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Articles 14011 - 14040 of 15281
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Strategies For Playing Closing Octagons Game In Some Situations, Thitiphut Leelathanakit
Strategies For Playing Closing Octagons Game In Some Situations, Thitiphut Leelathanakit
Chulalongkorn University Theses and Dissertations (Chula ETD)
Closing Octagons game is a combinatorial game for two players that we modify from Dots and Boxes game and Dots and Hexagons game. The game starts with an m × n array of octagons such that every two adjacent octagons has one common side and 0 points for both players. Two players alternately turn by the following rules. (i) A player moves by coloring one side of an octagon. (ii) A player who colors the eighth side of k octagons earns k points and takes one more move. The game ends when every side of octagons has been colored and …
Patterns Of Lines Intersecting On Plane, Wongtawan Chamnan
Patterns Of Lines Intersecting On Plane, Wongtawan Chamnan
Chulalongkorn University Theses and Dissertations (Chula ETD)
In this work, we are interested in patterns of n lines on the plane such that lines produce M intersecting points. One famous related problem is called Fourier's 17 line problem. Although there are only a few known necessary conditions for realization, some arrangements may not even drawable. Consequently, we try to find more necessary conditions for this problem that can lead to possible arrangements and realize the arrangements. We provide a systematic algorithm to draw the possible arrangements. We establish lemmas for the direct drawing and find some certain cases of arrangements which are drawable. We also provide another …
Design And Control Of A 2-Dof Rehabilitation Robot With A Task Defined In A Virtual Environment., Natthapong Angsupasirikul
Design And Control Of A 2-Dof Rehabilitation Robot With A Task Defined In A Virtual Environment., Natthapong Angsupasirikul
Chulalongkorn University Theses and Dissertations (Chula ETD)
This research proposes a novel upper-limb rehabilitation robotic system. Instead of an exoskeleton type, the proposed robot is designed as active 2-DOF end-effector type moving in a horizontal plane, with being compact and easy to use with the harmless image. The rehabilitation robot system consists of a robot, a controller system and a virtual environment (game). The proposed rehabilitation robot system has been evaluated with 2 healthy subjects. The robot system has been evaluated in passive, active non-assist and active intent-based assistive rehabilitation type.
Design And Development Of An Assistive Hand Device For Enhancing Compatibility And Comfortability, Siwakorn Toochinda
Design And Development Of An Assistive Hand Device For Enhancing Compatibility And Comfortability, Siwakorn Toochinda
Chulalongkorn University Theses and Dissertations (Chula ETD)
Currently, there are plenty of hand exoskeletons for rehabilitation and assistive purpose that have been developed. They have been designed for working with patient's limbs and can be used for hand positioning and executing task which help reduce therapist's workload and gives them an alternative way to rehabilitate patients. However, there are some patients with permanent impairment which cannot improve from rehabilitation further. Thus, portable assistive devices could greatly help them performing simple activities of daily living (ADL), but such device has not been fully explored yet, the present design of tendon routing cannot closely replicate finger orientation and motion …
Measurement Of Eye Lens Dose In Interventional Radiologist From Tace Procedures Using Osld, Mananchaya Vimolnoch
Measurement Of Eye Lens Dose In Interventional Radiologist From Tace Procedures Using Osld, Mananchaya Vimolnoch
Chulalongkorn University Theses and Dissertations (Chula ETD)
