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It's A Man's World: The Association Between Safe Sex Practices, Relationship Power, & Resilience Among African American Emerging Adults Between 18-24 In The Deep South, Jessica Morgan Sep 2024

It's A Man's World: The Association Between Safe Sex Practices, Relationship Power, & Resilience Among African American Emerging Adults Between 18-24 In The Deep South, Jessica Morgan

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The purpose of this dissertation was to examine the impact that power imbalance has on safe sex practices among African American emerging adults. The objectives included: provide a thorough review of preexisting literature that explores the impact of power imbalance on safe sex practices among African American women; understand the impact that power imbalance has on safe sex practices among African American emerging adults comparing data from men and women; and understand if resilience is associated with power imbalance among African American emerging adult women in the United States. Utilizing a retrospective, cross-sectional, quantitative study design, three methods were used …

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Biologic Evaluation Of 64cu & 67cu As Potential Theranostic Agents For Cancer Radiotherapy, Lakshmi Madhusoodanan Sep 2024

Biologic Evaluation Of 64cu & 67cu As Potential Theranostic Agents For Cancer Radiotherapy, Lakshmi Madhusoodanan

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Immunotherapy has become a mainstay in the treatment of several types of cancer, with the potential to induce durable remission, albeit in a limited percentage of patients. More recently, radiopharmaceuticals have gained recognition in cancer treatment due to their ability to localize within cancer cells and deliver radiation, reducing adverse effects precisely. Cancer radiotherapy has the potential to synergize with immunotherapy due to its induction of immunogenic cell death (ICD), which results in distinct cellular injuries such as the formation of single-strand breaks (SSBs) and double-stranded breaks (DSBs), disruption of mitochondrial integrity, and the excessive generation of reactive oxygen species …

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Determination Of Readthrough Susceptibility Among Different Schwann Cell Lines Carrying Nonsense Mutations, Trushali Vansadia Sep 2024

Determination Of Readthrough Susceptibility Among Different Schwann Cell Lines Carrying Nonsense Mutations, Trushali Vansadia

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Neurofibromatosis Type 1 (NF1) is a genetic disorder that affects the nervous system through the formation of tumors or neurofibromas. Encoded by the NF1 gene, neurofibromin functions as a tumor suppressor by converting active GTP-Ras to inactive GDP-Ras. 20% of NF1 patients carry a genomic nonsense mutation, which generates a premature termination codon (PTC) in the NF1 mRNA, leading to the formation of a truncated neurofibromin protein. Termination at PTCs can be suppressed by the incorporation of an amino acid at the site of the PTC, also known as readthrough. Readthrough results in continued translation elongation downstream of the PTC …

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Understanding Biopsychosocial Influences On Physical Activity And Quality Of Life In Breast Cancer Survivors, Erica A. Schleicher Sep 2024

Understanding Biopsychosocial Influences On Physical Activity And Quality Of Life In Breast Cancer Survivors, Erica A. Schleicher

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Receiving a breast cancer diagnosis and subsequent treatment can be life-altering, presenting numerous challenges. Breast cancer treatments are effective at allowing women to live longer, but often impose long-term side-effects that survivors must manage for years. Exercise is an effective way to address many long-term side-effects of breast cancer treatment, yet 63-83% of breast cancer survivors do not meet recommended physical activity (PA) guidelines. Due to the complexity of cancer and treatment options, cancer-related factors have potential biopsychosocial impacts that can influence exercise habits, attitudes toward PA (i.e., social cognitive theory (SCT) constructs), and potentially quality of life (QoL). It …

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Disruption Of Cochlear Development By Murine Cytomegalovirus Infection And Therapeutic Approaches That Prevent Hearing Loss, Matthew Smith Sep 2024

Disruption Of Cochlear Development By Murine Cytomegalovirus Infection And Therapeutic Approaches That Prevent Hearing Loss, Matthew Smith

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Human cytomegalovirus (HCMV) is a ubiquitous virus, infecting greater than 50% of most populations worldwide. Although rarely causing symptomatic infection in immunocompetent individuals, HCMV can cause life-threatening and severe end-organ disease in immunocompromised hosts including the developing fetus. HCMV can cross the placenta and is the most common viral infection of the developing fetus. Most newborn infants with congenital HCMV infection (cCMV) exhibit no clinical evidence of infection; however, up to 15% will develop long term neurodevelopmental sequelae including sensorineural hearing loss (SNHL). No prophylactic vaccines or effective antiviral treatments exist for cCMV infection, which may in part be secondary …

