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The Role Of Nitric Oxide And Cyclic Guanosine Monophosphate Signaling In Arteriovenous Fistula Maturation, Maheshika S. Somarathna Jan 2022

The Role Of Nitric Oxide And Cyclic Guanosine Monophosphate Signaling In Arteriovenous Fistula Maturation, Maheshika S. Somarathna

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Vascular access is the single most important component of the hemodialysis procedure and the arteriovenous fistula (AVF) is the most preferred type. However, 60% of AVFs created fail to mature successfully for dialysis use (AVF maturation failure). AVF maturation failure is primarily the result of 1) intimal hyperplasia formation (IH) and 2) poor vascular outward remodeling. Currently, a major unmet clinical need in the field is the lack of effective therapies to treat/prevent AVF maturation failure due to the poor understanding of molecular mechanisms. This proposal is designed to: 1) elucidate the pathologic significance of nitric oxide (NO) and cyclic …

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Life-Space Mobility In The Older Adult, Community-Dwelling Cancer Survivor In The Deep South: A Secondary Data Analysis, Richard A. Taylor Jan 2022

Life-Space Mobility In The Older Adult, Community-Dwelling Cancer Survivor In The Deep South: A Secondary Data Analysis, Richard A. Taylor

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By 2040, the U.S. is projected to have 26.1 million cancer survivors; 73% of these will be over 65 years old. Much is known about life-space mobility (LSM) in patients with non-cancer serious illnesses. Restricted LSM affects every aspect of an older adult’s life; their independence, autonomy, and quality of life (QOL). To date, there are no studies examining LSM in older cancer survivors. Therefore, we examined LSM, factors that affect LSM, and the relationship between LSM and QOL in older cancer survivors using existing data from the University of Alabama at Birmingham (UAB) Study of Aging (SOA) (NIA AG15062). …

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How Does Loss Of Pulsatility Lead To Non-Surgical Bleeding In Continuous Flow Ventricular Assist Device Patterns, Khahn Tu Nguyen Jan 2022

How Does Loss Of Pulsatility Lead To Non-Surgical Bleeding In Continuous Flow Ventricular Assist Device Patterns, Khahn Tu Nguyen

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The primary goal of this study is to evaluate the effect of diminished pulsatility associat-ed with Continuous Flow Ventricular Assist Devices (CF-VADs) on endothelial respons-es of pro-angiogenic/proinflammatory soluble factors and von Willebrand Factor (vWF). Non-surgical bleeding is one of the most common adverse events after CF-VAD implan-tation and is a major cause of morbidity in patients supported by CF-VAD therapy. Alt-hough the exact mechanisms remain unclear, development of arteriovenous malfor-mations (AVMs) and acquired von Willebrand factor syndrome (AVWS) are widely be-lieved to be major risk factors. Another challenge with the study of pulsatility is that pre-clinical studies to understand how …

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Leaders Of 21st Century Education: A Study Of School Administrator Perceptions Of Technology In Alabama, Caroline M. Obert Jan 2022

Leaders Of 21st Century Education: A Study Of School Administrator Perceptions Of Technology In Alabama, Caroline M. Obert

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School leaders occupy a crucial position to implement new initiatives in schools. Due to advancing education technology, school administrators are expected to adjust and improve their competencies to meet the current educational technology demands. This research study aims to investigate Alabama school administrators’ technological leadership behaviors based on their self-reported perceptions. Also, differences in leadership behaviors across demographics were explored. The research study involved a quantitative non-experimental research design using Schoenbart’s (2019) research study approach as the study template. Participants included Alabama elementary, middle, and high school administrators. Data were collected using the online ELTS questionnaire version. Data were analyzed …

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The Roles Of Repressive And Activating Epigenetic Factors In Vertebrates Neural And Neural Crest Development, Saeid Mohammad Parast Jan 2022

The Roles Of Repressive And Activating Epigenetic Factors In Vertebrates Neural And Neural Crest Development, Saeid Mohammad Parast

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The vertebrate nervous system comes from specific regions of the ectoderm that comprises of the neural plate and the neural crest. Although genetic mechanisms governing vertebrate neural development have been investigated in depth, there is a knowledge gap regarding the roles of epigenetic mechanisms in this process. As epigenetic modulators, the COMPASS (also known as SET1/MLL complex) and HP1 proteins are responsible for regulating chromatin accessibility to transcription factors. COMPASS is responsible for deposition of activating histone H3K4 methylation marks at promoters and enhancers and thus creates open chromatin domains. The critical structural and regulatory subunits of COMPASS, Dpy30 and …