For routine clinical service at Section of Interventional Radiology, Department of Radiology, King Chulalongkorn Memorial Hospital (KCMH), TACE procedure has been one of the high exposure procedures, which result in increasing eye lens dose in interventional radiologists. Thus, radiation dose should be evaluated in interventional radiology staff who may receive high eye lens dose. Currently, there is insufficient information to comply with the ICRP dose limit on the occupation exposure to the eye lens. One of the factors affecting the eye lens dose is the variation in tube directions in the interventional radiology (IR) laboratories. A preliminary study about tube …
Monitor Unit (Mu) Validation Using Various Types Of Dosimeters For Commissioning Small Field In Eclipse™ Treatment Planning System, Sammuel Mamesa
Monitor Unit (Mu) Validation Using Various Types Of Dosimeters For Commissioning Small Field In Eclipse™ Treatment Planning System, Sammuel Mamesa
Chulalongkorn University Theses and Dissertations (Chula ETD)
The objective of this study was to investigate the differences of calculated MU between commissioning using corrected FOF from single detector and commissioning using average uncorrected FOF from three detectors. Measurements were carried out on 6 MV flattened photon beams from 1x1 cm2 to 10x10 cm2. Four detectors were utilized to measure depth doses and beam profiles: IBA CC01, IBA PFD, IBA EFD and Sun Nuclear EDGE. For FOF determination, Sun Nuclear EDGE was not used. The determination of FOF was classified into corrected FOF according to IAEA/AAPM TRS 483 and uncorrected FOF from three detectors. Commissioning was undertaken in …
The Determination Of Optimal Protocol For Digital Chest Tomosynthesis, Sarawut Tongkum
The Determination Of Optimal Protocol For Digital Chest Tomosynthesis, Sarawut Tongkum
Chulalongkorn University Theses and Dissertations (Chula ETD)
Recently, digital chest tomosynthesis (DTS) is introduced as alternative technique in digital chest radiography for evaluating pulmonary disease and enhancing the internal structures in different slices. However, the radiation dose is higher compared to general chest radiography. The present study was to determine the optimal protocol for DTS in order to reduce the radiation dose to patients while maintaining the image quality. The multipurpose chest phantom N1 "LUNGMAN'' was scanned by digital radiographic systems model Definium 8000.Such phantom was inserted with simulated nodules with size diameter of 3, 5, 8, 10, 12 mm, and the data were acquired using chest …
Ct Number And Electron Density Relationship For Photon Dose Calculation In Head And Neck, Chest, Spine And Pelvic Regions, Siriporn Wong
Ct Number And Electron Density Relationship For Photon Dose Calculation In Head And Neck, Chest, Spine And Pelvic Regions, Siriporn Wong
Chulalongkorn University Theses and Dissertations (Chula ETD)
CT images supply the HU information that relates to electron density (ρe). The ρe is important for tissue inhomogeneity correction for accurate dose calculation. The purpose of this study was to evaluate the dosimetric effect on CT images on different kVp setting using single HU-ρe curve. Anthropomorphic phantom was scanned using Siemens-SOMATOM Definition AS with 120 kVp setting and used as a reference image set. The procedures were repeated with DECT option (80/140 kVp), 80 and 140 kVp. The 120 kVp HU-ρe relationship curve from Gammex 467 tissue characterization phantom was created and applied into Eclipse treatment planning system. The …
Radiation Dose And Image Quality In Chest Region Using Single- And Dual-Energy Ct: Phantom Study, Taninchai Jutawiriya
Radiation Dose And Image Quality In Chest Region Using Single- And Dual-Energy Ct: Phantom Study, Taninchai Jutawiriya
Chulalongkorn University Theses and Dissertations (Chula ETD)
Chest CT examinations are routinely performed by using single energy protocol (SE). As CT had been evolved by using dual energy protocol (DE), the patients with underlying lung nodules or pulmonary nodules will be followed up by CT examination several times. The purpose of this study is to study the radiation dose and image quality between single-energy CT (SECT) and dual-energy CT (DECT) protocols in chest phantom at King Chulalongkorn Memorial Hospital. The Lungman Kyoto Kagaku phantom inserted by five simulated lesions of various diameters was scanned by dual-source CT system (Somatom Force, Siemens Healthineers). The acquisition protocols consist of …
