Digital Commons Network^™

Zonulin As A Mediator Of Psychological Stress And Periodontal Disease, Casey D. Wright

Graduate Theses, Dissertations, and Problem Reports (ETD)

The prevalence of chronic inflammatory diseases is on the rise. Some have posited the permeability of tight junctions in gastrointestinal epithelium tissues as a potential mechanism for precipitating inflammatory processes throughout the body. Zonulin is the only known modulator of tight junction permeability and has been implicated in numerous chronic inflammatory processes (e.g., proinflammatory cytokine production) and diseases, more generally. The role of zonulin in oral inflammation, however, has yet to be explored. Periodontal disease is the most common oral inflammatory condition and primary perpetrator of tooth loss. Periodontal disease also is associated with a number of other health problems …

Ion Velocity Distribution Functions In Cutting-Edge Plasmas, Mitchell Cameron Paul

Graduate Theses, Dissertations, and Problem Reports (ETD)

Cutting-edge plasma experiments continue to push the frontiers of plasma science. Two such groups of experiments, helicon sources and laboratory magnetic reconnection, are the focus of this thesis. The relatively high plasma density achieved for modest input powers makes helicon source plasmas ideal testbeds for fusion-relevant phenomena without the complexities associated with fusion devices. Examples include plasma-material interaction (PMI) studies, divertor region studies, and boundary physics studies. As advancements in helicon source design and technology make operation at higher power for longer times possible, understanding of the plasma dynamics, particularly ion dynamics, is vital.

Laboratory experiments are essential to advancing …

Modeling, Fabrication, And Characterization Of Rf-Based Passive Wireless Sensors Composed Of Refractory Semiconducting Ceramics For High Temperature Applications, Kavin Sivaneri Varadharajan Idhaiam

Graduate Theses, Dissertations, and Problem Reports (ETD)

Real-time health monitoring of high temperature systems (>500^oC) in harsh environments is necessary to prevent catastrophic events caused by structural failures, varying pressure, and chemical reactions. Conventional solid-state temperature sensors such as resistance temperature detectors (RTDs) and thermocouples are restricted by their operating environments, sensor dimensions and often require external power sources for their operation. The current work presents the research and development of RF-based passive wireless sensing technology targeting high temperatures and harsh environmental conditions. Passive wireless devices are generally classified as near-field and far-field devices based on the interrogation distance. Near-field sensors are placed at …

Carbon Monoxide Sensing Of Nickel Oxide At 1000 ℃ To 1200 ℃ For In Situ Combustion Control: Behavior, Mechanism, And Application, Yi Wang

Graduate Theses, Dissertations, and Problem Reports (ETD)

An advanced smart sensor network is essential to a combustion system, which is in favor of in situ, locally placed, and low-cost gas sensors. However, most chemical/electrochemical sensors fail to work in a combustion boiler, due to the demanding working temperatures (> 1000 ℃). This work for the first time reports a well-functioning mixed-potential type CO sensor at 1000 ℃ - 1200 ℃ using nickel oxide (NiO) as the sensing material. The influence of feed gas flow rate, electrode thickness, and porosity on sensor behavior is investigated, delivering notable and fast responses to 1000 ppm in 3% O₂: …

Appalachian Adolescents In An Out-Of-School-Time Program: Examining The Role Of Social Support From Family And Friends For Coping Skills And Intellectual Risk-Taking Outcomes, Summer Kuhn

Graduate Theses, Dissertations, and Problem Reports (ETD)

Research on young adults has emphasized the importance of social support for generating positive physical, mental, and academic outcomes. This study aims to understand the impact of social support from family and friends on coping skills and intellectual risk-taking among high school seniors participating in an Out-of-School-Time (OST) program in Appalachia. Data from the program’s annual evaluation (2014-2018) was analyzed to measure associations between perceived social support from family and friends and students’ coping skills and intellectual risk-taking. Moreover, potential differences in these associations across genders were considered. Analyses found a significant association between family-based social support and coping skills, …

Adverse Childhood Experiences And Alcohol Use Trajectories In College Students, Rebekah Lynn Damitz

Graduate Theses, Dissertations, and Problem Reports (ETD)

Heavy alcohol use during college can result in numerous negative outcomes (e.g., accidents, worse academics, risky sexual behaviors, etc.). Understanding the risk-factors associated with elevated alcohol use in college are needed so prevention and/or interventions can be implemented to inhibit such dangerous behavior. Adverse childhood experiences have been identified as one key factor in the initiation and escalation of alcohol use, but there is limited research on samples that are in emerging adulthood. Specifically, the transition to college is a time when many students escalate drinking and can form the basis for longer term drinking patterns. It is not yet …

