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Articles 901 - 930 of 2753
Full-Text Articles in Entire DC Network
Nano-Magnetic Resonance Imaging (Nano-Mri) Gives Personalized Medicine A New Perspective, Lorenzo Rosa, Jonathan Blackledge, Albert Boretti
Nano-Magnetic Resonance Imaging (Nano-Mri) Gives Personalized Medicine A New Perspective, Lorenzo Rosa, Jonathan Blackledge, Albert Boretti
Articles
This paper reviews some of the major and most recent advances in nanoscale-magnetic resonance imaging (nano-MRI) for personalized medicine (PM). Nano-MRI may drastically expand the capabilities of the traditional magnetic resonance images (MRI), down to the nanometer scale and possibly, in the near future, at the atomic scale. Nano-MRI is potentially able to observe structures which cannot be seen using today’s molecular imaging, with sensitivities of many billions of times better than MRI as currently used in hospitals, for example. The paper briefly reports on the foremost research themes in nano-MRI.
Strengthening The Development Of The Short-Rotation Plantations Bioenergy Sector: Policy Insights From Six European Countries, Carlos Parra-Lopez, Martin Holley, Kevin Lindegaard, Samir Sayadi, Gonzalo Esteban-Lopez, Victor Duran-Zuazo, Christoph Knauer, Hans-Georg Von Engelbrechten, Ralf Winterber, Annika Henriksson, Annette Lamley, Anders Nylander, Susanne Paulrud, Pauline Leonard, Patrick Daly, Lukasz Drzewaszewski, Wojciech Rzewuski
Strengthening The Development Of The Short-Rotation Plantations Bioenergy Sector: Policy Insights From Six European Countries, Carlos Parra-Lopez, Martin Holley, Kevin Lindegaard, Samir Sayadi, Gonzalo Esteban-Lopez, Victor Duran-Zuazo, Christoph Knauer, Hans-Georg Von Engelbrechten, Ralf Winterber, Annika Henriksson, Annette Lamley, Anders Nylander, Susanne Paulrud, Pauline Leonard, Patrick Daly, Lukasz Drzewaszewski, Wojciech Rzewuski
Articles
This paper, based on a participatory methodological framework involving expert stakeholders and researchers from six European countries (Germany, Ireland, Poland, Spain, Sweden and UK), analyses the priority issues for the development of short-rotation plantations (SRP), and proposes a series of policy strategies to strengthen this development. The results indicate that there is a lack of awareness of the multifaceted benefits of SRP at the level of farmers, policy makers and public authorities. More research is required to put a value on the multifunctionality of SRP and justify its public support. Small-scale projects using established technologies are also required with energy …
Consciousness, Evidence, And Moral Standing, Irina Mikhalevich
Consciousness, Evidence, And Moral Standing, Irina Mikhalevich
Articles
Woodruff (2017) claims to have identified the neural correlates of phenomenal consciousness (“p-consciousness”) in fishes, and argues that these neurological data, along with behavioral evidence, suggest that teleost fishes are in all probability sentient organisms. Woodruff’s case may be strengthened by challenging key assumptions behind a common criticism of accounts such as his: that fishes cannot be p-conscious because they lack the cortical structures necessary for p-consciousness. A more serious objection to Woodruff’s proposal would be that his evidence for p-consciousness establishes only that fishes are “access-conscious” (“a-conscious”), where a-conscious states are cognitive representations that are made available to cognitive …
Exploiting Conservation Lands: Can Hydrofracking Be Consistent With Conservation Easements, Jessica Owley, Collin Doane
Exploiting Conservation Lands: Can Hydrofracking Be Consistent With Conservation Easements, Jessica Owley, Collin Doane
Articles
No abstract provided.
Simplexity: Plain Language And The Tax Law, Joshua D. Blank, Leigh Osofsky
Simplexity: Plain Language And The Tax Law, Joshua D. Blank, Leigh Osofsky
Articles
In recent years, federal government agencies have increasingly attempted to use plain language in written communications with the public. The Plain Writing Act of 2010, for instance, requires agencies to incorporate "clear and simple" explanations of rules and regulations into their official publications. In the tax context, as part of its "customer service" mission, the Internal Revenue Service bears a "duty to explain" the tax law to hundreds of millions of taxpayers who file tax returns each year. Proponents of the plain language movement have heralded this form of communication as leading to simplicity in tax compliance, more equitable access …
Zone Of Nondeference: Chevron And Deportation For A Crime, Rebecca Sharpless
Zone Of Nondeference: Chevron And Deportation For A Crime, Rebecca Sharpless
Articles
No abstract provided.