Involvement Of Notch Signaling In Interleukin-4-Stimulated Human Macrophages, Naunpun Sangphech
Involvement Of Notch Signaling In Interleukin-4-Stimulated Human Macrophages, Naunpun Sangphech
Chulalongkorn University Theses and Dissertations (Chula ETD)
Macrophages respond to various stimuli, resulting in distinct effector phenotypes that range from LPS-stimulated proinflammatory to IL-4-activated pro-healing phenotype. The regulatory mechanism of this polarization is not fully understood. Notch signaling pathway is a conserved signaling pathway involved in polarization of macrophages, especially proinflammatory macrophages. However, the role of Notch signaling in IL-4 stimulated macrophages (M(IL-4)) is not well defined. PPARgamma is a signature nuclear receptor in M(IL-4) that function mainly in regulating lipid metabolism. There are many reports that revealed the interaction of Notch signaling and PPARgamma in various cells but not in macrophages. In this study, the interaction …
Ctl-Mediated Immune Evasion In Hiv Viraemic Controllers And Non-Controllers, Prathanporn Kaewpreedee
Ctl-Mediated Immune Evasion In Hiv Viraemic Controllers And Non-Controllers, Prathanporn Kaewpreedee
Chulalongkorn University Theses and Dissertations (Chula ETD)
Objective: To compare T cell response and to identify the mechanism of escape in HIV-infected volunteers. Methods: HIV-infected volunteers (CD4>450 cells/µL) were enrolled from the anonymous clinic. Volunteers were classified into two groups based on HIV plasma viral load; viraemic controllers (VC) (VL<2000 cp/mL) and non-controllers (NC) (VL>2000 cp/mL). EDTA-whole blood was collected and determined the response against Gag p24 by IFNγ ELISpot assay. Population sequencing within the Gag p24 region was performed to identify escape mutations. Results: Demographic data [age, gender, sexual preference and the presence of protective alleles (HLA-B27, -B57 and –B58)] between VC (n=23) and NC (n=41) were no statistical …
Development Of Gold Nanoparticle-Based Lateral Flow Immunoassay For Detection Of Pathogenic Leptospiral Antigen, Prayoon Lae-Ngee
Development Of Gold Nanoparticle-Based Lateral Flow Immunoassay For Detection Of Pathogenic Leptospiral Antigen, Prayoon Lae-Ngee
Chulalongkorn University Theses and Dissertations (Chula ETD)
Leptospirosis, caused by pathogenic Leptospira spp., is a global re-emerging zoonosis and endemic disease in tropical and sub-tropical countries including Thailand. Point-of-care testing (POCT) for rapid diagnosis of leptospirosis is needed for prompt and appropriate treatment particularly in resource-poor settings. Lateral flow immunoassay (LFA)-based POCT devices are rapid, user friendly, cheap, have one-step analysis, and need no sophisticated equipment. LipL32 is a common target for diagnostic tests of leptospirosis because it is the major outer membrane protein (OMP) that is specific and highly conserved among pathogenic Leptospira. This study aimed to develop the gold nanoparticle (AuNP)-based LFA for detection of …
Characterization Of Antimicrobial-Resistant Nontyphoidal Salmonella Isolated From Humans And Food Animals In Thailand 172252256, Sirirat Luk-In
Characterization Of Antimicrobial-Resistant Nontyphoidal Salmonella Isolated From Humans And Food Animals In Thailand 172252256, Sirirat Luk-In
Chulalongkorn University Theses and Dissertations (Chula ETD)
The emergence and increase of resistance to antimicrobial agents, especially to extended-spectrum cephalosporins (ESCs) and fluoroquinolones in nontyphoidal Salmonella have recently become a serious therapeutic problem. The objectives of this study were to characterize antimicrobial resistance mechanisms, the clonality, and plasmid profiles among nontyphoidal Salmonella isolates from human and food animals in Thailand. A total of 897 nontyphoidal Salmonella isolates, 617 isolates from human and 280 isolates from food animal in Thailand during 2005 to 2007 and 2012 to 2016 were included in this study. The significantly higher resistance rates were found in S. Choleraesuis compared with other serotypes to …
