Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Medicine and Health Sciences (326171)
- Social and Behavioral Sciences (259457)
- Law (183231)
- Education (154023)
- Arts and Humanities (123253)
-
- Life Sciences (116492)
- Medical Specialties (77122)
- Physical Sciences and Mathematics (64906)
- Higher Education (59386)
- Public Health (55695)
- Business (51312)
- History (50486)
- Psychology (48889)
- Medical Sciences (45254)
- Sociology (44001)
- Communication (43627)
- Engineering (41093)
- Nursing (34188)
- Public Affairs, Public Policy and Public Administration (33234)
- Library and Information Science (25740)
- Environmental Sciences (24959)
- United States History (21836)
- Religion (21822)
- Diseases (21762)
- Journalism Studies (21680)
- Mass Communication (21326)
- Economics (18009)
- Educational Administration and Supervision (18004)
- Rehabilitation and Therapy (16650)
- Social History (16395)
- Institution
-
- University of New Mexico (56071)
- University of New Hampshire (43700)
- University of Nebraska - Lincoln (37650)
- University of Montana (27880)
- The Texas Medical Center Library (27498)
-
- University of Colorado Law School (24806)
- University of Mississippi (24700)
- University of South Florida (22929)
- Murray State University (21736)
- Washington University School of Medicine (20212)
- University of Kentucky (18292)
- Georgia Southern University (18177)
- San Jose State University (17420)
- Chulalongkorn University (17318)
- Walden University (16849)
- Utah State University (16518)
- Western Kentucky University (16401)
- Thomas Jefferson University (16392)
- Western Michigan University (16145)
- Gallaudet University (15146)
- Eastern Illinois University (15079)
- Sigma Theta Tau International Honor Society of Nursing (14746)
- Nova Southeastern University (14547)
- University of Central Florida (14426)
- University of Alabama at Birmingham (14418)
- Virginia Commonwealth University (14283)
- University of North Dakota (14250)
- California Polytechnic State University, San Luis Obispo (13719)
- Brigham Young University (12758)
- Bowling Green State University (12540)
- Keyword
-
- Newspaper (30168)
- Humans (28558)
- Female (13594)
- Education (13407)
- COVID-19 (12864)
-
- Student newspaper (12365)
- Male (11833)
- Newspapers (10319)
- Newsletter (9999)
- Animals (9215)
- Bowling Green State University (8945)
- Spartan Daily (8774)
- EIU (8524)
- Michigan (7935)
- History (7330)
- United States (7295)
- Higher education (7292)
- Eastern Illinois University (7250)
- Daily Eastern News (7142)
- Adult (7036)
- BG News (7010)
- Faculty (6315)
- N.M. (6305)
- Mental health (6228)
- Pennsylvania (6209)
- B.G. News (5981)
- Mice (5908)
- Collegeville (5821)
- Middle Aged (5775)
- Students (5688)
- Publication Year
-
- 2026 (49277)
- 2025 (75667)
- 2024 (79565)
- 2023 (77320)
- 2022 (76358)
-
- 2021 (76673)
- 2020 (74490)
- 2019 (65565)
- 2018 (62001)
- 2017 (60664)
- 2016 (57412)
- 2015 (53356)
- 2014 (48977)
- 2013 (45581)
- 2012 (44659)
- 2011 (38434)
- 2010 (35762)
- 2009 (32225)
- 2008 (29313)
- 2007 (26436)
- 2006 (24614)
- 2005 (22448)
- 2004 (20430)
- 2003 (18915)
- 2002 (17904)
- 2001 (16945)
- 2000 (16447)
- 1999 (15100)
- 1998 (14752)
- 1997 (14302)
- Publication
-
- Theses and Dissertations (30815)
- Walden Dissertations and Doctoral Studies (15656)
- Electronic Theses and Dissertations (15365)
- Faculty Publications (14376)
- Faculty, Staff and Student Publications (13689)
-
- Dissertations (12717)
- Session Laws 1951-2000 (12443)
- Faculty Scholarship (10233)
- Spartan Daily (School of Journalism and Mass Communications) (8078)
- Faculty, Staff and Students Publications (7773)
- Daily Mississippian (all digitized issues) (7637)
- Articles (7470)
- Open Access Publications (7412)
- 2020-Current year OA Pubs (7411)
- BG News (Student Newspaper) (7107)
- Santa Fe New Mexican, 1883-1913 (6966)
- Master's Theses (6844)
- Montana Kaimin, 1898-present (6764)
- Theses (6568)
- Chulalongkorn University Theses and Dissertations (Chula ETD) (6481)
- Browse All News (6430)
- Masters Theses (6389)
- The Murray Ledger & Times (6370)
- Honors Theses (5931)
- Doctoral Dissertations and Projects (5817)
- Session Laws 2001-Present (5710)
- USF Tampa Graduate Theses and Dissertations (5473)
- International Nursing Research Congress (INRC) (5330)
- Graduate Theses, Dissertations, and Problem Reports (ETD) (5148)
