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2009

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Articles 1381 - 1392 of 1392

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Preparation Of The Chinese Sweet Leaf Tea Extract And Its Anti-Obesity Effect In Rodents, Gar Yee Koh Jan 2009

Preparation Of The Chinese Sweet Leaf Tea Extract And Its Anti-Obesity Effect In Rodents, Gar Yee Koh

LSU Master's Theses

The aqueous leaf extract of Rubus suavissimus (Chinese sweet leaf tea) was active in inhibiting angiogenesis, which could be used to suppress adipogenesis and cause weight loss. Following this revelation and approach, the anti-obesity effect was thoroughly investigated in normal and obese rat models. The investigations began with the preparation of quality-controlled extract. First, the crude extraction methods were examined leading to the characterization of the chemical composition. Second, the impure components were removed by alcohol precipitation and column chromatography, resulting in a standardized sweet leaf tea extract (RUS). Third, three bioavailable compounds identified from the urine analyses were re-constituted …

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Dose Titration Of Sericea Lespedeza Leaf Meal On Haemonchus Contortus Infection In Crossbred Lambs, Dana Alicia Pollard Jan 2009

Dose Titration Of Sericea Lespedeza Leaf Meal On Haemonchus Contortus Infection In Crossbred Lambs, Dana Alicia Pollard

LSU Master's Theses

Gastrointestinal nematode (GIN) parasitism is a problem for small ruminant producers. Haemonchus contortus is the most detrimental because of substantial economic losses. Over the past decades, chemical anthelmintics have been used to control GINs. Recently, GINs have developed resistance to most anthelmintics, and now reliance on anthelmintics is not possible. Alternative control methods are needed. Also, the use of fewer chemicals in agricultural products has called for alternative methods to be less synthetic and more organic. One promising alternative method is the feeding of condensed tannin (CT) containing forages as either fresh forage or dried products such as hay, ground …

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Influence Of Tick Transmission On The Host Response To Rickettsial Infection, Soma Chowdhury Jan 2009

Influence Of Tick Transmission On The Host Response To Rickettsial Infection, Soma Chowdhury

LSU Master's Theses

Several members of the spotted fever group (SFG) of Rickettsia are transmitted to the host through infected ixodid (hard) ticks, which can serve as both vectors and reservoirs. Multiple studies have demonstrated that ticks secrete proteins into the bite site of the host that suppress innate and adaptive immune responses. While this suppression of immune responses is beneficial to the tick, it may also be beneficial to the transmitted Rickettsia. We hypothesize that Rickettsia utilize the tick’s ability to alter the host immune response at the tick feeding site to successfully establish infection. In the current study, we analyzed how …

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A Modular Approach To High Throughput Microsystems, Pin-Chuan Chen Jan 2009

A Modular Approach To High Throughput Microsystems, Pin-Chuan Chen

LSU Doctoral Dissertations

A modular high throughput microsystem was developed using microfabrication technology and nucleic acid analysis. The purpose of developing this microsystem is to identify acute infectious disease and prevent contagious outbreak in a matter of time. This microsystem included three major components, a reagent distribution device, a 96 CFPCR array, and a multi-zone thermal system, to efficiently amplify specific DNA fragments to determine the disease status or precisely pinpoint a disease from multiple patients. Polymerase chain reaction (PCR) is the key component in the nucleic acid analysis for disease because it can be used to amplify interested DNA fragments by repeatedly …

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Maternal Knowledge, Attitudes And Practices And Health Outcomes Of Their Preschool-Age Children In Urban And Rural Karnataka, India, Angela Lloyd Jan 2009

Maternal Knowledge, Attitudes And Practices And Health Outcomes Of Their Preschool-Age Children In Urban And Rural Karnataka, India, Angela Lloyd

USF Tampa Graduate Theses and Dissertations

This cross-sectional, community-based study was designed to compare the health outcomes of 2 - 5 year-old children in different types of preschools. The Integrated Child Development Services (ICDS), run by the government of India, created a system of preschools, called anganwadis, to combat malnutrition, provide health education for mothers, and preschool for children 2 - 6 years old in 1975. Many children attend their local anganwadis, while others attend private schools, and others do not attend school at all. A pre-tested questionnaire was used to interview 125 urban and 130 rural mothers regarding their knowledge, attitudes, and practices about acute …

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Functional Characterization Of Cytochrome B5 Reductase And Its Electron Acceptor Cytochrome B5 In Plasmodium Falciparum, Lucio Malvisi Jan 2009

Functional Characterization Of Cytochrome B5 Reductase And Its Electron Acceptor Cytochrome B5 In Plasmodium Falciparum, Lucio Malvisi

USF Tampa Graduate Theses and Dissertations

Malaria is a disease of major public health importance, killing approximately one million people and causing about 250 million cases of fever annually. It mostly affects children under the age of five and pregnant women in many developing countries, making it a prominent issue in international health and maternal and child health. The most aggressive form of malaria is caused by the parasite Plasmodium falciparum which is responsible for 80% of infections and 90% of deaths from malaria, and is most prevalent in sub-Saharan Africa. Public Health interventions include the implementation of prevention programs, health education, and chemotherapy. The latter …

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Tthe Rad9-Rad1-Hus1 Complex And Bif-1 Regulate Multiple Mechanisms That Affect Sensitivity To Dna Damage, Cheryl L. Meyerkord Jan 2009

Tthe Rad9-Rad1-Hus1 Complex And Bif-1 Regulate Multiple Mechanisms That Affect Sensitivity To Dna Damage, Cheryl L. Meyerkord