Characterization Of T Cell Secreted Cytokines And Cytotoxic Mediators Profiling In Knee Osteoarthritis Patients, Thitiya Sae-Jung
Characterization Of T Cell Secreted Cytokines And Cytotoxic Mediators Profiling In Knee Osteoarthritis Patients, Thitiya Sae-Jung
Chulalongkorn University Theses and Dissertations (Chula ETD)
Osteoarthritis (OA) is a chronic disease associated with morphological joint changes that results in the breakdown of joint cartilage and underlying bone with erosive inflammation. Factors of OA are intrinsic factor and extrinsic factor. The pathogenesis of OA relates with immune responses and immune cells, T cells, B cells, and macrophages etc., T cells both CD4+ and CD8+ T cell are immune cells that have been suggested to play a role in OA. However, we found many finding in CD8+ T cells such as a high proportion of CD8+ T cell was observed in tissue of knee joint. In addition, …
Antimicrobial Effect Of High Dose Ascorbate In Mouse Model With Bacterial Infection, Chulamartd Wirapakorn
Antimicrobial Effect Of High Dose Ascorbate In Mouse Model With Bacterial Infection, Chulamartd Wirapakorn
Chulalongkorn University Theses and Dissertations (Chula ETD)
Ascorbate or Vitamin C is a vitamin that is important to the body. It contributes to the immunity, involves the collagen formation, acts as an antioxidant and has the ability to destroy cancer cells and bacteria. These abilities depend on the concentration of ascorbate. Bactericidal properties of ascorbate were interesting, especially in the high concentrations. Staphylococcus aureus, Pseudomonas aeruginosa, Acinetobacter baumannii, and Escherichia coli are a common etiologies of nosocomial infection in Thailand and worldwide. These bacteria have developed mechanisms of antibiotics resistance and cause more violence in the disease. Hence, the time-killing assay was used to explore the bactericidal …
Immune Response In Pythiosis Patients Treated With Pythium Insidiosum Antigen (Pia), Navaporn Worasilchai
Immune Response In Pythiosis Patients Treated With Pythium Insidiosum Antigen (Pia), Navaporn Worasilchai
Chulalongkorn University Theses and Dissertations (Chula ETD)
Immunotherapy using Pythium insidiosum antigen (PIA) is one of the combination treatment for P. insidiosum infected patients along with amputation and certain antifungal agents. The protocol of first prime (day0) after diagnosis and six booster doses (at 0.5, 1, 1.5, 3, 6, 12 months; mo.) along a year period were performed based on previous study. The switching of T-helper2 (Th2) to Th1 after immunotherapy along with the clinical improvement in equine and rabbit models were revealed whereas studies in human are very limited. To investigate the immune response in PIA treated pythiosis patients, cytokine profile (CMI response), P. insidiosum specific …
The Antiviral Activity Of Phenolic Lipids Group Against Dengue Virus, Parichat Kanyaboon
The Antiviral Activity Of Phenolic Lipids Group Against Dengue Virus, Parichat Kanyaboon
Chulalongkorn University Theses and Dissertations (Chula ETD)
Dengue virus causes a global burden that specific chemotherapy has not been established in a clinical setting. A previous report suggested that anacardic acid saturated (C15:0), a member of phenolic lipids, inhibited hepatitis C virus infection. Here, we explored structure activity relationship of phenolic lipids homologues with anti-DENV properties in the cell-based system. Our results indicated that Cardol triene (C15:3) expressed DENV1-4 inhibition, but not to Zika virus (SV0010/15) with the EC50s of 5.35 ± 1.16 µM, 7.13 ± 0.72 µM, 8.98 ± 1.77 µM, and 8.21 ± 0.34 µM, respectively. Also, the compound showed good CC50s to Vero cells …
Induction Of Interleukin-1 Receptor Antagonist (Il-1ra) By Porcine Reproductive And Respiratory Syndrome Virus (Prrsv), Teerawut Nedumpun
Induction Of Interleukin-1 Receptor Antagonist (Il-1ra) By Porcine Reproductive And Respiratory Syndrome Virus (Prrsv), Teerawut Nedumpun
Chulalongkorn University Theses and Dissertations (Chula ETD)
