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Diagnostic Imaging Approaches: Pet Imaging In Monitoring Immune Responses In Oncology And Tuberculosis, Chanelle Hunter Jan 2024

Diagnostic Imaging Approaches: Pet Imaging In Monitoring Immune Responses In Oncology And Tuberculosis, Chanelle Hunter

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Positron emission tomography (PET) imaging agents play a transformative role in personalized medicine through their application in disease diagnosis and immunotherapy monitoring, focusing on chemokine receptors, TH1-activated immune cells, and tuberculosis (TB) diagnostics. In immuno-oncology, accurately assessing TH1-activated immune cells in the tumor microenvironment (TME) is vital for evaluating cancer immunotherapy efficacy. Chemokine receptors, crucial in cellular signaling and inflammatory reactions, play a significant role in TH1 responses, thus serving as a potential area of interest in elucidating these anti-tumor responses. Through our work a novel CXCR3-targeting immunoPET probe, [89Zr]DFO-αCXCR3, was developed to detect and quantify these cells. This probe …

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Titanium-45 Radiochemistry For The Development Of Pet Radiopharmaceuticals, Fnu Shefali Jan 2024

Titanium-45 Radiochemistry For The Development Of Pet Radiopharmaceuticals, Fnu Shefali

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Imaging using nuclear medicine techniques has enabled non-invasive measurements of biomarkers for a wide range of diseases including cancer and neurodegenerative disorders. The production and characterization of new radioisotopes are crucial steps in designing radiopharmaceuticals for nuclear imaging applications. 45Ti is a novel radionuclide with desired physical characteristics for use in Positron Emission Tomography (PET) imaging. The half-life of 3.08 h is ideal for the imaging of small peptides. In addition, the 45Ti decay by positron emission (85 %) and a low mean positron energy (0.439 MeV) offers high spatial resolution. The production route of 45Ti is straightforward due to …

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Phosphate Drives Pulmonary Inflammation Through Fgfr1, Erk, And Akt Signaling, Seth Bollenbecker Jan 2024

Phosphate Drives Pulmonary Inflammation Through Fgfr1, Erk, And Akt Signaling, Seth Bollenbecker

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Chronic kidney disease (CKD) is characterized as irreversible progressive loss of renal function and affects over one tenth of the global population. Although CKD-associated comorbidities contribute significantly to its mortality, the lungs are often not considered. Lung diseases make up three of the top six leading causes of death worldwide and share many comorbidities with CKD. Clinical reports show that CKD patients are more likely to develop obstructive and restrictive lung diseases, but the mechanisms underlying this propensity for CKD-associated pulmonary complications are unknown. Hyperphosphatemia and associated elevations of fibroblast growth factor (FGF) 23, two of many consequences of reduced …

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Predictive Modeling Using Clinical Data And Compositional Microbiome Data, Li Zhang Jan 2024

Predictive Modeling Using Clinical Data And Compositional Microbiome Data, Li Zhang

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This dissertation focuses on developing predictive modeling using data from two areas: clinical data and microbiome data. Compositional data in real life are mainly represented by relative proportions. With the advancement of next-generation sequencing (NGS) technology, researchers can now collect a large volume of metagenomic sequencing data, which is valuable for investigating associations between the microbiome and host diseases. Current methods for dealing with such data are either constrained by generalization or limited by application. In the first part, to address this, we propose Bayesian compositional generalized linear models for analyzing microbiome data (BCGLM). This model incorporates a structured regularized …

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Using Hope To Cope: Chronic Stress, Religious Coping, And Masked Hypertension In African American Adults: The Jackson Heart Study, Miriam Miles Jan 2024

Using Hope To Cope: Chronic Stress, Religious Coping, And Masked Hypertension In African American Adults: The Jackson Heart Study, Miriam Miles

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USING HOPE TO COPE: CHRONIC STRESS, RELIGIOUS COPING, AND MASKED HYPERTENSION IN AFRICAN AMERICAN ADULTS: THE JACKSON HEART STUDY ABSTRACT Chronic stress experienced at home or work has been associated with acute increases in blood pressure (BP) measured in the doctor’s office. Few data are available on the association of chronic stress with BP measured outside of the office setting. Religious coping, applying religious beliefs to adapt to stressful situations, and functional and structural social support may protect against MHT by promoting active coping behaviors and increasing emotional well-being. High levels of religious involvement and high social support have been …

