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Crystallization Behavior Of Waxes, Sarbojeet Jana May 2016

Crystallization Behavior Of Waxes, Sarbojeet Jana

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Partially hydrogenated oil (PHO) has no longer GRAS status. However, PHO is one of the important ingredients in bakery and confectionary industry and therefore the food industry is seeking for an alternative fat to replace PHO. Waxes have shown promise to fulfill that demand because of its easy availability and cheap in price. Waxes with high melting points (> 40 °C) help in the crystallization process when mixed with low melting point oils. A crystalline network is formed in this wax/oil crystallization process where liquid oil is entrapped in wax crystal network. A new material is formed which is neither …


Hybridization, Population Genetic Structure And Gene Expression In The Genus Boechera, Martin Peter Schilling May 2016

Hybridization, Population Genetic Structure And Gene Expression In The Genus Boechera, Martin Peter Schilling

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

When we look at life on earth, we can see a lot of different life forms, but we still do not fully understand how these different life forms came to be and at which points in time these life forms began to be different enough from each other so we could call them by different names, or species. Some groups of species on earth, especially plants, seem to reproduce with each other, even though they are already very different from each other so that we call them different species. This process is called hybridization, and it can stir up the …


Invasive Coqui Frogs Serve As Novel Prey For Birds In Hawaii, And Not As Competitors, Robyn L. Smith May 2016

Invasive Coqui Frogs Serve As Novel Prey For Birds In Hawaii, And Not As Competitors, Robyn L. Smith

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The Puerto Rican coqui frog was introduced the Hawaiian Islands in the late 1980s. Because of the frog's loud call and high abundance, the State of Hawaii has spent millions of dollars on its eradication. Conservationists are also concerned that the frog could negatively impact Hawaii's endemic birds, which are already threatened by a host of other invasive species, either by competing with them for insects or by increasing bird predators. The purpose of this research was to investigate the impacts of coquis on Hawaiian birds. First, we examined overlap in prey resources between coquis and birds, and second, we …


Influence Of Disturbance On Greater Sage-Grouse Habitat Selection In Southern Utah, Erica P. Hansen May 2016

Influence Of Disturbance On Greater Sage-Grouse Habitat Selection In Southern Utah, Erica P. Hansen

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The greater sage-grouse (Centrocercus urophasianus; sage-grouse) is a species of conservation concern that occupies sagebrush-dominated (Artemisia spp.) landscapes across the western United States and southern Canada. The U. S. Fish and Wildlife Service (USFWS) reviewed the status of the sage-grouse in September 2015 and determined that it did not warrant protection under the Endangered Species Act due to collaborative efforts between numerous public and private stakeholders. However, this decision hinged on federal and state commitments to continue science-based management of sagebrush habitats. As human development increases across the west, there is an increasing need for understanding …


Cluster-Based Salient Object Detection Using K-Means Merging And Keypoint Separation With Rectangular Centers, Robert Buck May 2016

Cluster-Based Salient Object Detection Using K-Means Merging And Keypoint Separation With Rectangular Centers, Robert Buck

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The explosion of internet traffic, advent of social media sites such as Facebook and Twitter, and increased availability of digital cameras has saturated life with images and videos. Never before has it been so important to sift quickly through large amounts of digital information. Salient Object Detection (SOD) is a computer vision topic that finds methods to locate important objects in pictures. SOD has proven to be helpful in numerous applications such as image forgery detection and traffic sign recognition. In this thesis, I outline a novel SOD technique to automatically isolate important objects from the background in images.


An Economic Analysis Of Factors Affecting Pre-Weaned Dairy Calf Growth And Profit Optimization In Dairy Calf Operations, Vincent T. Hess May 2016

An Economic Analysis Of Factors Affecting Pre-Weaned Dairy Calf Growth And Profit Optimization In Dairy Calf Operations, Vincent T. Hess

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

This study was an extension of a study submitted in April 2014 by Sheldon D. Holt entitled “Ambient Temperature, Calf Intakes, and Weight Gains on Preweaned Dairy Calves”.

