Digital Commons Network^™

Meat Quality Of Limousin Young Bulls Slaughtered At 6, 9 And 12 Months Of Age, Maria Markiewicz-Keszycka, Grażyna Czyżak-Runowska, Bożena Grześ, Edward Pospiech, Jolanta Komisarek

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The aim of this study was to compare the quality of meat of the young Limousin bulls slaughtered at the age of 6, 9 and 12 months, with particular regard to the residual glycogen content in the meat and the value of the glycolytic potential. The study was conducted on bovine longissimus lumborum muscle. The residual glycogen content, glycolytic potential value (96 h post-mortem), pH value (45 min, 24 h, 48 h and 96 h post-mortem), IMP/ATP index (45 min post-mortem), colour parameters (L*, a* and b*), natural and cooking losses, free water content, the chemical composition, sensory parameters (aroma, …

Laser Induced Breakdown Spectroscopy For Quantification Of Sodium And Potassium In Minced Beef: A Potential Technique For Detecting Beef Kidney Adulteration, Y. Dixit, Maria Piedad Casado-Gavalda, R. Cama-Moncunill, Xavier Cama-Moncunill, Maria Markiewicz-Keszycka, Patrick J. Cullen, Carl Sullivan

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Beef is a rich source of important minerals, with potassium (K) being the most abundant mineral quantitatively except in cured meats where sodium (Na) from the added salt predominates. This study evaluates the capability of LIBS for quantification of the Na and K contents of minced beef as a potential method of detecting beef kidney adulteration. Additionally, the study aims to demonstrate the ability of LIBS to provide spatial mineral information of minced beef. A LIBS system was employed to collect spectral information of adulterated minced beef samples. Atomic absorption spectroscopy (AAS) was used to obtain reference values for Na …

The Antibacterial Activity Of Metal Complexes Containing 1, 10-Phenanthroline: Potential As Alternatire Therapeutics In The Era Of Antibiotic Resistance, Livia Viganon, Orla L. Howe, Pauraic Mccarron, Malachy Mccann, Michael Devereux

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The “antibiotic era”, characterized by the overuse and misuse of antibiotics, over the last half-century has culminated in the present critical “era of resistance”. The treatment of bacterial infections is challenging because of a decline in the current arsenal of useful antibiotics and the slow rate of new drug development. The discovery of a new gene (mcr-1) in 2015, which enables bacteria to be highly resistant to polymyxins (such as colistin), the last line of antibiotic defence left, heralds a new level of concern as this gene is susceptible to horizontal gene transfer, with alarming potential to be spread between …

The Future Of Fast Food Governance, Andrew Elmore

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No abstract provided.

Changing Course, Sergio J. Campos

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No abstract provided.

Contracting Correctness: A Rubric For Analyzing Morality Clauses, Patricia S. Abril, Nicholas Greene

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Morality clauses give a contracting party the right to terminate if the other party behaves badly or embarrassingly. A curious product of twentieth-century Hollywood, these contract clauses have traditionally been used to control the antics of entertainers and athletes. The current politically-sensitive historical moment, combined with the internet's ability to broadcast widely and permanently, has put everyone's off-duty speech, conduct, and reputation under the microscope. Media reports detailing people's digital falls from grace abound. For fear of negative association, businesses are more attuned than ever to the extracurricular acts of their agents and associates-and are increasingly binding them to morality …

Label-Free, High Content Screening Using Raman Microspectroscopy: The Toxicological Response Of Different Cell Lines To Amine-Modified Polystyrene Nanoparticles, Esen Efeoglu, Alan Casey, Hugh Byrne, Marcus A. Maher

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Nanotoxicology has become an established area of science due to growing concerns over the production and potential use of nanomaterials in a wide-range of areas from pharmaceutics to nanomedicine. Although different cytotoxicity assays have been developed and are widely used to determine the toxicity of nanomaterials, the production of multi-parametric information in a rapid and non-invasive way is still challenging, when the amount and diversity of physicochemical properties of nanomaterials are considered. High content screening can provide such analysis, but is often prohibitive in terms of capital and recurrent costs in academic environments. As a label-free technique, the applicability of …

Thermostability Of The Coating, Antigen And Immunostimulator In An Adjuvanted Oral Capsule Vaccine Formulation, Stephanie Longet, Vincenzo Aversa, Daire O'Donnell, Joshua Tobias, Monica Rosa, Jan Holmgren, Ivan Coulter, Ed Lavelle