Porcine respiratory and reproductive syndrome virus (PRRSV) is one of the major pathogens affecting pig production industry worldwide. Impaired innate and adaptive immune responses are evidenced through the course of PRRSV infection. Several evidences indicate that PRRSV suppresses host immune responses via several immune evasion strategies. Interleukin-1 receptor antagonist (IL-1Ra) is known as an early inhibitory cytokine that suppresses innate immune functions and T lymphocyte responses. The aims of this study were to explore the induction of IL-1Ra by PRRSV and the negative immunomodulatory effects of PRRSV-induced IL-1Ra on porcine immune responses. In this study, the previous monocytes-derived dendritic cells …
Combination Effect Of Cepharanthine And 5-Fluorouracilon Human Colon Cancer In A Mouse Xenograft Model, Chanaporn Kongsaden
Combination Effect Of Cepharanthine And 5-Fluorouracilon Human Colon Cancer In A Mouse Xenograft Model, Chanaporn Kongsaden
Chulalongkorn University Theses and Dissertations (Chula ETD)
Cepharanthine (CEP), an alkaloid isolated from the root of Stephania cepharantha Hayata, was reported to possess anticancer activity in various cancers, including colon cancer. Recently, it has been shown to enhance anti-cancer activity of 5-fluorouracil (5-FU) against human colon cancer in vitro. The present study aimed to evaluate the effect of CEP alone and CEP in combination with 5-FU in a colon cancer xenograft model. HT-29 tumors were established in the right flank of nude mice. Then, HT-29 tumor bearing mice were treated with either 5-FU or CEP alone or 5-FU combined with CEP by intraperitoneal injection every other day …
Cadaveric Evaluation Of The Location Of Arteries And Their Anastomotic Territories On The Face: The Feasibility Determination Of Risky Severe Complications Regarding To The Filler Injections Sites, Benrita Jitaree
Chulalongkorn University Theses and Dissertations (Chula ETD)
The facial aging features are most concerns; therefore, the filler injection procedures are selected to provide the youthful face. However, the several complications following arterial devastating have been reported continually. Therefore, this study objectively evaluated the arterial location relative to filler injection sites. Furthermore, the arterial anastomoses and arterial supply of each injection site were also studied to verify the filler embolic pathways. This dissection was performed on 62 hemi-faces Thai embalmed cadavers to investigate nearest artery and its location of all injection sites. While, the 20 hemi-faces Thai embalmed cadavers were employed with Sihler's staining procedure to examine the …
Molecular Epidemiology And Genome Analysis Of Hepatitis E Virus In Swine And Blood Donors, Duangnapa Intharasongkroh
Molecular Epidemiology And Genome Analysis Of Hepatitis E Virus In Swine And Blood Donors, Duangnapa Intharasongkroh
Chulalongkorn University Theses and Dissertations (Chula ETD)
Hepatitis E virus (HEV) infection affects approximately 20 million individuals and results in more than 50,000 deaths each year. The highest prevalence is in Asia where contaminated food and water are often the sources of infection. There was the difference among the genotype of human Hepatitis E virus which genotype 1 to 4 can infect human. HEV genotypes 1 and 2 are found only in humans and are responsible for viral hepatitis outbreaks, while genotypes 3 and 4 are zoonotic. The HEV infection in Thailand caused by HEV genotype 3f and usually found among adult males. However, the route of …
Vitamin D Receptors Distribution And Mapk Activation In Cigarette Smoke Induced Emphysema Rats, Fatist Okrit
Vitamin D Receptors Distribution And Mapk Activation In Cigarette Smoke Induced Emphysema Rats, Fatist Okrit
Chulalongkorn University Theses and Dissertations (Chula ETD)
Rat model was used in this study in order to investigate subcellular vitamin D receptors (VDR) distribution and mitogen activated protein kinase (MAPK) alteration in the lungs of emphysema development after cigarette smoke exposure for 7 days (acute) and 14 days (subacute). Thirty male Wistar rats were randomly divided into 3 groups per each time point; 1) control (air exposed), 2) no-filter (smoke exposed without cigarette filter) and 3) filter (smoke exposed with cigarette filter) (n=5 per group). Each rat was daily and constantly exposed to 6 cigarettes smoke for 7 or 14 days. After 24 hours of the last …
