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Is Trimethylamine N-Oxide A Friend, Foe, Or Hormetic Agent In Patients With Parkinson’S Disease: A Focused Review Of One Microbial Metabolite, Abraham B. Alton

Student Works

This review synthesizes recent literature examining trimethylamine N-oxide (TMAO) synthesis and its potential role in Parkinson’s Disease (PD) pathology. An increase in TMAO plasma and CSF concentration is associated with PD progression and severity. TMAO biosynthesis is a two-step process. First, precursors including carnitine and choline are converted to trimethylamine (TMA) by gut microbes. Second, TMAO is oxidized to TMAO in the liver. Once absorbed into circulation TMAO crosses the blood brain barrier and may influence PD disease pathology by increasing neuroinflammation and astrocyte activation and damaging the cerebral lymphatic system. These mechanisms may contribute to the cognitive and motor …

On The Brink Of Silence: Ethnographic Perspectives On Hunting And Forest Life Among The Awa Guajá In Eastern Amazonia, Uirá Garcia

Tipití: Journal of the Society for the Anthropology of Lowland South America

The central theme of this article basically resides in the relationship established by indigenous peoples between their hunting practices and the forest. Indigenous ways of connecting ‘hunting’ and ‘forest’ necessarily pass through other modes of knowing, only marginally – if it all – dependent on vision. On the contrary, sounds, smells and even dreams are, for many South American indigenous collectives, more trustworthy indices than what the eye sees. This article divides into two parts. In the first, I set out the main ideas related to the anthropological study of hunting in Amazonia at a conceptual level. In the second, …

Between The Root And The Stem: On Women-Plant Relations, Predation And Familiarisation Among The Awajún (Upper Amazonas, Peru), Nils Haukeland Vedal

Tipití: Journal of the Society for the Anthropology of Lowland South America

What to do with the problem of predation? This is not only a conundrum for anthropologists working in what has become known as animist societies. The gardening activities of the Awajún people of northern Peru’s high jungle are modelled on the teachings of the original mother of cultivated plants, Núgkui, who granted the Awajún their cultivars. Yet gardening is not an easy matter. The manioc sprouts seek to suck the blood of gardeners unless they are treated correctly. This article explores how predation is constantly kept at bay through familiarisation practices in which garden plants are made into the vegetative …

Making Noise Through Law: Indigenous Legal Mobilisation Against A Power Plant In “French” Guiana, Pierre Auzerau

Tipití: Journal of the Society for the Anthropology of Lowland South America

In so-called “French” Guiana, or Guyane, the Kali’na village of Atopo Wipi has fought for years against a hydrogen power plant being built on their land. Drawing on ethnographic fieldwork conducted between 2023 and 2024 in Guyane and Western Europe, where I collaborated with various stakeholders to support Atopo Wipi’s resistance to the power plant, my research focuses on the legal dimensions of the Kali’na’s struggle to protect their land. Specifically, this article examines how the Kali’na navigated different normative frameworks, including international human rights standards and French law, to fight the project. Through this analysis, I show how the …

“Ese Dia Que Se Va El Patron An Hecho Fiesta”.* Historicities Of Successful Resistance Against Hacienda Bosses Among The Kukama (Peru, 1933-1945), Arno R. Holl

Tipití: Journal of the Society for the Anthropology of Lowland South America

This paper analyzes two cases of resistance by Kukama workers within the debt slavery system of habilitación in the Peruvian Amazon during the first half of the twentieth century. It discusses the similarities and differences between the two cases, and positions the workers and their accounts of events and agency within the historical, social and cosmological framework of the time and region. Through the examples studied here, the hierarchies, power dynamics, spirituality, lifestyles, traditions, and cultural changes that shaped Kukama communities at the time become visible from an emic perspective. The paper places special emphasis on how historical events are …

Simplification Of Technical Language In Tagesschau News For B1-Level German Vocabulary Learning, Syaula Qonit Helga, Dewi Kartika Ardiyani

Journal of Innovation and Teacher Professionalism

This study aims to identify and categorize the types of Fachsprache (specialized language) found in simplified Tagesschau news and to explore their potential use for B1-level German vocabulary learning. The study employs a qualitative descriptive approach using content analysis. Data were collected from news videos available on the Tagesschau YouTube channel and analyzed according to three categories: (1) CEFR level, (2) subject area, and (3) usage context. The data were processed through data reduction techniques to simplify Fachsprache terms at higher CEFR levels, followed by data display and interpretation to examine the identification results, and finally, conclusion drawing. The findings …

Can Behavioral Interventions Promote Health Equity In Pediatric Type 1 Diabetes? A Narrative Review Of Promising Treatments, Paul T. Enlow, Jaquelin Flores Garcia, Julia Price, Kristen A. Torres, David V. Wagner

Department of Pediatrics Faculty Papers

Purpose of review: Synthesize data on whether existing behavioral interventions can improve health equity among youth with type 1 diabetes.