A major component in a profitable dairy operation is the raising of female calves as replacement heifers; but since no direct income is generated by calf raising alone, it is often overlooked as a potential profit area on a dairy farm. Calf management practices that ultimately impact milk productivity and reproductive performance during a heifer’s lifetime begin at birth. This study examines the effect of calf starter intake on calf growth, measuring …


An Analysis Of The Feasibility Of Anaerobic Digestion On Small-Scale Dairies In Utah, Steven Chans Lund May 2016

An Analysis Of The Feasibility Of Anaerobic Digestion On Small-Scale Dairies In Utah, Steven Chans Lund

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

With an ever increasing concern for the environment, different methods of managing organic waste on dairy farms have been explored and analyzed. Anaerobic digestion has long been a popular method of managing organic waste. Its popularity stems from the potential to decrease greenhouse gases, improve air quality and provide a source of additional revenue for the farm. Problems with implementing anaerobic digestion arise from high failure rates, high start-up costs and continuous maintenance and equipment replacement.

Subsidies for the initial investment and improved technology have increased the possibility of large-scale dairy farms to adopt anaerobic digestion. Due to economies of …


Evapotranspiration Estimation: A Study Of Methods In The Western United States, Clayton S. Lewis May 2016

Evapotranspiration Estimation: A Study Of Methods In The Western United States, Clayton S. Lewis

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Theoretical water use of well-watered vegetation in the western United States was investigated by comparing a gridded dataset developed from satellite and ground instruments to weather stations representative of irrigated agricultural conditions. Since wetter environments are cooler and therefore subject to lower levels of evaporation than the same scenario with warmer temperatures, models derived from dryland and often populated areas overestimate potential plant needs in semi-arid or arid conditions. Evaluation of the model revealed an acceptable fit for air temperatures and solar radiation but with less confidence in humidity and wind speeds. Ultimately, the last two parameters were minor components …


Perceived Alzheimer's Disease Threat As A Predictor Of Behavior Change To Lower Disease Risk: The Gray Matters Study, Christine Clark May 2016

Perceived Alzheimer's Disease Threat As A Predictor Of Behavior Change To Lower Disease Risk: The Gray Matters Study, Christine Clark

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Alzheimer’s disease is a growing public health concern with an estimated five million Americans currently afflicted. That number is projected to triple by 2050 as the baby boomer generation approaches age 65, the most common age where people begin to show symptoms of cognitive decline stemming from changes in the brain related to Alzheimer’s. Since there is currently no cure or preventive pharmacological treatment, AD prevention research is now recognized as an important enterprise. Modifiable lifestyle factors that can reduce AD risk or delay its onset have been identified as reasonable targets for behavioral intervention, including increased physical activity, healthier …


Comparing Conventional And Noninvasive Monitoring Techniques For Assessing Cougar Population Size In The Southern Greater Yellowstone Ecosystem, Peter D. Alexander May 2016

Comparing Conventional And Noninvasive Monitoring Techniques For Assessing Cougar Population Size In The Southern Greater Yellowstone Ecosystem, Peter D. Alexander

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Determining the abundance or density of wildlife populations is needed for informed decision-making by wildlife biologists. Cougars (Puma concolor), however, are a highly secretive species occurring at very low densities across the landscape, and thus their populations are difficult for biologists to accurately assess. The conventional, and most trusted, method entails physically trapping and radio-collaring as many cougars as possible in a population, and then performing a simple count to determine a minimum population size. While accurate, this method is prohibitively expensive, logistically challenging, and behaviorally disruptive to the study animal. Many noninvasive surveying techniques, such as camera …


Anaerobic Hydrogen And Methane Production From Dairy Processing Waste: Experiment And Modeling, Jianming Zhong May 2016

Anaerobic Hydrogen And Methane Production From Dairy Processing Waste: Experiment And Modeling, Jianming Zhong