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The Effect Of Progranulin On Lysosomal Function In Bv2 Cells, Michelle Park Sep 2024

The Effect Of Progranulin On Lysosomal Function In Bv2 Cells, Michelle Park

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Neurodegenerative diseases afflict nearly 7 million people in United states, constituting a significant portion of the 600 known neurological disorders. Characterized by the gradual loss of neurons and axons within the central nervous system (CNS), these conditions stem from chronic inflammatory activation of the brain. Chronic inflammation disrupts important processes such as autophagy lysosome pathway, a self-degradative process that eliminates protein aggregates and damaged organelles. Trehalose, a non-reducing disaccharide that triggers autophagic flux in neuronal cells and promotes the clearance of protein aggregates; however, without understanding the mechanism behind how trehalose affects these functions, it lacks value. In our study, …

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Cardiomyocyte-Specific Modified Mrna For Myocardial Regeneration In A Porcine Myocardial Infarction Model, Jiacheng Sun May 2024

Cardiomyocyte-Specific Modified Mrna For Myocardial Regeneration In A Porcine Myocardial Infarction Model, Jiacheng Sun

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The inability of adult mammalian cardiomyocytes (CMs) to undergo cell renewal following ischemic injury stands as a major impediment to heart function recovery and contributes to heart failure (HF). Current therapeutic approaches do not offer an effective approach of reactivating CM cell division to prevent HF in humans. Recognizing this challenge, gene therapy has emerged as a promising approach to promote CM proliferation and enhance cardiac repair. A particularly notable approach is the utilization of modified mRNA (modRNA), which provides a safe, controlled, transient, non-viral, and clinically relevant means of gene delivery. The study was conducted using a novel cardiomyocyte …

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Investigating The Electrostatics Of Mucins As Key Contributors To Mucus Stasis In Cystic Fibrosis, Elex Skylar Rose May 2024

Investigating The Electrostatics Of Mucins As Key Contributors To Mucus Stasis In Cystic Fibrosis, Elex Skylar Rose

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Cystic fibrosis (CF) is a genetic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which encodes a channel responsible for the transport of chloride and bicarbonate ions across the apical cell surface. In the respiratory tract, defective CFTR results in viscous and adherent mucus that becomes static within the airway, which leads to chronic infections, progressive lung damage, and early mortality. Historically, CF mucus stasis has been attributed to significant airway dehydration; however, growing evidence has demonstrated that aberrant electrostatic properties of mucins also contribute to mucus stasis in CF. Mucins are large, polymeric glycoproteins …

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Towards A Biobehavioral And Social-Structural Model Of Inflammation And Executive Function In Pediatric Obesity: A Pilot Longitudinal Study, Kathryn P. King Jan 2024

Towards A Biobehavioral And Social-Structural Model Of Inflammation And Executive Function In Pediatric Obesity: A Pilot Longitudinal Study, Kathryn P. King

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Pediatric chronic health conditions (CHCs) prevalence has increased post-COVID- 19, and CHCs affect children’s psychosocial development while representing significant family and societal financial burden. Interventions addressing CHC outcomes and psychosocial sequelae would benefit from examining and targeting biobehavioral and social-structural influences on such outcomes. Chronic inflammation and executive function (EF) deficits represent cross-cutting biobehavioral processes, promising novel targets, are vulnerable to social-structural influences, and common across CHC populations. Pediatric obesity represents a model CHC to examine, given its strong ties to chronic inflammation, EF deficits, health behavior, and SES, in addition to its increased prevalence in the wake of COVID-19. …

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Electromechanical Mapping Of The In Vivo Porcine Heart And Stomach, Haley Nesmith Patton Jan 2024

Electromechanical Mapping Of The In Vivo Porcine Heart And Stomach, Haley Nesmith Patton