USF Tampa Graduate Theses and Dissertations

The resistance of cancer cells to traditional chemotherapeutic agents is a major obstacle in the successful treatment of cancer. Cancer cells manipulate a variety of signaling pathways to enhance resistance to anticancer agents; such mechanisms include disrupting the DNA damage response and hyperactivating survival signaling pathways. In an attempt to better understand the molecular mechanisms that underlie resistance to chemotherapeutic agents, we investigated multiple processes regulated by the Rad9-Rad1-Hus1 (9-1-1) complex and Bif-1. The 9-1-1 complex plays an integral role in the response to DNA damage and regulates many downstream signaling pathways. Overexpression of members of this complex has been …

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Quantitative Real-Time Polymerase Chain Reaction (Qpcr) Assay As A Molecular Tool To Assess Rickettsial Replications In Tick Hosts, Andrea S. Zanetti Jan 2009

Quantitative Real-Time Polymerase Chain Reaction (Qpcr) Assay As A Molecular Tool To Assess Rickettsial Replications In Tick Hosts, Andrea S. Zanetti

LSU Master's Theses

During the past century, many species of the Spotted Fever Group Rickettsia (SFGR)have been described, especially, through the introduction of a variety of molecular techniques applied to detect rickettsiae inside of their host. In this study we developed a quantitative realtime polymerase chain reaction (qPCR) assay (1) to characterize the growth and the distribution of a SFGR of unrecognized pathogenicity in naturally infected Amblyomma americanum ticks during physiological events; and (2) to terminate the influence of the host cell specificity in the replication patterns of recognized and unrecognized SFGR during a reciprocal rickettsiae challenge in both mammalian and tick cell …

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The Modification, System Software Development, Validation, And Clinical Trial Of A Novel Ankle Stiffness Testing Device, T. Tyler Clement Jan 2009

The Modification, System Software Development, Validation, And Clinical Trial Of A Novel Ankle Stiffness Testing Device, T. Tyler Clement

LSU Master's Theses

The purpose of this project is to modify, validate, and gather preliminary clinical data on a novel ankle stiffness device that measures stiffness (torque / degree) and range of motion (ROM) of the ankle joint complex (AJC). The initial device was designed by a mechanical engineering design group at Louisiana State University in 2006, but had not been tested on human participants. Clinical evaluation of the ankle joint is important in patients afflicted with diabetes mellitus, Hansen’s disease, or peripheral neuropathies. The combination of peripheral neuropathies, decreased ankle range of motion, and increased stiffness pose a threat to these patients, …

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Exploring The Secrets Of The Three-Dimensional Architecture Of Phototrophic Biofilms In Caves, Mònica Roldán, Mariona Hernández-Mariné Jan 2009

Exploring The Secrets Of The Three-Dimensional Architecture Of Phototrophic Biofilms In Caves, Mònica Roldán, Mariona Hernández-Mariné

International Journal of Speleology

Caves with dim natural light, and lighted hypogean environments, have been found to host phototrophic microorganisms from various taxonomic groups. These microorganisms group themselves into assemblies known as communities or biofilms, which are associated with rock surfaces. In this work, the phototrophic biofilms that colonise speleothems, walls and floors in three tourist caves (Spain) were studied. Confocal laser scanning microscopy (CLSM) and scanning electron microscopy (SEM) were used to study these organisms and acquire three-dimensional data on their biofilm structure. CLSM was used in a multi-channel mode whereby the different channels map individual biofilm components. Cyanobacteria, green microalgae, diatoms, mosses …

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The Discovery And Pursuit Of American Boutonneuse Fever: A New Spotted Fever Group Rickettsiosis', J. Goddard, A. Varela-Stokes Jan 2009

The Discovery And Pursuit Of American Boutonneuse Fever: A New Spotted Fever Group Rickettsiosis', J. Goddard, A. Varela-Stokes

Midsouth Entomologist

There is a new tick-borne disease similar to Rocky Mountain spotted fever (RMSF) that was recently described from the southern United States. Cases of the disease are a subset of reported RMSF cases and therefore constitute a “disease within a disease.” The causative agent of this RMSF-like disease, however, is Rickettsia parkeri as opposed to R. rickettsii, the pathogen causing RMSF. Both organisms are in the spotted fever group (SFG) of rickettsiae, cross-react in laboratory tests used to diagnose RMSF, and therefore are difficult to differentiate serologically. The new malady has been tentatively named “American Boutonneuse Fever” (ABF) based on …

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Combined Effects Of Hyperglycemic Conditions And Hiv-1 Nef: A Potential Model For Induced Hiv Neuropathogenesis., Edward A Acheampong, Cassandra Roschel, Muhammad Mukhtar, Alagarsamy Srinivasan, Mohammad Rafi, Roger J Pomerantz, Zahida Parveen Jan 2009

Combined Effects Of Hyperglycemic Conditions And Hiv-1 Nef: A Potential Model For Induced Hiv Neuropathogenesis., Edward A Acheampong, Cassandra Roschel, Muhammad Mukhtar, Alagarsamy Srinivasan, Mohammad Rafi, Roger J Pomerantz, Zahida Parveen

Department of Neurology Faculty Papers

Hyperglycemic conditions associated with diabetes mellitus (DM) or with the use of antiretroviral therapy may increase the risk of central nervous system (CNS) disorders in HIV-1 infected patients. In support of this hypothesis, we investigated the combined effects of hyperglycemic conditions and HIV-1 accessory protein Nef on the CNS using both in vitro and in vivo models. Astrocytes, the most abundant glial cell type required for normal synaptic transmission and other functions were selected for our in vitro study. The results show that in vitro hyperglycemic conditions enhance the expression of proinflammatory cytokines including caspase-3, complement factor 3 (C3), and …

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