children are reduced compared to other races. Few studies have identified factors that influence vaccination decisions of African-American mothers. This study assessed the mothers' vaccination decisions using a self-administered questionnaire and a screening instrument for determining health literacy. This instrument is called Rapid Estimate of Adult Literacy in Medicine (REALM). The sample was 92 African American mothers, recruited from a large metropolitan church in Jacksonville, Florida, who had at least one child under the age of seven. A cross-sectional research design was used to administer survey instruments to identify and interpret parental …

Varying Effects Of Agricultural Pesticides On Host-Pathogen Interactions And Aquatic Ecosystems In An Amphibian System, Shane Michael Hanlon

Electronic Theses and Dissertations Archive

Due to the displacement of natural habitats by anthropogenic landscapes (e.g. agricultural fields), the use of agrochemicals (e.g. pesticides) has increased exponentially and non-target organisms such as amphibians are often at risk of exposure through direct overspray, runoff, or spraydrift. Because agricultural landscapes are encroaching on amphibian habitats, interactions likely occur between environmental pressures such as disease and contamination. Accordingly, I assessed the effects of pesticides on the amphibian pathogen Batrachochytrium dendrobatidis (Bd) host-pathogen interactions. As Bd-infected individuals have been found in agricultural-adjacent landscapes, pesticides can potentially alter host-pathogen interactions. In chapter two I demonstrated that pesticides can kill Bd …

Work Hope And The Socioemotional Functioning Of Offenders, David Guion

Theses and Dissertations

For offenders returning to society at record levels, securing work looms as one of the most crucial factors in successful reentry. Work hope is a construct that seeks to measure the relative presence of goals of securing desired work, thoughts about how to achieve those goals, and agency to achieve those goals, even in the presence of obstacles. This study sought to examine relationships among work hope, the socioemotional variables of attachment, emotion regulation, physical, relational, and workplace victimization, and coping, and the career-related variables of perceptions of career-related barriers and complexity level of career goals. The sample comprised cohorts …

From (Un)Willingness To Involvement: Development Of A Successful Study Brand For Recruitment Of Diverse Msm To A Longitudinal Hiv Research, Paula M. Frew, Victoria A. Williams, Eve T. Shapiro, Travis Sanchez, Eli S. Rosenberg, Vincent L. Fenimore, Patrick S. Sullivan

Environmental & Global Health Faculty Research

Background. HIV continues to be a major concern among MSM, yet Black MSM have not been enrolled in HIV research studies in proportionate numbers to White MSM. We developed an HIV prevention research brand strategy for MSM. Methods. Questionnaires and focus groups were conducted with 54 participants. Descriptive statistics and chi-square analyses were performed and qualitative data were transcribed and content analyzed to identify common themes. Results. Formative research results indicated that younger Black MSM (18–29 years) were less likely to think about joining prevention studies compared to older (≥30 years) Black MSM (, ). Qualitative and quantitative results indicate …

A Two-Step Estimation Procedure And A Goodness-Of-Fit Test For Spatial Extremes Models, Hongwei Shang

Doctoral Dissertations

Parametric max-stable processes are increasingly used to model spatial extremes. Since the dependence structure is specified for block maxima, the data used for inference are block maxima from all sites. To improve the estimation efficiency, we propose a two-step approach with composite likelihood that utilizes site-wise daily records in addition to block maxima. Besides the parameter estimation, there is no formal model checking and diagnosis method for spatial extremes modeling yet. Model diagnosis in practice has been informal and mostly based on visual checking tools such as residual plot and quantile-quantile plot. We proposed a goodness-of-fit test for max-stable processes …

2013 Northeastern Illinois University Fourth Annual Faculty Research Symposium - Abstracts, Symposium Steering Committee

Faculty Research and Creative Activities Symposium 2010-2017

No abstract provided.

