Digital Commons Network^™

Seasonal Variation And Tracking Of Climate Niche Of A Migratory Bird, Javier Gutiérrez Illán, Guiming Wang, D. Tommy King, Fred L. Cunningham

United States Department of Agriculture Wildlife Services: Staff Publications

Migratory birds inhabit different areas during breeding and non-breeding seasons. Depending on the time of the year, they may utilize different resources available in seasonal habitats, but also are subjected to changing climate regimes during their annual life cycle. Migratory birds may adopt ecological niche tracking to cope with different environmental conditions between breeding and non-breeding grounds. The American White Pelican (Pelecanus erythrorhynchos, hereafter ‘AWPE’) is a short-distance migrant between the Gulf of Mexico coastal regions (nonbreeding grounds) and the Northern Great Plains (breeding grounds) of Canada and the US. The American White Pelican is a piscivore, feeding …

The Understanding Of Mycorrhizae Networks: A Historical Approach, Jake Sun

The Confluence

The growth of mycorrhizal fungi into plant roots used to be viewed as a parasitic relationship between plants and fungi, where the fungal symbiont benefits and the plant host is harmed. Current research elucidates a mutualistic relationship. The mycorrhizae network assists the plants by increasing the capabilities for nutrient absorption in the soil. In exchange, the fungi receive carbon supply from the photosynthetic plants for growth. Our scientific understanding of other topics like species specificity, seed germination, and co-evolutionary influence of mycorrhizae and plants has also progressed. Additionally, we now understand that the mycorrhizal mutualism is not limited to the …

An Application Of Differential Mathematical Modeling Techniques To Study The Ongoing Rabies Epizootic In China, Christopher Turner

Electronic Theses and Dissertations

Rabies remains a global public health issue with a wide variety of neurological symptoms such as confusion, slight paralysis, hypersalivation, and hydrophobia. Rabies is usually fatal once symptoms appear. Many species are reservoirs for rabies, such as foxes, racoons, and wild dogs, which in turn can transmit the disease to humans, leading to complex transmission chains. There is a long latent period of rabies, between 1 to 3 months after infection, which further complicates control efforts. Mathematical modeling is a valuable tool in the study of infectious disease outbreaks and there have been many models applied to rabies outbreaks. However, …

Factors Affecting Time To Recovery: A Covid-19 Survival Analysis, Fernanda Montoya

Honors Capstones

This project is focused on the recovery rates of patients diagnosed with COVID-19 after different clinical trial drug treatments. Data for the clinical trial studied was obtained from the National Institute of Allergy and Infectious Diseases for the primary purpose of a survival analysis on patient time to recovery under a placebo and therapeutic drug treatment. Specifically, patients in this clinical trial were randomly selected to receive remdesivir, an antiviral drug, in combination with a placebo or baricitinib, a janus kinase inhibitor drug. Cox PH models were used to identify how the different treatment drugs affect time to recovery and …

The Efficacy Of The Covid-19 Vaccine In Mississippi, Ilyse Miriam Levy

Honors Theses

The Efficacy of The COVID-19 Vaccine in Mississippi

(Under the direction of Dr. Xin Dang)

By tracking and analyzing fifty-three weeks of COVID-19 data, this thesis analyzes the efficacy of the COVID-19 vaccine within the State of Mississippi. Over the course of these fifty-three weeks, I have also been able to calculate the confidence intervals for vaccination efficacy and the risk reduction due to vaccination by using data regarding the correlations between deaths and vaccination status, provided to me by the Mississippi Office of Epidemiology. My analysis demonstrates that the COVID-19 vaccine is effective not only in Mississippi but also …

Progression Magazine, 2022 Spring, Coastal Carolina University

Progression Magazine

Magazine of the College of Science at Coastal Carolina University.

Assessing The Influence Of Health Policy And Population Mobility On Covid-19 Spread In Arkansas, Tayden Barretto

Industrial Engineering Undergraduate Honors Theses

The outbreak of COVID-19 has created a major crisis across the world since its start in 2019, and its influence on every realm of society is undeniable. Globally, more than 500 million cases have been recorded since March 2020, with almost 6 million deaths. In the wake of this crisis, many governments and health organizations have taken steps and precautions to mitigate its spread. These steps involve public mandates of information, reducing frequency of personal contact, and use of masks to minimize the risk of transmission. Current access to mobility data released from Google detailing population movements has provided a …

The Impact Of Social Controls And Vaccination On The Spread Of Covid-19 In New Jersey, Ariel J. Bonneau

Theses, Dissertations and Culminating Projects

The emergence of the novel coronavirus (SARS-CoV-2) in late 2019 has led to a global pandemic (COVID-19) which continues to cause enormous public health and economic challenges around the world. It is therefore important to improve our understanding of the outbreak and spread of COVID-19 as well as to investigate how one might contain or stop the spread of COVID-19 via different control measures. In this thesis, we consider a COVID-19 model based on an SEIR compartmental model. The model includes susceptible, vaccinated, exposed, pre-symptomatic, symptomatic infectious, asymptomatic infectious, hospitalized, recovered, and deceased compartments, each of which is sub-divided into …

