Digital Commons Network^™

Contribution Of The Infection-Associated Complement Regulator-Acquiring Surface Protein 4 (Erpc) To Complement Resistance Of Borrelia Burgdorferi, Claudia Hammerschmidt, Teresia Hallström, Christine Skerka, Reinhard Wallich, Brian Stevenson, Peter F Zipfel, Peter Kraiczy

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Borrelia burgdorferi evades complement-mediated killing by interacting with complement regulators through distinct complement regulator-acquiring surface proteins (CRASPs). Here, we extend our analyses to the contribution of CRASP-4 in mediating complement resistance of B. burgdorferi and its interaction with human complement regulators. CRASP-4 (also known as ErpC) was immobilized onto magnetic beads and used to capture proteins from human serum. Following Western blotting, factor H (CFH), CFH-related protein 1 (CFHR1), CFHR2, and CFHR5 were identified as ligands of CRASP-4. To analyze the impact of native CRASP-4 on mediating survival of serum-sensitive cells in human serum, a B. garinii strain was generated …

Antibodies Against The Envelope Glycoprotein Promote Infectivity Of Immature Dengue Virus Serotype 2, Julia M. Da Silva Voorham, Izabela A. Rodenhuis-Zybert, Nilda Vanesa Ayala Nunez, Tonya M. Colpitts, Heidi Van Der Ende-Metselaar, Erol Fikrig, Michael S. Diamond, Jan Wilschut, Jolanda M. Smit

Open Access Publications

No abstract provided.

Psoriasis Patients Are Enriched For Genetic Variants That Protect Against Hiv-1 Disease, Haoyan Chen, Genki Hayashi, Olivia Y. Lai, Alexander Dilthey, Peter J. Kuebler, Tami V. Wong, Maureen P. Martin, Marcelo A. Fernandez Vina, Gil Mcvean, Matthias Wabl, Kieron S. Leslie, Toby Maurer, Jeffrey N. Martin, Steven G. Deeks, Mary Carrington, Anne M. Bowcock, Douglas F. Nixon, Wilson Liao

Open Access Publications

No abstract provided.

Distinct Repeat Motifs At The C-Terminal Region Of Caga Of Helicobacter Pylori Strains Isolated From Diseased Patients And Asymptomatic Individuals In West Bengal, India, Santanu Chattopadhyay, Rajashree Patra, Raghunath Chatterjee, Ronita De, Jawed Alam, T. Ramamurthy, Abhijit Chowdhury, G. Balakrish Nair, Douglas E. Berg, Asish K. Mukhopadhyay

Open Access Publications

No abstract provided.

The Metal Ion-Dependent Adhesion Site Motif Of The Enterococcus Faecalis Ebpa Pilin Mediates Pilus Function In Catheter-Associated Urinary Tract Infection, Hailyn V. Nielsen, Pascale S. Guiton, Kimberly A. Kline, Gary C. Port, Jerome S. Pinkner, Fabrice Neiers, Staffan Normark, Birgitta Henriques-Normark, Michael G. Caparon, Scott J. Hultgren

Open Access Publications

No abstract provided.

A Glycosylphosphatidylinositol Anchor Is Required For Membrane Localization But Dispensable For Cell Wall Association Of Chitin Deacetylase 2 In Cryptococcus Neoformans, Nicole M. Gilbert, Lorina G. Baker, Charles A. Specht, Jennifer K. Lodge

Open Access Publications

No abstract provided.

Short Report: Genetic Characterization Of Atypical Mansonella (Mansonella) Ozzardi Microfilariae In Human Blood Samples From Northeastern Peru, Luis A. Marcos, Nancy Arrospide, Sergio Recuenco, Cesar Cabezas, Gary J. Weil, Peter U. Fischer

Open Access Publications

No abstract provided.

Identifying Genomic And Metabolic Features That Can Underlie Early Successional And Opportunistic Lifestyles Of Human Gut Symbionts, Catherine Lozupone, Karoline Faust, Jeroen Raes, Jeremiah J. Faith, Daniel N. Frank, Jesse Zaneveld, Jeffrey I. Gordon, Rob Knight

Open Access Publications

No abstract provided.

Intravital 2-Photon Imaging Of Leukocyte Trafficking In Beating Heart, Wenjun Li, Ruben G. Nava, Alejandro C. Bribriesco, Bernd H. Zinselmeyer, Jessica H. Spahn, Andrew E. Gelman, Alexander S. Krupnick, Mark J. Miller, Daniel Kreisel

Open Access Publications

No abstract provided.