- Saudi Medical Journal (5073)
- Publication Type
Articles 3451 - 3480 of 1793209
Full-Text Articles in Entire DC Network
Breaking The Cycle: From Victimization To Offending Through The Lens Of Human Services, Colette R. Penalosa
Breaking The Cycle: From Victimization To Offending Through The Lens Of Human Services, Colette R. Penalosa
Master of Arts in Human Services
The victim-offender overlap challenges the common view that victims and offenders are separately labeled by recognizing that both groups have experienced significant childhood trauma, physical, emotional, and psychological abuse, neglect, and other adverse childhood experiences (ACEs). Current research implies these experiences can increase the risk of offending as they all influence cognitive and behavioral development while leaving criminal behavior undetermined. The purpose of this capstone is to analyze the relationship between childhood victimization and offending from a human service perspective; analyzing the pathways a victim takes on the road to offending. Research conducted will focus on exploring the victim-offender overlap, …
An Exceptional Model At Sea: Functionalist Targeting And The Legal Vulnerability Of Maritime Civil Defense In Japan, Kentaro Furuya
An Exceptional Model At Sea: Functionalist Targeting And The Legal Vulnerability Of Maritime Civil Defense In Japan, Kentaro Furuya
International Law Studies
The intensifying security competition in East Asia, characterized by persistent territorial disputes and the potential for major regional contingencies, has placed the Japan Coast Guard (JCG) at a strategic crossroads. The 2023 Control Guideline, which outlines the JCG’s role during armed attacks, has further heightened interest in the agency’s legal status. This article examines the critical gap between Japan’s domestic legal framework and the international law of naval warfare, specifically addressing how the potential classification of JCG assets as military objectives undermines the safety of maritime civil defense operations.
While the Japanese government firmly maintains the JCG’s status as a …
Endothelin Receptor Antagonists In Resistant Hypertension And Proteinuric Kidney Disease: Receptor Strategy And Volume Management, Corey Keith Goldman, Jesse M. Goldman
Endothelin Receptor Antagonists In Resistant Hypertension And Proteinuric Kidney Disease: Receptor Strategy And Volume Management, Corey Keith Goldman, Jesse M. Goldman
Division of Nephrology Faculty Papers
This narrative review examines how endothelin receptor antagonists (ERAs) can be used at the intersection of difficult-to-control hypertension, chronic kidney disease (CKD), and albuminuria or proteinuria. For clinicians, the central question is not receptor selectivity alone, but whether a specific agent, indication, dose, background therapy, and monitoring plan can deliver meaningful blood-pressure or kidney benefit without unacceptable fluid retention. Pulmonary arterial hypertension established the pharmacology and major safety liabilities of the class; the current implementation questions for hypertension and kidney specialists arise in systemic hypertension and proteinuric kidney disease. Aprocitentan is the first and only ERA approved for hypertension; in …
How Non-Secular Leaders In Culturally Homogeneous Faith-Based Organizations Understand And Experience Cultural Intelligence Training, Marlon Anthony Ayers
How Non-Secular Leaders In Culturally Homogeneous Faith-Based Organizations Understand And Experience Cultural Intelligence Training, Marlon Anthony Ayers
Walden Dissertations and Doctoral Studies
Over the past five decades, shifts in U.S. immigration policy, demographic change, and civil rights reforms have increased cultural diversity across the U.S. workforce, while many faith based leaders lack the cultural intelligence (CQ) needed to navigate diverse interactions effectively. Non secular leaders in culturally homogeneous faith based organizations (FBOs) need to understand this concern as a leading indicator of challenges associated with cross-cultural engagement, organizational effectiveness, and community inclusion. The specific research problem is that it is unknown how non-secular leaders in culturally homogeneous FBOs understand and experience the challenges of managing cultural diversity in the absence of CQ …