The Effects Of Human Activity On Reintroduced Bighorn Sheep (Ovis Canadensis) Populations, Justine Cherovsky

Department of Environmental Studies: Undergraduate Student Theses

Since the decimation of North America’s bighorn sheep (Ovis canadensis) populations due to human impacts, translocations have been the primary conservation strategy to repopulate the native habitat. Following the extirpation of the species in Nebraska, bighorns were reintroduced with the hope to establish a stable population, but nearly four decades of management has resulted in large-scale die-offs and unstable herds. Ongoing human impacts have created similar results across the country as reintroductions struggle to establish independent bighorn herds. A systematic literature review was conducted to analyze current human related effects, evaluate the effectiveness of management practices, and compare these findings …

Statistical Methods For Assessing Drug Interactions And Identifying Effect Modifiers Using Observational Data., Qian Xu

Electronic Theses and Dissertations

This dissertation consists of three projects related to causal inference based on observational data. In the first project, we propose a double robust to identify the effect modifiers and estimate optimal treatment. Observational studies differ from experimental studies in that assignment of subjects to treatments is not randomized but rather occurs due to natural mechanisms, which are usually hidden from the researchers. Many statistical methods to identify the treatment effect and select the optimal personalized treatment for experimental studies may not be suitable for observational studies any more. In this project, we propose a exible outcome model to select the …

Monitoring Sars-Cov-2 Risk With Co2. The Importance Of Ventilation, Masks, And Vaccinations., Preston Betz

Earth Sciences Theses and Dissertations

To assess airborne pathogen infection risk, concentrations of interior carbon dioxide and changes in relative humidity serve as proxies for human respiration products. Yanes and Yapp, 2010, demonstrated that interior air carbon dioxide concentrations and ¹³C/¹²C ratios display a two-component mixing relationship between respiration carbon dioxide which is highly concentrated (>100x atmospheric) in respiration air CO₂ at >40,000 ppm compared with ambient air (~410 ppm). In the absence of combustion carbon dioxide, the concentration of carbon dioxide, in an interior space, depends on the rate of respiration CO₂ addition relative to the amount of …

The Executive’S Guide To Getting Ai Wrong, Jerrold Soh

Asian Management Insights

This article explores how we see AI and argues that we mostly get it wrong. In the process, it explains the reasons backed by social science research on why we tend to get AI wrong and illustrates the dangers of doing so from a managerial and law-making perspective. Some readers may also find the article useful as a guide on how and when to manipulate portrayals of AI in your favour.

Relative Palatability And Efficacy Of Brodifacoum-25d Conservation Rodenticide Pellets For Mouse Eradication On Midway Atoll, Peter J. Kappes, Shane R. Siers, Israel L. Leinbach, Robert T. Sugihara, Wesley J. Jolley, Jonathan H. Plissner, Elizabeth N. Flint, Kelly L. Goodale, Gregg R. Howald

United States Department of Agriculture Wildlife Services: Staff Publications

Invasive mice (Mus spp.) can negatively impact island species and ecosystems. Because fewer island rodent eradications have been attempted for mice compared to rats (Rattus spp.), less is known about efficacy and palatability of rodenticide baits for mouse eradications. We performed a series of bait acceptance and efficacy cage trials using a standard formulation of brodifacoum-based rodenticide on wild-caught mice from Sand Island, Midway Atoll, to help inform a proposed eradication there. Mice were offered ad libitum brodifacoum pellets along with various alternative food sources, and a “no choice” treatment group received only bait pellets. Mortality in the no choice …

Point Of Use Technologies To Increase Access To Clean Water In Rural Communities, Elena Arroway

Undergraduate Theses, Capstones, and Recitals

Access to clean water is an issue that many communities around the world struggle with. While large-scale efforts such as piping infrastructure have been successful, these are less effective at reaching small, rural communities. To supplement these efforts, point of use (POU) methods for water treatment can be implemented. These include boiling, chemical treatment, filters, and several additional technologies. These have all shown effectiveness in a lab setting, but their implementation in the real world, specifically in rural communities, has not been nearly as effective. In this paper, several different POU methods are evaluated for their effectiveness on a small-scale, …

Intercontinental Movement Of Highly Pathogenic Avian Influenza A(H5n1) Clade 2.3.4.4 Virus To The United States, 2021, Sarah N. Bevins, Susan A. Shriner, James C. Cumbee Jr., Krista E. Dilione, Kelly E. Douglass, Jeremy W. Ellis, Mary Lea Killian, Mia K. Torchetti, Julianna B. Lenoch

United States Department of Agriculture Wildlife Services: Staff Publications

We detected Eurasian-origin highly pathogenic avian influenza A(H5N1) virus belonging to the Gs/GD lineage, clade 2.3.4.4b, in wild waterfowl in 2 Atlantic coastal states in the United States. Bird banding data showed widespread movement of waterfowl within the Atlantic Flyway and between neighboring flyways and northern breeding grounds.