Cooperative Role Of Antibodies Against Heat-Labile Toxin And The Etpa Adhesin In Preventing Toxin Delivery And Intestinal Colonization By Enterotoxigenic Escherichia Coli, Koushik Roy, David J. Hamilton, James M. Fleckenstein

Open Access Publications

No abstract provided.

Human Polyomaviruses In Children Undergoing Transplantation, United States, 2008-2010, Erica A. Siebrasse, Irma Bauer, Lori R. Holtz, Binh-Minh Le, Sherry Lassa-Claxton, Charles Canter, Paul Hmiel, Shalini Shenoy, Stuart Sweet, Yumirle Turmelle, Ross Shepherd, David Wang

Open Access Publications

No abstract provided.

Paragonimus Kellicotti Fluke Infections In Missouri, Usa, Michael A. Lane, Mary C. Barsanti, Carlos A. Santos, Michael Yeung, Sam J. Lubner, Gary J. Weil

Open Access Publications

No abstract provided.

Reply To Herigon And Newland, Stephanie A. Fritz, Bernard C. Camins, Jonathan Dukes, Gregory A. Storch

Open Access Publications

No abstract provided.

Increased Prevalence Of Anellovirus In Pediatric Patients With Fever, Erin Mcelvania Tekippe, Kristine M. Wylie, Elena Deych, Erica Sodergren, George Weingstock, Gregory A. Storch

Open Access Publications

No abstract provided.

Constitutively Activated Nlrp3 Inflammasome Causes Inflammation And Abnormal Skeletal Development In Mice, Sheri L. Bonar, Susannah D. Brydges, James L. Mueller, Matthew D. Mcgeough, Carla Pena, Debbie Chen, Susan K. Grimston, Cynthia L. Hickman-Brecks, Soumya Ravindran, Audrey Mcalinden, Deborah V. Novack, Daniel L. Kastner, Roberto Civitelli, Hal M. Hoffman, Gabriel Mbalaviele

Open Access Publications

No abstract provided.

18fdg Pet-Ct Imaging Detects Arterial Inflammation And Early Atherosclerosis In Hiv-Infected Adults With Cardiovascular Disease Risk Factors, Kevin E. Yarasheski, Erin Laciny, E. T. Overton, Dominic N. Reeds, Michael Harrod, Steven Baldwin, Victor G. Davila-Roman

Open Access Publications

No abstract provided.

An Analysis Of The Transcriptome Of Teladorsagia Circumcincta: Its Biological And Biotechnological Implications, Ranjeeta Menon, Robin B. Gasser, Makedonka Mitreva, Shoba Ranganathan

Open Access Publications

No abstract provided.

A Randomized Trial Of 7-Day Doripenem Versus 10-Day Imipenem-Cilastatin For Ventilatorassociated Pneumonia, Marin H. Kollef, Jean Chastre, Marc Clavel, Marcos I. Restrepo, Bart Michiels, Kone Kaniga, Iolanda Cirillo, Holly Kimko, Rebecca Redman

Open Access Publications

No abstract provided.

Transcription Profiling Reveals Stage- And Function-Dependent Expression Patterns In The Filarial Nematode Brugia Malayi, Ben-Wen Li, Zhengyuan Wang, Amy C. Rush, Makedonka Mitreva, Gary J. Weil

Open Access Publications

No abstract provided.

Natural Killer Cell Regulation By Micrornas In Health And Disease, Jeffrey W. Leong, Ryan P. Sullivan, Todd A. Fehniger

Open Access Publications

No abstract provided.

Development Of A New Humanized Mouse Model To Study Acute Inflammatory Arthritis, Alexander V. Misharin, G K. Haines, Shawn Rose, Angelical K. Gierut, Richard S. Hotchkiss, Harris Perlman

Open Access Publications

No abstract provided.

Polyclonal Mucosa-Associated Invariant T Cells Have Unique Innate Functions In Bacterial Infection, Wei-Jen Chua, Steven M. Truscott, Christopher S. Eickhoff, Azra Blazevic, Daniel F. Hoft, Ted H. Hansen

Open Access Publications

No abstract provided.

Distinguishing The Contribution Of Type 1 Pili From That Of Other Qseb-Misregulated Factors When Qsec Is Absent During Urinary Tract Infection, Maria Kostakioti, Maria Hadjifrangiskou, Corinne K. Cusumano, Thomas J. Hannan, James W. Janetka, Scott J. Hultgren

Open Access Publications

No abstract provided.