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Using The Social Ecological Model To Assess The Correlates Of Unprotected Sex Among African American Emerging Adults, Shirlacia S. Gray Jan 2024

Using The Social Ecological Model To Assess The Correlates Of Unprotected Sex Among African American Emerging Adults, Shirlacia S. Gray

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USING THE SOCIAL ECOLOGICAL MODEL TO ASSESS THE CORRELATES OF UNPROTECTED SEX AMONG AFRICAN AMERICAN EMERGING ADULTS SHIRLACIA S. GRAY DEVELOPMENTAL PSYCHOLOGY ABSTRACT Background: The Centers for Disease Control and Prevention (CDC) reported that HIV diagnoses for Black/African American men and women are 8x and 15x higher than white individuals, respectively. While the social determinants of health largely influence HIV transmission rates, reducing risky behaviors can lower the risk for HIV. This current study used the Social Ecological Model to investigate correlates of unprotected sex. Methods: Participants were recruited through respondent-driven sampling. Participant's demographics (age, gender, years of education, financial …

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Predicting Maximum Concentric And Eccentric Squat Strength From Maximum Isometric Squat Strength, Michael A. Dunn Jan 2024

Predicting Maximum Concentric And Eccentric Squat Strength From Maximum Isometric Squat Strength, Michael A. Dunn

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Resistive squat exercise is a well-established technique to enhance the strength of muscles and bone of the back in humans. Such type of exercise could prove highly beneficial for individuals with pathological condition of the back such as osteoporosis. Notably, the rehabilitation programs aimed at strengthening the muscles and bone of the back require the knowledge of the patient’s one repetition maximum (1RM). Finding the 1RM squat value could lead to injury due to the higher weights involved. In addition, testing for 1RM could be not feasible in older populations or young population with chronic back conditions The isometric squat …

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Effect Bioactive Material Have On Tooth Demineralization, Taillk Gomes Jan 2024

Effect Bioactive Material Have On Tooth Demineralization, Taillk Gomes

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The objective of this in vitro study is to compare the inhibition of demineralization of root dentin caused by the presence of different restorative materials using Vickers Hardness (HV) test (microhardness) test and polarized light microscopy (PLM).

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A Thematic Analysis Of Health Literacy And Education Disparities Regarding Medical Needs For Transgender Individuals, Rachel Mcmullen Jan 2024

A Thematic Analysis Of Health Literacy And Education Disparities Regarding Medical Needs For Transgender Individuals, Rachel Mcmullen

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Transgender individuals experience many challenges within the healthcare system including discrimination, socioeconomic struggles, financial strains, a lack of educated healthcare providers, and a health system framework that makes it even more challenging for them to receive their medical needs (Korpaisarn and Safer). One contributing factor to this lack of education is that on average medical schools in the United States only spend approximately five hours total on the health needs related to lesbian, gay, bisexual, transgender, and queer (LGBTQ) individuals (Miller et al.). Another contributing factor is the stigma around LGBTQ individuals within the medical community. The stigma is concerning …

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3d Microtissue Model Of The Aged Ovarian Tumor Microenvironment, Peyton Clark Jan 2024

3d Microtissue Model Of The Aged Ovarian Tumor Microenvironment, Peyton Clark

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Ovarian cancer is the 5th leading cause of cancer deaths for women, primarily due to treatment resistant and/or recurrent disease. Most cases of ovarian cancer are not diagnosed until distant metastases have formed, which drastically reduces overall survival. The median age at diagnosis is 63 and most cases occur in patients who are peri- and post-menopausal. There is a critical gap between the clinical presentation of ovarian cancer and the preclinical models used to study the disease. Most preclinical in vivo investigations use mice who are between 6 and 12 weeks old, which corresponds to roughly a 20-year-old human. Therefore, …

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Temporal And Epigenetic Mechanisms Underlying Dietary Phytochemicals In Breast Cancer Prevention, Andrew Brane Jan 2024

Temporal And Epigenetic Mechanisms Underlying Dietary Phytochemicals In Breast Cancer Prevention, Andrew Brane