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The Integrative Systeomics Framework To Prioritize Genes And/Or Pathways In Skin Imflammation, Bharat Mishra Jan 2022

The Integrative Systeomics Framework To Prioritize Genes And/Or Pathways In Skin Imflammation, Bharat Mishra

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The accelerated growth in sequencing technology assisted us to explore the bio-logical systems comprehensively through a top-down approach rather than the conven-tional bottom-up approach. The top-down approach is a part of systems biology that gen-erates massive data that has driven this course of investigation to decipher the system-wide genetic perturbations. To reduce the complexity of humongous datasets, the graph (network)-based techniques facilitate the easy handling, analysis, and interpretation of biological associations. Networks are the graphical representation of nodes (biomole-cules) and edges (associations/interactions). The most common biological networks are correlation-based gene co-expression network (GCN), gene regulatory network (GRN), and protein-protein interaction …

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Acute Superior Vena Cava (Svc) Syndrome, An Unusual Occurrence, Muhammad Mohsin Zafar, Christopher Terrell, Imamuddin F. Mohammed, Alan Baggett Jan 2022

Acute Superior Vena Cava (Svc) Syndrome, An Unusual Occurrence, Muhammad Mohsin Zafar, Christopher Terrell, Imamuddin F. Mohammed, Alan Baggett

UAB Huntsville Research Day - All Presentations

2022 clinical vignette poster

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Predictors And Disparities Associated With Pain (Pandda-P) Study: A Comparison Of Pediatric Rheumatology Patients, Kathryn Ann Thompson Jan 2022

Predictors And Disparities Associated With Pain (Pandda-P) Study: A Comparison Of Pediatric Rheumatology Patients, Kathryn Ann Thompson

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Background: Chronic pain is a prominent feature of many pediatric rheumatic conditions. However, the diagnosis, experience, and treatment of musculoskeletal pain varies by condition. Therefore, the overall aim of the present study is to elucidate group differences and examine biopsychosocial correlates of pain in children with juvenile idiopathic arthritis (JIA), juvenile primary fibromyalgia syndrome (JPFS), non-specific chronic pain (NSCP), and pain-free controls.Methods: We recruited 117 (66% female, 73% White) school-aged children from Children’s of Alabama Rheumatology and Allergy Clinics and the community. Participants self-reported their pain, physical function, sleep, pain-related stigma, and somatic symptoms and underwent experimental pain tasks. Caregivers …

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Effect Of Saliva Contamination On Crown Retention Strengths Of Resin And Rmgi Cements, Bushra Nizami Jan 2022

Effect Of Saliva Contamination On Crown Retention Strengths Of Resin And Rmgi Cements, Bushra Nizami

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Background: The most common contaminant in the oral cavity is saliva. Many studies have shown that contamination with saliva negatively affects the strength of the resin-dentin bond. A literature review by Nair et al reported that 64.6% of studies on the topic show a detrimental effect of salivary contamination on adhesive materials. No published studies were found that thoroughly studied the effects of saliva contamination on RMGIs and resin cements with regards to crown retention rates. Objective: To study the effect of salivary contamination on crown retention strengths of RMGI and resin cements at various stages of bonding and in …

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The Effect Of Maxillary Sinus Anatomical Variations, Surgical Considerations, And Patient Factors On Volumetric Changes Following Lateral Wall Sinus Floor Elevation Technique For Up To 8 Years, Mengyi Shi Jan 2022

The Effect Of Maxillary Sinus Anatomical Variations, Surgical Considerations, And Patient Factors On Volumetric Changes Following Lateral Wall Sinus Floor Elevation Technique For Up To 8 Years, Mengyi Shi

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jectives: The aim of this retrospective study is to assess the long-term dimensional stability, or shrinkage, of the lateral window sinus grafts using cone beam computed tomography scans (CBCT) and radiographic software. Material and Methods: All patients from UAB Periodontal Graduate Clinic with available records of sinus augmentation via the lateral window approach with delayed implant placement between 2014 and 2019 were screened for having two follow up CBCT scans of diagnostic quality. The first scan must be completed within 6-9 months of lateral window sinus floor elevation (LWSFE) and prior to implant placement. The second CBCT must be taken …