"Revenge Porn" Reform: A View From The Front Lines, Mary Anne Franks
"Revenge Porn" Reform: A View From The Front Lines, Mary Anne Franks
Articles
The legal and social landscape of "revenge porn" has changed dramatically in the last few years. Before 2013, only three states criminalized the unauthorized disclosure of sexually explicit images of adults and few people had ever heard the ternm "revenge porn." As of July 2017, thirty-eight states and Washington, D.C. had criminalized the conduct; federal criminal legislation on the issue had been introduced in Congress; Google, Facebook, and Twitter had banned nonconsensual pornography from their platforms; and the term "revenge porn" had been added to the Merriam- Webster Dictionary. I have had the privilege of playing a role in many …
Constitutional Advice And Transnational Legal Order, Tom Ginsburg
Constitutional Advice And Transnational Legal Order, Tom Ginsburg
Articles
No abstract provided.
Chevron Step One-And-A-Half, Daniel Hemel, Aaron Nielson
Chevron Step One-And-A-Half, Daniel Hemel, Aaron Nielson
Articles
No abstract provided.
Competence And Culpability: Delinquents In Juvenile Courts, Youths In Criminal Courts, Barry Feld
Competence And Culpability: Delinquents In Juvenile Courts, Youths In Criminal Courts, Barry Feld
Articles
No abstract provided.
Free Speech And National Security Bootstraps, Heidi Kitrosser
Free Speech And National Security Bootstraps, Heidi Kitrosser
Articles
No abstract provided.
Life Cycle Analysis And Transportation Energy, Alexandra Klass, Andrew Heiring
Life Cycle Analysis And Transportation Energy, Alexandra Klass, Andrew Heiring
Articles
No abstract provided.
Reconstituting The Federalism Battle In Energy Transportation, Alexandra Klass, Jim Rossi
Reconstituting The Federalism Battle In Energy Transportation, Alexandra Klass, Jim Rossi
Articles
No abstract provided.
Macrophage Migration Inhibitory Factor Enhances Pseudomonas Aeruginosa Biofilm Formation, Potentially Contributing To Cystic Fibrosis Pathogenesis, Aisling Tynan, Leona Mawhinney, Michelle Armstrong, Ciaran O'Reilly, Sarah Kennedy
Macrophage Migration Inhibitory Factor Enhances Pseudomonas Aeruginosa Biofilm Formation, Potentially Contributing To Cystic Fibrosis Pathogenesis, Aisling Tynan, Leona Mawhinney, Michelle Armstrong, Ciaran O'Reilly, Sarah Kennedy
Articles
Macrophage migration inhibitory factor (MIF) is a key proinflammatory mediator that we have previously shown to be associated with an aggressive clinical phenotype in cystic fibrosis. It possesses unique tautomerase enzymatic activity. However, to date, no human-derived substrate has been identified that has the capacity to interact with this cytokine's unique tautomerase activity. This led us to hypothesize that MIF may have the capacity to interact with external substrates. We describe for the first time how Pseudomonas aeruginosa can utilize human recombinant MIF (rMIF) to significantly (P < 0.01) enhance its endogenous biofilm formation. Our in vivo studies demonstrate that utilizing a small-molecular-weight inhibitor targeting MIF's tautomerase activity (SCD-19) significantly reduces the inflammatory response in a murine pulmonary chronic P. aeruginosa model. In addition, we show that in in vitro experiments, pretreatment of P. aeruginosa with rMIF is associated with reduced bacterial killing by tobramycin. Our novel findings support the concept of an anti-MIF strategy that targets this enzymatic activity as a potential future antibacterial therapeutic approach.-Tynan, A., Mawhinney, L., Armstrong, M. E., O'Reilly, C., Kennedy, S., Caraher, E., Jülicher, K., O'Dwyer, D., Maher, L., Schaffer, K., Fabre, A., McKone, E. F., Leng, L., Bucala, R., Bernhagen, J., Cooke, G., Donnelly, S. C. Macrophage migration inhibitory factor enhances Pseudomonas aeruginosa biofilm formation, potentially contributing to cystic fibrosis pathogenesis.