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Breast cancer (BC) is a widespread malignancy that, despite advancements in treatments and improvements in survival, had an estimated 297,790 new cases and 43,170 mortalities in 2023. With around 1 in every 8 women in the US expected to be diagnosed with BC at some point in their lives, the economic, societal, and healthcare burdens associated with this disease cannot be understated. Because of this, treatments and preventions that are affordable, efficacious, and easily administered are in high demand. Preventive therapies have shown great promise in reducing disease burden with relatively few serious side effects. BC prevention through the consumption …

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The Association Between Cardiovascular Disease Risk And Fractures In Postmenopausal Women, Rafeka Hossain Jan 2024

The Association Between Cardiovascular Disease Risk And Fractures In Postmenopausal Women, Rafeka Hossain

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Background: Fragility fractures pose a significant healthcare and economic burden in the United States. While age and bone mineral density (BMD) are the primary established risk factors for fragility fractures, the relationship between cardiovascular disease (CVD) and fractures remains underexplored. The primary objective of this analysis was to estimate the association of CVD risk with fractures in postmenopausal women. Methods: Utilizing 30 years of data from the WHI, Atherosclerotic Cardiovascular Disease (ASCVD) risk scores were computed using baseline age, race, systolic blood pressure, total cholesterol, high-density lipoprotein, diabetes, anti-hypertension medications, and smoking. Fracture outcomes encompassed any clinical fracture, major osteoporotic …

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Comparative Enzymatic Analysis Of Different Isoforms Of Group A Streptococcal Bacteriophage H4489a Hyaluronidase, Urvi Prakash Rawal Jan 2024

Comparative Enzymatic Analysis Of Different Isoforms Of Group A Streptococcal Bacteriophage H4489a Hyaluronidase, Urvi Prakash Rawal

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The Hyaluronate Lyase derived from Group A streptococcal bacteriophage H4489A gene (HylP) is known for cleaving the glycosidic bonds of high molecular weight hyaluronic acid (HMWHA), a substance often overexpressed in certain types of cancer cells. This enzymatic action produces HA oligosaccharides. Previous research, conducted by our team, has demonstrated that these oligosaccharides play a significant role in reducing the invasion, migration, and proliferation of breast cancer cells. This effect occurs through the disruption of Erk1/2 activation and RhoA expression. This bacteriophage hyaluronate lyase (HylP), a 40kDa protein, possesses a unique collagen-like sequence, consisting of 30 amino acids in a …

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Mixed Martial Arts, Meaning, And Behavioral Peace: Examining Social Relationships In A Diverse Environment, Dana Dawson Jan 2024

Mixed Martial Arts, Meaning, And Behavioral Peace: Examining Social Relationships In A Diverse Environment, Dana Dawson

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This thesis investigates the manifestation of behavioral peace within the diverse subcultures of mixed martial arts (MMA) gyms, drawing from the operational definition provided by peace ethology, which encompasses more than just the absence of violence. Peace ethology investigates how behavioral peace is achieved through mutual interests, tolerance, helping, sharing, and the avoidance of aggressive confrontation. This thesis explores how behavioral peace manifests in environments characterized by controlled violence and vulnerability, focusing on three MMA gyms in Alabama. Employing an ethnographic and ethological framework, the methodology blends autoethnography with participant observations and semi-structured interviews to comprehend the cultural, environmental, and …

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Investigating Impacts Of Caregiving On Cognitive Function: Role Of Social Support, Lu Tian Jan 2024

Investigating Impacts Of Caregiving On Cognitive Function: Role Of Social Support, Lu Tian

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Study Aim: Using the stress process model as a framework, this dissertation aims to investigate the role of social support on the influence of informal caregiving on cognitive function of caregivers aged 50 years and older and to look at potential gender and racial differences in this association. Method: Leveraging data from the 2016 to 2020 waves of the Health and Retirement Study (HRS), this research employs Ordinary Least Squares (OLS) regression analysis to examine the influence of caregiving on the cognitive function of older adults. To comprehensively understand the pathways through which caregiving impacts cognitive outcomes, I use mediation …

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Novel Roles Of Rab35 In Development And Disease, Kelsey Ruth Clearman Jan 2024