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Experimental Characterization Of A Multispecies Plasma In The Pulsed Laser Deposition Of Thin Films, Braden Spiller Jan 2022

Experimental Characterization Of A Multispecies Plasma In The Pulsed Laser Deposition Of Thin Films, Braden Spiller

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laser deposition (PLD) is a versatile technique for growing epitaxial heterostructures of a wide variety of novel materials combinations. Achieving low-defect layers with atomically sharp interfaces by PLD requires careful management of crystal growth conditions. Control over the flux of depositing particles, their kinetic energy, and the substrate temperature, is generally assumed to be sufficient to obtain high-quality single crystal epitaxy in vacuum. In this thesis, we explore measurements of other parameters of the PLD plasma, such as the ion and electron densities, which may provide quick in-situ guidance and insights into the tuning of the crystal growth and processing …

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A Comparison Of Growth Factor Release Between Platelet Rich Fibrin And Recombinant Human Platelet Derived Growth Factor Bb (Rhpdgf-Bb) And Beta-Tricalcium Phosphate: An In Vitro Analysis, Maggie Ann Misch Jan 2022

A Comparison Of Growth Factor Release Between Platelet Rich Fibrin And Recombinant Human Platelet Derived Growth Factor Bb (Rhpdgf-Bb) And Beta-Tricalcium Phosphate: An In Vitro Analysis, Maggie Ann Misch

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Patients presenting with significant alveolar bone loss can pose challenges for the clinician. Traditional bone augmentation techniques may be inadequate in achieving necessary gains to restore missing teeth with dental implants. The adjunctive use of growth factors may accelerate the healing process and enhance tissue regeneration. GEM21S is a product that includes a recombinant growth factor approved by the Federal Drug Administration for oral surgery. It is delivered as a two-component system: 1) recombinant human platelet-derived growth factor-BB (rhPDGF-BB) and 2) betatricalcium phosphate (β-TCP).[1] The research on GEM 21S for ridge augmentation is mostly limited to case studies.[2- 4] Biologically, …

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Effect Of Etch Time On Sbs Of Machinable Lithium Disilicate Glass Ceramics Using Variolink Esthetic Lc, Mayur Chandrakant Nayee Jan 2022

Effect Of Etch Time On Sbs Of Machinable Lithium Disilicate Glass Ceramics Using Variolink Esthetic Lc, Mayur Chandrakant Nayee

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The purpose of this study is to measure the shear bond strength between dental cement and four different machinable, lithium disilicate glass ceramics, under varied etch time with hydrofluoric acid. Ten specimens each of 4 different machinable blocks of lithium disilicate were mounted in cylinders of pink acrylic resin. Each specimen was subjected to etching with hydrofluoric acid, rinsing with water from an air / water nozzle, drying with compressed air, application of a silane primer (Monobond Plus, Ivoclar Vivadent) for at least 60 seconds, then mounted in an Ultradent jig and Variolink Esthetic LC (Ivoclar Vivadent) cement extruded through …

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Evaluating Cannabinoid Interference And Drug Stability In Oral Fluid For Dui/D Testing, Jasmine Maxwell Jan 2022

Evaluating Cannabinoid Interference And Drug Stability In Oral Fluid For Dui/D Testing, Jasmine Maxwell

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Oral fluid (OF) drug testing was first applied in the workplace and pain management facilities, and is now being applied to DUI/D (Driving Under the Influence of Drugs) cases to help establish probable cause and for laboratory evidentiary confirmation. OF drug testing is efficient due to its easy, fast, gender-neutral and OF sample collection is minimally invasive compared to blood and urine. The objective of this study is to investigate the stability of cannabinoids in OF specimens over time. Limit of detection and potential matrix and analyte interference will also be evaluated. The ANSI/ASB Standard 036 for Method Validation in …

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Regional Variations In The Incidence Of Brain Glioma In Adults In Alabama, Mina Lobbous Jan 2022

Regional Variations In The Incidence Of Brain Glioma In Adults In Alabama, Mina Lobbous

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Purpose: Gliomas are the most common primary brain tumor in adults in the US with an annual age-adjusted incidence rate of 4.67 to 5.73 per 100,000 persons. Exposure to ioniz-ing radiation is the only established risk factor for non-hereditary glioma risk. There are several sources of carcinogenic contaminants in northeast Alabama and western Georgia with the Coosa River serving as the region’s primary water source. In this study, we aimed to examine the incidence rate of glioma in northeast Alabama compared to the rest of the state as well as the association of possible environmental exposure on disease risk and …