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Electrical excitation and mechanical function are integral to the physiologic activity of both the heart and stomach. Electrical depolarization through the myocardium triggers contraction in the heart. When normal sequences of electrical activity are disturbed, the heart’s mechanical function may also be disturbed, affecting its ability to pump blood effectively, sometimes fatally. Similarly, electrical waves called slow waves initiate gastric peristalsis. Abnormalities in slow wave propagation patterns can disturb the stomach’s ability to mechanically process gastric contents, sometimes resulting in delayed gastric emptying, nausea, and vomiting. The relationship between mechanical function and electrophysiology is not unidirectional, though. Mechanical stimuli can …

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The Role Of Fibroblast Growth Factor Receptors In Inflammatory Airway Diseases, Molly Easter Jan 2024

The Role Of Fibroblast Growth Factor Receptors In Inflammatory Airway Diseases, Molly Easter

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Chronic inflammation plays a role in the development and progression of airway diseases such as chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF). COPD is caused primarily by chronic cigarette smoke exposure. Conversely, CF is a single gene disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator gene (CFTR). Although the causes of COPD and CF are different, there are common pathological features. Studies show that chronic inflammation plays a significant role in the pathogenesis of both COPD and CF. Moreover, chronic inflammation induces ageing-associated pathomechanisms like cellular senescence, which exacerbates chronic inflammation. Previous work demonstrates that …

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Genotype And Sex Specific Effects Of Methionine Restriction On The Life And Healthspan Of Drosophila Melanogaster, Joshua Robert Smith Jan 2024

Genotype And Sex Specific Effects Of Methionine Restriction On The Life And Healthspan Of Drosophila Melanogaster, Joshua Robert Smith

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Reduced dietary intake of the amino acid methionine has been reported to significantly extend the lifespan of common laboratory model organisms including Saccharomyces cerevisiae, Mus musculus, and Drosophila melanogaster. Methionine restriction (MR) has also been achieved via non-dietary means such as metabolite supplementation and CRISPR-Cas9 gene editing. MR along with protein and calorie restriction are known as dietary interventions capable of producing pro-longevity benefits through regulation of nutrient sensing pathways. Recent studies in model organisms have also identified beneficial effects of a low methionine diet on aging-associated phenotypes and markers of overall healthspan. However, the effects of this intervention on …

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Characterizing The Reproductive System Of Avrainvillea In HawaiʻI, Brinkley Mikayla Thornton Jan 2024

Characterizing The Reproductive System Of Avrainvillea In HawaiʻI, Brinkley Mikayla Thornton

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Sex has generated incredible life cycle diversity across eukaryotes. Differences in the timing of meiosis and fertilization have generated tremendous variation in the duration of haploid and diploid phases. To understand what drives eukaryotic sexual diversity, there remains a need to determine the rates of sexual and asexual reproduction in natural populations. Moreover, life cycle diversity is predicted to be correlated with the reproductive system. Yet, most studies on reproductive variation have focused on diploid or diploid dominant organisms, hindering the ability to understand sex. Macroalgae can serve as useful models to overcome this limitation via life cycle and reproductive …

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The Impact Of O-Glcnac Signaling On Dna Hydroxymethylation In Temporal Lobe Epilepsy, Rudhab Bahabry Jan 2024

The Impact Of O-Glcnac Signaling On Dna Hydroxymethylation In Temporal Lobe Epilepsy, Rudhab Bahabry

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Temporal Lobe Epilepsy (TLE) is the most prevalent form of focal epilepsy and the most treatment-resistant type. This condition is characterized by recurrent, unprovoked seizures typically originating in the hippocampus. Epigenetic modifications such as DNAme changes have been implicated in brain functions such as synaptic plasticity, learning and, memory, and cognition. The oxidation of DNA 5-methylcytosine (5-mC) and its oxidized form, 5-hydroxymethylcytosine (5-hmC) catalyzed by Ten-Eleven Translocation (TET) family of dioxygenases and linked to epilepsy's hyperexcitable state. Post‐translational modifications (PTMs) of proteins, such as O-GlcNAcylation, facilitate cells' immediate responses to intracellular or extracellular environmental stimuli by modifying the functions of …

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Optical Absorption Of Defects In Aluminum Nitride, Mackenzie Siford Jan 2024