Who Decides The Dead? Interpreting Washington’S Disposition Of Remains Statute, Wyatt Young
Who Decides The Dead? Interpreting Washington’S Disposition Of Remains Statute, Wyatt Young
Seattle University Law Review
Washington’s disposition-of-remains statute, RCW 68.50.160, is designed to honor a decedent’s expressed wishes regarding the control and disposition of their body after death. Yet recent litigation reveals a critical gap between the statute’s intent-centered design and its practical enforceability. In Larotonda v. Blackburn, a trial court acknowledged that irreparable harm would occur if a decedent’s burial wishes were ignored but nonetheless denied relief on the grounds that the individual designated to carry out those wishes lacked standing. The result was a legal paradox: a statute that recognizes decedent autonomy in theory but withholds any meaningful mechanism for its enforcement …
The Bg News August 26, 2026, Bowling Green State University
The Bg News August 26, 2026, Bowling Green State University
BG News (Student Newspaper)
The BGSU campus student newspaper. August 26, 2026. Volume 106-Issue 01.
The Effects Of Home Blood Pressure Monitoring And Hospital Readmission For Hypertensive Patients, Danielle Alston
The Effects Of Home Blood Pressure Monitoring And Hospital Readmission For Hypertensive Patients, Danielle Alston
Walden Dissertations and Doctoral Studies
Within this executive summary, the type of project discussed is an organization change project to address a health issue in chronic disease management, which is hypertension. Nearly 116 million American adults are affected by hypertension, which remains a leading force for preventable hospitalizations, emergency department visits, and cardiovascular-related mortality in the United States. Unexpected readmissions due to hypertension create system-wide strains, increased financial burden and decreased patient satisfaction. Hence, the question: In adults with hypertension, does remote home blood pressure monitoring, compared with standard office-based follow-up, reduce the rate of urgent care visits and hospital admissions over a 30-day period? …
The Individual And Combined Effects Of Individualism-Collectivism Orientation And Mental Health Stigma On Perceived Social Support In Firefighters, Emma Schafer Schutte
The Individual And Combined Effects Of Individualism-Collectivism Orientation And Mental Health Stigma On Perceived Social Support In Firefighters, Emma Schafer Schutte
Walden Dissertations and Doctoral Studies
Repetitive trauma exposure predisposes firefighters to a variety of mental health issues. Despite efforts to expand mental health resources and peer support, stigma remains a significant barrier to formal (professional) and informal (peer) support-seeking within the fire service. According to social influence theory, firefighters may avoid using available support services because they perceive support-seeking as stigmatized by their peers and feel compelled to conform. Research across cultural groups suggests that individualism-collectivism orientation, which defines how individuals assign value to individual or group needs, has nuanced effects on perceptions of social support. However, the interplay of individualism-collectivism orientation, stigma, and perceived …
Are Individual Mental Health Issues Treated Fairly By The Criminal Justice System?, Taylor Anderson
Are Individual Mental Health Issues Treated Fairly By The Criminal Justice System?, Taylor Anderson
Master of Arts in Human Services
The intersection of mental health and the criminal justice system is a critical area of inquiry that highlights the complexities of addressing psychological disorders within our legal frameworks. This paper explores the prevalence of mental health issues among incarcerated individuals and examines how systemic deficiencies contribute to a cycle of recidivism and inadequate treatment. By analyzing the existing literature, the research aims to illuminate the pressing need for a reform in the handling of mentally ill offenders, advocating for a shift towards more rehabilitative approaches rather than punitive measures. The implications of those findings extend beyond individual cases to societal …
The Rider (2026-08-26), Daniela Chapa-Reyes
Draft Final 2023 Reclamation Improvement Sites Sampling: Bres No. 31 – Waste Dump #5 Site Evaluation Summary Report, Pioneer Technical Services, Inc.