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Measuement Of Translucency, Biaxial Flexural Strength, And Radiopacity Of Different Lithium Disilicate Materials, Preshtha Mangla Jan 2022

Measuement Of Translucency, Biaxial Flexural Strength, And Radiopacity Of Different Lithium Disilicate Materials, Preshtha Mangla

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Objective: To measure translucency parameter, biaxial flexural strength, radiopacity and microstructure of various lithium disilicate materials used for dental restorations. Materials and Methods: CAD/CAM lithium disilicate glass-ceramic blocks: IPS e.max CAD (Ivoclar Vivadent), CerecTessera (Dentsply Sirona), and Amber Mill (Hassbio America) were used (shade A2, HT, and MT). Blocks of each material were milled (PrograMill PM7, Ivoclar Vivadent) into cylinders (diameter = 14 mm) and cut using circular sectioning saw (IsoMET 1000 Precision Saw, Buehler) into disc-shaped specimens (thickness = 1.00 ± 0.05 mm) (n=5/group). They were hand polished to 1200 grit with SiC paper under water lubrication. The translucency …

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A Systematic Study Of Data Security Issues In Smart Home Iot Devices, Hilal Nur Issi Jan 2022

A Systematic Study Of Data Security Issues In Smart Home Iot Devices, Hilal Nur Issi

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The best description of IoT comes from the International Telecommunication Union (ITU), which defines it as "a global infrastructure for the information society, enabling advanced services by interconnecting things based on existing and evolving interoperable information and communication technologies" (ITU, 2013). Different things, equipment, and household are employed in daily living in our world. The advantages that smart technology provides have piqued the curiosity of academics and practitioners alike. Home appliances have received a lot of attention, since smart technology has been extensively explored and put into practice. A great deal of research has gone into automating the house, making …

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The Association Between Paraquat Exposure And Parkinson's Disease Mortality: A County-Level Ecological Study In The United States, Alexander Kozuch Jan 2022

The Association Between Paraquat Exposure And Parkinson's Disease Mortality: A County-Level Ecological Study In The United States, Alexander Kozuch

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Objectives: The current study reports the results of an ecological study regarding the association between PQ exposure and Parkinson’s disease mortality in the United States. Methods: The outcome of interest for this study was mortality due to Parkinson’s disease, obtained from CDC Wonder. The exposure of interest was PQ exposure at the county level which was obtained from the United States Geological Survey (USGS). Statistical analysis was done using the mortality data, grouped into ten-year age groups, and focused on data from 2015-2019 to account for the lag time between initial Paraquat exposure and Parkinson’s Disease mortality. A Negative Binomial …

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The Relationship Between Psychological Profiles And Longitudinal Pain Trajectories In People With Chronic Knee Pain, Daniel Alexander Kusko Jan 2022

The Relationship Between Psychological Profiles And Longitudinal Pain Trajectories In People With Chronic Knee Pain, Daniel Alexander Kusko

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Considerable evidence demonstrates that radiographic findings (e.g., osteophytes) are only modestly associated with the severity of knee pain, suggesting that other biopsychosocial factors likely influence symptom severity. Multiple psychological factors have been linked to worse health outcomes in people with chronic knee pain; however, it remains unclear whether psychological profiles might help explain variability in knee pain severity. The primary goal of this study was to identify unique psychological differences among people with and without chronic knee pain, and then examine whether psychological profiles longitudinally predicted knee pain trajectories over two years. Individuals with (n = 175) and without (n …

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Diagnostic Electrophysiology Of The Eye, Brooke Nicole Conner-Tsang Jan 2022

Diagnostic Electrophysiology Of The Eye, Brooke Nicole Conner-Tsang

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Aging and age-related changes in the brain are known to parallel functional and anatomical changes in the eye, especially in certain degenerative diseases. This study explores the potential of combining ERG, specifically the Pattern Electroretinogram (PERG), which has a black and white checkerboard pattern, and OCT tests to monitor retinal ganglion cell health. We compared ERG and OCT findings from ten normal females, ages ranging from 18 to 30 years old to ascertain if ganglion cell layer volume is a reliable indicator of ganglion cell function as measured by ERG. Our results from these healthy subjects will serve as prelude …