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Dairy processing waste (DPW) is the waste produced from manufacturing dairy products: cheese, yogurt, ice cream, milk, butter, etc. DPW is high in chemical oxygen demand (COD) due to its lactose, fat and protein content, and therefore needs to be appropriately treated. An investigation was conducted to produce energy (hydrogen and methane) from DPW by anaerobic digestion. This project developed an effective engineering method for stable methane production from DPW without adding pH control chemicals. This study also explored the optimal operational condition for hydrogen production from DPW. We further built a mathematical model to help us monitor and predict …


The Demography And Determinants Of Population Growth In Utah Moose (Alces Alces Shirasi), Joel S. Ruprecht May 2016

The Demography And Determinants Of Population Growth In Utah Moose (Alces Alces Shirasi), Joel S. Ruprecht

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Moose (Alces alces) occur widely in northern regions of the world. Across their distribution, the species is considered to be of high intrinsic, ecological and recreational value. Populations of moose along their southern range limit in North America have shown erratic population dynamics in recent decades including severe numeric declines in some areas. Moose in Utah belong to the Shiras subspecies, which is a relatively understudied population segment. Additionally, moose in Utah represent the southernmost naturally occurring moose populations worldwide. Concerns over possible declines and a paucity of baseline data on moose within the state prompted the Utah …


Greater Sage-Grouse Vital Rate And Habitat Use Response To Landscape Scale Habitat Manipulations And Vegetation Micro-Sites In Northwestern Utah, Charles P. Sandford May 2016

Greater Sage-Grouse Vital Rate And Habitat Use Response To Landscape Scale Habitat Manipulations And Vegetation Micro-Sites In Northwestern Utah, Charles P. Sandford

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The greater sage-grouse (Centrocercus urophasianus; sage-grouse) has been a species of conservation concern since the early 20th century. The decline of populations has largely been attributed to loss and degradation of sagebrush (Artemisia spp.) habitats. To contribute to the knowledge of sage-grouse ecology and quantify the effectiveness of landscape scale habitat manipulations intended to benefit sage-grouse, I monitored habitat use and vital-rates (i.e., nest and brood success) of 45 sage-grouse females in the Box Ender Sage-Grouse Management Area (SGMA) in northwestern Utah. Using telemetry locations of sage-grouse females with known nest and brood fates, I generated …


Effect Of Chronic Administration Of Oxytocin On Corpus Luteum Function In Cycling Mares, Katherine Clissold Parkinson May 2016

Effect Of Chronic Administration Of Oxytocin On Corpus Luteum Function In Cycling Mares, Katherine Clissold Parkinson

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Undesirable and variable behavior in mares related to the reproductive cycle is a common issue reported in the equine industry, especially for female horses in a performance setting. These behaviors can interfere with and decrease, overall performance. The objective of this study was to determine if administration of 60 units of the hormone oxytocin once daily for 29 days, regardless of when treatment was initiated during the estrous cycle, would induce prolonged corpus luteum function in cycling mares. Mares were randomly assigned to two groups: 1) saline-treated control (n=7) and 2) oxytocin-treated (n=9). Control mares received 3 cc saline and …


A Spatiotemporal Mountain Pine Beetle Outbreak Model Predicting Severity, Cycle Period, And Invasion Speed, Jacob P. Duncan May 2016

A Spatiotemporal Mountain Pine Beetle Outbreak Model Predicting Severity, Cycle Period, And Invasion Speed, Jacob P. Duncan

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The mountain pine beetle (MPB, Dendroctonus ponderosae), a tree-killing bark beetle, has historically been part of the normal disturbance regime in lodgepole pine (Pinus contorta) forests. In recent years, warm winters and summers have allowed MPB populations to achieve synchronous emergence and successful attacks, resulting in widespread population outbreaks and resultant tree mortality across western North America. We develop an age-structured forest demographic model that incorporates temperature-dependent MPB infestations: the Susceptible-Infested-Juvenile (SIJ) model. Stability of equilibria is analyzed as a function of population growth rates, and indicates the existence of periodic outbreaks that intensify as growth rates …


Motionscan: Towards Brain Concussion Detection With A Mobile Tablet Device, Shantanu Saxena May 2016

Motionscan: Towards Brain Concussion Detection With A Mobile Tablet Device, Shantanu Saxena