Rapid Differentiation Between Livestock-Associated And Livestock-Independent Staphylococcus Aureus Cc398 Clades, Marc Stegger, Cindy M. Liu, Jesper Larsen, Katerina Soldanova, Maliha Aziz, Tania Contente-Cuomo, Andreas Petersen, Stien Vandendriessche, Judy N. Jiménez, Caterina Mammina, Alex Van Belkum, Saara Salmenlinna, Frederic Laurent, Robert L. Skov, Anders R. Larsen, Paal S. Andersen, Lance B. Price

Environmental and Occupational Health Faculty Publications

Staphylococcus aureus clonal complex 398 (CC398) isolates cluster into two distinct phylogenetic clades based on single-nucleotide polymorphisms (SNPs) revealing a basal human clade and a more derived livestock clade. The scn and tet(M) genes are strongly associated with the human and the livestock clade, respectively, due to loss and acquisition of mobile genetic elements. We present canonical single-nucleotide polymorphism (canSNP) assays that differentiate the two major host-associated S. aureus CC398 clades and a duplex PCR assay for detection of scn and tet(M). The canSNP assays correctly placed 88 S. aureusCC398 isolates from a reference collection into …

Evidence For Finely-Regulated Asynchronous Growth Of Toxoplasma Gondii Cysts Based On Data-Driven Model Selection, Adam M. Sullivan, Xiaopeng Zhao, Yasuhiro Suzuki, Eri Ochiai, Stephen Crutcher, Michael A. Gilchrist

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Toxoplasma gondii establishes a chronic infection by forming cysts preferentially in the brain. This chronic infection is one of the most common parasitic infections in humans and can be reactivated to develop life-threatening toxoplasmic encephalitis in immunocompromised patients. Host-pathogen interactions during the chronic infection include growth of the cysts and their removal by both natural rupture and elimination by the immune system. Analyzing these interactions is important for understanding the pathogenesis of this common infection. We developed a differential equation framework of cyst growth and employed Akaike Information Criteria (AIC) to determine the growth and removal functions that best describe …

Increased Cell Surface Free Thiols Identify Effector Cd8+ T Cells Undergoing T Cell Receptor Stimulation, Samuel Troy Pellom, Ryan D. Michalek, Katie E. Crump, P. Kent Langston, Daniel G. Juneau, Jason M. Grayson

Biology Faculty Articles

Recognition of peptide Major Histocompatibility Complexes (MHC) by the T cell receptor causes rapid production of reactive oxygen intermediates (ROI) in naïve CD8+ T cells. Because ROI such as H2O2 are membrane permeable, mechanisms must exist to prevent overoxidation of surface proteins. In this study we used fluorescently labeled conjugates of maleimide to measure the level of cell surface free thiols (CSFT) during the development, activation and differentiation of CD8+ T cells. We found that during development CSFT were higher on CD8 SP compared to CD4 SP or CD4CD8 DP T cells. After activation CSFT became elevated prior to division …

The Daily Egyptian, November 12, 2013, Daily Egyptian Staff

November 2013

No abstract provided.

Um, Usda And Dod Join Forces To Protect Troops Deployed Abroad, Barbara Lago

University of Mississippi News

Their mission: Neutralize threats posed by blood-feeding, disease-carrying insects

In-Situ Quantification Of The Interfacial Rheological Response Of Bacterial Biofilms To Environmental Stimuli, Patrick Rühs, Lukas Böni, Gerald Fuller, R. Inglis, Peter Fischer

Biology Department Faculty Works

Understanding the numerous factors that can affect biofilm formation and stability remain poorly understood. One of the major limitations is the accurate measurement of biofilm stability and cohesiveness in real-time when exposed to changing environmental conditions. Here we present a novel method to measure biofilm strength: interfacial rheology. By culturing a range of bacterial biofilms on an air-liquid interface we were able to measure their viscoelastic growth profile during and after biofilm formation and subsequently alter growth conditions by adding surfactants or changing the nutrient composition of the growth medium. We found that different bacterial species had unique viscoelastic growth …

Older Msm And Hiv/Aids: A Grounded Theory Study To Inform Prevention, Johnnie O'Neal

Theses and Dissertations

This study sought to increase knowledge as it relates to HIV-prevention for older adults, especially for MSM who are HIV-negative. In participating in this study, participants shared their experiences, stories and feelings related to their exposure to HIV and HIV-prevention initiatives. Using a Traditional Grounded Theory method, 22 interviews with older MSM were conducted with the aim of producing a theory that explained how these men lived prior to HIV, the different ways they responded to the onset of the virus, how they have lived their lives over the last three decades, and the extent to which the virus continues …