Draft Final 2023 Reclamation Improvement Sites Sampling: Bres No. 31 – Waste Dump #5 Site Evaluation Summary Report, Pioneer Technical Services, Inc.
Silver Bow Creek/Butte Area Superfund Site
This Butte Priority Soils Operable Unit (BPSOU) Reclamation Improvement (RI) Site Evaluation Summary Report (SESR) presents results of soil sampling conducted on October 16, 2023, at the Butte Reclamation Evaluation System (BRES) No. 31 – Waste Dump #5 Site and adjacent areas (referred to herein as Site) within the BPSOU. The BPSOU Consent Decree (CD) (referred to herein as BPSOU CD; EPA, 2020) Appendix D, Attachment C Further Remedial Elements Scope of Work (FRESOW) prescribed further evaluation of sites reclaimed prior to establishment of the Butte Hill Revegetation Specifications (BHRS) (Appendix A to the BPSOU CD), which were initially established …
Legal Malpractice In Washington: Use Of The Rules Of Professional Conduct, Angelo Tadrous
Legal Malpractice In Washington: Use Of The Rules Of Professional Conduct, Angelo Tadrous
Seattle University Law Review
Legal malpractice claims are difficult to prove. They are difficult to prove because many jurisdictions require that a plaintiff prove that, but for the lawyer’s misconduct, the client would have fared better. Thus, in a malpractice suit, a plaintiff must try a case within a case. Despite this difficulty, many jurisdictions prohibit the use of the Rules of Professional Conduct when litigating a malpractice case. Washington State is one of these jurisdictions. The Washington Supreme Court held in Hizey v. Carpenter that the Rules of Professional Conduct may not be referred to during trial. This Note argues that this prohibition …
Converting Buildings Is Hard: Why Seattle’S Municipal Government Should Streamline Commercial-To-Residential Conversions, Tyler M. King
Converting Buildings Is Hard: Why Seattle’S Municipal Government Should Streamline Commercial-To-Residential Conversions, Tyler M. King
Seattle University Law Review
The conversion of commercial buildings into housing is a promising solution to the growing housing crisis in many urban areas. However, despite its potential benefits, the process of repurposing commercial spaces is often stymied by complex zoning codes, high conversion costs, and bureaucratic hurdles. This Article argues that the local and state governments in Seattle should adopt more streamlined policies and offer greater incentives to developers to facilitate these conversions. By reforming zoning regulations and providing targeted financial support, municipalities can reduce the barriers to conversion and unlock the potential of underutilized commercial properties. This article examines the legal and …
Hudson Hospital Opco Llc V. Cigna Health And Life Insurance Co
Hudson Hospital Opco Llc V. Cigna Health And Life Insurance Co
2026 Decisions
USDC for the District of New Jersey
Restorative Practices And Resilience Among Trauma-Impacted Elementary Students, Rose E. Ostenson
Restorative Practices And Resilience Among Trauma-Impacted Elementary Students, Rose E. Ostenson
Graduate Teacher Education