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

This thesis reports on a study to determine the viability of using a mobile tablet device as a brain concussion detection tool. The research builds upon the results of a prior method of collecting data for measuring motion sensitivity, where a user presses and releases a force sensor to balance a rising and falling line on a computer display. The motion sensitivity data collected using this force sensor device was shown to have less irregularity in persons with concussion. The MotionScan application, developed for this research, uses the accelerometer of a tablet device to record motor movement of a user …


Effects Of Carboxymethyl-Lysine In Heat Processed Foods On The Plasma Metabolome In Mice, Zhou Fang May 2016

Effects Of Carboxymethyl-Lysine In Heat Processed Foods On The Plasma Metabolome In Mice, Zhou Fang

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Carboxymethyl-lysine (CML), an advanced glycation end product (AGEs), is formed during the cooking process and may induce toxic effects on human health. The effect of dietary CML on the plasma metabolite profile was investigated. Mice were fed with one of five different diets: AIN93 diet (negative control), a 45% kcal from fat Diet Induced Obesity diet (DIO; positive control); CML0, TWD (Total Western Diet) with low CML; CML1, TWD with medium CML, and CML2, TWD with high CML for 8 weeks, and the plasma metabolome was determined by Gas Chromatography-Mass Spectrometry (GC-MS). In addition quantitative analysis of plasma glucose level …


The Market Potential For Food And Agricultural Tourism In Utah, Miranda Bradshaw May 2016

The Market Potential For Food And Agricultural Tourism In Utah, Miranda Bradshaw

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Tourism is one of the largest and most economically important industries in Utah. Local businesses and government agencies may increase their tourism-related profits through targeted marketing and product development. As tourists may differ from one another in terms of trip planning, party size, the activities they participate in, and more, it is important to understand who tourists are. The primary research purpose of this study was to explore and better understand the different types of tourists who visit Utah.

Data on tourists were collected through an in-person survey. This data was then used to place tourists into groups according to …


Biodiversity, Community Dynamics, And Novel Foraging Behaviors Of A Rich Native Bee Fauna Across Habitats At Pinnacles National Park, California, Joan M. Meiners May 2016

Biodiversity, Community Dynamics, And Novel Foraging Behaviors Of A Rich Native Bee Fauna Across Habitats At Pinnacles National Park, California, Joan M. Meiners

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Global concern about honeybee declines has spurred feverish research about the status and protection of this single species, yet our understanding of the ecology and issues impacting thousands of species of native bees lags behind. Pinnacles National Park, America's newest, near Salinas, California, is currently the most densely biodiverse area for native bees known on the planet. Recent work by researchers at Utah State University and the USDA-ARS has documented 479 species of native bees in only 42 square miles of this park. During two years of field studies and 308 collector days, we assembled data on 52,853 bee specimens …


Developing A Method For Quantifying Nitrogen Transformation Rates Using In Situ Benthic Chambers Dosed With Isotopically Labeled Nitrate, Chelsea A. Stewardson May 2016

Developing A Method For Quantifying Nitrogen Transformation Rates Using In Situ Benthic Chambers Dosed With Isotopically Labeled Nitrate, Chelsea A. Stewardson

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Nitrogen, a nutrient required for biological growth, is a common water quality parameter of concern as too much nitrogen can cause a strain on aquatic environments and even death of plants and animals. One way high levels of nitrogen are introduced into aquatic systems is by anthropogenic sources such as effluent from water reclamation facilities. A method was designed to observe the fate of nitrogen and measure the rates of its transformation into different nitrogen species within a stream receiving the effluent from the Silver Creek Water Reclamation Facility in Park City, Utah.