Sleep And Cardiovascular Reactivity To An Acute Virtual Stressor, Alaina Grace Tiani

Graduate Theses, Dissertations, and Problem Reports (ETD)

Inappropriate response and magnitude of cardiovascular reactivity (CVR) to stress is a proposed mechanism through which environmental stressors are linked with poor cardiovascular health outcomes (Chida & Steptoe, 2010; Krantz & Manuck, 1984). Studies of reactivity to various laboratory tasks commonly control for factors known to influence CVR such as smoking, medication use, caffeine intake, and BMI; however, few have considered the influence of sleep on CVR. In order to determine whether sleep characteristics need to be assessed and considered in studies of CVR, this study aimed to examine the association between indices of sleep quality and the magnitude and …

Relation Of Child Feeding Behaviors & Caregiver Qualities To Adherence To Nutritional Therapy In Type 1 Diabetes Management, Corrine N. Ahrabi-Nejad

Graduate Theses, Dissertations, and Problem Reports (ETD)

Type 1 diabetes (T1D) is a chronic illness, typically diagnosed within childhood, that affects the ability of the pancreas to produce insulin. Significant daily self-management behaviors are required to maintain metabolic control for patients with T1D. Nutritional therapy, including adequate intake of macronutrients, is one self-management behavior necessary to optimize health. Adherence to such nutritional guidelines is associated with improved glycemic control, decreased instances of acute health complications (e.g., hyperglycemia, hypoglycemia), and can also prevent insulin resistance. Despite the critical importance of nutritional therapy, adherence to these guidelines remains low within pediatric populations. Therefore, it is important and necessary to …

Air-Assisted Communications Using Line-Of-Sight Links, Shaikha A. Alkandari

Graduate Theses, Dissertations, and Problem Reports (ETD)

Recently, there has been a rapid increase in the use of air-assisted communications involv-
ing the use of airborne platforms such as unmanned aerial vehicles (UAVs). In air-assisted
networks, the UAVs can act like base stations in a traditional cellular network as long as an
appropriate backhaul is available. Alternatively, the UAVs could serve as relays, for instance,
connecting two ground-based users who are within range of the UAV. UAVs have the benefit
of being deployed and reconfigured rapidly and on demand.
Meanwhile, there has been a trend towards the use of higher and higher frequencies,
including those in millimeter-wave …

Low- And High-Wattage Vaping During Pregnancy Influence Aortic Structure And Function In Rat Offspring, James Ian Frazier

Graduate Theses, Dissertations, and Problem Reports (ETD)

Introduction: Electronic cigarettes (e-cigs) are being marketed as a healthier alternative to traditional cigarettes, yet the health consequences of e-cig usage (also called vaping) are still being investigated. E-cigs are easily customized for user preferences. For example, the choice of flavors, nicotine concentration, and/or the temperature (i.e., wattage) used to heat the e-liquid can be selected in many devices. Emerging evidence suggests that vaping during pregnancy impairs cerebral vascular function in rodent offspring. In this study, we sought to investigate the potential effects of changes to e-cig device wattage (i.e., 5W vs. 30W) with maternal vaping during pregnancy on vascular …

Development Of Oxide Dispersion Strengthening (Ods) Alloys Powder For Additive Manufacturing, Changyu Ma

Graduate Theses, Dissertations, and Problem Reports (ETD)

Additive manufacturing (AM) fabricated oxide dispersion strengthened (ODS) alloys are given high expectations for critical structural components such as the first stage turbine blade for their excellent creep strength and oxidation resistance compared to superalloys. However, the powder feedstock processing is still an open question since current state-of-the-art processes are not capable of achieving ultrafine strengthening elements such as Y₂O₃ in powder which leads to agglomeration issues in as-consolidated alloys. In this research, the oxidation behavior and stability of ultrafine oxide in AM-printed alloys using mechanically alloyed powders were evaluated at 1100 ^oC. In addition, a …

Combinatorial Approaches For Effective Design, Synthesis, And Optimization Of Enzyme-Based Conjugates, Jordan Scott Chapman

Graduate Theses, Dissertations, and Problem Reports (ETD)

