Digital Commons Network^™

Dysregulation Of The Mitogen Granulin In Human Cancer Through The Mir-15/107 Microrna Gene Group, Wang-Xia Wang, Natasha Kyprianou, Xiaowei Wang, Peter T. Nelson

Pathology and Laboratory Medicine Faculty Publications

Granulin (GRN) is a potent mitogen and growth factor implicated in many human cancers, but its regulation is poorly understood. Recent findings indicate that GRN is regulated strongly by the microRNA miR-107, which functionally overlaps with miR-15, miR-16, and miR-195 due to a common 5′ sequence critical for target specificity. In this study, we queried whether miR-107 and paralogs regulated GRN in human cancers. In cultured cells, anti-argonaute RNA coimmunoprecipitation with downstream microarray analyses indicates that GRN mRNA is directly targeted by numerous miR-15/107 miRNAs. We further tested this association in human tumors. MiR-15 and miR-16 are known to be …

Challenging Supremacy: Virginia's Response To The Patient Protection And Affordable Care Act, Matthew R. Farley

University of Richmond Law Review

No abstract provided.

Community Development Authorities, Andrew A. Painter

University of Richmond Law Review

Today, CDAs of varying sizes and purposes have been authorized by at least fourteen Virginia localities, and approximately twenty have issued bonds." Despite progress, CDAs occupy anarea of Virginia law largely in its infancy. Case law directly related to their use remains limited, and many localities remain uncertain about their use since the unique marriage of private development and public power inherent in the CDA process has, at times, fostered controversy and apprehension. While this article does not directly address the public policy implications of using CDAs to finance infrastructure, the author hopes this review will generate further ideas for …

Lines And Sines Of Primate Evolution, Miriam K. Konkel, Jerilyn A. Walker, Mark A. Batzer

Faculty Publications

The primate order is a monophyletic group thought to have diverged from the Euarchonta more than 65 mya.1 Recent paleontological and molecular evolution studies place the last common ancestor of primates even earlier (≥ 85 mya).2 More than 300 extant primate species are recognized today,3, 4 clearly emphasizing their diversity and success. Our understanding of the evolution of primates and the composition of their genomes has been revolutionized within the last decade through the increasing availability and analyses of sequenced genomes. However, several aspects of primate evolution have yet to be resolved. DNA sequencing of a wider array of primate …

Development Of Microsatellites For Genetic Analyses And Population Assignment Of The Cat Flea (Siphonaptera: Pulicidae), Claudia Husseneder, Susan P. Garner, Lane D. Foil, Kevin R. Macaluso

Faculty Publications

Cat fleas, Ctenocephalides felis (Bouch) (Siphonaptera: Pulicidae), are common ectoparasites of companion animals that negatively impact their hosts directly by causing dermatitis and blood loss during feeding and indirectly through the potential transmission of disease causing agents. We isolated and characterized seven novel microsatellite loci from a partial genomic library of the cat flea enriched for di-, tri-, and tetranucleotide repeats. We screened these loci in cat fleas from two laboratory colonies and one wild-caught population collected at a temporary animal shelter (Parker coliseum) in Baton Rouge, LA. Six loci were polymorphic, with two to 15 alleles per locus and …

The Collegian (2010-11-01), Christine Cavazos

UTB/TSC Archives - The Collegian [Newspaper]

Vol. 63, No. 11

Editorial: And So It Goes..., Jemina Napier

International Journal of Interpreter Education

No abstract provided.

Mentoring: A Vital Learning Tool For Interpreter Graduates, Jemina Napier

International Journal of Interpreter Education

In 2007, the Australian Sign Language Interpreters Association [Victoria; ASLIA (VIC)] and the Victorian Deaf Society (Vicdeaf) ran a twelve-month pilot mentoring program for new graduate sign language interpreters who lived in the state of Victoria, in collaboration with Macquarie University and the Centre of Excellence for Students who are Deaf and Hard of Hearing at the Northern Melbourne Institute of Technical and Further Education (NMIT). Fourteen mentees and matching mentors participated in the program. Both ASLIA (VIC) as a professional body, and Vicdeaf as an employer, shared a commitment to professional development for practitioners and also a keen desire …