This paper examined how restorative practices may promote resilience among trauma-impacted elementary school students. Fifteen peer-reviewed studies were analyzed to address the following research question: How do restorative practices promote resilience among trauma-impacted students in elementary schools? Three consistent themes emerged from the literature: relationship building and relational safety, school connectedness and belonging, and emotional regulation and co-regulation. These themes represent crucial protective factors associated with resilience among children who have experienced trauma. Although resilience was not directly measured in most of the studies reviewed, the findings consistently suggested that restorative practices may strengthen the relational, social, and emotional conditions …
‘Passing’ The Baton Of Trauma: Queer Failure Of The Women’S Sport Policy Working Group’S Anti-Trans ‘Position’, Meredith M. Bagley, Mary Anne Taylor, Sarah F. Price
‘Passing’ The Baton Of Trauma: Queer Failure Of The Women’S Sport Policy Working Group’S Anti-Trans ‘Position’, Meredith M. Bagley, Mary Anne Taylor, Sarah F. Price
Publications and Research
Engaging in critical rhetorical theory and methodology, we interrogate the contemporary landscape of anti-trans backlash in women’s sport. Specifically, we read the ‘TERF wars’ (Pearce et al.) across critiques of biofeminism (Pape) and whiteness (Fischer) while drawing upon critical social science research into trauma-bonding, bullying, and the structural impacts of gender verification policies. Our analysis focuses on the Women’s Sports Policy Working Group (WSPWG), offering a trauma-informed reading of the WSPWG’s ‘Position’ statement to illuminate how lesbian female athletes who were previously slandered for failing to meet femininity norms in sport are unable to overcome that trauma to recognize and …
Translational Initiative To Minimize Childhood Hemiparesis After Asymmetrical Perinatal Brain Injury, Susan V. Duff, Emily Garavatti, Terrie Inder
Translational Initiative To Minimize Childhood Hemiparesis After Asymmetrical Perinatal Brain Injury, Susan V. Duff, Emily Garavatti, Terrie Inder
Physical Therapy Faculty Articles and Research
The purpose of this perspective paper is to present a translational approach aimed at identifying the critical periods in brain development during which to provide neuroprotective and neurorestorative strategies, followed by prehensile training, to minimize hemiparesis and foster skill acquisition after asymmetrical perinatal brain injury (APBI). We contend that hemiparesis could be minimized after APBI through a multimodal sequential approach based on timely implementation of evidence-based intervention strategies. If APBI is identified early, neuroprotective techniques can be used in the first 10 days of life to minimize cell death. This can be followed in the next 3 months by the …
A Stackable Multi-Mppt Power Architecture With Paralleled Inputs For Scalable Cubesat Solar Energy Harvesting, Muhammed Syedali N., Anamika A. Kamath, Nithin Krishnan S. S., Ashfaque K. P., Sijo George, Arun P., Jr-Chiun Roger Tsai, Tensae Ali, Jesmin Jose, Athira B. S.
A Stackable Multi-Mppt Power Architecture With Paralleled Inputs For Scalable Cubesat Solar Energy Harvesting, Muhammed Syedali N., Anamika A. Kamath, Nithin Krishnan S. S., Ashfaque K. P., Sijo George, Arun P., Jr-Chiun Roger Tsai, Tensae Ali, Jesmin Jose, Athira B. S.
Small Satellite Conference
In traditional CubeSat configurations, the Maximum Power Point Tracking (MPPT) circuit acts as a critical single point of failure because all harvested solar energy is funneled through a single, non-redundant conversion stage. Consequently, the failure of this individual component completely blocks power delivery to the system, permanently stranding otherwise healthy solar arrays and batteries and causing catastrophic mission termination.