Optical Absorption Of Defects In Aluminum Nitride, Mackenzie Siford

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Aluminum nitride (AlN) is an ultrawide bandgap semiconductor material known for its applications in high power microelectronic and optoelectronic devices due to its high thermal conductivity and high electrical resistivity. Point defects are known to hinder the material’s properties and are therefore a subject of interest in semiconductor materials research. The samples used in this work were grown by physical vapor transport (PVT) at Hexatech and they exhibit amber and clear coloration as well as a nonuniformity of charge, which was investigated. Experiments were carried out by electron paramagnetic resonance (EPR) and photo-EPR spectroscopy in order to detect the defect …

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Evaluation Of Feed Intake, Growth, And Reproduction In The Zebrafish, Danio Rerio, Fed A Gel-Based Diet, Thomas Logan Holfelder Jan 2024

Evaluation Of Feed Intake, Growth, And Reproduction In The Zebrafish, Danio Rerio, Fed A Gel-Based Diet, Thomas Logan Holfelder

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EVALUATION OF FEED INTAKE, GROWTH, AND REPRODUCTION IN THE ZEBRAFISH, DANIO RERIO, FED A GEL-BASED DIET THOMAS LOGAN HOLFELDER BIOLOGY ABSTRACT The zebrafish, Danio rerio, is a valuable pre-clinical model, aiding human health understanding and translational aquaculture. Comprehensive documentation of the culture of this model exists, with ongoing efforts to optimize husbandry requirements, particularly in the areas of diet and nutrition. Labor or mechanical costs related to feeding are high in most laboratories and alternative protocols to reduce feed handling would be beneficial and could allow the capability to monitor feed consumption. A commercially produced gel-based diet has a high …

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The Freshman Life And Student Health (Flash) Study: Using Social Network Analysis To Understand How Obesity And Stigma Impact Emerging Adult Health, Alena C. Borgatti Jan 2024

The Freshman Life And Student Health (Flash) Study: Using Social Network Analysis To Understand How Obesity And Stigma Impact Emerging Adult Health, Alena C. Borgatti

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Both racial discrimination and weight stigma have been identified as risk factors for poorer mental, physical, and social health. College students are vulnerable to the effects of stigma, as they greatly value peer acceptance and friendships during a pivotal time of emotional and health behavior development. The present study was the first to use social network analysis to examine the impact of weight and racial discrimination on the development of college social relationships and how these experiences influence students’ physical and mental health. 1330 participants (69% of on-campus freshmen) completed a brief survey on social networks, physical health, mental health, …

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Early Childhood Educators’ Perceptions, Attitudes, And Beliefs On Use Of The Modern Classrooms Project: A Case Study, Christina Arriagada Jan 2024

Early Childhood Educators’ Perceptions, Attitudes, And Beliefs On Use Of The Modern Classrooms Project: A Case Study, Christina Arriagada

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The purpose of this qualitative study was to explore how early childhood educators perceive the use of Modern Classrooms Project (MCP) in their classrooms. MCP is an instructional model that promotes blended, self-paced, and mastery-based learning with ties to constructivist teaching ideals. Data were collected using a teacher interview, observations, and the review of teacher resources such as lesson plans and student learning paths. Previous research found MCP was effective at the secondary level. Findings of this study showed that early childhood educators found MCP to be an effective instructional model to use in their classrooms. I identified three themes: …

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Investigating Hiv-1 Transmission To Human Cervix Using Reporter Virus Technologies, Dana Frances Indihar Jan 2024

Investigating Hiv-1 Transmission To Human Cervix Using Reporter Virus Technologies, Dana Frances Indihar

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Around 39 million people globally are currently infected with Human immunodeficiency virus 1 (HIV-1), more than half of whom are women. HIV-1 is a retrovirus that infects and depletes an individual’s immune cells, culminating in the development of acquired immunodeficiency syndrome (AIDS) if not managed with anti-retroviral therapies (ART). Most women acquire HIV-1 through heterosexual intercourse. However, the early mechanisms and virologic determinants of HIV-1 transmission to women remain unclear. Herein, we demonstrate transmitted/founder (TF) HIV-1 representing two genetically and pathogenically distinct subtypes (A and D) in vivo have distinct replication phenotypes in an ex vivo cervical explant tissue (CET) …

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Environmental Influences On The Physiology Of Cnidarians And Their Symbionts, Shelby Gantt Jan 2024