Recent findings: While existing behavioral interventions demonstrated efficacy in improving health and/or psychosocial outcomes, evidence that these same interventions may improve health equity were lacking. Most interventions were evaluated using predominantly White and affluent samples and some studies did not report on racial, ethnic, or sociodemographic characteristics of their sample. Only a few interventions have been adapted for youth from minoritized backgrounds. Recent multisystemic and technology/mHealth interventions recruited samples that were sociodemographically representative of youth experiencing disparities, suggesting that these …

Choline Counteracts Pregnancy Undernutrition-Associated Colitis In Sheep By Restoring Microbiota Driven Bile Acid Metabolism, Weibin Wu, Peng Jiao, Yamei Gu, Huizhen Lu, Caiyun Fan, Zheng Sun, Lizhuang Hao, Shengyong Mao, Jianbo Cheng, Yanfeng Xue

Faculty, Staff and Students Publications

High-fertility sheep experience undernutrition during late gestation, which induces body metabolic disruption and intestinal inflammation. Crucially, the gut microbiota-bile acid axis is a promising intestinal inflammation target, but how choline modulates this axis in livestock enteritis is unknown. This study investigated choline's protective mechanisms against undernutrition-induced intestinal inflammation in sheep, focusing on gut microbiota and bile acid regulation. Choline consistently alleviates colitis severity, restores epithelial barrier integrity, and suppresses intestinal inflammation. These protective effects are accompanied by pronounced remodeling of the colonic microbial ecosystem, characterized by the enrichment of Clostridiales bacterium to elevate bile salt hydrolase activity and regulate bile …

Designing Captcha Systems With Reinforcement Learning For Adaptive Defense, Meghana Indukuri, Eman Naseerkhan, Joshua Rose, Martin Tran, Younghee Park

Faculty Research, Scholarly, and Creative Activity

CAPTCHA (Completely Automated Public Turing test to tell Computers and Humans Apart) systems remain a widely deployed defense against automated abuse, but advances in machine learning have reduced the effectiveness of traditional challenge-based designs and exposed limitations in proprietary risk-scoring systems. This paper presents an adaptive, reinforcement learning-based CAPTCHA defense framework for high-security web applications. The proposed system formulates bot detection as a partially observable Markov decision process and uses a Proximal Policy Optimization (PPO) agent with Long Short-Term Memory to analyze streamed behavioral telemetry, including mouse movements, clicks, keystrokes, and scrolling, over sequential interaction windows. During the observation phase, …

Posts, Not Personae: Why Influencer Personae Fall Outside The Doctrine Of Character Copyright, Abbey Brantley

Journal of Intellectual Property Law

Over the past decade, social media has enabled an increasing number of people to pursue influencing as a full-time career on platforms such as TikTok, Instagram, and YouTube. To succeed commercially, these creators make repeated stylistic choices that both conform to online trends and project a carefully curated persona. As these personae become profitable, however, they also become susceptible to imitation. This dynamic raises the question whether copyright law, specifically the doctrine of character copyright, can protect influencers from unauthorized copying of their online identities. This Note argues that influencer personae do not and should not qualify for such protection, …

Patents And Technology Evolution: Altering Innovations And Innovators Via Patent Influences, Richard Gruner

Journal of Intellectual Property Law

Technologies improve primarily through evolutionary change not rational optimization. New technologies emerge as attempts to solve practical problems, the technologies are tested in marketplaces to determine if they are superior in cost and function to alternatives, and those that fare well in the testing gain widespread adoption.  Widely adopted technologies, and their problems, form the basis for the next round of technology improvements and evolution.  Through these steps, evolutionary processes lacking rational direction can generate changing technologies matched to the desires and problems of present society.