Novel Roles Of Rab35 In Development And Disease, Kelsey Ruth Clearman

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As the largest and most dynamic family of GTPases within the mammalian cell, Rabs play an essential role as molecular switches in regulating intracellular vesicular trafficking and serve as significant signaling transducers. Over the last few decades, Rabs have been identified to regulate endocytic, transcytosis, and exocytotic pathways, and mutations in Rabs, or alterations in downstream effectors lead to embryonic lethality and diseases such as cancer and ciliopathies. Ciliopathies are a class of pathologies that result from defects in structure or function of the primary cilia. Primary cilia, found on virtually all mammalian cells, is a microtubule-derived appendage that relies …

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The Modification Of Single Domain Antibody Framework And Variable Regions To Impart Novel Pharmacodynamic And Pharmacokinetic Properties, Lucinda Ann Hall Jan 2024

The Modification Of Single Domain Antibody Framework And Variable Regions To Impart Novel Pharmacodynamic And Pharmacokinetic Properties, Lucinda Ann Hall

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In recent years, nanobodies have become important theranostic molecules, and research has focused on improving their pharmacokinetics and binding for novel targets. Nanobodies are characterized by their high kidney uptake, leading to potentially unsafe exposure of the kidneys when delivering cytotoxic payloads. Researchers hypothesize that positively charged amino acids contribute to this kidney uptake. To address this, we assessed the impact of substituting lysine residues within the 2Rs15d HER2 nanobody scaffold to alanine on its in vivo pharmacokinetics using positron emission tomography (PET) imaging. We found that nanobodies bearing lysine-to-alanine substitutions maintained their affinity for HER2. Characterization of the K88A …

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Catecholamines And Catecholamine Resistance In Animal Models Of Metabolic Syndrome, Robert Follett Rosencrans Jan 2024

Catecholamines And Catecholamine Resistance In Animal Models Of Metabolic Syndrome, Robert Follett Rosencrans

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The sympathetic nervous system is a key regulator of energy homeostasis, in part, through the control of white adipose tissue lipolysis. Sympathetic nerves modulate adipose tissue physiology through the release of catecholamines, particularly norepinephrine, onto alpha- and beta-adrenergic receptors (a-AR; B-AR). Lipolysis refers to the breakdown of triglycerides into glycerol and free fatty acids, often in response to activation of B2/3-AR. Beta adrenergic activation of lipolysis is widely known to be impaired in patients with metabolic syndrome and animal models thereof (catecholamine resistance). Recent studies have demonstrated that catecholamine regulation of adipokine release is also disrupted, suggesting that catecholamine resistance …

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Fentanyl Overdoses And Use Of Randox Multistat For Investigative Purposes, Clarissa Danielle Lawen Jan 2024

Fentanyl Overdoses And Use Of Randox Multistat For Investigative Purposes, Clarissa Danielle Lawen

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The opioid epidemic started in the early 1990s with the rise of prescription overdoses. In more recent years, heroin and fentanyl use has rapidly increased. Fentanyl, specifically, is 50 to 100 times more potent than morphine. To keep up with the ever-evolving epidemic, the Randox MultiSTAT was validated for use in the medical examiner autopsy suite for the potential to aid medical examiners in triaging the need for a full autopsy versus an external examination with toxicology testing. The Randox MultiSTAT is a triage tool and investigatory screen designed to provide presumptive test results across multiple matrices. It can detect …

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Development Of Radiochemistry Of 52mn For Pet Imaging Applications, James Mokaya Omweri Jan 2024

Development Of Radiochemistry Of 52mn For Pet Imaging Applications, James Mokaya Omweri

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No abstract provided.

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The Role Of Altered Cell-Cell Communication Between Glia And Neurons In Alzheimer’S Disease, Tabea Marga Soelter Jan 2024

The Role Of Altered Cell-Cell Communication Between Glia And Neurons In Alzheimer’S Disease, Tabea Marga Soelter

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Alzheimer’s disease is the most prevalent neurodegenerative disease and is characterized by progressive memory loss and cognitive decline, affecting behavior, speech, and motor abilities. The neuropathology includes the formation of extracellular amyloid-β plaques and intracellular neurofibrillary tangles of phosphorylated tau. Additionally, neurons become functionally impaired before degenerating and dying. While neuronal loss is a disease hallmark, glia maintain neuronal health and homeostasis through cell-cell communication with neurons. Cellular crosstalk is mediated through the release of chemical intermediates (i.e., ligands), which are taken up by cell surface membrane receptors. Previous studies have shown dysregulation of global cell-cell communication patterns and communication …