Food Safety Education Cube For Native Americans, Kelsey Crews Bair, Rachel C. Sinley, Julie A. Albrecht

RURALS: Review of Undergraduate Research in Agricultural and Life Sciences

Foodborne illnesses impact millions of individuals each year, with young children at high risk of contracting such diseases. Many of these pathogens responsible for these illnesses can be destroyed with proper food handling techniques. Research has shown there is a need for improved food safety education among the general public. This project sought to increase food safety knowledge by developing a food safety educational tool that expands on current meat handling information. A “Food Safety Cube” was developed that expands on the current Food Safety and Inspection Service (FSIS) “Safe Handling Instructions” label. This tool was positioned throughout several high …

Emergency Department Utilization Among Recently Released Prisoners: A Retrospective Cohort Study, Suyanpeng Zhang, Allie Silverman, Sze Chaun Suen, Christina Andrews, Brian Chen

Faculty Publications

Background: The population of ex-prisoners returning to their communities is large. Morbidity and mortality is increased during the period following release. Understanding utilization of emergency services by this population may inform interventions to reduce adverse outcomes. We examined Emergency Department utilization among a cohort of recently released prisoners.

Methods: We linked Rhode Island Department of Corrections records with electronic health record data from a large hospital system from 2007 to 2009 to analyze emergency department utilization for mental health disorders, substance use disorders and ambulatory care sensitive conditions by ex-prisoners in the year after release from prison in comparison to …

The City, Farm, And Wilderness: The Politics Of Nature, Mariel L. Smith

Morehead State Theses and Dissertations

A thesis presented to the faculty of the College of Business and Public Affairs at Morehead State University in partial fulfillment of the requirements for the Degree of Master of Public Administration by Mariel L. Smith in November of 2013.

Progress Notes, Lehigh Valley Health Network

Progress Notes

No abstract provided.

The Need To Include Animal Protection In Public Health Policies, Aysha Akhtar

Animal Welfare Collection

Many critical public health issues require non-traditional approaches. Although many novel strategies are used, one approach not widely applied involves improving the treatment of animals. Emerging infectious diseases are pressing public health challenges that could benefit from improving the treatment of animals. Other human health issues, that overlap with animal treatment issues, and that warrant further exploration, are medical research and domestic violence. The diverse nature of these health issues and their connection with animal treatment suggest that there may be other similar intersections. Public health would benefit by including the treatment of animals as a topic of study and …

The Constraint Of Dignity: Lawrence V. Texas And Public Morality, Kristian R. Mukoski

Notre Dame Law Review

This Note will proceed in four parts. Part I will catalogue the jurisprudential and philosophical conflict over the legitimacy of morals legislation. Part II will examine the Supreme Court’s jurisprudence regarding reproductive and sexual liberty, noting the trend towards conflating liberty with autonomy that culminated in Lawrence v. Texas. Part III will closely scrutinize the characterization of liberty in Lawrence, demonstrating that it is restricted by associational and spatial limitations. Part IV will connect those limitations to the description of dignity Justice Kennedy employed in Lawrence and in other cases. This conception of dignity embodies substantive values concerning the appropriate …

Molecular Detection Of Culture-Confirmed Bacterial Bloodstream Infections With Limited Enrichment Time, Miranda S. Moore, Chase D. Mccann, Jeanne Jordan

Epidemiology Faculty Publications

Conventional blood culturing using automated instrumentation with phenotypic identification requires a significant amount of time to generate results. This study investigated the speed and accuracy of results generated using PCR and pyrosequencing compared to the time required to obtain Gram stain results and final culture identification for cases of culture-confirmed bloodstream infections. Research and physician-ordered blood cultures were drawn concurrently. Aliquots of the incubating research blood culture fluid were removed hourly between 5 and 8 h, at 24 h, and again at 5 days. DNA was extracted from these 6 time point aliquots and analyzed by PCR and pyrosequencing for …