Digital Commons Network^™

Industrial Grade 2d Molybdenum Disulphide (Mos2): An In-Vitro Exploration Of The Impact On Cellular Uptake, Cytotoxicity, And Inflammation, Caroline Moore, Hugh Byrne, Jonathan N. Coleman, Yuri Volkov, Jennifer Mcintyre

Articles

The recent surge in graphene research, since its liquid phase monolayer isolation and characterization in 2004, has led to advancements which are accelerating the exploration of alternative 2D materials such as molybdenum disulphide (MoS2), whose unique physico-chemical properties can be exploited in applications ranging from cutting edge electronic devices to nanomedicine. However, to assess any potential impact on human health and the environment, the need to understand the bio-interaction of MoS2 at a cellular and sub-cellular level is critical. Notably, it is important to assess such potential impacts of materials which are produced by large scale production techniques, rather than …

New Directions For European Race Equality Law: Chez Razpredelenie Bulgaria Ad V. Komisia Za Zashtita Ot Diskriminatsia, Anelia Nikolova, Julie C. Suk

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The CJEU's decision in CHEZ Razpredelenie Bulgaria AD v. Komisia za zashtita ot diskriminatsia expands the scope of racial discrimination law by allowing non-minority individuals to challenge practices that disadvantage minority groups, thereby promoting inclusive societies. The court broadened the definition of indirect discrimination, emphasizing the impact of practices rather than intent, and highlighted societal goals over individual harm.

Differential Fasting Plasma Glucose And Ketone Body Levels In Ghrko Versus 3xtg-Ad Mice: A Potential Contributor To Aging-Related Cognitive Status?, Chelsea M Griffith, Lauren N Macklin, Andrzej Bartke, Peter R Patrylo

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Cognitive function declines with age and appears to correlate with decreased cerebral metabolic rate (CMR). Caloric restriction, an antiaging manipulation that extends life-span and can preserve cognitive function, is associated with decreased glucose uptake, decreased lactate levels, and increased ketone body (KB) levels in the brain. Since the majority of brain nutrients come from the periphery, this study examined whether the capacity to regulate peripheral glucose levels and KB production differs in animals with successful cognitive aging (growth hormone receptor knockouts, GHRKOs) versus unsuccessful cognitive aging (the 3xTg-AD mouse model of Alzheimer's disease). Animals were fasted for 5 hours with …

The Concepts Of Law, Nicholas Stephanopoulos, Tom Ginsburg

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No abstract provided.

Disentangling Miranda And Massiah: How To Revive The Sixth Amendment Right To Counsel As A Tool For Regulating Confession Law, Eve Brensike Primus

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Fifty years after Miranda v. Arizona, many have lamented the ways in which the Burger, Rehnquist, and Roberts Courts have cut back on Miranda's protections. One underappreciated a spect of Miranda's demise is the way it has affected the development of the pretrial Sixth Amendment right to counsel guaranteed by Massiah v. United States. Much of the case law diluting suspects' Fifth Amendment Miranda rights has bled over into the Sixth Amendment right to counsel cases without consideration of whether the animating purposes of the Massiah pretrial right to counsel would support such an importation. This development is unfortunate …

Trabalho Escravo: L'Esclavage Contemporain Au Brésil, Rebecca J. Scott, Jean Hebrard

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"Le gouvernement brésilien a engagé, il y a quelques années, une ambitieuse campagne de lutte contre l’exploitation de travailleurs dans une condition « analogue » à celle d’esclave. Cette politique répondait à des campagnes de protestation réitérées et à des pressions internationales, mais elle se formula en référence à une histoire nationale dont l’esclavage était inséparable. Les révélations de la Commission pastorale de la terre, les plaintes déposées auprès de la Cour interaméricaine des droits de l’homme, les actions de nombreux organismes gouvernementaux ou non-gouvernementaux ont certainement été déterminantes dans les choix qui ont alors été faits. Toutefois, tout au …