This work introduces a modular, stackable solar energy architecture that distributes power conditioning across multiple identical, autonomous modules connected to shared PV and battery buses. By relying purely on analog input-voltage regulation at a common operating point, it eliminates radiation-vulnerable digital …
Spartan Daily, August, 26, 2026, San Jose State University, School Of Journalism And Mass Communications
Spartan Daily, August, 26, 2026, San Jose State University, School Of Journalism And Mass Communications
Spartan Daily, 2026
Volume 167, Issue 03
Deep Learning-Based Burned Area Mapping Of California Wildfires Using Sentinel-2 And Landsat-8 Imagery Enhanced With Super-Resolution Techniques, Youngmin Seo, Seung Hee Kim, Menas Kafatos, Jinsoo Kim, Yangwon Lee
Deep Learning-Based Burned Area Mapping Of California Wildfires Using Sentinel-2 And Landsat-8 Imagery Enhanced With Super-Resolution Techniques, Youngmin Seo, Seung Hee Kim, Menas Kafatos, Jinsoo Kim, Yangwon Lee
Institute for ECHO Articles and Research
The increasing frequency of wildfires under a changing climate has led to extensive ecosystem destruction, highlighting the need for reliable burned area assessment using satellite imagery. Single-satellite data are constrained by observation gaps and interference from smoke and clouds, whereas multi-satellite data fusion can mitigate these limitations. Nonetheless, the fusion techniques still encounter challenges such as spatial information loss from resolution differences and cross-satellite domain mismatch. This study presents a burned area mapping framework that integrates super-resolution (SR) with transfer learning to address spatial and domain gaps in multi-satellite data. Specifically, Landsat-8 imagery is super-resolved to 7.5 m resolution, and …
Advancing Clean Mobility: Hydrogen Fuel Cell Electric Bus Workforce Development For Transit Agencies, Manideep Tummalapudi, Shantanu Kumar, Jaskaran Singh
Advancing Clean Mobility: Hydrogen Fuel Cell Electric Bus Workforce Development For Transit Agencies, Manideep Tummalapudi, Shantanu Kumar, Jaskaran Singh
Mineta Transportation Institute
Hydrogen fuel cell electric buses (FCEBs) are rapidly transforming public transportation in the United States. However, while transit agencies are investing heavily in new zero-emission vehicles and fueling infrastructure, far less attention has been paid to the workforce needed to operate and maintain them. As agencies accelerate toward ambitious climate and fleet transition goals, they are also confronting a critical challenge: preparing workers for an entirely new set of technologies, safety requirements, and operational demands. This study addresses that gap by systematically identifying the knowledge, skills, and abilities (KSAs) required for FCEB vehicle operators and maintenance technicians, assessing current training …
Midweek Memo, Georgia Southern University
Midweek Memo, Georgia Southern University
Midweek Memo
- Applaud
- Remember
- Share
- Experience
- Around the Nest
Inclusive Leadership And Employee Engagement In Multigenerational Nigeria’S Public Sector, Monday Kohwo Unurhiere
Inclusive Leadership And Employee Engagement In Multigenerational Nigeria’S Public Sector, Monday Kohwo Unurhiere
Walden Dissertations and Doctoral Studies
Ineffective leadership continues to engender disengaged employees whose work ethics contribute to inefficient and ineffective public service delivery across several African countries. The specific research problem is the inadequacy of knowledge about leadership behaviors that foster a sense of being valued among employees of different generational cohorts, leading to intellectual, social, and emotional engagement at work. The purpose of this quantitative correlational cross-sectional study was to investigate the influence of inclusive leadership (openness, availability, and accessibility) on employee engagement (intellectual, social, and affective) in the multigenerational Nigerian public sector. The theoretical framework included the constructs of inclusive leadership, employee engagement, …
Mentor Evaluation Of A Black Male Youth Mentoring Program, Kenneth Brown
Mentor Evaluation Of A Black Male Youth Mentoring Program, Kenneth Brown
Walden Dissertations and Doctoral Studies
This study was an exploration of how Black male mentors perceived organizational practices, culturally responsive mentoring, relational safety, and systems level barriers shaping their effectiveness and continued participation. The purpose was to examine early mentor-mentee match dissolution and low mentor retention in a nonprofit youth mentoring through the lens of the ecological systems theory and program evaluation framework. The practice-focused research questions were: How do volunteer mentors and program staff perceive the organizational practices and culturally responsive strategies that influence mentor effectiveness and retention in youth mentoring programs, and what organizational and systemic challenges do Black male mentors encounter in …
Uncovering The Genetic Landscape Of Pediatric Hearing Loss Along The Texas–Mexico Border, Desiree Lanehart, Michelle Gray, Roberta Sierra, Camille Maldonado, Daniel Brooks, Hongzheng Dai, Aaly Rahimtoola, Sandy Magallan, Alberto Allegre, Lori Berry
Uncovering The Genetic Landscape Of Pediatric Hearing Loss Along The Texas–Mexico Border, Desiree Lanehart, Michelle Gray, Roberta Sierra, Camille Maldonado, Daniel Brooks, Hongzheng Dai, Aaly Rahimtoola, Sandy Magallan, Alberto Allegre, Lori Berry
School of Medicine Publications
Children in Health Professional Shortage Areas (HPSAs), including the US border regions, experience delays in the diagnosis of hereditary hearing loss (HL), driven primarily by limited access to specialized genetic services. Although approximately 60% of congenital HL has a genetic etiology, many affected children in these communities remain undiagnosed, delaying timely intervention. Project GIVE is an NIH-funded virtual genomics program that expands access to genome sequencing (GS) for children with undiagnosed multisystemic conditions along the Texas–Mexico border in the Rio Grande Valley (RGV) and El Paso regions of Texas, USA. Children (0–18 years) with suspected rare diseases were referred by …