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Use Of Force By Correctional Officers: A Test Of General Strain And Scial Bond Theories, Benjamin Hixon Jan 2022

Use Of Force By Correctional Officers: A Test Of General Strain And Scial Bond Theories, Benjamin Hixon

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Use of force in corrections is significantly less studied when compared to other fields, such as policing. This is a problem as unnecessary and unjustified use of force in corrections needlessly raises the violence level in correctional facilities, which endangers persons in custody and correctional officers alike. The current study examines use of force in corrections using a theoretical approach. First, Robert Agnew’s general strain theory is applied to understand use of force encounters between persons in custody and correctional officers. Second, Travis Hirschi’s social bond theory is used to investigate whether certain social bonds may relate to reductions in …

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Intracerebral Hemorrhage Hospitalizations And Outcomes: Comparisons Between Institutional And National Data, Zhuobin Huang Jan 2022

Intracerebral Hemorrhage Hospitalizations And Outcomes: Comparisons Between Institutional And National Data, Zhuobin Huang

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Intracerebral hemorrhage (ICH) is associated with a high risk of in-hospital mortality therefore we decided to define the effect of procedures and other risk factors on in-hospital mortality among different regions in the US. South and UAB Hospital. We used 2 datasets, the University of Alabama at Birmingham Hospital data and the National Inpatient Sample (NIS). We included 425 patients with a diagnosis of intracerebral hemorrhage over 18 years of age from the UAB Hospital stroke registry between 2016 to 2019; in NIS between 2016 to 2018, 68525 patients age 18 or above met inclusion criteria selected by International Classification …

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Comparison Of [18f]Fdg With 18f-Labeled Amino Acids For Pet Imaging Of Breast Cancer, Ugur Akca Jan 2022

Comparison Of [18f]Fdg With 18f-Labeled Amino Acids For Pet Imaging Of Breast Cancer, Ugur Akca

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Triple-negative breast cancer (TNBC) are identified by their lack of estrogen re-ceptor, progesterone receptor, and overexpression of human epidermal growth factor re-ceptor 2-gene. The glucose analog, 2-deoxy-2-[18F]-fluoro-D-glucose (FDG) is the most often utilized PET tracer for imaging TNBC. The use of FDG for imaging primary and metastatic brain tumors is limited by high FDG uptake in normal brain tissue and some forms of inflammation. Also, MRI brain imaging methods have limitation in determining the differentiation between recurrent malignant and treatment effect. Radiolabeled amino acids (AAs), which have a lower uptake in normal brain and inflammation compared to FDG, can be …

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A 15-Year Retrospective Analysis On After-Hours Dental Emergencies In A Children's Hospital Setting, Alexandra An-Yen Chen Jan 2022

A 15-Year Retrospective Analysis On After-Hours Dental Emergencies In A Children's Hospital Setting, Alexandra An-Yen Chen

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Dental emergencies are one of the most common oral health complications and can exhibit a detrimental impact on a child’s physical and psychological development; additionally, it may impose economic challenges for the family. Purpose: The purpose of this study was to analyze the after-hours dental emergency visits in the past 15 years at the Children’s of Alabama (COA) Hospital Emergency Department. Methods: A retrospective chart review between January 2007 and December 2021 was conducted. Patients’ demographics, type of dental complaint, and management were evaluated for overall characteristics in the 15 years and trends in 5-year increments. The impact of the …

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What "Makes A Monster Of Their Minds": The Influence Of Honor Culture, Shame, And Homsociality On Anxious Masculinity In Shakespearean Cuckoldry Plots, Hannah M. Cutting Jan 2022

What "Makes A Monster Of Their Minds": The Influence Of Honor Culture, Shame, And Homsociality On Anxious Masculinity In Shakespearean Cuckoldry Plots, Hannah M. Cutting

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In early modern drama, cuckoldry is used as the focal point for jokes and as a major plot device. Playwrights who use cuckoldry as a plot point often put the burden of blame on the women of these trysts, regardless of if they have made the women guilty or not, while failing to critique the behavior of men who act out in the face of these accusations. Unlike his contemporaries, Shakespeare seems to criticize men who choose to believe accusations of cuckoldry by putting their faith in homosocial bonds over their marital bonds. Across the timeline of Shakespeare’s plays, four …

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The Seekers, Rachel Houghton Jan 2022