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Oral vaccines present an attractive alternative to injectable vaccines for enteric diseases due to ease of delivery and the induction of intestinal immunity at the site of infection. However, susceptibility to gastrointestinal proteolysis, limited transepithelial uptake and a lack of clinically acceptable adjuvants present significant challenges. A further challenge to mass vaccination in developing countries is the very expensive requirement to maintain the cold chain. We recently described the effectiveness of a Single Multiple Pill® (SmPill®) adjuvanted capsule approach to enhance the effectiveness of a candidate enterotoxigenic Escherichia coli (ETEC) oral vaccine. Here it was demonstrated that this delivery system …

Graphene Toxicity As A Double-Edged Sword Of Risks And Exploitable Opportunities: A Critical Analysis Of The Most Recent Trends And Developments, Yuri Volkov, Jennifer Mcintyre, Adriele Prina-Mello

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Increased production volumes and a broadening application spectrum of graphene have raised concerns about its potential adverse effects on human health. Numerous reports demonstrate that graphene irrespective of its particular form exerts its effects on a widest range of living organisms, including prokaryotic bacteria and viruses, plants, micro-and macro-invertebrates, mammalian and human cells and whole animals in vivo. However, the available experimental data is frequently a matter of significant divergence and even controversy. Therefore, we provide here a critical analysis of the most recent (2015-2016) reports accumulated in the graphene-related materials biocompatibility and toxicology field in order to elucidate the …

Symposium: Conference On The Ethics Of Legal Scholarship: Introduction, Carissa Byrne Hessick, Paul Horwitz, Chad Oldfather

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Our Shrinking First Amendment: On The Growing Problem Of Reduced Access To Public Property For Speech Activity And Some Suggestions For A Better Way Forward Symposium: The Expanding First Amendment, Ronald J. Krotoszynski Jr.

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No abstract provided.

Clerking For Grown-Ups: A Tribute To Judge Ed Carnes Writing In Tribute To Chief Judge Carnes' 25 Years On The U.S. Court Of Appeals For The Eleventh Circuit, Paul Horwitz

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Clientless Lawyers, Russell M. Gold

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Contracting For Torts, J. Shahar Dillbary

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This article focuses on agreements to commit or induce the commission of a tort Examples include an agreement between factories to use a production process that would pollute a lake or an agreement where one entices another to publish a false statement by promising to share the cost of the injury Such agreements are unenforceable under contract law However the article reveals that tort law not only enforces such wrongdoings it encourages them Tort law picks up where contract law leaves off Tort law allows the injurers who acted on the agreement the polluting factories and the publisher to recover …

A Geo-Statistical Investigation Of Agricultural And Infrastructural Risk Factors Associated With Primary Verotoxigenic E. Coli (Vtec) Infection In The Republic Of Ireland, 2008–2013, Paul Hynds, Jean O'Dwyer, Una B. Fallon, Coilín Oscar Óhaiseadha

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Ireland reports the highest incidence of verotoxigenic Escherichia coli (VTEC) infection in Europe. This study investigated potential risk factors for confirmed sporadic and outbreak primary VTEC infections during 2008-2013. Overall, 989 VTEC infections including 521 serogroup O157 and 233 serogroup O26 were geo-referenced to 931 of 18488 census enumeration areas. The geographical distribution of human population, livestock, unregulated groundwater sources, domestic wastewater treatment systems (DWWTS) and a deprivation index were examined relative to notification of VTEC events in 524 of 6242 rural areas. Multivariate modelling identified three spatially derived variables associated with VTEC notification: private well usage (odds ratio (OR) …

Lost In Transplantation: The Supreme Court's Post-Prudence Jurisprudence, Adam N. Steinman

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This essay is an invited response to Fred Smiths Vanderbilt Law Review article Undemocratic Restraint Smith critiques an important trend in the Supreme Courts decisions on standing the transformation of concepts that had been viewed as judiciallycreated prudential limits on a partys standing to sue into concepts grounded in positive law such as federal statutes or the Constitution This essay uses two Supreme Court decisions which coincidentally came down weeks after Smiths article was published to highlight some questions and concerns regarding two areas of standing doctrine that Smith examines One subject of doctrinal transplantation has been the zone of …

Civilizing Criminal Settlements, Russell M. Gold, Carissa Byrne Hessick, F. Andrew Hessick

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No abstract provided.