2026 Final Bpsou Backfill And Cover Material Quality Assurance Project Plan (Qapp), Pioneer Technical Services, Inc.
2026 Final Bpsou Backfill And Cover Material Quality Assurance Project Plan (Qapp), Pioneer Technical Services, Inc.
Silver Bow Creek/Butte Area Superfund Site
This Butte Priority Soils Operable Unit (BPSOU) Backfill and Cover Material Quality Assurance Project Plan (QAPP) provides the procedures and protocols necessary to conduct sampling and geotechnical characterization activities on import borrow and other externally sourced materials that will be used in backfill, cover soil, or engineered caps for upcoming BPSOU remediation activities described in the BPSOU Consent Decree (CD) (referred to as BPSOU CD; EPA, 2020a) Further Remedial Elements Scope of Work (FRESOW) (Attachment C of Appendix D to the BPSOU CD), the 2020 Residential Metals Abatement Program (RMAP) Unilateral Administrative Order (UAO) Amendment (EPA, 2020a), and ongoing maintenance …
Neuronal Expression Of Bromodomain Proteins Alters Neuronal Health And Peripheral Protein Homeostasis To Promote Longevity, Naibedya Dutta, Daniel Hicks, Edgar Esparza, Anna Entin, Priyadharshini Vijayakumar, Caitlin M Lange, Tripti Nair, Elijah A Roditi, Athena Alcala, Maxim Averbukh, Matthew Vega, Rebecca Aviles Barahona, Caitlin Mctygue, Veronica Kuo, Juri Kim, Herbert Anson, Aeowynn J Coakley, George Wang, Steven E Pilley, Max A Thorwald, Whitaker Cohn, Sean P Curran, Nicolas Brouilly, Caroline Kumsta, Rachel N Arey, Peter J Mullen, Gilberto Garcia, Ryo Higuchi-Sanabria
Neuronal Expression Of Bromodomain Proteins Alters Neuronal Health And Peripheral Protein Homeostasis To Promote Longevity, Naibedya Dutta, Daniel Hicks, Edgar Esparza, Anna Entin, Priyadharshini Vijayakumar, Caitlin M Lange, Tripti Nair, Elijah A Roditi, Athena Alcala, Maxim Averbukh, Matthew Vega, Rebecca Aviles Barahona, Caitlin Mctygue, Veronica Kuo, Juri Kim, Herbert Anson, Aeowynn J Coakley, George Wang, Steven E Pilley, Max A Thorwald, Whitaker Cohn, Sean P Curran, Nicolas Brouilly, Caroline Kumsta, Rachel N Arey, Peter J Mullen, Gilberto Garcia, Ryo Higuchi-Sanabria
Faculty, Staff and Students Publications
Longevity and stress resilience require precise coordination of gene expression programs across tissues. Here, we demonstrate that overexpression of the chromatin reader bet-1 specifically in neurons of Caenorhabditis elegans promotes organismal longevity and stress resistance via cell-nonautonomous signaling. Neuronal bet-1 elicits a neurotransmitter-dependent signal that activates the conserved stress-responsive transcription factor HSF-1 in the intestine, enhancing proteostasis, oxidative stress resistance, metabolic remodeling, and immune defense. Life span extension by neuronal bet-1 requires both hsf-1 and daf-16 in neurons but only requires hsf-1 in peripheral tissues. Using bulk RNA sequencing, we reveal distinct prolongevity pathways that include enhanced heat-shock response, proteostasis, …
Heritable Transgenic Schistosomes As A Living Platform For Sars-Cov-2 Neutralizing Antibody Secretion, Wannaporn Ittiprasert, Bruce A Rosa, Sergej Djuranovic, Makedonka Mitreva, Et Al.