As they operate to advance diverse technologies, evolutionary processes governing technology change are subject …

The Prestige Economy Of Legal Scholarship, Jeffrey A. Katz, Jacob Sandler

Florida Law Review

Law reviews sit at the center of American legal scholarship, but their role is widely misunderstood. They are not peer-reviewed, yet the academy treats their placement decisions as markers of scholarly merit. This Essay argues that law reviews function as participants in a prestige economy—one in which reputation, familiarity, and institutional brand often matter more than substantive judgment. Tracing the student-edited model from its pedagogical origins to its modern professional consequences, this Essay shows how prestige became currency, how that currency shapes editorial and authorial behavior, and why the system strains under political and methodological pressure. It concludes by urging …

Fate Of Nitrogen Applied To Grassland In Animal Wastes, M Sherwood

IGC Proceedings (1977-2023)

The experiment was designed to determine the effects of land spreading of animal manures on the nutrient content of surface runoff water and infiltrating soil water. This report deals only with nitrogen (N) and attempts to quantify the losses through runoff, leaching, and volatilization of ammonia (NH3) as well as N uptake in the grass over a 3-year period. Experimental plots sited on grassland, on two soil types (a moderately drained loam and an impermeable gley), were equipped to collect surface runoff water. Ceramic probes were installed in each plot at 15-, 30-, 60-, and 100-cm depths to extract in­filtrating …

Nitrogen Losses From Urine-Affected Areas Of A New Zealand Pasture, Under Contrasting Seasonal Conditions, P R. Ball, D R. Keeney

IGC Proceedings (1977-2023)

Grazing ruminants aggregate large quantities of forage nitrogen (N) into urine patches. Pasture plots treated with urine N were studied to assess its fate under contrasting seasonal conditions: cool-moist (representing winter-spring); warm-moist (late spring-early summer), and warm-dry (late summer-autumn). A permanent ryegrass (Lolium perenne L.)-white clover (Trifolium repens L.) sward on free-draining alluvial soil was studied. 'freatments were replicated in randomized blocks. Urine N was applied at 30 or 60 g N/m2• Relevant measurements were then continued until treatment differences disappeared. Apparent N balances for urine treatments were compiled. Fixation by white clover was always greatly reduced in …

Effects Of Water Stress On Herbage Quality, J R. Wilson

IGC Proceedings (1977-2023)

Uncertainty exists about whether drought is detrimental to the nutritive quality of herbage. This paper tries to resolve this uncertainty by examining the influence of soil moisture on some herbage-quality characteristics. Unpublished data from my own work and review of published literature are presented. Field plots of three tropical grasses, green panic (Panicum maximum var. trichoglume), buffelgrass (Cenchrus ciliaris), and speargrass (Heteropogon contortus), were subjected to perioqs of controlled drought, and herbage from these plots was compared with that from well-watered plots. Leaf and stem dry-matter ?igestibility of water-stressed herbage was either similar to or higher than that of unstressed …

Consumption Rates And Desert Grassland Herbivores, R D. Pieper

IGC Proceedings (1977-2023)

Studies were conducted on a desert grassland range in southern New Mexico for 3 years to determine relative consumption rates of the main herbivores utilizing these range areas. Consumption of some groups (cattle, pronghorn antelope, and rabbits) was determined from direct estimates of intake/individual, and density was determined from censusing procedures or known stock rates. Consumption by other groups (birds, rodents, and invertebrates) was determined from census information relating to age structure of the population and metabolic rate. Consumption by all herbivores averaged less than 5 % of the above-ground net primary productivity for the 3 years of the study. …

Performance Of A Subtropical Legume-Grass Pasture Under Different Grazing Management Systems, G E. Maraschin, S C. Mella, G S. Irulegui, J Riboldi

IGC Proceedings (1977-2023)

Agronomic evaluation of the dynamics of tropical legume-based pastures is relevant in assessing the response of their com­ponents within systems of grazing management. The response of tropical legume-grass mixtures to periods of rest and grazing pressure and the combinations that result in meaningful legume content in the mixture need to be known. A central composite design was used to study the performance of a Desmodium intortum (Mill.) U rb. and Paspalum gttenoarum Arech. pasture mixture to 14, 28, 42, 56, and 70daysofrestcombinedwith 2.0%, 3.5%, 5.0%, 6.5%, and 8.0% BW(i.e., kg dry matter (DM) on offer/day/100 kg body weight) as grazing …