The specificity and efficiency with which enzymes catalyze selective chemical reactions far exceeds the performance of traditional heterogeneous catalysts that are predominant in industrial applications such as conversion of commodity chemicals to value-added products, fuel cells, and petroleum refinement. Moreover, biocatalysts exhibit exceptionally high product turnover at ambient conditions with little health and environmental burden. These advantageous qualities have led to the prolific use of enzyme catalysis in pharmaceutical, detergents, and food preservation industries wherein their use has greatly reduced waste generation, Unfortunately, the full slate of benefits that enzymes can impart to a broader range of chemical processes is …

Analysis Of Emissions Profiles Of Hydraulic Fracturing Engine Technologies, Nicholas Joseph Wells

Graduate Theses, Dissertations, and Problem Reports (ETD)

In the past twenty years natural gas production in the United States has significantly increased. This is largely due to technological advancements in unconventional methods of horizontal drilling and hydraulic fracturing. With these new and improved technologies, the United States has been able to increase its natural gas dry production per year by 14.5 trillion cubic feet per year from 2001-2021, a 74.1% increase. Horizontal drilling allows the wellbore to have more contact with the source rock, thus allowing more hydrocarbons to be extracted. Hydraulic fracturing allows oil and gas companies to have access to low permeable source rock, previously …

Playing-Related Medical Injuries And Health Conditions In Collegiate Saxophonists: A Survey Of Saxophonists In North American Universities, Michael Anne Tolan

Graduate Theses, Dissertations, and Problem Reports (ETD)

When compared to other areas of musical performance, medical research on the performing arts is limited when it comes to studies on woodwind players, particularly saxophonists. The gap in research may be attributed to the circumstances surrounding selection processes and identifying subjects for study. For example, saxophonists are not salaried professionals in orchestras, which are commonly pooled for medical research. Establishing contact with saxophonists to conduct studies can prove difficult due to the wide range of genres that utilize the saxophone. Some issues may also be attributed to research methodology. To find the onset of injuries, researchers in previous studies …

Assessment Of Quechers Extraction Protocol For The Lc-Ms/Ms Detection Of Emerging Fentanyl Analogs In Biological Specimens For Clinical And Forensic Purposes, Kylea M. Morris

Graduate Theses, Dissertations, and Problem Reports (ETD)

Drug abuse within the United States is a dynamic and pervasive issue that affects the quality and life expectancy of our society. One of the major drug classes that are constantly utilized is opioids. Opioids are prescribed for pain management in patients suffering from cancer and other medical illnesses. Long-term use of opioids could lead to tolerance in humans, which poses a risk of reaching fatal overdose levels. Unfortunately, opioids are abused recreationally, and in some instances, individuals are unaware of the presence of dangerous synthetic drugs like fentanyl, hidden in materials such as heroin, cocaine, oxycodone, and methamphetamine. Recent …

Investigating The Marketing Language Among Online Retailers Of Violin Strings To Determine The Implied Aesthetic, Kira Kay Browning

Graduate Theses, Dissertations, and Problem Reports (ETD)

The aim of this research is to determine if language in the advertising of violin strings is acting as an exclusionary tool in favor of a Western art music “sound” produced by “classical” violinists. It posits that the marketing of strings to violinists is a topic laden with unacknowledged biases and values of musicians within Western art music. The aesthetic values attached to playing Western art music for the violin in the United States are passed on through pedagogic practice and acculturation of language. Product descriptions for strings in the United States employ language which adheres to these cultural values …

Evaluation Of A Comprehensive Diabetes Mellitus Protocol At A Rural, Federally Qualified Health Center In Southern West Virginia, Hannah D. Davis

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: Diabetes mellitus is a chronic disease that affects nearly 34 million Americans. In rural Appalachia, the population is affected disproportionately at a rate of 14% compared to the national average of 10%. Diabetes is a lifelong, chronic condition managed best by a multidisciplinary team-based approach to achieve optimal disease control. Best practices in the care of diabetes support the use of evidenced based care protocols and leveraging technology to decrease the burden of disease. Type 2 diabetes mellitus (T2DM) is the most common type, making it the focal population for evaluation.