Environmental Influences On The Physiology Of Cnidarians And Their Symbionts, Shelby Gantt

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Corals and other cnidarians maintain complex symbioses that include photosynthetic endosymbiotic dinoflagellates (Symbiodiniaceae), protozoans, fungi, bacteria, archaea, and other metazoans, collectively known as the holobiont. The stability of these associations is crucial for holobiont resilience and adaptation to environmental conditions and are the results of long-term ecological and evolutionary processes. Environmental factors such as light availability, seasonal environmental fluctuations, and warmer, more acidic conditions can disrupt these symbiotic associations and alter holobiont functioning. To understand the influence of different environments on cnidarian host and symbiont physiology, two framework coral species (Acropora palmata and Orbicella faveolata) from nursery-raised and wild populations …

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Examining Anti-Racist Attitudes In Maternity Care Workers, Angelina Aduke Toluhi Jan 2024

Examining Anti-Racist Attitudes In Maternity Care Workers, Angelina Aduke Toluhi

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Racism in maternity care has been identified as one of the major contributors to the persistent racial disparities in maternal health outcomes in the United States (US). Antiracism is a term used to describe the practice of actively identifying and opposing racism with the goal of changing policies, attitudes, behaviors, and beliefs that continue to foster racist ideas and actions. The results of this convergent mixed method research study reveal that racism and other forms of racial discrimination during maternity care may lead to adverse pregnancy outcomes in Non-Hispanic Black (NHB) pregnant patients in Southern US. In the first aim, …

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Non-Catalytic Regulators Of The Secretory Pathway, Peyton Vanwinkle Jan 2024

Non-Catalytic Regulators Of The Secretory Pathway, Peyton Vanwinkle

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This thesis focuses on two key questions: 1) how are bone development and regeneration regulated by the CREB3L1 transcription factor; and 2) what is the mechanism of action of the endoplasmic reticulum resident protein JAGN1, which when dysregulated, causes severe congenital neutropenia (SCN)? CREB3L1 regulates bone development and regeneration in mammalian models by facilitating the expression of COL1A1 and components of the secretory pathway required for collagen secretion. We generated two zebrafish models of Creb3l1 dysfunction (creb3l1ΔbZIP/ΔbZIP and creb3l1TA+/TA+). Both models showed that Creb3l1 functions in regulating col1a1a transcription and overall regenerate size are conserved in zebrafish. However, we also …

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Knocking At The Door: The Life And Legacy Of Dr. James Montgomery, Haley Eloise Wells Jan 2024

Knocking At The Door: The Life And Legacy Of Dr. James Montgomery, Haley Eloise Wells

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The life and work of Black Birmingham cardiologist, Dr. James T. Montgomery, demonstrates the importance of viewing the history of health activism and Birmingham civil rights history as two interconnected histories that influenced each other. Traditionally, secondary scholarship on the Birmingham civil rights movement and scholarship on the history of healthcare have been treated as two separate areas of study. Scholars such as Glenn Eskew and Diane McWhorter have written extensively on the civil rights movement in Birmingham, but their scholarship excludes any comprehensive discussion of the fight for racial justice within Birmingham’s medical field. Conversely, scholars such as Thomas …

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Unmasking Molecular Mechanisms Of Multiple Maladies Through Multiomic Methodologies, Luke Potter Jan 2024

Unmasking Molecular Mechanisms Of Multiple Maladies Through Multiomic Methodologies, Luke Potter

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Much modern biomedical research is invested in determining causative molecular mechanisms and identifying potential therapeutics within human disease or injury. Traditional experiments such as over-expressing or “knocking out” the level of a gene’s abundance can determine the specific contribution of a single gene to a pathology and are a vital component of scientific research. However, taking a big picture approach through the application of ‘omics technologies can lead to a broader overall understanding of a pathology and can potentially generate numerous specific hypotheses to be tested using the more traditional molecular approaches. In this dissertation, transcriptomic and epigenomic technologies, measuring …

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Barbara Dane: The Forgotten Activist, Jacob Kennedy Jan 2024