Remedial Restraint In Administrative Law, Nicholas Bagley

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When a court determines that an agency action violates the Administrative Procedure Act, the conventional remedy is to invalidate the action and remand to the agency. Only rarely do the courts entertain the possibility of holding agency errors harmless. The courts’ strict approach to error holds some appeal: Better a hard rule that encourages procedural fastidiousness than a remedial standard that might tempt agencies to cut corners. But the benefits of this rule-bound approach are more elusive, and the costs much larger, than is commonly assumed. Across a wide range of cases, the reflexive invalidation of agency action appears wildly …

A Comparison Study Of Saliency Models For Fixation Prediction On Infants And Adults, Ali Mahdi, Mei Su, Matthew Schlesinger, Jun Qin

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Various saliency models have been developed over the years. The performance of saliency models is typically evaluated based on databases of experimentally recorded adult eye fixations. Although studies on infant gaze patterns have attracted much attention recently, saliency based models have not been widely applied for prediction of infant gaze patterns. In this study, we conduct a comprehensive comparison study of eight state-ofthe- art saliency models on predictions of experimentally captured fixations from infants and adults. Seven evaluation metrics are used to evaluate and compare the performance of saliency models. The results demonstrate a consistent performance of saliency models predicting …

Quantitative Analysis Of Supporting Cell Subtype Labeling Among Creer Lines In The Neonatal Mouse Cochlea, Melissa M Mcgovern, Joseph Brancheck, Auston C Grant, Kaley A Graves, Brandon C Cox

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Four CreER lines that are commonly used in the auditory field to label cochlear supporting cells (SCs) are expressed in multiple SC subtypes, with some lines also showing reporter expression in hair cells (HCs). We hypothesized that altering the tamoxifen dose would modify CreER expression and target subsets of SCs. We also used two different reporter lines, ROSA26 (tdTomato) and CAG-eGFP, to achieve the same goal. Our results confirm previous reports that Sox2 (CreERT2) and Fgfr3-iCreER (T2) are not only expressed in neonatal SCs but also in HCs. Decreasing the tamoxifen dose did not reduce HC expression for Sox2 (CreERT2) …

Beyond Zero-Sum Environmentalism, Jessica Owley, Shalanda Baker, Robin Kundis Craig, John Dernbach, Keith Hirokawa, Sarah Krakoff, Melissa Powers, Shannon Roesler,, Jonathan Rosenbloom, J. B. Ruhl, Jim Salzman, Inara Scott, David Takacs

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Environmental law and environmental protection are often portrayed as requiring trade offs: "jobs versus environment," "markets versus regulation," "enforcement versus incentives." In the summer of 2016, members of the Environmental Law Collaborative gathered to consider how environmentalism and environmental regulation can advance beyond this framing to include new constituents and offer new pathways to tackle the many significant challenges ahead. Months later, the initial activities of the Trump Administration highlighted the use of zero-sum rhetoric, with the appointment of government officials and the issuance of executive orders that indeed seem to view environmental issues as in a zero-sum relationship with …

Effect Of Pulse Flours On The Physiochemical Characteristics And Sensory Acceptance Of Baked Crackers., Kim A. Millar, Catherine Barry-Ryan, Roisin Burke, Sinead Mccarthy, Eimear Gallagher

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Pulse flours offer nutritional alternatives to wheat flour in the production of baked snacks due to their high protein and fibre levels and low glycaemic index. In this study, broad-bean (Vicia faba), yellow-pea and green-pea (Pisum sativum) flours were each blended with wheat flour at 40% in the formulation of chemically leavened crackers. The effects of flour type and baking time on the physiochemical properties, sensory acceptability, nutritional composition and antioxidant activity of the crackers were observed in comparison with 100% wheat crackers. Broad-bean crackers had the highest protein content and antioxidant activity (13 g per 100 g DM and …