Purpose: The purpose of this project was to …

Development And Testing Of A Biochar Combustor For A Stirling Engine, Kyle Bryant Vickery

Graduate Theses, Dissertations, and Problem Reports (ETD)

Nonrenewable resources persist as a necessity for perpetuating the current technology and standards of living maintained throughout the world. Biochar is an alternative and renewable fuel source that constitutes the potential to provide energy comparable to coal. Designing and fabricating components that can efficiently harness biochar’s energy to power machinery would demonstrate a successful renewable energy source. The scope of this research is to explain the feasible design, fabrication, and results of technology involving the burning of biochar and transference of hot combustion products for the purpose of powering a Stirling Engine. This design consists of a solid fuel burner, …

Bone Marrow Stroma-Induced Transcriptome Signatures Of Multiple Myeloma As Modulated By Junb, Jasleen Kaur Gandhi

Graduate Theses, Dissertations, and Problem Reports (ETD)

The bone marrow (BM) microenvironment acts as a breeding ground for drug resistance in multiple myeloma (MM). The interaction with bone marrow stromal cells (BMSCs) confer environment-mediated drug resistance (EMDR) to multiple myeloma. We investigated BM stroma-induced transcriptome signatures of MM cells through a sophisticated analysis of gene expression. In particular, we defined transcription program modulated by JunB, an emerging regulator of MM pathogenesis and a member of the transcription factor superfamily activator protein 1 (AP-1), in response to BM stimulation. The data and results lay down a foundation for future studies to illustrate the regulatory role of JunB in …

Post-Processing Precise Point Positioning Solutions With Parameter Optimization, Maria A. Gonzalez Castaneda

Graduate Theses, Dissertations, and Problem Reports (ETD)

Precise Point Positioning (PPP) technique can offer position solutions with centimeter-level accuracy by fusing precise satellite orbits and clocks with un-differenced, dual-frequency, pseudo-range, and carrier-phase observables. PPP presents a compelling alternative to Differential Global Positioning Systems, with the benefit that it only requires a single receiver and does not require simultaneous observations from many stations, making it appealing for ongoing research on hydro-graphic survey applications. The National Oceanic and Atmospheric Administration has been working on a buoy system tracked with a Global Positioning Systems receiver and Inertial Measurement Unit sensor using the PPP technique. In the interest of obtaining accurate …

Three Essays In Healthcare Economics And Policy Analysis, Tuyen Pham

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation research consists of three essays on healthcare economics and policy analysis. Chapter 1 investigates and explains the failure of a proposition on limiting dialysis clinic profits in California in 2018. The proposition would have required dialysis clinics to issue refunds to patients or their payers for revenue that exceeds 115% of the direct cost of treatment. In this chapter, a conceptual framework of how voters weigh costs and benefits is developed and two different empirical approaches, simple OLS and Double Post LASSO, are employed to identify key determinants of the voting outcome. The empirical results suggest that counties …

Three Essays In Public Economics, Joylynn Michelle Pruitt

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation presents three chapters related to each other in their application to public economics. In the study of how utility-maximizing or goal-seeking units achieve economic outcomes, this dissertation presents results for a diverse range of agents including prosecutors and liberal arts colleges. Co-authored with Dr. Bryan McCannon of West Virginia University, the first chapter examines an interesting feature of prosecutor elections, where the pool of potential challengers to an incumbent comes primarily from subordinates within the office. We develop a signaling model that analyzes whether entry into the political race by a subordinate provides voters with useful information. In …

Psychosocial Influences On And Behavioral Characteristics Of Young Adult Food Addiction, Rachel A. Wattick

Graduate Theses, Dissertations, and Problem Reports (ETD)

Introduction. Research on food addiction has increased in recent years, but there are few studies focusing on college-attending young adults, who may be at risk of developing food addiction due to the stress of the college environment. Additionally, causes and characteristics of food addiction are under-explored.

Aim. This dissertation aims to 1) determine the impact of adverse childhood experiences (ACEs) and other early life influences on the development of food addiction in college-attending young adults and 2) determine the psychosocial and behavioral characteristics of young adults with food addiction.

Methods. A sequential explanatory mixed-methods design was used for aims 1 …

Electrochemical And Mass Spectrometry Methods For Identification Of Gunshot Residues (Gsr) In Forensic Investigations, Kourtney A. Dalzell

Graduate Theses, Dissertations, and Problem Reports (ETD)

Gun violence continues to be one of most significant challenges straining the USA society causing thousands of human lives lost every year. In 2020 alone, firearm-related incidents including homicide, accidents, and suicides, reached a staggering number of over 43,000.^1,2 With the increase in these types of incidents, several service areas in crime laboratories are heavily impacted by the number of cases run on a yearly basis. These include firearm examinations, gunshot residue (GSR) analysis, bullet hole identification, and shooting distance determination, which are crucial to support a criminal investigation and, overall, the justice system in our country. These areas …

Development Of Methane Emissions Model To Assess Fuel Recovery Potential At Gas Well Sites Using On Site Compression, Nicholas G. Lindenfeldar

