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Design And Evaluation Of Oligonucleotide Microarrays For The Detection Of Bovine Pathogens, Ryan Weldon Black

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Two microarray designs were developed and produced to screen for multiple bovine pathogens commonly found in the cattle industry today. The first microarray was designed, built, and processed in-house using conventional material and equipment and targeted Pasteurella multocida, Manheimia haemolytica, Histophilus somni, and Arcanobacterium pyogenes. For each pathogen, 12 perfect-match oligonucleotide probes, which were also designed in-house, targeted different sections of the respective 16S ribosomal genes, and were coupled with 12 corresponding mismatched probes for background. These arrays were able to produce distinct hybridization patterns for each pathogen that were easily visible without the need for …

Development And Psychometric Evaluation Of The Provider Response To Emergency Pandemic (Prep) Tool, Linda Suzzanne Good Phd

Dissertations

Background: History and science would suggest that a worldwide influenza pandemic is near and its implications are on the minds of healthcare workers (HCWs). Previous studies revealed that HCW have loss-related fears and concerns associated with working during a disaster, especially one with a biologic component. Most healthcare organizations have well-crafted disaster plans in place; however, these plans often rely on the assumption that HCWs will report to work as usual, which may not be the case. Objective: The purpose of this study was to determine if HCWs' fears and concerns are a predictor of their willingness to report to …

Annotation Consistency Tool: The Assessment Of Jcvi Microbial Genome Annotations, Rhea I. Sanchez

Theses

BRC-Pathema is one of eight National Institute of Allergy and Infectious Diseases (NIAID) Bioinformatics Resource Centers. It consists of sophisticated, clade-specific Web resources targeting the data and analysis needs of different scientific communities. Among those resources are sophisticated bioinformatics software, a comprehensive library of scientific literature, and manually curated data. Periodical evaluations by the BRC-Central determine Pathema's level of completeness, accuracy, and consistency. The results of these evaluations have revealed the need to develop customized tools for the maintenance of acceptable levels of accuracy and consistency within Pathema's curated databases of annotated microbial genomes. The Annotation Consistency Tool, or ACT, …

Training Tomorrow’S Providers And Expanding Access To Peginterferon/Ribavirin Combination Therapyfor Chronic Hepatatis C In Underinsured/Uninsured Patients: Final Outcomes Of A Pilot, Resident-Initiated, Multidisciplinary, Hepatitis C Clinic, Nicole M. Agostino Do, Suzanne J. Templer Do, Edward Norris Md, Fapm, Charles M. Brooks Md, Eric J. Gertner Md, Mph, Joseph L. Yozviak Do, Facp

Department of Medicine

No abstract provided.

Defining An Emerging Epidemic: Hcv Seroprevalence In A Large, Tertiary-Care Health Network In Pennsylvania, Margaret Hoffman-Terry Md, Facp, Joseph L. Yozviak Do, Facp, K Nadeem Ahmed Md, Sherrine Eid Mph, Timothy J. Friel Md, Kimberly A. Pacella, Luther Rhodes Iii Md

Department of Medicine

No abstract provided.

Vaksin Dna: Vaksin Generasi Keempat, Maksum Radji

Majalah Ilmu Kefarmasian

Vaccines have been developed for a range of different infectious diseases. The complex-ity of microbial infections requires novel approaches to vaccine design. The first-generation of vaccines were live attenuated pathogens. Because of safety concerns, the second-generation of vaccines, chemically or physically inactivated pathogens were later developed. Purified or synthetic proteins represent a third generation, and recent advances in molecular biology and genetic engineering have led to the development of the fourth vaccine generation, which includes DNA and virus vector-based vaccines. This review discusses on the genetic elements and construction of DNA vaccines, comparison of DNA vaccines and conventional vaccines, the …

Maritime Security Issues In Southeast Asia, An Indonesian Perspective, Nugroho Wisnumurti

Indonesian Journal of International Law

In this globalize world the new threats to security are civil violence, transnational organized crime, terrorism and weapons of mass destruction, poverty, deadly infectious disease and environmental degradation. Transnational Organized Crime emerges into a serious threat to national and international security and stability with an increasingly adverse economic and social impact on States and civil society. This paper will discuss maritime security issues relevant to the situation in Southeast Asia, particularly in Indonesia and in the Straits of Malacca and Singapore. This article will focus on trafficking in persons in the context of maritime security and its challenges in the …

Washington University Record, April 30, 2009

Washington University Record

No abstract provided.