Hypoxia Reduces The Pathogenicity Of Pseudomonas Aeruginosa By Decreasing The Expression Of Multiple Virulence Factors, Bettina Schaible, Javier Rodriguez, Amaya Garcia, Alexander Von Kriegsheim, Siobhan Mcclean, Caitríona Hickey, Ciara E. Keogh, Eric Brown, Kirsten Schaffer, Alexis Broquet, Cormac T. Taylor
Hypoxia Reduces The Pathogenicity Of Pseudomonas Aeruginosa By Decreasing The Expression Of Multiple Virulence Factors, Bettina Schaible, Javier Rodriguez, Amaya Garcia, Alexander Von Kriegsheim, Siobhan Mcclean, Caitríona Hickey, Ciara E. Keogh, Eric Brown, Kirsten Schaffer, Alexis Broquet, Cormac T. Taylor
Articles
Our understanding of how the course of opportunistic bacterial infection is influenced by the microenvironment is limited. We demonstrate that the pathogenicity of Pseudomonas aeruginosa strains derived from acute clinical infections is higher than that of strains derived from chronic infections, where tissues are hypoxic. Exposure to hypoxia attenuated the pathogenicity of strains from acute (but not chronic) infections, implicating a role for hypoxia in regulating bacterial virulence. Mass spectrometric analysis of the secretome of P. aeruginosa derived from an acute infection revealed hypoxia-induced repression of multiple virulence factors independent of altered bacterial growth. Pseudomonas aeruginosa lacking the Pseudomonas prolyl-hydroxylase …
Differentiating Responses Of Lung Cancer Cell Lines To Doxorubicin Exposure: In Vitro Raman Micro Spectroscopy, Oxidative Stress And Bcl-2 Protein Expression, Zeineb Farhane, Franck Bonnier, Marcus A. Maher, Jane Bryant, Alan Casey, Hugh Byrne
Differentiating Responses Of Lung Cancer Cell Lines To Doxorubicin Exposure: In Vitro Raman Micro Spectroscopy, Oxidative Stress And Bcl-2 Protein Expression, Zeineb Farhane, Franck Bonnier, Marcus A. Maher, Jane Bryant, Alan Casey, Hugh Byrne
Articles
The potential of Raman micro spectroscopy as an in vitro, non-invasive tool for clinical applications has been demonstrated in recent years, specifically for cancer research. To further illustrate its potential as a high content and label free technique, it is important to show its capability to elucidate drug mechanisms of action and cellular resistances. In this study, cytotoxicity assays were employed to establish the toxicity profiles for 24 hr exposure of lung cancer cell lines, A549 and Calu-1, to the commercially available drug, doxorubicin (DOX). Raman spectroscopy, coupled with Confocal Laser Scanning Microscopy and Flow Cytometry, was used to track …
Valuing Identity, Osamudia R. James
A Natural, Calcium-Rich Marine Multi-Material Complex Preserves Bone Structure, Composition And Strength In An Ovariectomized Rat Model Of Osteoporosis, Orlaith Brennan, Joseph Sweeney, Brian O'Meara, Amro Widaa, Franck Bonnier, Hugh Byrne, Denis O'Gorman, Fergal O'Brien
A Natural, Calcium-Rich Marine Multi-Material Complex Preserves Bone Structure, Composition And Strength In An Ovariectomized Rat Model Of Osteoporosis, Orlaith Brennan, Joseph Sweeney, Brian O'Meara, Amro Widaa, Franck Bonnier, Hugh Byrne, Denis O'Gorman, Fergal O'Brien
Articles
Calcium supplements are used as an aid in the prevention of osteopenia and osteoporosis and also for the treatment of patients when used along with medication. Many of these supplements are calcium carbonate based. This study compared a calcium-rich, marine multi-mineral complex (Aquamin) to calcium carbonate in an ovariectomised rat model of osteoporosis in order to assess Aquamin’s efficacy in preventing the onset of bone loss. Animals were randomly assigned to either non-ovariectomy control (Control), ovariectomy (OVX) plus calcium carbonate, ovariectomy plus Aquamin or ovariectomy plus Aquamin delay where Aquamin treatment started 8 weeks post OVX. At the end of …
Rodrigo's Footnote: Multi-Group Oppression And A Theory Of Judicial Review, Richard Delgado
Rodrigo's Footnote: Multi-Group Oppression And A Theory Of Judicial Review, Richard Delgado
Articles
No abstract provided.