Legume Establishment In Grass-Dominant Swards: Concept And History In Kentucky, T H. Taylor, W C. Templeton Jr

IGC Proceedings (1977-2023)

Grassland farming has been practiced for 2 centuries in central Kentucky and for shorter periods in other parts of the state. Savannas and tallgrass prairies were severely grazed by domestic animals and row-cropped by early settlers, destroying most of the indigenous plant species. By the early part of the 19th century, beef cattle were being produced on bluegrass (Poa pratensis L.) pastures and driven on foot to east-coast markets. During the first century of settlement, farmers learned to top-seed legumes into grass sods, and in the course of the last hundred years development of grassland technology for establishing legumes …

Seed And Seedling Dynamics Of Annual Medic Pastures In South Australia, E D. Carter

IGC Proceedings (1977-2023)

Annual species of Medicago (i.e., medics) are the key to successful cereal-pasture rotations in the integrated crop-livestock farming systems on the neutral to alkaline soils of southern Australia. However, many medic stands have deteriorated in recent years. This deterioration has prompted research on the effects of grazing sheep on the seed-seedling dynamics of annual medic­based pastures in the Mediterranean environment of South Australia, aiming to quantify the impact of medic seed reserves in or on the soil upon pasture establishment and productivty.

Animal-house experiments involving the feeding of purepod and pod-chaff diets to sheep and a field experiment have been …

Physiology Of Growth Of A Grazed Sward, E L. Leafe, A J. Parsons

IGC Proceedings (1977-2023)

To improve our understanding of grassland utilization under grazing, the physiology of a grazed sward was investigated. An enclosure method, infrared gas analysis, and radiocarbon were used to measure sward and single-leaf photosynthesis and assimilate utilization. Intake by sheep was also measured. Expanding and recently expanded leaves had high rates of net photosynthesis but leaf sheaths, whose projected area in a "hard" grazed sward equaled that of the lamina, had low efficiency and contributed little to canopy photosynthesis. But because high leaf efficiency did not compensate for the small leaf area, canopy photosynthesis decreased markedly as grazing intensity increased. Twice …

Grassland Development In The Southern Highlands Of Peru, E J. Stevens, P Villalta

IGC Proceedings (1977-2023)

This paper describes grassland development in Peru. Vegetation of the high alpine region of Peru, which occupies some 4 million ha, is dominated by native grasses normally producing less than 2,000 kg/ha dry matter annually. On land with ade­quate soil moisture, pastures based on perennial ryegrass (Lolium perenne L.) and white clover (Trifolium repens L.) were established successfully, but on drier sites alfalfa proved superior, producing over 12,000 kg/ha/yr in some trials. Alfalfa and clovers were also successfully introduced into improved native pastures by mechanical direct seeding and by hand sowing. With direct seeding, dry-matter production increased from about …

Pasture Evaluation In The Desertic Zone Of Venezuela For The Development Of Goat Production, A Gallardo, A Leone

IGC Proceedings (1977-2023)

The desertic zone of Venezuela is an area of approximately 4.1 million ha that represents 4.8 % of the total national territory, on which there are two million goats. Goats represent the main, if not the only, income source for 60,000 rural families. According to UNESCO (1973), the desertic zone of the country comprises two vegetation types, evergreen scrub and deciduous scrub. In each of these zones the plant species consumed by goats were collected and, for those plant parts consumed by the animals, chemically analyzed to determine nutritive value. Forage plants from other tropical countries were also in­troduced and …

Evaluation Of Biological Components In Decision-Making In Forage Allocation, J E. Skiles, G M. Van Dyne

IGC Proceedings (1977-2023)

Forage allocation to mixtures of large herbivores is accomplished by minimizing the difference between the available herbage and the required forage for animals on rangeland. Availability is determined in part by the plant's physiological tolerance to grazing or its allowable-use factor and the animal preference for that plant, measured in part by the proper-use factor. The mix of large herbivores on the rangeland must also be considered. The grazing requirements for animals are dependent on animal preference for plant species and on the total forage intake rates. This paper presents an analysis of these concepts and published information. The concept …

Effect Of Converting Chaparral To Grassland On Soil Fertility In A Mediterranean-Type Climate, M B. Jones, R L. Koenigs, C E. Vaughn, A H. Murphy

