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Checkup, Lehigh Valley Health Network

Checkup

No abstract provided.

Adenosine Deaminase From Plasmodium Falciparum As A Potential Drug Target In Anti- Malarial Drug Designing: A Bioinformatic Approach, S. Sriram, J. Kavitha Srilakshmi, V. Meenaa, C. Sasikumar

Ethnobotanical Leaflets

Parasites are responsible for a wide variety of infectious diseases causing an enormous health and economical blight. Malaria is one such prominent disease that causes widespread infections in humans and results in innumerable deaths annually. The development of resistance of the malarial parasites to the conventional drugs has signaled for an urgent need to design new drugs in an effective way and also to identify and study new drug targets to combat this disease. The rational design of a drug is usually based on the biochemical and physiological differences between the pathogen and the host. So in this current study …

Adhesion Of Jurkat Cells In Defined Media And Substrates, Sarah De Leo

Honors Capstones

No abstract provided.

The Physician's Response To Climate Change., Mona Sarfaty, Safiya Abouzaid

Department of Family & Community Medicine Faculty Papers

Climate change will have an effect on the health and well-being of the populations cared for by practicing physicians. The anticipated medical effects include heat- and cold-related deaths, cardiovascular illnesses, injuries and mental harms from extreme weather events, respiratory illnesses caused by poor air quality, infectious diseases that emanate from contaminated food, water, or spread of disease vectors, the injuries caused by natural disasters, and the mental harm associated with social disruption. Within several years, such medical problems are likely to reach the doorsteps of many physicians. In the face of this reality, physicians should assume their traditional roles as …

High-Rate Channel Catfish Fingerling Production In The Partitioned Aquaculture System, Tim Wells

All Theses

The objective of this 4-year research project was to evaluate the performance of channel catfish (Ictalurus punctatus) fingerling production in the Partitioned Aquaculture System (PAS). The goal was to demonstrate production of 80-gram minimum sized fingerlings in a single growing season, allowing for 100% market-size fish production after one additional season in the grow-out PAS.
A series of 2-inch airlift pumps fed by a single 3-hp low-head blower was found to be capable of supplying sufficient water flow-rate (in 2005, 2006, and 2007) of gpm per container to 9 cohorts. A series of 0.75-hp axial flow pumps (in 2005, 2006, …

Transition Of Blame: The Othering Of Aids From Homosexuals To Africans, Claire S. Zillman

Renée Crown University Honors Thesis Projects - All

In 1983, the first year The New York Times wrote more than one story on AIDS — acquired immune deficiency syndrome — the newspaper printed 77 articles that included the word “AIDS” and the word “homosexual.” This total reached its peak in 1987, when 314 articles that included the two words were written. In 1990, this total was down to 109, and at the turn of the century in 2000, only 29 articles that mentioned these two words were published.

Conversely, in 1983, only nine Times articles included “AIDS” and “Africa.” In 1987, when articles about the connection between AIDS …

Synthetic Studies Of Laulimalide Analogues, Ian Addison Mcalexander

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Chapter 1 provides some background information on the disease area of cancer and current modes of treatment. Chemotherapy treatment is discussed with a focus on the major cellular targets for these drugs: DNA and microtubules. For each target, classes of active compounds are described along with their mode of action. The microtubule stabilizing agent laulimalide is introduced and a case is made for analogue synthesis.

Chapter 2 describes our first generation efforts toward synthesis of des-methyl laulimalide. The target compound is divided into a northern and southern fragment with the synthesis of each fragment described. The preparation of landmark intermediates …

Impact Of Cost Sharing Levels On Adherence To Controller Drugs And Consequent Outcomes Among Asthma Patients, Varun Vaidya

Theses and Dissertations (ETD)

Prescription drug cost sharing is an effective tool to reduce the excessive drug consumption. However, many times it could have a negative impact on the drug utilization especially in case of chronic conditions. Chronic conditions such as asthma require appropriate utilization of controller medication to keep the inflammation and symptoms under control. Literature on asthma drug utilization has consistently reported underuse of controller drugs among asthma patients. The present study attempted to investigate the impact of prescription drug cost sharing levels on the controller adherence among the privately insured asthma population with moderate persistent asthma. The study also analyzed the …

Soundings 2009-05, N/A N/A

Soundings

No abstract provided.

Do We Have An Agreement? Examining The Constitutionality And Legality Of The Security And Prosperity Partnership Of North America, And The Legal Ramifications Of Its Informality, R. Chris Van Landingham

Penn State International Law Review (1982 - 2011)

No abstract provided.