Cytosolic Clearance Of Replication-Deficient Mutants Reveals Francisella Tularensis Interactions With The Autophagic Pathway, Audrey Chong, Tara D. Wehrly, Robert Child, Bryan Hansen, Seungmin Hwang, Herbert W. Virgin, Jean Celli

Open Access Publications

No abstract provided.

Re-Orientation Of Clinical Research In Traumatic Brain Injury: Report Of An International Workshop On Comparative Effectiveness Research, Andrew I.R. Maas, David K. Menon, Hester F. Lingsma, Jose A. Pineda, M. Elizabeth Sandel, Geoffery T. Manley

Open Access Publications

No abstract provided.

The Chinese Health Care System: An Analysis Of The Current And Emerging Health Care Needs, Karen Giuliano, Courtney Droms

Scholarship and Professional Work - Business

This paper presents an overview of the health care system, current and anticipated health care challenges, and the potential for medical technology to address the health care needs of the People’s Republic of China. The implications of these topics for the modification of current strategies or development of new technologies to address the current and emerging health care needs in China will be reviewed in order to assess the industry’s current plans for expansion of their operations to the health care market in the People’s Republic of China.

Urinary Antimicrobial Peptides And The Urinary Microbiota In A Uti-Susceptible Population Of Female Pelvic Floor Surgery Patients, Vanessa Nienhouse

Master's Theses

Urinary tract infections (UTI)s are a national priority. Women who undergo surgery for pelvic floor disorders such as pelvic organ prolapse (POP) or urinary incontinence (UI) are at increased risk for UTI, as 10-30% will contract a post-instrumentation UTI (postI-UTI) within six weeks after surgery. Currently, the factors that contribute to the high rate of postI-UTI are unknown, and there is currently no clinical assessment to identify at-risk patients. However, antimicrobial peptides (AMPs) and characteristics of the urinary microbiota have the potential to serve as biomarkers, identifying patients at UTI risk and facilitating clinical prevention studies.

While it was previously …

Binge Ethanol Leads To Decreased Macrophage Accumulation In Infected Cutaneous Wounds, Sara Hlavin

Master's Theses

Trauma patients who consumed alcohol prior to sustaining injuries have higher rates of morbidity and mortality than those with comparable injuries who did not drink. Additionally, those who drank had impaired wound healing and increased susceptibility to infection. Despite these clinical observations, few studies have explored the effect of ethanol on the innate immune cell function in a healing wound or how this may alter resolution of cutaneous infection. A murine model of ethanol and cutaneous wound infection was used to examine bacterial growth and recruitment of innate immune cells. Mice were given either ethanol (2.2 g/kg) or saline 30 …

Molecular Crosstalk Between A Chemical And A Biological Stressor And Consequences On Disease Manifestation In Rainbow Trout, Richard Burki, Aleksei Krasnov, Kathrin Bettge, Caird E. Rexroad Iii, Sergey Afanasyev, Miia Antikainen, Patricia Burkhardt-Holm, Thomas Wahli, Helmut Segner

United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications

The aim of the present study was to examine the molecular and organism reaction of rainbow trout, Oncorhynchus mykiss, to the combined impact of two environmental stressors. The two stressors were the myxozoan parasite, Tetracapsuloides bryosalmonae, which is the etiological agent of proliferative kidney disease (PKD) and a natural stressor to salmonid populations, and 17β-estradiol (E2) as prototype of estrogen-active chemical stressors in the aquatic environment. Both stressors, the parasite and estrogenic contaminants, co-exist in Swiss rivers and are discussed as factors contributing to the decline of Swiss brown trout populations over the last decades. Using a microarray …

Influence Of Dietary Selenium Supplementation Form On Hepatic Transcriptome Profiles Of Maturing Beef Heifers, Zhi Zhang

Theses and Dissertations--Animal and Food Sciences

Our objective was to know how the hepatic transcriptome expression of growing beef (Angus-cross) heifers (0.5 kg gain/day) was affected by the feeding of different sources of dietary (3 mg/day) Se supplements: inorganic Se (ISe, sodium selenite), organic (OSe, Sel-Plex®), or a blend (1.5 mg:1.5 mg) of ISe:OSe (Mix), compared to the adequate but non-Se supplemented “Control”. The biopsied hepatic tissues of these four groups heifers collected at day 168 (when liver Se assimilation had stabilized) after supplements of Se, was subjected to the microarray analysis to assess Se treatment effects.

The results suggest that there were clear differences in …