Interpersonal And Shared Decision Making Models Of Communication Applied To Simulated Requests For Organ Donation, Daniel Baughn

Theses and Dissertations

Using an analogue format, the present study evaluated the viability of relationship and interactional concepts that have been applied to the physician-patient interaction to the field of organ donation by examining the donation request process between procurement coordinators and simulated families. Interpersonal processes were assessed using behavioral ratings by independent observers. Procurement coordinators were viewed as being more submissive than dominant and more friendly than hostile. Family members were viewed as being more hostile than friendly, more dominant and hostile than submissive or friendly, disclosing slightly more personal information than medical information, and engaging in slightly more shared decision making …

Plant Vaccines: An Immunological Perspective., Douglas C. Hooper

Department of Cancer Biology Faculty Papers

The advent of technologies to express heterologous proteins in planta has led to the proposition that plants may be engineered to be safe, inexpensive vehicles for the production of vaccines and possibly even vectors for their delivery. The immunogenicity of a variety of antigens of relevance to vaccination expressed in different plants has been assessed. The purpose of this article is to examine the utility of plant-expression systems in vaccine development from an immunological perspective.

Nucleic Acids Encoding Sarcocystis Neurona Antigen And Uses Thereof, Daniel K. Howe

Veterinary Science Faculty Patents

The present invention provides novel isolated nucleic acids encoding antigenic proteins derived fromSarcocystis neurona, or unique fragments thereof. In particular, the invention provides novel isolated nucleic acids encoding membrane-associated polypeptides SnSAG2, SnSAG3, and SnSAG 4. Also provided are purified antigenic polypeptide fragments encoded by the novel nucleic acid sequences set forth herein that encode for SnSAG2, SnSAG3, and SnSAG 4. Also provided are isolated nucleic acids capable of selectively hybridizing with the nucleic acid from Sarcocystis neurona. The invention also provides vectors comprising the nucleic acids of the invention encoding an antigenic protein derived from Sarcocystis neurona or a …

Telework In The Federal Government: The Overview Memo, Workplace Flexibility 2010, Georgetown University Law Center

Memos and Fact Sheets

Flexible Work Arrangements (FWAs) alter the time and/or place that employees work on a regular basis in a manner that is manageable and predictable for both employees and employers.1 Telework, also called telecommuting, refers to an FWA that enables an employee to work from an alternative place to the employer’s usual worksite, typically home or a satellite work center. Telework technically refers to work performed with the use of a telecommunications connection to the workplace (e.g., computer, telephone), but the term is also

Primary Care Use Among Hiv Positive Inpatients At An Inner City Public Hospital: The Impact Of Crack Cocaine Use, Toye H. Brewer, Lisa R. Metsch, Marsha Mullings, Gabriel Cardenas, Margaret Pereyra

Florida Public Health Review

We studied factors associated with HIV care utilization in symptomatic HIV-positive crack-using and non-using patients at a public hospital in Miami, Florida. A bedside survey conducted with 89 HIV-positive crack-users and 93 HIV-positive non-users examined health care knowledge, perceived health status, drug use, and HIV care patterns. A multi-nominal model was utilized to calculate the adjusted odds ratio (AOR) of three levels of care: currently receiving care (having seen an HIV provider in the past 4 months), having dropped out of care (having seen an HIV provider at least once but not in the past 4 months), and never having …

Leadership Approaches To Providing Quality Hiv Prevention Care For Older Adults

Florida Public Health Review

Americans continue to face risks associated with human immunodeficiency virus (HIV). One population that receives little attention concerning HIV is that of older adults. Approximately 20% of all HIV cases are among adults aged 50 and older. Older adults and younger populations are at risk for HIV; however, few programs are in place to reduce the incidence of HIV among this priority population. Many cases of HIV among older adults go unnoticed because health care professionals perceive older adults as asexual. Many physicians and other health professionals, including health educators, are uncomfortable in discussing sexual histories with older adults, so …

Perceived Effects Of International Volunteering: Reports From Alumni, Benjamin Lough, Amanda Moore Mcbride, Margaret S. Sherraden

Center for Social Development Research

Perceived Effects of International Volunteering: Reports From Alumni

A Mathematical Model For Anti-Malarial Drug Resistance, Amanda Matthews

Theses and Dissertations

Despite the array of medical advances of our modern day society, infectious diseases still plague millions of people worldwide. Malaria, in particular, causes substantial suffering and death throughout both developed and developing countries. Aside from the socioeconomic challenges presented by the disease's prevalence in impoverished nations, one of the major difficulties scientists have encountered while attempting to eradicate the disease is the parasite's ability to become resistant to new drugs and methods of treatment. In an effort to better understand the dynamics of malaria, we analyze a mathematical model that accounts for both the treatment aspect as well as the …

The Bg News April 27, 2009, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. April 27, 2009. Volume 99-Issue 143.

American Society Of Parasitologists Newsletter, V. 31, No. 1, April 26, 2009, Scott Lyell Gardner

American Society of Parasitologists: Newsletter

An issue of the American Society of Parasitologists' quarterly newsletter, also called the Journal of Parasitology Newsletter.