Lower Crime Rates And Prisoner Recidivism, Stephanie Stravinskas

Honors College Theses

The transition from prison life back into society is not simple. The number of ex-prisoners that recidivate is alarming. Ex- offenders must find a residence, purchase life’s necessities and locate a job. In addition, many prisoners have not been rehabilitated, developed skills, or obtained an education while in prison. Focusing funds on rehabilitation programs instead of the construction of new prisons may be a more effective long-term strategy to reduce criminal activity. Strategies to reduce recidivism are discussed along with an analysis of what their implementation might entail.

Molecular Epidemiology Of Methicillin-Resistant Staphylococcus Aureus (Mrsa), Ilene Bautista

UNLV Theses, Dissertations, Professional Papers, and Capstones

Staphylococcus aureus is a frequent cause of a myriad of infections in hospitals, healthcare facilities and community settings. It is often related to skin and soft tissue infection, but it can also cause other diseases varying from food poisoning to endocarditis and toxic shock syndrome. According to a study by Kuehnert et al. (2006) there has been a strong association between Staphylococcus aureus (S. aureus) carriage and risk factors for subsequent infections. Subsequent infection from S. aureus , including methicillin-resistant S. aureus (MRSA) infection, can be projected by looking at the presence of S. aureus nasal colonization. The purpose of …

Carbohydrate Derivatives In Antibiotics Research, Yi Liang

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

In this study, we investigated the potential applications of carbohydrates in the development of new antibiotics. To tackle the problem of multidrug-resistant variants of M. tuberculosis (MDR-TB), we investigated the biosynthesis pathways of trehalose, which has contributed to significant drug resistance. Some new methods were developed for the synthesis of potential inhibitors (6-azido-trehalose and 6,6'-diazido-trehalose) that have been designed to imitate the intermediate molecule (trehalose 6-phosphate, TPP) of OtsA-OtsB pathway. At the same time, some new antibacterial agents based on trehalose have been synthesized. Members of the 1,2,3-triazole family have shown interesting biological properties. Steroid derivatives have been developed in …

An Evaluation Of Methicillin Resistant Staphylococcus Aureus Survival On Five Environmental Surfaces Under Two Different Humidities, With And Without The Addition Of Bovine Serum Albumin, Courtney Ann Coughenour

UNLV Theses, Dissertations, Professional Papers, and Capstones

The spread of antibiotic resistant bacteria is a major public health concern, as they result in greater healthcare costs and increased morbidity and mortality rates. Methicillin resistant Staphylococcus aureus (MRSA) is one organism of particular concern, with the number of infections increasing in epidemic proportion. Bacterial surface contamination with MRSA is significant, as it may serve as a reservoir for transmission and have negative health implications. The purpose of this study was to evaluate survival of MRSA on five environmental surface materials; glass, wood, vinyl, plastic, and cloth. The effect of relative humidity (RH) and bovine serum albumin (BSA) were …

Breaking The Yardstick: The Dangers Of Market-Based Governance, Don J. Deyoung

Defense Horizons

In the middle of the last century, America became a superpower. It happened, in part, because of a well-balanced technological partnership between the Federal Government and commercial sector. After winning a world war against fascism, this public-private alliance went on to cure infectious diseases, create instant global communications, land humans on the Moon, and prevail in a long Cold War against communism. This, and more, was accomplished without bankrupting the Nation’s economy. The partnership’s record of service to the American people and the world has been remarkable.

The State Of Mental Health Care In Post-Katrina New Orleans, Heather D'Antonio

Louisiana Law Review

No abstract provided.

Native American Elementary Education In The Syracuse City School District: A Microcosm Of The Native American Struggle For Self-Determination And Tribal Sovereignty, Margaret Eleni Mcweeney

Renée Crown University Honors Thesis Projects - All

This intent of this paper is to research Native American education in theSyracuseCitySchool District. This paper examines the relationship of the Onondaga Nation and the New York State Department of Education. The Onondaga Nation is a Native American Nation that neighbors the City ofSyracuse. The Nation is one of a Confederacy of Six Native American Nations inNew YorkStatecalled the Haudenosaunee.

Native American students across theUnited Stateshave extremely low graduation rates in city public schools. The Onondaga Nation attributes this to policies of marginalization and insensitive curriculum materials in public school. Many theories have been proposed that minority students often suffer …

What Is The Evidence For Treating Post-Traumatic Stress Disorder In Nurses Who Have Been Involved In Taking Care Of Victims From A School Shooting Tragedy?, Crystal Peltier

Theses and Dissertations

To combat consequences of long-term effects of posttraumatic stress disorder (PTSD) caused by \\'Orking conditions during and after a school shooting event, administration must ensure that their employees are offered adequate treatment. It is important to identify and address areas of work-related stress. Therefore, employees should be aware of the health needs of their staff following a traumatic event in the workplace. The purpose of this project was three fold: I) to explore current literature to discover experiences of nurses receiving victims of a school shooting at a health care facility; 2) to determine what the literature reveals about how …