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Dact1, The “Super-Crosslinker”: Regulation Of Non-Canonical Wnt Signaling During Vertebrate Convergent Extension By Modulating Dishevelled Oligomerization, Allyson Angermeier Jan 2023

Dact1, The “Super-Crosslinker”: Regulation Of Non-Canonical Wnt Signaling During Vertebrate Convergent Extension By Modulating Dishevelled Oligomerization, Allyson Angermeier

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A broad spectrum of human birth defects arise from the disruption of morphogenesis, the critical process through which tissues and organs acquire their proper shape. Convergent extension (CE) is a universal morphogenetic engine that promotes polarized extension of diverse tissues and organs by regulating directional cell behavior, such as oriented cell intercalation. In vertebrates, CE is regulated by non-canonical Wnt/Planar Cell Polarity (PCP) pathway, an ancient signaling pathway that was originally discovered to coordinate the cellular polarity in the plane of the epithelium. Non-canonical Wnt/PCP signaling shares the Frizzled (Fz) receptor and cytoplasmic signal transducer Dishevelled (Dvl) with the canonical …

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Modifiable Risk Factors And Subsequent All-Cause And Cause-Specific Late Mortality After Blood Or Marrow Transplanta-Tion (Bmt), Nora Balas Jan 2023

Modifiable Risk Factors And Subsequent All-Cause And Cause-Specific Late Mortality After Blood Or Marrow Transplanta-Tion (Bmt), Nora Balas

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The objective of this dissertation was to examine the association between modifiable risk factors and subsequent all-cause and cause-specific late mortality among blood or marrow transplantation (BMT) recipients. I analyzed data for participants who were ≥18 years (y) at study participation from the BMT Survivor Study (BMTSS). BMTSS (U01 CA213140, PI: Bhatia) is a cohort study designed to examine the long-term outcome of individuals who survived ≥2y after undergoing BMT between 1974 and 2014, at the University of Alabama at Birmingham, City of Hope, or University of Minnesota. BMTSS also examines outcomes in an unaffected comparison group drawn from the …

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Regulatory Elements Of Polyphosphate Biosynthesis, Marvin Qortez Bowlin Jan 2023

Regulatory Elements Of Polyphosphate Biosynthesis, Marvin Qortez Bowlin

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Polyphosphate (polyP) is an ancient, conserved, inorganic biomolecule. Biological systems have adapted many functions for this high-energy molecule, ranging from immune regulation in mammals to gene regulation in prokaryotes. Of particular interest is its use in bacterial stress responses. Bacteria use polyP to resist hazardous environmental elements like toxic molecules or nutrient starvation. In many bacterial species, polyP is synthesized by polyphosphate kinases (PPKs). PPK – discovered in Escherica coli (E. coli) – hydrolyzes adenosine-5’-triphosphate (ATP) to synthesize polyP. Species that use PPK develop multiple pathogenic defects when PPK activity is impaired, including, among others, antibiotic susceptibility. There is no …

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Investigation Of Reversibility And Nucleotide Effects In The Kinetic Mechanisms Of Nucleotide Addition In The Eukaryotic Rna Polymerases, Kaila B. Fuller Jan 2023

Investigation Of Reversibility And Nucleotide Effects In The Kinetic Mechanisms Of Nucleotide Addition In The Eukaryotic Rna Polymerases, Kaila B. Fuller

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Eukaryotes utilize at least three multi-subunit DNA dependent RNA polymerases (Pol I, II, and III) to synthesize RNA. The Pols are similar in structure but have distinct kinetic mechanisms that describe nucleotide addition. The product of Pol I synthesis, ribosomal RNA (rRNA) comprises the majority of the ribosome and is necessary for gene expression. Despite the importance of Pol I transcription in the cell, there is still much to understand about the roles of specific subunits in Pol I and the different factors that affect the kinetic mechanism of nucleotide addition catalyzed by Pol I. Our group has previously published …

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The Influence Of Proximity On Patient Outcomes For Differently Structured Ambulatory Surgery Centers, Wendy Michelle Smith Jan 2023

The Influence Of Proximity On Patient Outcomes For Differently Structured Ambulatory Surgery Centers, Wendy Michelle Smith