Graduate Theses, Dissertations, and Problem Reports (ETD)

The US natural gas production and consumption has increased 85.5% since 2005 primarily due to the unconventional production methods of horizontal drilling and hydraulic fracturing. Natural gas used as a fuel has a lower greenhouse gas (GHG) footprint than coal and petroleum due to lower Carbon Dioxide (CO₂) emissions when combusted. However, the “greener” benefit to natural gas may be consumed by leaks in production and transmission systems. Methane (CH₄), the primary hydrocarbon in natural gas, has an estimated Global Warming Potential (GWP) of 28-36 over 100 years, meaning it can absorb 28-36 more energy than …

Theoretical Investigation Of Sofc/Soec Degradation Mechanisms And Mitigations, Fuming Jiang

Graduate Theses, Dissertations, and Problem Reports (ETD)

America has a rapid growth in the development of renewable power generation in the twenty-first century. Hydrogen energy especially is the major topic in development of renewable power generation because it has the ability to provide for energy in transportation, combined heat and power generation and energy storage systems with little or no impact on the global ecosystem. Electrolysis and fuel cell technology for hydrogen energy storage has brought interest to the researchers worldwide.

Solid oxide electrolysis cells (SOECs) and Solid oxide fuel cells (SOFCs) are promising hydrogen energy technologies that can utilize chemical energy to produce and store electricity. …

Using Drones To Evaluate Revegetation Success On Natural Gas Pipelines, Anthony Nelson Mesa

Graduate Theses, Dissertations, and Problem Reports (ETD)

The Appalachian region of the United States has significant growth in the production of natural gas. Developing the infrastructure required for this resource creates significant disturbances across the landscape, as both well pads and transportation pipelines must be created in this mountainous terrain. Midstream infrastructure, which includes pipeline rights-of-way and associated infrastructure, can cause significant environmental degradation, especially in the form of sedimentation. The introduction of this non-point source pollutant can be detrimental to freshwater ecosystems found throughout this region. This ecological risk has necessitated the enactment of regulations related to midstream infrastructure development. Weekly, inspectors travel afoot along pipeline …

Genetic Analysis And Telemetry Study Of Migration Habits Of The Endangered Atlantic Sturgeon, Cassia Marie Busch

Graduate Theses, Dissertations, and Problem Reports (ETD)

Atlantic sturgeon are a long-lived anadromous fish that ranged from Labrador, Canada to Florida, US. Due to overharvest in the late 1800’s and 1900’s, Atlantic sturgeon populations across the coast experienced a dramatic population crash. Recovery of this species has faced challenges due to anthropogenic threats, such as vessel strikes, bycatch, and habitat degradation. In 2012, Atlantic sturgeon were added to the United States Endangered Species Act (ESA). Under the ESA, populations were listed as five distinct population segments (DPS), reflecting their geographic arrangement and genetic structure: Gulf of Maine DPS (threatened), New York Bight DPS (endangered), Chesapeake DPS (endangered), …

Uav Path Planning And Multi-Modal Localization For Mapping In A Subterranean Environment, Kieren Yoshiki Samarakoon

Graduate Theses, Dissertations, and Problem Reports (ETD)

The use of Unmanned Aerial Vehicles (UAVs), especially quadcopters, have become popular in academia and industry due to their small size and maneuverability. These UAVs can be programmed to autonomously execute missions that are usually difficult and risky for humans, such as subterranean exploration, infrastructure surveying, and even disaster response. However, inaccessible and remote environments pose a challenge in terms of navigation as they often lack access to Global Navigation Satellite System (GNSS) connections and lack features. To address these challenges, UAVs are equipped with multiple sensors to acquire different types of data. These include range, acceleration, and even images, …

Short-Term International Sport For Development And Peace Programs: A Retrospective Analysis And Critique Informed By Stakeholders’ Perspectives In A Two-Year Follow-Up, Adam Hansell

Graduate Theses, Dissertations, and Problem Reports (ETD)

Sport for Development and Peace (SDP) programs are a popular approach to promoting positive development throughout the world, spanning health, education, peace, and social issues. However, scholars have identified critical shortcomings of SDP work, including the potential to reinforce neoliberalist tendencies and values imposition from the Global North to the Global South. Deporte y Cambio Social was a short-term SDP program established through partnership between American and Mexican constituent groups with aims to empower girls and women through soccer. Through six semi-structured, two-year retrospective interviews, the purpose of the present study was to explore cross-cultural understandings of power and intercultural …