The Soybean Gmsnap18 Gene Underlies Two Types Of Resistance To Soybean Cyst Nematode, Shiming Liu, Pramod K. Kandoth, Naoufal Lakhssassi, Jingwen Kang, Vincent Colantonio, Robert Heinz, Greg Yeckel, Zhou Zhou, Sadia Bekal, Johannes Dapprich, Bjorn Rotter, Silvia Cianzio, Melissa G. Mitchum, Khalid Meksem

Articles

Two types of resistant soybean (Glycine max (L.) Merr.) sources are widely used against soybean cyst nematode (SCN, Heterodera glycines Ichinohe). These include Peking-type soybean, whose resistance requires both the rhg1-a and Rhg4 alleles, and PI 88788-type soybean, whose resistance requires only the rhg1-b allele. Multiple copy number of PI 88788-type GmSNAP18, GmAAT, and GmWI12 in one genomic segment simultaneously contribute to rhg1-b resistance. Using an integrated set of genetic and genomic approaches, we demonstrate that the rhg1-a Peking-type GmSNAP18 is sufficient for resistance to SCN in combination with Rhg4. The two SNAPs (soluble NSF attachment …

Characterization Of The Soluble Nsf Attachment Protein Gene Family Identifies Two Members Involved In Additive Resistance To A Plant Pathogen, Naoufal Lakhssassi, Shiming Liu, Sadia Bekal, Zhou Zhou, Kris Lambert, Abdelali Barakat, Khalid Meksem

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Proteins with Tetratricopeptide-repeat (TPR) domains are encoded by large gene families and distributed in all plant lineages. This study aims to characterize a subfamily of TPR containing proteins named Soluble NSF-Attachment Protein (GmSNAP), of which GmSNAP18 has been reported to mediate resistance to soybean cyst nematode (SCN). This study uses a population of recombinant inbred lines from resistant and susceptible parents to analyse SNAP gene family divergence over time. Five members constitute the soybean SNAP gene family: GmSNAP18, GmSNAP11, GmSNAP14, GmSNAP02, and GmSNAP09. Phylogenetic analysis of genes from 22 diverse plant species showed that SNAP genes were distributed in …

Supporting Cells Remove And Replace Sensory Receptor Hair Cells In A Balance Organ Of Adult Mice, Stephanie A Bucks, Brandon C Cox, Brittany A Vlosich, James P Manning, Tot B Nguyen, Jennifer S Stone

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Vestibular hair cells in the inner ear encode head movements and mediate the sense of balance. These cells undergo cell death and replacement (turnover) throughout life in non-mammalian vertebrates. However, there is no definitive evidence that this process occurs in mammals. We used fate-mapping and other methods to demonstrate that utricular type II vestibular hair cells undergo turnover in adult mice under normal conditions. We found that supporting cells phagocytose both type I and II hair cells. Plp1-CreER(T2)-expressing supporting cells replace type II hair cells. Type I hair cells are not restored by Plp1-CreER(T2)-expressing supporting cells or by Atoh1-CreER(TM)-expressing type …

The Influence Of History On States’ Compliance With Human Rights Obligations, Adam S. Chilton, Eric A. Posner

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No abstract provided.

Characterization Of The Fad2 Gene Family In Soybean Reveals The Limitations Of Gel-Based Tilling In Genes With High Copy Number, Naoufal Lakhssassi, Zhou Zhou, Shiming Liu, Vincent Colantonio, Amer Abughazaleh, Khalid Meksem

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Soybean seed oil typically contains 18–20% oleic acid. Increasing the content of oleic acid is beneficial for health and biodiesel production. Mutations in FAD2-1 genes have been reported to increase seed oleic acid content. A subset of 1,037 mutant families from a mutagenized soybean cultivar (cv.) Forrest population was screened using reverse genetics (TILLING) to identify mutations within FAD2 genes. Although no fad2 mutants were identified using gel-based TILLING, four fad2-1A and one fad2-1B mutants were identified to have high seed oleic acid content using forward genetic screening and subsequent target sequencing. TILLING has been successfully used as a non-transgenic …

Sociology In The 21st Century: Reminiscence And Redefinition, Rana Jawad, Paddy Dolan, Tracey Skillington

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No abstract available.