The Cost Of Inexperience, Mirit Eyal-Cohen

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Free market entry is vital in preventing concentration of market power and eliminating large deadweight losses Yet in recent years studies show that newcomers are less successful than existing firms that have diversifies their products in the market What might explain this phenomenonThis Article unveils a regulatory catch 22 It reveals that although a regulation may be efficient in correcting a certain market failure its distributional effects may create another It exposes the degree to which "economies of experience" in regulation create significant disadvantages to newcomers and provide substantial advantages to oldtimers Being wellversed in their marketplace oldtimers possess knowledge …

Ethanol Extract Of Blighia Sapida Stem Bark Show Remarkable Prophylactic Activity In Experimental Plasmodium Berghei-Infected Mice., Olayinka O. Otegbade, Johnson A. Ojo, Dolapo I. Adefokun, Oyindamola O. Abiodun, Bolaji N. Thomas, Olusola Ojurongbe

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This work explores the antiplasmodial potential of ethanol extract of Blighia sapida (Lin. Sapindaceae) in chloroquine (CQ)- resistant Plasmodium berghei (ANKA strain)–infected mice. Chloroquine-resistant (ANKA) strain of P berghei was inoculated intraperitoneally into Swiss albino mice. Mice were treated orally for 4 consecutive days, before and after inoculation (prophylactic, suppressive, and curative models) with graded doses of the plant extracts with Artemether-Lumefantrine (Coartem) as control. Prophylactically, the extract showed a remarkable activity in the chemosuppression of P berghei parasites (P

Maternal Nutrient Intakes From Food And Drinks Consumed In Early Pregnancy In Ireland, Laura Mullaney, Shona Cawley, Rachel Kennedy, Amy C. O'Higgins, Daniel Mccartney, Michael J. Turner

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Background: The aim of this observational study was to measure food, macronutrient and micronutrient intakes of women presenting for antenatal care and assess compliance with current nutritional recommendations.

Sinapinic And Protocatechuic Acids Found In Rapeseed: Isolation, Characterisation And Potential Benefits For Human Health As Functional Food Ingredients, Leah Quinn, Steven G. Gray, Steve Meaney, Steven Fiinn, Owen Kenny, Maria Hayes

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Rapeseed is a globally valuable crop, and its production has steadily grown over the past 20 yr. Rapeseed is cultivated in China, India, Canada and Europe; however, in terms of rapeseed production, Europe is the largest producer (Carre, 2014). In the year 2013/2014, the European Union (EU) produced 9.93 million t of rapeseed oil, while China produced 6.58 million t (List, 2015). A by-product of the rapeseed oil industry, rapeseed meal contains bioactive constituents, such as the phenolics sinapinic acid (SA) and protocatechuic acid (PCA), which have potential uses as functional food ingredients and for use in cosmetic and pharmaceutical …

Advances In Control Of Food Mixing Operations, Patrick J. Cullen, Serafim Bakalis, Carl Sullivan

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Mixing is a ubiquitous unit operation within the food industry and employed not only to combine multiple ingredients, but also to control reactions and modify the structure of foods. Failure of the mixing process may result in poor quality, organoleptic or functional attributes of foods along with product safety concerns. The industry is increasingly adopting automation and advanced control strategies such as Process Analytical Technology. Sensors can provide both insights into the complex mechanisms of mixing along with effective control. Here we discuss some recent advances in the control of food mixing operations.

Extraction And Quantification Of Sinapinic Acid From Irish Rapeseed Meal And Assessment Of Angiotensin-I Converting Enzyme (Ace-I) Inhibitory Activity, Leah Quinn, Steven Gray, Steve Meaney, Stephen Finn, Padraig Mcloughlin, Maria Hayes

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Phenolic compounds, including phenolic acids, are known to play a protective role against the development of cardiovascular disease. The aim of this work was to generate a phenolic acid extract from Irish rapeseed meal, to determine the quantity of sinapinic acid (SA) in this fraction and to assess the ability of this fraction to inhibit the enzyme angiotensin-I converting enzyme (ACE-I; EC 3.4.15.1). A crude phenolic extract (fraction 1), free phenolic acid containing extract (fraction 2), and an extract containing phenolic acids liberated from esters (fraction 3) were generated from Irish rapeseed meal using a methanol:acetone:water solvent mixture (7:7:6). The …

Pcr-Ribotype Distribution Of Clostridium Difficile In Irish Pigs, Katharina Stein, Sarah Egan, Helen Lynch, Celine Harmanus, Lorraine Kyne, Celine Herra, Sinead Mcdermott, Ed Kuijper, Fidelma Fitzpatrick, Susan Fitzgerald, Lynda Fenelon, Denise Drudy

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Clostridium difficile is an important enteric pathogen in humans causing infections in the healthcare environment and the community. Carriage of C. difficile and C. difficile-related enterocolitis has been reported in piglets worldwide. The aim of this study was to investigate the rates of C. difficile isolation from pigs in Ireland. Faecal samples from piglet litters and sows were collected from six farms in 2015. The sows were non-diarrhoeal at the time of sampling. The diarrhoeal status of the piglets was unknown. C. difficile was isolated from 34/44 (77%) of piglet litter samples and from 33/156 (21%) of sow samples. The …