Molecular Epidemiology Of Human Enterovirus In Various Clinical Specimens With Suspected Enterovirus Infection, Jira Chansaenroj
Molecular Epidemiology Of Human Enterovirus In Various Clinical Specimens With Suspected Enterovirus Infection, Jira Chansaenroj
Chulalongkorn University Theses and Dissertations (Chula ETD)
Many infectious diseases have been well recognized caused by several genotypes of human enterovirus species which significantly in public health. Publications worldwide have reported on the emerging and re-emerging of enteroviruses. Until now, epidemiological surveillance data, clinical complication and evolutionary history regarding these viruses in actual on the Asia continent are still limited. To address these concerns, this study aimed to establish comprehensive population-based surveillances, and provided evidence for the evolution in many diseases such as acute haemorrhagic conjunctivitis, herpangina, hand foot mouth disease, acute gastroenteritis, poliovirus and meningitis caused by enteroviruses. Employing reverse transcription-polymerase chain reaction and sequencing approaches …
Generation And Characterization Of Hla-Universal, Ipsc-Derived Platelets, Phatchara Norbnop
Generation And Characterization Of Hla-Universal, Ipsc-Derived Platelets, Phatchara Norbnop
Chulalongkorn University Theses and Dissertations (Chula ETD)
Platelet demand has been increased around the world resulting from many factors including the rise of aging population, hematological malignancy incidence, and hematopoietic stem cell transplantation. In addition, inadequacy of donors or matched donors, time consuming, cost, the risk of transfusion-transmitted infections and transfusion-associated reactions, and platelet transfusion refractoriness are limits of this approach. To solve these problems, here we propose to generate platelets in vitro which do not induce alloimmunity to HLA class I, a major cause of immune factors in platelet transfusion refractoriness. In this study, we have knocked out β2-microglobulin gene (β2m) in iPSCs using paired CRISPR/Cas9 …
Assessment Of Human Papillomavirus Detection Using Different Methods And Clinical Samples, Pornjarim Nilyanimit
Assessment Of Human Papillomavirus Detection Using Different Methods And Clinical Samples, Pornjarim Nilyanimit
Chulalongkorn University Theses and Dissertations (Chula ETD)
Human papillomavirus (HPV) is the etiological agent implicated cancers include those of the cervix, vulva, vagina, penis, anus, rectum and oropharynx. Currently, the Papanicolaou (Pap) smear is the recommended for cervical cancer screening but only a small percentage of women follow this screening. Overall, this thesis aimed to develop the technique and type of specimen to detect HPV DNA in Thai population and to characterize of the HPV genotypes in Thai patients with anogenital warts. Cervical swab and urine sample of 116 women and 100 men were collected before the Pap smear test. The histological examination of women can classified …
Lipoic Acid-Incorporated Calcium Carbonate Nanoparticlesfor Controlling Of Adipose Derived Stem Cells (Adscs) Differentiation And Adipocyte Function, Sarocha Cherdchom
Lipoic Acid-Incorporated Calcium Carbonate Nanoparticlesfor Controlling Of Adipose Derived Stem Cells (Adscs) Differentiation And Adipocyte Function, Sarocha Cherdchom
Chulalongkorn University Theses and Dissertations (Chula ETD)
CaCO3 NPs has received a growing interest due to its potential properties as a safe drug carrier. The LA-CaCO3 NPs were synthesized by a chemical precipitation method and characterized using transmission electron microscopy, thermogravimetric analysis, and zeta potential measurement. We used LA-CaCO3 NPs to evaluate their therapeutic effects in lipid accumulation, lipolysis, adipogenesis, and adipokines expression in ADSCs and differentiated adipocytes. The average particle sizes were observed to be 10-20 nanometers. Thermogravimetric analysis results confirmed the percentages of LA in CaCO3 NPs. The zeta potential showed a negative charge -30.9 mV. Our findings indicated that LA-CaCO3 NPs were apparently more …