Training For Interpreting In Mental Healthcare In Ireland, Krisztina Zimány

International Journal of Interpreter Education

Interpreting in mental healthcare is a very specialized activity, and given the comparatively low demand, few interpreters receive full-time, area-specific training. As part of a larger research project completed in Ireland, mental health professionals who have worked with interpreters as well as interpreters with experience in working in mental health care shared their views on the subject. The interviews reveal what is available as well as what is lacking in terms of training for this specialised sub-domain of community interpreting. The findings, in general, suggest that there is room for improvement. In addition, there appears to be a difference between …

Culture Brokers, Advocates, Or Conduits: Pedagogical Considerations For Deaf Interpreter Education, Campbell Mcdermid

International Journal of Interpreter Education

In a qualitative review of interpretation and Deaf² studies programs in Canada, some educators described their experiences teaching Deaf students. Most of the Deaf instructors had worked as Deaf interpreters (DIs). Given the challenges they faced as a DI, and in light of research concerning interpreters from other minority cultures, the conceptualization of their subjectivity should consider their ethnicity; perhaps the role of culture broker or advocate is appropriate in some settings. The inclusion of Deaf students in the programs led to many benefits, as described by the participants, including a heightened awareness of power, Freire’s (2004) conscientização, …

Issues In Interpreting Pedagogy, Leelany Ayob

International Journal of Interpreter Education

This paper attempts to uncover some of the issues that are relevant to the training of interpreters: (a) optimal training at the undergraduate or postgraduate level; (b) training consisting of teaching language, as opposed to teaching translation only; (c) theoretical input as a means to assist and improve translation and interpreting; (d) text typologies as a pedagogical tool; and (e) evaluation and errors. These issues are also discussed in the Malaysian context. By uncovering the issues pertaining to the training of interpreters, steps can be taken to allow further improvements to be made, not only for training purposes but also …

International Development Of Interpreter Specialization: Assumptions And Principles For Interpreter Educators, Anna Witter- Merithew, Brenda S. Nicodemus

International Journal of Interpreter Education

Specialization of interpreting practice exists in the field of interpreting and interpreter education through de facto and de jure processes. Interpreters are de facto specialists when they self-designate as having specialized competence for working in a particular setting, with certain populations, or within unique functions. Conversely, interpreters may be designated as specialists through external (de jure) processes such as adhering to national standards, completing advanced educational programming in specialty areas, and achieving specialty certification. There are a variety of factors that have shaped the evolution of specialization in the United States—several of which have application to the specialization of practice …

Vital: Virtual Interpreting Training And Learning, Javier González, Francesca Gany

International Journal of Interpreter Education

This paper describes a distance learning solution for the training of medical interpreters: the Virtual Interpreting Training and Learning (VITAL) Program. VITAL was developed to offer an effective, efficient, and scalable learning alternative to conventional models. The main objective of VITAL is to increase the pool of trained medical interpreters, while providing the same quality of training as in-person programs. Currently, VITAL is used in training bilingual (i.e., English and Spanish) individuals to perform as medical interpreters. An expanded pool of trained medical interpreters will ultimately lead to enhanced communication between providers and their patients and reduce the occurrence of …

Cooperative Learning Applied To Interpreting Education, Lauri Krouse

International Journal of Interpreter Education

This action research project explored whether employing cooperative learning activities would improve participants’ perceptions of working in small groups. The action research model used in this study is based on a sequence of planning, implementation, observation, and reflection (Dana & Yendol-Silva, 2003; Hopkins, 2002; McLean, 1995). Action research is conducted by educators in their own classrooms and can lead to changes in curriculum, activities, or teaching methods. This style of research allows educators to reflect upon their teaching in a structured way, supported by valid research methods. Cooperative learning techniques (Johnson and Johnson, 1998) were applied in two interpreter education …

Follow-Up, A Key Component Of Successful Professional Development, Peter J. Smith, Diana Casey

Educational Leadership Faculty Publications

Inexperienced teachers' perceived classroom effectiveness of their planning and preparation, classroom environment, instruction, and professional responsibilities domains were analyzed to determine the effects of active follow-up compared to information-based follow-up of classroom management training (N = 50). Inexperienced teachers enrolled in I Can Do It Classroom Management Training were randomly assigned to active follow-up to the training (n = 24) or information-based follow-up to the training (n = 26). As reflected by the pretest and posttest evaluation form measuring their perceived effectiveness in the domains of planning and preparation, classroom environment, instruction, and professional responsibilities, teachers participating in active follow-up …

Checkup, Lehigh Valley Health Network

Checkup

No abstract provided.