Institutional Pluralism And The (Hoped-For) Effects Of Candor And Integrity In Legal Scholarship Symposium: Conference On The Ethics Of Legal Scholarship, Paul Horwitz
Articles
No abstract provided.
Positive Pluralism Now Review, Paul Horwitz
The Work Of International Law, Monica Hakimi
The Work Of International Law, Monica Hakimi
Articles
This Article crystallizes and then critiques a prominent view about the role of international law in the global order. The view - what I call the "cooperation thesis" - is that international law serves to help global actors cooperate, specifically by: (1) curbing their disputes, and (2) promoting their shared goals. The cooperation thesis often appears as a positive account of international law; it purports to explain or describe what international law does. But it also has normative force; international law is widely depicted as dysfunctional when it does not satisfy the thesis. In particular, heated or intractable conflict is …
Toward A History Of The Democratic State, William J. Novak, Stephen W. Sawyer, James T. Sparrow
Toward A History Of The Democratic State, William J. Novak, Stephen W. Sawyer, James T. Sparrow
Articles
Over the past generation, the history of the state has been experiencing a much-noted renaissance, especially in France and the United States. In the United States as late as 1986, Morton Keller complained to William Leuchtenburg in the Journal of American History: “To say that ‘there is much still to be learned about the nature of the State in America’ is … a major understatement. There is close to everything to be learned about the State.” In France as late as 1990, Pierre Rosanvallon’s powerful introduction to L’État en France suggested that an ambitious history of the state could not …
Novel Myopia Genes And Pathways Identified From Syndromic Forms Of Myopia, Daniel Ian Flitcroft, James Loughman, Christine Wildsoet, Cathy Williams, Jeremy A. Guggenheim
Novel Myopia Genes And Pathways Identified From Syndromic Forms Of Myopia, Daniel Ian Flitcroft, James Loughman, Christine Wildsoet, Cathy Williams, Jeremy A. Guggenheim
Articles
PURPOSE. To test the hypothesis that genes known to cause clinical syndromes featuring myopia also harbor polymorphisms contributing to nonsyndromic refractive errors. METHODS. Clinical phenotypes and syndromes that have refractive errors as a recognized feature were identified using the Online Mendelian Inheritance in Man (OMIM) database. One hundred fifty-four unique causative genes were identified, of which 119 were specifically linked with myopia and 114 represented syndromic myopia (i.e., myopia and at least one other clinical feature). Myopia was the only refractive error listed for 98 genes and hyperopia and the only refractive error noted for 28 genes, with the remaining …
Novel Myopia Genes And Pathways Identified From Syndromic Forms Of Myopia, Daniel Ian Flitcroft, James Loughman, Christine F. Wildsoet, Cathy Williams, Jeremy A. Guggenheim
Novel Myopia Genes And Pathways Identified From Syndromic Forms Of Myopia, Daniel Ian Flitcroft, James Loughman, Christine F. Wildsoet, Cathy Williams, Jeremy A. Guggenheim
Articles
Clinical phenotypes and syndromes that have refractive errors as a recognized feature were identified using the Online Mendelian Inheritance in Man (OMIM) database. One hundred fifty-four unique causative genes were identified, of which 119 were specifically linked with myopia and 114 represented syndromic myopia (i.e., myopia and at least one other clinical feature). Myopia was the only refractive error listed for 98 genes and hyperopia and the only refractive error noted for 28 genes, with the remaining 28 genes linked to phenotypes with multiple forms of refractive error. Pathway analysis was carried out to find biological processes overrepresented within these …
Novel Myopia Genes And Pathways Identified From Syndromic Forms Of Myopia, Daniel Ian Flitcroft, James Loughman, Christine F. Wildsoet, Cathy Williams, Jeremy A. Guggenheim
Novel Myopia Genes And Pathways Identified From Syndromic Forms Of Myopia, Daniel Ian Flitcroft, James Loughman, Christine F. Wildsoet, Cathy Williams, Jeremy A. Guggenheim
Articles
P URPOSE . To test the hypothesis that genes known to cause clinical syndromes featuring myopia also harbor polymorphisms contributing to nonsyndromic refractive errors.