Whatever Happened To Old Mac Donald's Farm… Concentrated Animal Feeding Operation, Factory Farming And The Safety Of The Nation's Food Supply, Julie Follmer, Roseann B. Termini

Journal of Food Law & Policy

Today, livestock farming is a far stretch from the nostalgic notion of animals grazing in green pastures, roaming free in the fresh country air and returning at the end of the day to a cozy barn. Simply stated, livestock farming is a large scale business, where tens of thousands of animals are swiftly raised industrial-style for maximum profit. Under the "factory farm" model, large corporate owned operations grow quantities of animals for slaughter for human consumption as food. In fact, livestock farms now raise 40% of all animals in the United States.

A Pharmacokinetics And Pharmacodynamics (Pk/Pd) Guided Approach To Lead Optimization Of Nitrofuranylamide Anti-Tuberculosis Agents, Nageshwar Rao Budha

Theses and Dissertations (ETD)

Currently used treatment strategies for tuberculosis (TB) involve administration of multiple drug combinations for a minimum of 6-9 months. However, these prolonged regimens do not always achieve sterilization, as evidenced by post-therapy relapse in a subgroup of treated individuals. In an effort to develop novel therapeutic agents for TB a new class of chemical agents, nitrofuranylamides, is being developed at the University of Tennessee Health Science Center. We hypothesized that the application of an iterative pharmacokinetics and pharmacodynamics (PK/PD) guided approach would facilitate the optimization of nitrofuranylamide lead compounds suitable for further development.

First, we examined the biopharmaceutic properties and …

Structural And Kinetics Studies Of The Enzyme Dihydropteroate Synthase And The Implications For Antibiotic Resistance, Katherine A. Ayers

Theses and Dissertations (ETD)

The goal of this study is to develop small molecule inhibitors of DHPS for the treatment of a variety of infectious diseases. According to the World Health Organization (WHO), infectious diseases kill more than 13 million people worldwide every year making it the second leading cause of death behind cardiovascular disease. The sulfonamide class of drugs has been in use since the 1930’s to treat many infectious agents and act by targeting the enzyme dihydropteroate synthase (DHPS) of the prokaryotic and lower eukaryotic folate pathway.

DHPS is an ideal drug target because humans do not synthesize folate de novo and …

Evolutionary Analysis Of Host Proteins Cd4, Cxcr4 And Ccr5, And Hiv/Siv Gp12, Lana Bunning

Biological Sciences

The acquired immune deficiency syndrome, AIDS, is a growing epidemic in the United States and the world. Since its discovery in 1981, the virus that causes AIDS, human immunodeficiency virus (HIV), has escalated. .Certain African ape (i.e., chimpanzees and gorillas) and monkey species are known to harbor forms of the virus termed SIV (simian immunodeficiency virus). Chimpanzees are the natural hosts of the SIV strains from which HIV-I evolved, but do not rapidly progress to AIDS, unlike their human relatives. In the wild, gorillas have been observed to harbor SIV, but this species' disease progression is currently unknown. As the …

Effect Of Work Intensification And Work Extensification On Women’S Health In The Globalised Labour Market, Jinky Leilanie Lu

Journal of International Women's Studies

This study examined the association between labour intensification due to work intensification and work extensification and ill health in women in certain manufacturing work in the Philippines. Work intensification is defined as more workload for each worker, and work extensification as less deadtime or work rest and more overtime. The sample was 23 establishments and 630 respondents. Workplace environment monitoring showed exposure to hazards such as noise, chemicals, poor ventilation, and poor illumination. The most prevalent illnesses and health problems were headache and coughs and colds. Results of focus group discussions showed adverse work conditions, hazard exposures among women workers, …

Targeted Delivery Of Surface Modified Nanoparticles: Modulation Of Inflammation For Acute Lung Injury, Hari R. Desu

Theses and Dissertations (ETD)

The objective of the study is to demonstrate alleviation of pulmonary inflammation associated with acute lung injury (ALI) using novel surface modified nanoparticles. ALI is characterized by three main pathological events: I) pulmonary edema, II) excessive pro-inflammatory cytokines and chemokines production from alveolar epithelial and endothelial cells and III) leukocyte migration from blood circulation into alveoli. Currently, there is no FDA approved pharmacological treatment available except the supportive mechanical ventilation therapy. Numerous clinical trials involving pharmacological therapies aimed at different pathological targets turned unsuccessful. National Institute of Heart Lung and Blood Institute (NHLBI) cited underappreciation of drug delivery systems as …

Lack Of Detection Of Human Papillomavirus Infection By Hybridization Test In Prostatic Biopsies, Faten S. Gazzaz, Hisham A. Mosli