The Seekers, Rachel Houghton

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The Seekers is a collection of connected short stories that follows the lives of nomads, travelers, and adventurers who leave one place in search of another. The work explores themes of belonging, visibility, grief, friendship, and survival. The characters in each story weave in and out of each other’s lives as they crisscross the country—fueled by a desire to find home, find themselves, and find connection with others. While they travel, there is the ever-present tension of finding food and shelter, catching rides, and avoiding authorities. In the midst of these challenges, the characters in The Seekers keep moving. Dumpy …

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Correlates Of Early Adversity In Children And Adolescents: Examining The Interrelatedness Of Aggression, Post-Traumatic Stress, And Suicidal Behaviors, Elizabeth Mcrae Jan 2022

Correlates Of Early Adversity In Children And Adolescents: Examining The Interrelatedness Of Aggression, Post-Traumatic Stress, And Suicidal Behaviors, Elizabeth Mcrae

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The negative outcomes associated with adverse childhood experiences, especially child maltreatment ACEs (CM-ACEs), often emerge concomitantly with these experiences and have cascading negative effects across the lifespan. For example,childhood aggression, post-traumatic stress, and suicidal behaviors have all been identified as negative sequelae of CM-ACEs. They have been associated with each other, as well, and share several common underlying mechanisms. Thus, it might be that these outcomes collectively exacerbate the risk of experiencing negative effects of CM-ACEs, yet most existing research has examined these risk factors independently. Moreover, these outcomes often emerge early in development, yet most related research has been …

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Nox2-Derived Superoxide And Mda5-Dependant Responses Contribute To Autoimmune Diabetes, Samuel Isaac Blum Jan 2022

Nox2-Derived Superoxide And Mda5-Dependant Responses Contribute To Autoimmune Diabetes, Samuel Isaac Blum

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NADPH oxidase 2 (NOX2)-derived superoxide, a precursor for many reactive oxygen species (ROS), regulates cell signaling, cellular trafficking, melanoma differentiation-associated protein 5 (MDA5) responses, and Type 1 diabetes (T1D). Previously, we demonstrated that NOX2-derived superoxide promotes chemokine synthesis, spontaneous and virus-accelerated T1D, and MDA5 responses to coxsackievirus B3 (CVB3), an associated environmental trigger for T1D. Yet, it remains unknown if ROS is necessary for diabetogenic T cell trafficking into islets or how MDA5 responses affect T1D. First, using non-obese diabetic (NOD) mice that contain an in-frame deletion within the helicase 1 domain of MDA5 (ΔHel1) or lack MDA5 expression (KO), …

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Changes In Pain Intensity And Physical Activity Levels In Individuals With Acetabular Dysplasia Undergoing Periacetabular Osteotomy: A Longitudinal Cohort Study, Naif Z. Alrashdi Jan 2022

Changes In Pain Intensity And Physical Activity Levels In Individuals With Acetabular Dysplasia Undergoing Periacetabular Osteotomy: A Longitudinal Cohort Study, Naif Z. Alrashdi

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Acetabular dysplasia (AD) is a condition of the hip joint that is characterized by incomplete acetabulum development leading to lack of bony coverage of the femoral head. As a result of intra-articular injury from lack of bony congruency, often, individuals with AD report hip joint instability, pain, decreased hip-related function, and are at high risk for early development of hip osteoarthritis (OA). AD is primarily affects young-to-middle-aged adults, is more common in females and those with history of a breech birth position. Periacetabular osteotomy (PAO) is the currently-recommended surgical treatment for AD that aims to reposition the acetabulum to increase …

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Optical Absorption Of Point Defects In Doped Gallium Oxide Determined By Photo-Induced Electron Paramagnetic Resonance Spectroscopy, Suman Bhandari Jan 2022

Optical Absorption Of Point Defects In Doped Gallium Oxide Determined By Photo-Induced Electron Paramagnetic Resonance Spectroscopy, Suman Bhandari

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Beta-gallium oxide (β-Ga2O3) is an ultrawide bandgap semiconductor with promising applications in high-power electronics. The ability of Ga2O3 to be grown from the melt will enable the production of potentially low-cost native substrates, unlike competing materials like GaN and diamond. To fully develop the potential of Ga2O3 as a material for device application, it is critical to have a thorough understanding and control of defects, as well as knowledge of the defect’s thermodynamic transition energy or defect level. This work investigates Fe or Mg, which are used to make semi-insulating Ga2O3 substrates useful for device fabrication, and determines the defect …

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