The Economic Impact Of Antimicrobial Resistance In Patients With Nosocomial Staphylococcus Aureus Bacteremia, Suzanne Phillips

Theses and Dissertations

Background: The proportion of nosocomial Staphylococcus infections caused by methicillin-resistant Staphylococcus aureus (MRSA) has increased from 22% in 1995 to 63% in 2004. Blood stream infections, more commonly referred to as bacteremias, represented the majority (75.5%) of hospital-onset MRSA cases. The economic impact of Staphylococcus aureus bacteremia merits investigation. Methods: This was a retrospective cohort analysis within Cerner HealthFacts data warehouse. Eligible patients were those who had Staphylococcus aureus bacteremia and were discharged between January 1, 2000, and December 31, 2006. Inclusion criteria include age > 18 years old and onset of infection > 48 hours post admission. The crude association was …

April 23, 2009, James Madison University

The Breeze, 2000-2009

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

The Cowl - V. 73 - N. 19 - Apr 23, 2009

The Cowl

The Cowl - student newspaper of Providence College. Volume 73 - Number 19 - April 23, 2009. 32 pages.

The Presence Of Amphibian Ranavirus In Virginia Warm Water Fish Hatchery Ponds, Elizabeth Nelson

Theses and Dissertations

Amphibian declines have been occurring world wide over the past several decades. Infectious disease and environmental changes have been implicated as the causative agents in these declines. Fish stocking from hatcheries provides a unique opportunity for organisms, including infectious diseases, to travel over long distances. Ranavirus was previously found in two ponds at Harrison Lake National Fish Hatchery in Charles City County, Virginia. Therefore, the primary objective of this study was to determine if ranavirus is present in tadpoles from four warm water fish hatcheries in Virginia. A secondary objective of this study was to determine if there are relationships …

Washington University Record, April 16, 2009

Washington University Record

No abstract provided.

Animal Health Matters, Russ Daly

Animal Health MATTERS Newsletter

Head/Director's Message [Page] 1- ADRDL: The R is for Research [Page] 1- Veterinary Science Department’s Young to Collaborate With Nobel Prize Winner [Page] 2- Inside the Serology Section [Page] 3- Digital Coggins Test Submission and Results Service Now Available Through Global Vet Link [Page] 4- James Bailey Conference Held February 14 at SDSU [Page] 4- SDSU Extension Veterinarian Receives Merit Award [Page] 6- Sampling Size, Epidemiology Software Available Free on the Web [Page] 6- Enrollment Jumps for “Introduction to Veterinary Medicine” at SDSU [Page] 6- Sampling Size, Epidemiology Software Available Free On the Web [Page] 7- “Dumb Things Animals Sometimes …

Identification Of Binding Partners Of A Novel P. Falciparum Exported Protein, Monica Zapata

Theses and Dissertations

Plasmodium falciparum is the causative agent of the most severe form of malaria. This parasite drastically modifies its host cell, the erythrocyte, to create a hospitable environment for its growth and reproduction. In order for these modifications to occur, the parasite secretes proteins into the erythrocyte. While the secretion machinery is still unknown, many secreted proteins have been found to have a hydrophobic signal sequence and a novel host-targeting signal downstream of the hydrophobic sequence. A novel P. falciparum protein has been shown to be secreted from the parasitophorous vacuole, yet it lacks both a hydrophobic signal sequence and a …

Increases In Cytosolic Calcium Ion Levels In Human Natural Killer Cells In Response To Butyltin Exposure, Rhonda Lane, Sabah O. Ghazi, Margaret M. Whalen

Chemistry Faculty Research

This study investigated whether exposures to butyltins (BTs), tributylin (TBT), and dibutyltin (DBT) were able to alter cytosolic calcium levels in human natural killer (NK) cells. Additionally, the effects of cytosolic calcium ion increases on the activation state of mitogen-activated protein kinases (MAPKs) in NK cells were also investigated. NK cells are an intital immune defense against the development of tumors or viral infections. TBT and DBT are widespread environmental contaminants, due to their various industrial applications. Both TBT and DBT have been shown to decrease the ability of NK cells to lyse tumor cells (lytic function). TBT has also …

The George-Anne, Georgia Southern University

The George-Anne

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Preventive Dental Services For Infants And Subsequent Utilization Of Dental Services, Elizabeth Berry

Theses and Dissertations

The purpose of this study was to examine the use of dental services for young children following a preventive oral health intervention in a pediatric medical clinic. Over a 3 year period (2005-2008), children 0-36 months of age, enrolled in Medicaid, were provided preventive oral health services in a medical setting. Descriptive statistics and multivariate logistic regression were used to determine the effect receiving the preventive oral health services in a medical setting with the outcomes of dental utilization. 15% were determined to have dental caries at the intervention and 42% found to have a dental visit post-intervention. Children determined …

2009-04-09 Unm News Minute, University Of New Mexico Communication And Marketing Department

UNM News Minute 2009

No abstract provided.

Washington University Record, April 9, 2009

Washington University Record

No abstract provided.