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THE INFLUENCE OF PROXIMITY ON PATIENT OUTCOMES FOR DIFFERENTLY STRUCTURED AMBULATORY SURGERY CENTERSWENDY SMITH HEALTH SERVICES ADMINISTRATION ABSTRACT This study examines the complication rates and patient-reported outcome measures (PROMs) for total hip and knee replacement surgeries conducted in one of two differently structured ambulatory surgical centers (ASCs) with varying interprofessional surgical teams. There is an ongoing shift from in-hospital total joint replacement surgeries to ASCs. Additionally, there is specialization occurring within ASCs. In this study, we compare single specialty ASCs designed to perform solely TJR surgeries with one orthopedic group and interprofessional team, with multi-specialty ASCs that perform an array …

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The Impact Of Diabetes On At-Fault Motor Vehicle Collisions In Older Adults: Visual Function, Medication, And Crash Characteristics, Thomas A. Swain Jan 2023

The Impact Of Diabetes On At-Fault Motor Vehicle Collisions In Older Adults: Visual Function, Medication, And Crash Characteristics, Thomas A. Swain

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Older drivers represent one of the fastest growing age groups of drivers in the United States. Crash risk among older adults, who have the highest prevalence of vision impairment, has been shown to be related to worse visual function. Diabetes mellitus is a chronic health condition affecting more than 23.1 million Americans, and one in three have pre-diabetes. Persons with diabetes are at increased risk of conditions which cause vision loss. Research indicates those with diabetes have higher rates of MVCs. Despite the increased MVC risk among each of these groups, work has yet to evaluate if diabetes modifies the …

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Analytical Fundamentals For Advancing Aero-Road/Terrain Multibody Morphing Dynamics And Stability Of Autonomous Utility Truck In Hazardous Environments, Parth Y. Patel Jan 2023

Analytical Fundamentals For Advancing Aero-Road/Terrain Multibody Morphing Dynamics And Stability Of Autonomous Utility Truck In Hazardous Environments, Parth Y. Patel

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Severe weather conditions have steadily increased over the last two decades. Therefore, the safety of the rescue and repair team is of paramount importance while they attend to emergencies due to these severe weather conditions. Utility trucks are the first responders in these extreme climate and weather situations for cutting trees to restore traffic, recovering life beings from destroyed properties, repairing electric posts, and restoring power. Such trucks with morphing capabilities of the boom equipment can increase the possibility of road accidents in several ways and create hazardous situations on the roads and off-road conditions while moving and performing critical …

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Manipulation And Dependence On Host Cell Cycle By Human Rna And Dna Viruses: Human Coronavirus Oc43 And Bk Polyomavirus, Jason M. Needham Jan 2023

Manipulation And Dependence On Host Cell Cycle By Human Rna And Dna Viruses: Human Coronavirus Oc43 And Bk Polyomavirus, Jason M. Needham

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Cell cycle is a universal necessity of cellular life and impacts nearly every process within the cell. However, despite over one hundred years of research, there still remain questions concerning the mechanisms and regulation of eukaryotic cell cycle. From the beginning, viruses have informed our knowledge of cell cycle. Many key regulators such as the E2F transcription factors, Src kinase, and p53 were originally discovered while studying the interactions between viruses and the cell. Herein, we continue the investigation of viral interactions with cell cycle machinery by researching an RNA virus and a DNA virus. These viruses, human coronavirus OC43 …

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A Tale Of Two Waves: The Role Of Genomic Enhancers In Regulating Transcriptional And Epigenetic Responses To Neuronal Activitiy, Robert A. Phillips Jan 2023

A Tale Of Two Waves: The Role Of Genomic Enhancers In Regulating Transcriptional And Epigenetic Responses To Neuronal Activitiy, Robert A. Phillips

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The mesolimbic dopamine (DA) pathway, which consists of dopaminergic neurons that project from the ventral tegmental area (VTA) to the nucleus accumbens (NAc), is heavily implicated in drug addiction. Exposure to drugs of abuse results in increases in extracellular concentrations of DA in the NAc, which in turn activates an immediate early gene (IEG) expression program that primarily consists of activity-dependent transcription factors, such as the AP1 subunits Fos and JunB. IEGs engage a set of temporally and functionally distinct genes, termed the late response gene (LRG) expression program. While gene expression changes are critical for drug-dependent adaptations, two major …

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