Barbara Dane: The Forgotten Activist, Jacob Kennedy

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Barbara Dane is best understood as an unsung hero of the New Left and Folk Revival because since her graduation from high school in 1945, she has used every resource at her disposal to support and grow various movements. She has picketed for the labor movement, canvassed for the Progressive party, traveled to Mississippi to perform for the civil rights movement and SNCC, marched for peace as part of the anti-war movement, and performed and advocated for the Feminist movement throughout her lifetime. Dane has traveled the globe from war-torn Prague in 1947, Cuba in 1966, and Northern Vietnam in …

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Physiologically Relevant Cardiac Tissue Chips For Cardiovascular Disease Modeling, Sachin Budhathoki Jan 2024

Physiologically Relevant Cardiac Tissue Chips For Cardiovascular Disease Modeling, Sachin Budhathoki

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Despite significant advances in our understanding of the molecular basis of cardiovascular diseases (CVD) and the development of new therapeutics, it remains the number one cause of death worldwide, particularly affecting the aging population. This necessitates the development of models that can more accurately recreate aspects of aging and the interaction of the heart with other organs and systems in the body, including the immune system. Tissue chip models are being increasingly considered for studying cardiac diseases as they can potentially address translational hurdles associated with animal models, yet several challenges hinder their full potential. These include a lack of …

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Growing Need For A Standardized Response To Radiopharmaceutical Extravasations, Michael Richard Drelich Jan 2024

Growing Need For A Standardized Response To Radiopharmaceutical Extravasations, Michael Richard Drelich

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Extravasations are medical occurrences where an injected or infused pharmaceutical is unintentionally deposited into the soft tissue near the injection site, rather than into the bloodstream. With radiopharmaceuticals, extravasations can result in potentially large radiation doses to skin and tissue. The current rate of extravasations in clinical settings is estimated to be between 3-23%. In the interest of patient safety, a clearer understanding of the dosimetry and differences in extravasation scenarios to simplify dose estimation is needed. Similarly, the NRC is considering modifying regulations to include extravasations as reportable medical events rather than to continue considering them as patient interventions. …

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Insulin Responses, Diet Composition, And Fat Loss, Amanda Finn Jan 2024

Insulin Responses, Diet Composition, And Fat Loss, Amanda Finn

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Some but not all studies show participants who have higher baseline insulin responses lose more weight on a low glycemic load compared to a high glycemic load diet. Most prior research tested the relationship between insulin and weight changes with only one insulin response variable, such as insulin from an orally or intravenously (IV) administered metabolic test. We tested whether insulin responses (IV or oral) predicted changes in body fat among participants undergoing diet-induced weight loss. This study was a secondary analysis of a clinical trial. In the parent study, participants were randomized to either a reduced carbohydrate (ReducedCHO) or …

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Does Ceo Education Matter? The Relationship Between Doctoral-Educated Hospital Ceos And Organizational Performance, Kofi Ali Cash Jan 2024

Does Ceo Education Matter? The Relationship Between Doctoral-Educated Hospital Ceos And Organizational Performance, Kofi Ali Cash

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One of the most pressing issues in healthcare strategic leadership research is identifying which hospital chief executive officer (CEO) characteristics possess a significant and favorable relationship to organizational performance. However, little is known about the relationship between hospitals led by doctoral-educated CEOs and organizational performance. This study adds to our knowledge by examining the relationship between doctoral-educated hospital CEOs and selected financial and patient safety outcomes. UET served as the theoretical framework and guided the examination of the relationship between the selected dependent and independent variables. This study’s population included 509 acute-care hospitals across nine states, requiring a minimum four-year …

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Utilization Of Romosozumab During Covid-19 Pandemic Among U.S. Medicare Beneficiaries, Ye Liu Jan 2024

Utilization Of Romosozumab During Covid-19 Pandemic Among U.S. Medicare Beneficiaries, Ye Liu

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Osteoporosis is increasingly recognized as a major public health issue in the aging U.S. population. Shortly after the licensure of romosozumab, an injectable medication indi-cated for women with postmenopausal osteoporosis at high risk of fracture administered by health care provider monthly, the COVID-19 pandemic broke out, which caused ma-jor disruptions to the delivery of health care across the nation. The pandemic dispropor-tionately affected minority and economically disadvantaged communities, exacerbating many pre-existing health disparities. Romosozumab has the highest dosing frequency among common injectable osteoporosis medications in the U.S. that require an office visit for injection, making romosozumab adherence more susceptible to …

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