IGC Proceedings (1977-2023)

In the region of Mediterranean-type climate in California, brush is converted to grassland to reduce fire hazards, increase feed for herbivores, and increase water yields. There is little information on how this change of cover type affects soil fertility over a long period. Research was initiated to measure the long-term effect of converting brush to grass on the availability of nutrients in the soil. In 1956 chaparral growing on Los Gatos soil (fine-loamy, mixed mesic family of typic argixerolls) was crushed, burned, and seeded to grasses and clovers, and half the area was fenced to exclude herbivores. Sprouting brush either …

Resource Allocation For Animal-Grassland Systems, G W. Thomas

IGC Proceedings (1977-2023)

The production of animal products from grasslands is dependent upon an adequate resource base-particularly the availabil­ity ofland, water, and energy. In addition, range and pasture production systems must be designed to adjust to climatic varia­tions and to minimize adverse environmental impacts. Several new developments will have a significant impact on the future allocation of resources for animal agriculture: (1) in­creased competition for land and water, which is leading to transfers from agricultural to nonagricultural uses; (2) increasing costs and decreasing availability of "cultural energy" (particularly fossil fuels); (3) more pressure to divert grains and feed con­centrates from animals to direct …

Multiple Use Of Grassland Resources (Grasslands To Provide Natural Resource Conservation And A Quality Environment For Mankind), P J. Edwards

IGC Proceedings (1977-2023)

The grasslands of the world ( and communities closely akin to them, such as shrub and savanna types) provide not only a very effective mantle for protection of the soil, but also the main source of feed for herbivores. They also cater to many other needs of mankind. Increasing population results in competition between types of grassland use for specific sites. Sound planning is necessary to resolve this conflict in the way most beneficial to mankind. In order to plan logically it is necessary to make an inventory of the resources, to consider the various uses to which grasslands can …

Nitrogen Relationships In Grassland Ecosystems, A Lazenby

IGC Proceedings (1977-2023)

Some recent findings affecting nitrogen (N) cycling in grassland ecosystems are discussed, and an indication is given of major problems requiring research and development. The importance of modern techniques is stressed to enable further quantification of the pathways and processes of the nutrient in grassland; such data are needed both to improve understanding and to enable more efficient use of N in practice. A brief description of the N in soil organic matter is followed by an account of symbiotic N fixation by legumes, including estimated levels and rates of fixation and factors affecting the process. Data are presented on …

Contribution Of Forages To Worldwide Food Production: Now And In The Future, E F. Henzell

IGC Proceedings (1977-2023)

Herbivorous livestock provided during the 1970s an estimated minimum 7%-17% of the total dietary protein in Asia and Africa compared with about 30 % in Latin America and just over 30 % in the developed countries. Cattle accounted for approx­imately 70% of the world's domestic animals (calculated in units weighted for size), buffaloes for 10%, and sheep and goats for 11 % . About 69 % of these animal units were in the developing countries, but productivity was higher in the developed coun­tries. Forages, defined broadly to include all edible plant materials except grains and concentrates, provided more than 90% …

Potential Productivity Of Temperate And Tropical Grassland Systems, G O. Mott

IGC Proceedings (1977-2023)

Grasses of temperate regions of the world belong primarily to the subfamily Festucoideae, whereas tropical regions are populated by tribes of the Panicoideae subfamily. Temperate grasses have a C3 biochemical pathway of photosynthesis in con­trast to tropical grasses, which have a C4 photosynthetic mechan-ism. Both tropical and temperate legumes are C3 plants. Com­patible mixtures of legumes and grasses have long been successful in many temperate regions, but combining C4 grasses and C3 legumes as mixtures in the tropics has been only moderately successful. Maximum net primary productions of temperate and tropical grasslands are in the order of 25 and 80 …

Use Of Genetic Resources For Improvement Of Forage Species, J R. Harlan

IGC Proceedings (1977-2023)

The use of genetic resources of forage species poses some special problems because of the number of species involved, the in­adequacy of our knowledge about them, the fact that they are often used in combination and should be evaluated in terms of livestock product, and so on. Collections should be as comprehensive as possible at the outset of improvement programs; other­wise, there may be much use of inferior material and much waste of time and effort. Most of the forage species in use come from (1) Europe (excluding Mediterranean zones), (2) Mediterranean Basin and Near East, (3) African savannas (mostly …