Habitus, The Writings Of Irish Hunger Strikers And Elias's The Loneliness Of The Dying, John Connolly, Paddy Dolan

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»Habitus, die Texte der irischen Hungerstreikenden und Elias', Die Einsamkeit der Sterbenden'«. Elias maintained that over the course of several centuries death has become associated with greater shame and embarrassment feelings due mainly to four interwoven processes. In this paper we consider how these specific processes or 'special conditions' Elias referred to, in conjunction with other processes, shaped the experience of dying and the image of death for twentieth century Irish hunger strikers.

Combating The Forces Of Evil : Georges Bernanos' Vision Of The Priestly Function, Eamon Maher

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No abstract provided.

Arts And Humanities Research, Redefining Public Benefit, And Research Prioritization In Ireland, Andrew Gibson, Ellen Hazelkorn

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This article looks at the effects of a national policy of research prioritization in the years following Ireland’s economic crisis. A national research prioritization exercise initiated by policymakers redefined the purpose of higher education research, and designed policies in line with this approach. Placing research for enterprise to the fore, it emphasized the economic value that subjects could return on state investments. This article examines the post-crisis policy of prioritization, its relationship with and effects on arts and humanities research, and how the notion of the benefit of research can be broadened while still addressing economic needs. It draws on …

Thermal Inactivation Analysis Of Water-Related Pathogens In Domestic Hot Water Systems, Liam Mccarton, Sean O'Hogain

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This study aims to investigate whether hot water systems supplied with harvested rainwater present an increased risk to health over hot water systems supplied with potable mains water. It reviews previous studies investigating the health effects of utilising rainwater within domestic systems. The main risk to public health of mains-supplied hot water systems is the operation, maintenance, age, location and temperature of the system. Rainwater-harvesting systems contain an inherent water treatment train consisting of flocculation, settlement, sorption and bioreaction, and stored rainwater quality improves as metal and chemical contaminants settle to form sludge. Laboratory experiments were conducted using a variety …

Circumcision: Immigration, Religion, History, And Constitutional Identity In Germany And The U.S., David Abraham

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A four-year-old Muslim boy was brought to a local Cologne emergency room by his mother, who was concerned about minor bleeding around the site of a circumcision. A District Court there found that circumcision, notwithstanding parental consent or religious motivation, constituted a criminal bodily injury and child abuse. Ultimately, on July 19, 2012 the Bundestag resolved that "Jewish and Muslim religious life be viable in Germany," and in December a bill was passed that legislatively overrode the ruling of the District Court and recognized circumcision as a non-punishable undertaking when undertaken for religious reasons by someone professionally trained. Two years …

Positive Sum Design: Designing Affordances For Bias, Choice, And Coordination, Ian Gonsher

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No abstract provided.

Characteristics Of Different Systems For The Solar Drying Of Crops, Brian Norton

Articles

Solar dryers are used to enable the preservation of agricultural crops, food processing industries for

dehydration of fruits and vegetables, fish and meat drying, dairy industries for production of milk powder,

seasoning of wood and timber, textile industries for drying of textile materials. The fundamental concepts and

contexts of their use to dry crops is discussed in the chapter. It is shown that solar drying is the outcome of

complex interactions particular between the intensity and duration of solar energy, the prevailing ambient

relative humidity and temperature, the characteristics of the particular crop and its pre-preparation and the

design and …

Preface: Hydrogeology And Human Health, Paul Hynds, Mark A. Borchardt, Motomu Ibaraki

Articles

In the mid-1800s, Dr. John Snow (1813–1858), an obstetrician and anaesthesiologist, theorised that cholera, a highly infectious gastrointestinal infection associated with extremely high rates of mortality, was caused by faecal contamination of water supplies (Donaldson and Scally 2009). During the summer of 1854, a significant cholera outbreak occurred in the Soho district of London (UK), resulting in the deaths of 616 people. As part of this first modern epidemiological investigation, Dr. Snow noted that “within 250 yards of the spot where Cambridge Street joins Broad Street there were upwards of 500 fatal attacks of cholera in 10 days (…) suspected …