Sex-Differences In Adiponectin Levels And Body Fat Distribution: Longitudinal Observations In Afro-Jamaicans, Michael S. Boyne, Nadia R. Bennett, Richard S. Cooper, Tamika Y. Royal-Thomas, Franklyn I. Bennett, Amy Luke, Rainford J. Wilks, Terrence E. Forrester

Faculty Publications

We longitudinally explored the relationship of body size and adiponectin levels in 393 community-dwelling Afro-Jamaicans. Adiponectin levels were greater in women, increased with age and declined with abdominal adiposity. Multivariate regression analyses suggest that subcutaneous fat in women may contribute significantly to the variance in their adiponectin levels. © 2010 Elsevier Ireland Ltd.

Behavioral Flexibility And Species Invasions: The Adaptive Flexibility Hypothesis, T. F. Wright, J. R. Eberhard, E. A. Hobson, M. L. Avery, M. A. Russello

Faculty Publications

Behavioral flexibility is an important adaptive response to changing environments for many animal species. Such plasticity may also promote the invasion of novel habitats by introduced species by providing them with the ability to expand or change their ecological niche, a longstanding idea with recent empirical support. At the individual level, flexibility may arise through innovation, in which an individual invents a new behavior, or through social learning, in which an individual adopts a behavior used by others. There is increasing evidence that the adaptive value of these two modes of learning, and the overall expression of behavioral flexibility, may …

Effects Of Hurricane Katrina And Salvage Logging On Bachman's Sparrow, Matthew E. Brooks, Philip C. Stouffer

Faculty Publications

In the southeastern U. S., longleaf pine savannas, important habitat for grassland birds, are subject to hurricanes and subsequent management. The intensity of tropical storms is predicted to increase with climate change, heightening the importance of understanding the effects of storm disturbance and salvage logging on species of concern such as Bachman's Sparrow (Peucaea aestivalis), a pine-savanna specialist. To determine how Bachman's Sparrow occupancy varies with the age and salvage history of pine stands, and to identify the vegetation and post-hurricane habitat features influencing stand occupancy, we surveyed Bachman's Sparrows in Mississippi savannas affected by Hurricane Katrina. Our point counts …

Basic Education Program Review Committee Annual Report 2010, Tennessee. State Board Of Education.

Tennessee State Board of Education

No abstract provided.

Rhnull: A Rare Blood Group Phenotype, Adnan Qureshi, Muhammad Salman, Bushra Moiz

Section of Internal Medicine

Rhnull phenotype is a rare blood group characterized by the lack of expression of all Rh antigens (D, C, c, E and e) on the red cells. The phenotype is further classified into the regulator and amorph type based on underlying genetic defect. The clinical significance of its recognition is that such patients suffer from Rhnull syndrome associated with osmotically fragile red cells called stomatocytes with subsequent chronic haemolytic anaemia of varying degree. Another importance is that such subjects readily form alloantibodies on exposure to Rh antigens. We report herein rare Rhaull phenotype in a young pregnant female which was …

Nfκb Activation And Stimulation Of Chemokine Production In Normal Human Macrophages By The Gadolinium-Based Magnetic Resonance Contrast Agent Omniscan: Possible Role In The Pathogenesis Of Nephrogenic Systemic Fibrosis., Francesco Del Galdo, Peter J Wermuth, Sankar Addya, Paolo Fortina, Sergio A Jimenez

Jefferson Institute of Molecular Medicine Papers and Presentations

OBJECTIVE: Nephrogenic systemic fibrosis (NSF) is a generalised fibrotic disorder occurring in certain individuals with renal insufficiency exposed to gadolinium-based contrast agents (GdBCA) for MRI. Histopathological examination of affected tissues shows increased numbers of activated macrophages. To elucidate the mechanisms responsible for macrophage activation, the effects of the GdBCA Omniscan on normal human macrophage global gene expression, chemokine production and nuclear factor κB (NFκB) activation was examined.