Sealed chambers were designed and installed along …


Anthropogenic And Natural Stressors And Their Effect On Immunity, Reproduction, And The Stress Response, Lorin A. Neuman-Lee May 2016

Anthropogenic And Natural Stressors And Their Effect On Immunity, Reproduction, And The Stress Response, Lorin A. Neuman-Lee

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Animals must be able to cope with many natural and human-made stressors in order to successfully survive and reproduce. These stressors can come in many forms and are increasing as human activities become more and more prevalent across the globe. In order to cope with these stressors, organisms must allocate limited energy away from processes such as reproduction to mount a stress response. This stress response involves the activation of the hypothalamic-pituitary-adrenal axis and results in a cascade of hormones and down-stream effects, such as changes in reproduction and immune function. In order to understand how reptiles and amphibians cope …


Impulsive Choice, Alcohol Self-Administration, And Pre-Exposure To Reward Delay, Jeffrey S. Stein May 2016

Impulsive Choice, Alcohol Self-Administration, And Pre-Exposure To Reward Delay, Jeffrey S. Stein

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Prior research indicates that drug dependence is associated with a tendency to discount the future. For instance, compared to control participants, drug-dependent participants more strongly prefer small, immediate rewards (e.g., $10 now) over larger, delayed rewards (e.g., $100 in 6 months). Similarly, in animal models of addiction, impulsive preference for small, immediate over larger, delayed food rewards in rats is associated with greater consumption of a number of drugs of abuse, including alcohol, cocaine, and nicotine. These and other findings suggest that this form of impulsive choice plays a causal role in addiction; however, this account has not been tested …


Establishment And Trends In Persistence Of Selected Perennial Cool-Season Grasses, Craig W. Rigby May 2016

Establishment And Trends In Persistence Of Selected Perennial Cool-Season Grasses, Craig W. Rigby

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The choice of plant materials is an important factor in restoration or revegetation of disturbed rangelands. To better identify plant materials that could be adapted to increased competition from invasive grasses and fluctuations in temperature and precipitation, there is a need to understand potential seedling establishment, plant persistence, and dry-matter yield (DMY) as a measure of plant vigor in the newly developed varieties across a wide range of environmental conditions. Experiments were conducted on four semiarid range sites to compare these traits in 14 perennial cool-season grass species currently used for revegetation in the Western U.S.A. There were location differences, …


The Art Of Devotion: Style, Culture, And Practice In Mid-Nineteenth-Century Kashmir, Nina Cavazos May 2016

The Art Of Devotion: Style, Culture, And Practice In Mid-Nineteenth-Century Kashmir, Nina Cavazos

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Largely produced in the Kashmir Valley during the mid-nineteenth century, gutkas are pocket-sized anthologies of texts, hymns, and prayers that a Hindu would recite in a sacred place in the home, usually near an altar. In the past, these objects have been relegated to the periphery of art historical discourse due to scholarly discriminations against their unrefined, "folk" characteristics. However, despite the lack of academic interest, a critical study of gutka culture provides the ideal viewpoint from which to explore South Asian art history, cultural history, and historical Hindu practices. Although these objects were often left unsigned by their illiterate …


Utah Lotus: North American Legume For Possible Use In Rangeland Revegetation In The Southern Great Basin Of The Western United States, Jason M. Stettler May 2016

Utah Lotus: North American Legume For Possible Use In Rangeland Revegetation In The Southern Great Basin Of The Western United States, Jason M. Stettler

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

This thesis project explored the production and forage quality characteristics of Utah lotus (Lotus utahensis Ottley) and scrub lotus (L. wrightii (A. Gray) Greene) seed collections during a two-year period. The variation of 14 Utah lotus and five scrub lotus seed collections was evaluated by measuring important plant characteristics at three common garden sites in northern Utah. In addition, the genetic structure of the collections was determined by molecular biological techniques. Large variation was observed among collections for all phenotypic traits measured, with Utah lotus and scrub lotus being phenotypically quite different. Two collections of Utah lotus (LU-5 …


“Touched By Time”: Geopolitical Themes Of Estonian National Identity Through Folklore And Song Festivals, Mandy L. Hoggard May 2016

“Touched By Time”: Geopolitical Themes Of Estonian National Identity Through Folklore And Song Festivals, Mandy L. Hoggard