An In Vitro Study Of The Interaction Of The Chemotherapeutic Drug Actinomycin D With Lung Cancer Cell Lines Using Raman Micro-Spectroscopy, Zeineb Farhane, Hugh Byrne, Franck Bonnier

Articles

The applications of Raman micro-spectroscopy have been extended in recent years into the field of clinical medicine, and specifically in cancer research, as anon-invasive diagnostic method in vivo and ex vivo, and the field of pharmaceutical development as a label free predictive technique for new drug mechanisms of action in vitro. To further illustrate its potential for such applications, it is important to establish its capability to fingerprint drug mechanisms of action and different cellular reactions. In this study, cytotoxicity assays were employed to establish the toxicity profiles for 48 and 72 hrs exposure of lung cancer cell lines, A549 …

Effect Of Concrete Slats, Three Mat Types And Out-Wintering Pads On Performance And Welfare Of Finishing Beef Steers, Bernadette Earley, John Mcnamara, Stephen Jerrams, Edward G. O’Riordan

Articles

The objective was to investigate the effect of placing mats on concrete slatted floors on performance, behaviour, hoof condition, dirt scores, physiological and immunological variables of beef steers, and to compare responses with animals on out-wintering pads. Continental crossbred beef steers [n = 360; mean (±SD) initial live weight 539 kg (42.2)] were blocked by breed and live weight and randomly assigned to one of five treatments; (1) Concrete slats alone, (2) Mat 1 (Natural Rubber structure) (Durapak Rubber Products), (3) Mat 2 (Natural rubber structure) (EasyFix), (4) Mat 3 (modified ethylene vinyl acetate (EVA) foam structure) and (5) Out-wintering …

Validation Of A Membrane Touch Biosensor For The Qualitative Detection Of Igg Class Antibodies To Herpes Simplex Virus Type 2, Tony Loughman, Baljit Singh, Brian Seddon, Philip Noone, Padmanabhan Santhosh

Articles

A novel type of biosensor was assessed for application to the qualitative determination of circulating antibodies to herpes simplex virus type 2 (HSV-2). The device utilises a high activity HSV-2 type specific gG2 antigen for antibody capture and commercially available ELISA reagents. The study compares the diagnostic performance of a prototype HSV-2 biochip to well-established in vitro tests routinely applied in clinical procedures. A panel of human serum samples (n = 60) previously characterised for HSV-2 serological status using the DiaSorin LIAISON® HSV-2 chemiluminescent immunoassay were assayed on the HSV-2 biochip and the Focus Diagnostics HerpeSelect® 2 ELISA IgG kit …

Sharing Economy Meets The Sherman Act: Is Uber A Firm, A Cartel, Or Something In Between?, Mark Anderson

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The sharing economy is a new industrial structure that is made possible by instantaneous internet communication and changes in the life, work, and purchasing habits of individual entrepreneurs and consumers. Antitrust law is an economic regulatory scheme dating back to 1890 in the United States that is designed to address centrally controlled concentrations of economic power and the threats that those concentrations pose to consumer interests and economic efficiency. In order to accommodate a modern enterprise structure in which thousands or millions of independent contractors join forces to provide a service by agreement among themselves, antitrust law requires re-envisioning and …

An Analysis Of Academic Library 3d Printing Libguides, Jennifer J. Horton

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3D Printing is increasingly becoming a popular service provided by academic libraries throughout the United States. Many patrons have little or no awareness of this subject matter, so library staff have created LibGuides to promote resources. One hundred LibGuides from academic libraries were analyzed to find which types of resources and which specific titles are being promoted surrounding the subject of 3D printing. Three types of resources emerged in this study: 3D printing and 3D modeling software titles, 3D model repositories, and books related to 3D printing. This article lists and analyzes 3D printing resources.