METHODS: Normal human monocyte-derived macrophages were incubated with Omniscan (50 mM) and their gene expression analysed by microarrays and real-time PCR. Macrophage chemokine production was assayed by multiplex ELISA. NFκB activation was assessed …

A Bibliometric Analysis Of Publications By Staff From Mid Yorkshire Hospitals Nhs Trust, 2007 - 2009, Peter Gatiti

Libraries

No abstract provided.

Mediterranean Menu, Winston J. Craig

Lake Union Herald

No abstract provided.

A Pragmatic Assessment Of Government Support For Organic Agriculture In Ireland, Leslie Duram

Publications

Drawing on a pragmatic approach, this paper provides an analysis of governmental support for organic farming in Ireland. There are varying levels of encouragement and programmes provided to farmers in their conversion from conventional to organic production, and in their maintenance of organic production. Support policies vary across regions and are linked to European Union legislation, thus it is challenging to document the many types of support in place. This research investigates relevant technical, financial, and policy support available to organic farmers in Ireland. This exploratory study develops an assessment of Ireland within eight key categories of organic agricultural support: …

Vol. 39, No. 09 (November 1, 2010)

Indiana Law Annotated

No abstract provided.

Employees' Decade: Recent Developments Under The Mhra And The Employers' Potential Rebound, The, Dane C. Martin

Missouri Law Review

This Note will identify the considerable changes and varying interpretations of the MHRA over the last decade, analyze the optimal balance between the competing, important interests, and determine any potential need for amendment, including consideration of the various proposals currently before the legislature. Part 11 thus analyzes the four major areas of difficulty in the adjudication of MHRA claims in the last decade, including jury trials, available damages, the burden of proof, and individual liability. Next, Part III recognizes the most recent developments under the MHRA. And lastly, Part IV involves a two-part discussion beginning with the policy and effect …

Merging In The Shadow Of The Law: The Case For Consistent Judicial Efficiency Analysis, Jamie H. Moffitt

Vanderbilt Law Review

This Article examines current judicial interpretation of Section 7 of the Clayton Act through the lens of negotiation theory. The research exposes a gap between how courts state they are analyzing efficiency claims in Section 7 Clayton Act enforcement actions and what they are actually doing. During periods of lax antitrust enforcement, this pattern is not readily visible, since almost all proposed merger and acquisition ("M&A") deals are approved. With a shift to more aggressive antitrust policy, however, it is critical that merger review include appropriate weighing of transaction-generated efficiencies-something missing from courts' current antitrust analysis. Although only a small …

Functional And Bioactive Components From Mackerel (Scomber Scombrus) And Blue Whiting (Micromesistius Poutassou) Processing Waste, Zied Khiari

Doctoral

The use of fish processing waste from an oily fish model (mackerel, Scomber
scombrus) and a white fish model (blue whiting, Micromesistius poutassou) as a source of functional and bioactive compounds was investigated.
Gelatines were extracted from fish heads and skins using pre-treatment with
different organic acids (acetic, citric, lactic, tartaric and malic acids). Gelatines from fish bones were extracted after pre-treating the bones either chemically or enzymatically. The type of pre-treatment affected the yield, colour, turbidity, amino acid profiles as well as functional properties of fish gelatines. Mackerel gelatines formed stronger and more stable gels than blue whiting. Acetic …

Article I, Section 11: A Poor "Plan B" For Washington's Religious Pharmacists, Noel E. Horton

Washington Law Review

In Stormans, Inc. v. Selecky, a group of Washington pharmacists contended their religious beliefs precluded them from dispensing the drug Plan B, a post-coital emergency contraceptive. They based their argument on rights conferred by the Free Exercise Clause of the First Amendment to the United States Constitution. A United States District Court found in the pharmacists’ favor and enjoined enforcement of rules issued by the Washington State Board of Pharmacy requiring pharmacies to deliver medications. The Ninth Circuit reversed, finding that the district court erroneously applied a heightened level of scrutiny to a neutral law of general applicability. Interestingly, …