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Estonian national identity—how Estonians imagine their values, history, and place in the world—is defined by their centuries-long struggle for independence and autonomy. This thesis examines the struggle and resulting identity through the lens of the laulupidu, or song festival, and its employment as a vehicle of political mobilization and re-constructor of Estonian history. Regarding folklore, in this case festivals and folk songs, as containers of the soul of the nation, I show how Estonians have produced and reproduced their national identity through the practice which they hold sacred: choral singing. I implemented a critical geopolitical approach, which emphasizes the …


The Role Of Gpr84 In Medium-Chain Saturated Fatty Acid Taste Transduction, Yan Liu May 2016

The Role Of Gpr84 In Medium-Chain Saturated Fatty Acid Taste Transduction, Yan Liu

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The prevalence of overweight or obese in adults has nearly doubled during the past two decades, and obesity increases the risk of heart disease, diabetes, and even some types of cancer. One of the factors closely linked with the obesity epidemic is overconsumption of dietary fat. Accumulating evidence has supported the existence of the "taste of fat", and more and more studies have focused on identifying the mechanisms of fatty acid detection by gustatory system. In this study, I showed for the first time that medium-chain saturated fatty acids (MCFAs) were able to activate taste cells isolated from mice, and …


A Light In The Dark: Luminescence Dating Intermountain Ware Ceramics From Four Archaeological Sites In Northwestern Wyoming, Carlie J. Ideker May 2016

A Light In The Dark: Luminescence Dating Intermountain Ware Ceramics From Four Archaeological Sites In Northwestern Wyoming, Carlie J. Ideker

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The chronology of high-altitude archaeological sites in northwestern Wyoming is poorly understood due to limited reliable age constraints. While temporally diagnostic artifacts provide relative age control, fluctuations in atmospheric radiocarbon produce radiocarbon age results with multiple calibrated age-range intercepts that prove difficult to interpret. Age overestimates associated with the 'old wood' problem can be especially prominent at high-altitude sites where cold and semi-arid environments promote the presence of long-living trees and prolong the preservation of organic material. Moreover, regional droughts coupled with a pine beetle epidemic have resulted in increasing wildfire frequency and intensities that serve both as a benefit …


Effects Of Feeding High-Moisture Corn Grain With Slow-Release Urea In Dairy Diets On Lactational Performance, Energy And Nitrogen Utilization, And Ruminal Fermentation Profiles By Lactating Cows, Braden M. Tye May 2016

Effects Of Feeding High-Moisture Corn Grain With Slow-Release Urea In Dairy Diets On Lactational Performance, Energy And Nitrogen Utilization, And Ruminal Fermentation Profiles By Lactating Cows, Braden M. Tye

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The objective of this experiment was to determine if nutrient utilization and energy partitioning by lactating dairy cows would differ in response to dietary corn grain (CG) types [steam-flaked corn (SFC) vs. high-moisture corn (HMC)] and to test if the types of CG would interact with slow-release urea (SRU) on lactational performance and energy utilization. Eight multiparous Holstein cows (32 ± 8.2 days-in-milk) were used in a duplicated 4 × 4 Latin square with one square consisting of ruminally cannulated cows. A 2 × 2 factorial arrangement was used to test 4 dietary treatments: SFC without SRU, SFC with SRU, …


Synthesis, Structure-Activity Relationship Study, And Mode Of Action Study Of 1,4-Naphthoquinone Based Anticancer And Antimicrobial Agents, Jaya P. Shrestha May 2016

Synthesis, Structure-Activity Relationship Study, And Mode Of Action Study Of 1,4-Naphthoquinone Based Anticancer And Antimicrobial Agents, Jaya P. Shrestha

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The first three projects involve the synthesis and the mode of action study of 1,4-naphthoquinone based anticancer agents. These anticancer agents are highly potent against a wide range of cancer cell lines. These compounds showed ~8-fold selectivity towards the lung cancer cell line than the normal cell line. We also studied the mode of action and observed that generation of reactive oxygen species is the primary mode of action.

The final project involves the synthesis of multi-cationic antimicrobial agents. These compounds are active against both bacteria and fungi. These compounds are very easy to synthesize and can be scaled up …