Saudi Medical Journal

OBJECTIVE: To explore the possibility of finding human papillomavirus (HPV) infection in the prostate tissue of a cohort of Saudi men presenting with benign prostatic hyperplasia (BPH) or prostate cancer. METHODS: A cohort study on prospectively collected tissue samples was conducted at King Abdulaziz University Hospital (KAUH), Jeddah, Kingdom of Saudi Arabia from March 2007 to December 2008 on a total of 56 male patients, age range 50-93 years (average 68), diagnosed as having BPH or prostate cancer. The HPV DNA hybridization by hybrid capture 2 technology was performed on prostate biopsies of these patients to detect 18 types of …

The Investigation Of Congenital Toxoplasmosis In A Tertiary Care Hospital In Turkey, Gulden S. Tamer, Aysegul Yolasigmaz, Sema Ertug, Nazmiye Altintas

Saudi Medical Journal

OBJECTIVE: To elucidate the prevalence of congenital toxoplasmosis in Turkey. METHODS: This study was conducted in the Department of Parasitology, Faculty of Medicine, Ege University, Izmir, Turkey during the period of 2006 and 2007. Venous blood before delivery and cord blood during delivery were collected from 138 women, and we observed the presence of immunoglobulin (Ig)G and IgM antibodies by Enzyme Linked Immunosorbant Assay (ELISA), western blotting, and other serologic tests. RESULTS: The combination of ELISA and western blotting have the greatest sensitivity among the serological techniques used. The results of the cord and venous sera were comparable with no …

Spatial Ecology Of Raccoons Related To Cattle And Bovine Tuberculosis In Northeastern Michigan, Todd C. Atwood, Thomas J. Deliberto, Holly J. Smith, Justin S. Stevenson, Kurt C. Vercauteren

United States Department of Agriculture Wildlife Services: Staff Publications

In 1995, Mycobacterium bovis, the causative bacterium of bovine tuberculosis (bTB), was detected in 5 beef cattle operations in Alcona County, Michigan, USA. In accordance with Federal law, the operations were depopulated to prevent the spread of bTB. Subsequent wildlife surveillance programs identified high prevalence of M. bovis in mesocarnivores, including raccoons (Procyon lotor), which suggested that raccoons may be complicit in vectoring the pathogen among livestock operations. Our goal was to develop an empirical basis for generating hypotheses about the likelihood for raccoons to mediate the transmission of bTB to livestock. We found intersexual differences in scale-dependent …

A Concise Chronology Of The Rio Grande Delta From The Paleo-Indian Period To Early Spanish Exploration And Colonization, Kristina Solis

Theses and Dissertations - UTB/UTPA

The Rio Grande Delta's archaeological record is mostly unknown. This paper attempts to assemble scattered resources into a concise and understandable chronology of the Delta’s prehistoric cultures. The prehistoric environment is discussed to clear up the misconception that modern day and prehistoric environments were identical. Archaeological contributions are covered to illustrate the difficulties and successes that 20th century archaeologists experienced. Chapter III discusses a few major sites from the region to give an example of what archaeologists have discovered, and what kinds of cultural remnants have been found. A concise chronology covering the Paleo-Indian period through the Late Prehistoric follows. …

Taxonomic Revision Of Species Of The Genus Monoecocestus (Cestoda: Anoplocephalidae), Terry R. Haverkost

School of Biological Sciences: Dissertations, Theses, and Student Research

My dissertation research is an important contribution to the taxonomy of anoplocephalid cestodes. Almost all research conducted for these chapters was done by staining, mounting, and measuring anoplocephalid cestodes from the Bolivian Biodiversity Survey conducted in Bolivia from 1984-2000. These specimens were collected and processed in the field and deposited in the Harold W. Manter Laboratory of Parasitology. I was particularly interested in species of the genus Monoecocestus Beddard, 1914 that parasitize caviid and sigmodontine rodents. In all instances, the material studied has lead to the description of new species or the redescription of existing species of Monoecocestus. In …

Punta Toro Virus Infection In Mice: Strain Differences In Pathogenesis And Regulation Of Interferon Response Pathways, Michelle Mendenhall

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The Adames strain of Punta Toro virus (PTV-A) causes acute hepatic disease in hamsters and mice similar to that seen in natural Rift Valley fever virus (RVFV) infection, while the Balliet strain (PTV-B) is apathogenic. The ability of PTV-A to suppress the interferon (IFN) response has been demonstrated in hamsters and is thought to be a contributing factor to PTV-A's pathogenicity in hamsters. PTV-B is not assumed to exhibit this IFN-antagonistic activity, as it stimulates production of significantly higher IFN-β levels. To elucidate the role of IFN in resistance of mice to PTV-B infection, we utilized mice deficient in a …