1,10-Phenanthroline-5,6-Dione-Based Compounds Are Effective In Disturbing Crucial Physiological Events Of Phialophora Verrucosa, Marcela Queiroz Granato, Diego De Souza Goncalves, Sergio Henrique Seabra, Malachy Mccann, Michael Devereux, Andre Luis De Souza Dos Santos, Lucimar Ferreira Kneipp

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Phialophora verrucosa is a dematiaceous fungus able to cause chromoblastomycosis, phaeohyphomycosis and mycetoma. All these fungal diseases are extremely difficult to treat and often refractory to the current therapeutic approaches. Therefore, there is an urgent necessity to develop new antifungal agents to combat these mycoses. In this context, the aim of the present work was to investigate the effect of 1,10-phenanthroline-5,6-dione (phendione) and its metal-based derivatives [Ag(phendione)2]ClO4 = ([Ag(phendione)2]+) and [Cu(phendione)3](ClO4)2.4H2O = ([Cu(phendione)3]2+) on crucial physiological events of P. verrucosa conidial cells. Using the CLSI protocol, we have shown that phendione, [Ag(phendione)2]+ and [Cu(phendione)3]2+ were able to inhibit fungal proliferation, …

Privacy, Vulnerability, And Affordance, Ryan Calo

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This essay begins to unpack the complex, sometimes contradictory relationship between privacy and vulnerability. I begin by exploring how the law conceives of vulnerability — essentially, as a binary status meriting special consideration where present. Recent literature recognizes vulnerability not as a status but as a state — a dynamic and manipulable condition that everyone experiences to different degrees and at different times. I then discuss various ways in which vulnerability and privacy intersect. I introduce an analytic distinction between vulnerability rendering, i.e., making a person more vulnerable, and the exploitation of vulnerability whether manufactured or native. I also describe …

Artificial Intelligence Policy: A Primer And Roadmap, Ryan Calo

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Talk of artificial intelligence is everywhere. People marvel at the capacity of machines to translate any language and master any game. Others condemn the use of secret algorithms to sentence criminal defendants or recoil at the prospect of machines gunning for blue, pink, and white-collar jobs. Some worry aloud that artificial intelligence will be humankind’s “final invention.” This essay, prepared in connection with UC Davis Law Review's 50th anniversary symposium, explains why AI is suddenly on everyone's mind and provides a roadmap to the major policy questions AI raises. The essay is designed to help policymakers, investors, technologists, scholars, and …

How Adverse Outcome Pathways Can Aid The Development And Use Of Computational Prediction Models For Regulatory Toxicology, Clemens Wittwehr, Hristo Aladjov, Gerald Ankley, Hugh Byrne, Joop Deknecht

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Efforts are underway to transform regulatory toxicology and chemical safety assessment from a largely empirical science based on direct observation of apical toxicity outcomes in whole organism toxicity tests to a predictive one in which outcomes and risk are inferred from accumulated mechanistic understanding. The adverse outcome pathway (AOP) framework provides a systematic approach for organizing knowledge that may support such inference. Likewise, computational models of biological systems at various scales provide another means and platform to integrate current biological understanding to facilitate inference and extrapolation. We argue that the systematic organization of knowledge into AOP frameworks can inform and …

A Natural Calcium-Rich Multi-Mineral Complex Preserves Bones Structure, Composition And Strength In An Ovariectomized Rat Model Of Osteoporosis, Orlaith Brennan, Joseph Sweeney, Brian O'Meara, Amro Widaa, Franck Bonnier, Hugh Byrne, Denise O'Gorman, Fergal O'Brien

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Calcium supplements are used as an aid in the prevention of osteopenia and osteoporosis and also for the treatment of patients when used along with medication. Many of these supplements are calcium carbonate based. This study compared a calcium-rich, marine multi-mineral complex (Aquamin) to calcium carbonate in an ovariectomised rat model of osteoporosis in order to assess Aquamin’s efficacy in preventing the onset of bone loss. Animals were randomly assigned to either non-ovariectomy control (Control), ovariectomy (OVX) plus calcium carbonate, ovariectomy plus Aquamin or ovariectomy plus Aquamin delay where Aquamin treatment started 8 weeks post OVX. At the end of …

Regulating Cumulative Risk, Sanne H. Knudsen

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This Article proceeds in four parts. Part I describes how cumulative risk assessments tackle the real-world exposure problems that lie at the heart of public health. It shows how risk science has evolved and why policy, not science, lags behind. Part II then examines why key public health concerns cannot be answered through information disclosure or consumer choice models alone.

Having established that regulatory drivers are needed, Part III begins to examine how to move forward. It does so by looking backward and examining how TSCA and FIFRA have failed historically to provide this critical public health focus despite room …