Heritable Transgenic Schistosomes As A Living Platform For Sars-Cov-2 Neutralizing Antibody Secretion, Wannaporn Ittiprasert, Bruce A Rosa, Sergej Djuranovic, Makedonka Mitreva, Et Al.
2020-Current year OA Pubs
We report the generation and propagation of not only the first heritable transgenic schistosome line but also a line that secretes a functional therapeutic protein in vivo. Using multiplexed CRISPR/Cas-mediated homology-directed knock-in targeted to a predicted genomic safe-harbor, we inserted a VHH-IgG1 Fc (termed C5-Fc) transgene into Schistosoma mansoni eggs. Single-miracidium infections of Biomphalaria glabrata yielded parental P0 lines; serial passage through snail and mouse hosts produced an F2 cohort in which all parasites carried the C5-Fc transgene and secreted C5-Fc into the murine venous circulation. Molecular assays confirmed chromosomal insertion, germline transmission and systemic secretion. Sera from mice harboring …
Altered Postnatal Chromatin Development In The Nucleus Accumbens Primes Enduring Stress Sensitivity, Rebekah L Rashford, Lisa Z Fang, Michael Deberardine, Hye Ji J Kim, Laura W Hirschfield, Ella Cervi, Mason R Barrett, Jeremy M Thompson, Meaghan C Creed, Catherine Jensen Peña
Altered Postnatal Chromatin Development In The Nucleus Accumbens Primes Enduring Stress Sensitivity, Rebekah L Rashford, Lisa Z Fang, Michael Deberardine, Hye Ji J Kim, Laura W Hirschfield, Ella Cervi, Mason R Barrett, Jeremy M Thompson, Meaghan C Creed, Catherine Jensen Peña
2020-Current year OA Pubs
Early life stress (ELS) sensitizes individuals to subsequent stressors to increase lifetime risk for psychiatric disorders. Within the nucleus accumbens (NAc)-a key limbic and reward-associated brain region-ELS sensitizes both cellular and transcriptional response to later stress, which are programmed by enduring epigenetic changes. Among the histone modifications persistently enriched by ELS in NAc is H3K4me1, which is associated with open chromatin and epigenetic priming of genomic enhancers. Here, we sought to determine whether H3K4me1 enrichment in NAc was sufficient to prime cellular and behavioral responses to adult stress. Viral-mediated overexpression of the histone H3 monomethyltransferase
Lightweight Open Source On-Spacecraft Machine Learning With Mlpack And F Prime, Ryan R. Curtin, Scott M. Gilliland, Sterling L. Peet
Lightweight Open Source On-Spacecraft Machine Learning With Mlpack And F Prime, Ryan R. Curtin, Scott M. Gilliland, Sterling L. Peet
Small Satellite Conference
Onboard machine learning is an increasingly important topic in spaceflight systems, as machine learning and AI models are increasingly used for data processing, anomaly detection, attitude control systems, and other predictive applications. However, successfully deploying a machine learning model in a spaceflight computing environment is fraught with difficulty, as spaceflight computing environments are low-resource, but typical machine learning software solutions are implemented in languages like Python, which require an interpreter and other heavyweight dependencies. It is therefore virtually mandatory for any on-spacecraft machine learning to be written with lightweight toolkits that minimize dependencies and resource usage.
We demonstrate a solution …