Effects Of Genistein On Non-Alcoholic Steatohepatitis (Nash) Induced By High-Fat High-Fructose Diet In Bilateral Ovariectomized Rats, Sudaporn Pummoung
Effects Of Genistein On Non-Alcoholic Steatohepatitis (Nash) Induced By High-Fat High-Fructose Diet In Bilateral Ovariectomized Rats, Sudaporn Pummoung
Chulalongkorn University Theses and Dissertations (Chula ETD)
To investigate the effects of genistein on estrogen deficiency with high-fat high-fructose (HFHF) diet-induced NASH rats. Female Sprague-Dawley rats (n=48) were randomly divided into ovariectomized (OVX) and non-ovariectomized (non-OVX) group. Both rat groups, further allocated into 3 subgroups; controls, rats fed with HFHF diet (NASH), and rats fed with HFHF diet plus daily 16 mg/kg BW of genistein (NASH+Gen) for 8 weeks. Serum samples were collected for liver enzymes (AST and ALT) and TNF-α level analysis. Liver tissue samples were harvested for histopathology, hepatic lipid accumulation (oil red o stained, FFA and TG level), hepatic lipid peroxidation (MDA level), hepatic …
Evaluation Of Lipid Accumulation And Lipolysis Activity In Human Subcutaneous Adipocytes And Human Visceral Adipocytes By Α-Lipoic Acid, Α-Lipoic Acid-Incorporated Caco3 Nanoparticles And Caffeine., Sunisa Kaewdang
Chulalongkorn University Theses and Dissertations (Chula ETD)
Recently, much attention has been paid to natural plant-derived compounds as an alternative strategy for developing anti-obesity agents with minimal detrimental effects. Among various natural compounds, caffeine (1, 3, 7-trimethyl xanthine) and alpha lipoic acid (1, 2-dithiolane-3-pentanoic acid; LA) are the natural agents which show a promising result in decreasing fat deposit. Moreover, we have improved efficiencies of LA by CaCO3 NPs because LA had low bioavailability. In the present study, we investigated the effect of combination between caffeine and LA-CaCO3 NPs in lipid accumulation reduction and lipolysis stimulation in human subcutaneous adipocytes and human visceral adipocytes. Our results showed …
Effects Of Curcumin On Oxidative Stress, Inflammation And Apoptosis In L-Arginine Induced Acute Pancreatitis In Mice, Thidarat Chingchit
Effects Of Curcumin On Oxidative Stress, Inflammation And Apoptosis In L-Arginine Induced Acute Pancreatitis In Mice, Thidarat Chingchit
Chulalongkorn University Theses and Dissertations (Chula ETD)
L-arginine (L-arg) is an amino acid that has been used to induce acute pancreatitis (AP) in mice. Curcumin is an active ingredient constituent of rhizomes of the plant Curcuma longa Linn. It has been used for the treatment of inflammatory conditions and shown to exhibit a variety of biological activities such as anti-inflammatory and anti-oxidant. The present study aims to examine the effects of curcumin on oxidative stress, inflammation and apoptosis in AP. Male ICR mice were randomly divided into 4 groups. 1) Control group, mice will be received i.p. of 1% DMSO as a vehicle. 2) AP group, mice …
Effect Of Calcium Citrate In Calcium Carbonate Nanoparticles On Hk-2 Cells In Acidic Environment, Tipagorn Udomsinsirikul
Effect Of Calcium Citrate In Calcium Carbonate Nanoparticles On Hk-2 Cells In Acidic Environment, Tipagorn Udomsinsirikul
Chulalongkorn University Theses and Dissertations (Chula ETD)
Metabolic acidosis exerts several cellular and tissue dysfunctions, such as increases mineral bone and protein degradation, induces inflammation, oxidative stress and cell death. These complications lead to multiple organ failure, including chronic kidney disease. Sodium bicarbonate and Shohl's solution are commonly used to treat metabolic acidosis. However, these agents cause frequent gastrointestinal adverse effects. Hence, we invented the new calcium carbonate nanoparticles to use as a drug delivery system for carrying citrate to renal cell which we hypothesize to reduce adverse effects of metabolic acidosis. We studied the physical characteristics and pharmacological effects of calcium citrate nanoparticle (Cacit) and calcium …