Market Dimensions Of Industrial Juice Production, Anushree Priyadarshini
Market Dimensions Of Industrial Juice Production, Anushree Priyadarshini
Articles
The juice sector is currently demonstrating positive and dynamic growth mainly due to a change in lifestyle, the tendency of consumers to prefer healthy products, and an increase in purchasing power. Fruit juices form part of what are termed the “new age beverages.” In sync with growing consumer inclination toward healthier choices, manufacturers are moving over to healthier ingredients in their juices. Numerous new and innovative products are being launched globally by manufacturers to stimulate sales through innovations in flavor blends, calorie and sweetness levels, and functional benefits, very much shaped by the major lifestyle trends. This chapter aims to …
Nitrate-Rich Beetroot Juice Selectively Lowers Ambulatory Pressures And Ldl Cholesterol In Uncontrolled But Not Controlled Hypertension: A Pilot Study., Conor Kerley, Eamon Dolan, Liam Cormican
Nitrate-Rich Beetroot Juice Selectively Lowers Ambulatory Pressures And Ldl Cholesterol In Uncontrolled But Not Controlled Hypertension: A Pilot Study., Conor Kerley, Eamon Dolan, Liam Cormican
Articles
Background Dietary nitrate has been shown to increase nitrate/nitrite levels in multiple populations, with potential blood pressure lowering effects. However, there are few reports among hypertensives. Aims We aimed to assess the effect of daily nitrate in subject with controlled hypertension vs. uncontrolled hypertension. Methods On day 0, hypertensives wore an ambulatory BP monitor (ABPM) for 24h and fasting blood was taken. Subjects then consumed concentrated beetroot juice (12.9mmol nitrate) for 14 consecutive days. On day 14 subjects consumed their last nitrate dose after fasting blood was drawn and again had an ABPM for 24h. Results According to baseline ABPM, …
Quantification Of Copper Content With Laser Induced Breakdown Spectroscopy As A Potential Indicator Of Offal Adulteration In Beef, Maria Piedad Casado-Gavalda, Yash Dixit, David Geulen, Raquel Cama-Moncunill, Xavier Cama-Moncunill, Maria Markiewicz-Keszycka, Patrick J. Cullen, Carl Sullivan
Quantification Of Copper Content With Laser Induced Breakdown Spectroscopy As A Potential Indicator Of Offal Adulteration In Beef, Maria Piedad Casado-Gavalda, Yash Dixit, David Geulen, Raquel Cama-Moncunill, Xavier Cama-Moncunill, Maria Markiewicz-Keszycka, Patrick J. Cullen, Carl Sullivan
Articles
Laser induced breakdown spectroscopy (LIBS) is an emerging technique in the field of food analysis which provides various advantages such as minimal sample preparation, chemical free, rapid detection, provision of spatial information and portability. In this study, LIBS was employed for quantitative analysis of copper content in minced beef samples spiked with beef liver over three independent batches. Copper content was determined with graphite furnace atomic absorption spectroscopy (GFAAS) in order to obtain reference values for modelling. Partial least square regression (PLSR) was performed to build a calibration and validation model. A calibration model with a high Rcv2 of 0.85 …
Disrupted Superior Collicular Activity May Reveal Cervical Dystonia Disease Pathomechanisms, Eavan M. Mcgovern, Owen Killian, Shruti Narashimham, Brendan Quinlivan, John Butler, Rebecca Beck, Ines Beiser, Laura W. Williams, Ronan P. Killeen, Michael Farrell, Sean O'Riordan, Richard B. Reilly, Michael Hutchinson
Disrupted Superior Collicular Activity May Reveal Cervical Dystonia Disease Pathomechanisms, Eavan M. Mcgovern, Owen Killian, Shruti Narashimham, Brendan Quinlivan, John Butler, Rebecca Beck, Ines Beiser, Laura W. Williams, Ronan P. Killeen, Michael Farrell, Sean O'Riordan, Richard B. Reilly, Michael Hutchinson
Articles
Cervical dystonia is a common neurological movement disorder characterised by muscle contractions causing abnormal movements and postures affecting the head and neck. The neural networks underpinning this condition are incompletely understood. While animal models suggest a role for the superior colliculus in its pathophysiology, this link has yet to be established in humans. The present experiment was designed to test the hypothesis that disrupted superior collicular processing is evident in affected patients and in relatives harbouring a disease-specific endophenotype (abnormal temporal discrimination). The study participants were 16 cervical dystonia patients, 16 unaffected first-degree relatives with abnormal temporal discrimination, 16 unaffected …