Optimization Of Modular, Long-Range, Ultra-Fast Optical Tweezers With Fluorescence Capabilities For Single-Molecule And Single-Cell Based Biophysical Measurements, Subash C. Godar

All Dissertations

An Optical tweezer is a tightly focused laser beam that applies and senses precise and localized optical force to a dielectric microsphere and offers a unique and effective tool for manipulating the single cell or cell components, including nucleotides and dynein motor proteins. Here, I used highly stabilized optomechanical components and ultra-sensitive detection modules to significantly improve the measurement capabilities over a wide range of temporal and spatial scales. I combined the optical tweezer-based force spectroscopy technique with fluorescence microscopy to develop an integrated high-resolution force-fluorescence system capable of measuring displacements at sub-nanometer, forces at sub-piconewton over a temporal range …

Lipid Rafts, Exosomal Vesicles And Anti-Giardial Therapies, Brian Ivan Grajeda

Open Access Theses & Dissertations

Giardia lamblia, a protozoan parasite, is a major cause of waterborne infection, worldwide. While the trophozoite form of this parasite induces pathological symptoms in the gut, the cyst forms transmit the infection via contaminated water. Since Giardia is a non-invasive parasite, the actual mechanism by which it causes infection remains elusive. We have previously reported that Giardia assembles cholesterol and GM1 glycolipid-enriched lipid rafts (LRs) that participate in encystation and cyst production. To further delineate the role of LRs in pathogenesis, we isolated LRs from Giardia and subjected them to proteomic analysis. Various cellular proteins including the virulent proteins—e.g., giardins, …

Integration Of Genetic Isothermal Amplification On Low-Cost Hybrid Paper/Polymer Microfluidic Biochips For High Sensitivity Point-Of-Care Disease Diagnosis, Hamed Tavakoli

Open Access Theses & Dissertations

Infectious diseases and cancer have been two main causes of global death and disability, leading to a significant impact on public health and economies globally. Early diagnosis of these diseases can improve prevention, treatment, and prognosis in clinical practice. However, current laboratory diagnostic approaches require expensive and bulky equipment, well-trained personnel, and time-consuming processes, which puts a great challenge to conventional methods to address, especially in resource-limited settings. Microfluidic lab-on-a-chip presents a unique opportunity for various biomedical applications due to multiple advantages such as low reagent consumption, integration, miniaturization, portability, and automation. Since different microfluidic platform substrates have their advantages …

Groundwork For The Development Of Gpu Enabled Group Testing Regression Models, Paul Cubre

All Dissertations

In this dissertation, we develop novel techniques that allow for the regression analysis of data emerging from group testing processes and set the groundwork for graphic processing units (GPU) enabled implementations. Group testing primarily occurs in clinical laboratories, where it is used to quickly and cheaply diagnose patients. Typically, group testing tests a pooled specimen--several specimens combined into one sample--instead of testing individual specimens one-by-one. This method reduces costs by using fewer tests when the disease prevalence is low. Due to recent advances in diagnostic technology, group testing protocols were extended to incorporate multiplex assays, which are diagnostic tests that, …

A Socio-Ecological Model To Assess Tuberculosis In Migrant Farmworkers In The Us-Mexico Border Region, Amit U. Raysoni

School of Earth, Environmental, & Marine Sciences Faculty Publications

The migrant and seasonal farmworker toiling in the fields and orchards of the United States of America surmounts innumerable problems daily. Some of these problems pertain to the overall health of the farmworker in addition to the various occupational hazards that he or she faces. This research paper focuses on Tuberculosis infection—both latent and active—in the migrant farmworkers in the United States with a special focus on the US-Mexico border. Using the Socio-Ecological Model as a theoretical framework, the TB health issues faced by this group are studied. The various determinants of health at every level of the Socio-Ecological Model …

Implications Of Metal Coordination In Damage And Recognition Of Nucleic Acids And Lipid Bilayers, Ana Dreab

Chemistry & Biochemistry Theses & Dissertations

Metal ions have a myriad of biological functions from structural stability to enzymatic (de)activation and metabolic electron transfer. Redox-active metals also mediate the formation of reactive oxygen species which may either cause oxidative damage or protect cellular components. Computational modeling is used here to investigate the role of (1) metal-ion binding to antimicrobial peptides, (2) metal-ion removal and disulfide formation on zinc finger (ZF) proteins, and (3) coordination of thiones/selones for the prevention of metal-mediated redox damage.

Piscidins, natural-occurring antimicrobial peptides, efficiently kill bacteria by targeting their membranes. Their efficacy is enhanced in vitro by metal-binding and the presence of …

The Feasibility And Utility Of Harnessing Digital Health To Understand Clinical Trajectories In Medication Treatment For Opioid Use Disorder: D-Tect Study Design And Methodological Considerations, Lisa A. Marsch, Ching-Hua Chen, Sara R. Adams, Asma Asyyed, Monique B. Does, Saeed Hassanpour, Emily Hichborn, Melanie Jackson-Morris, Nicholas C. Jacobson, Heather K. Jones, David Kotz, Chantal A. Lambert-Harris, Zhiguo Li, Bethany Mcleman, Varun Mishra, Catherine Stanger, Geetha Subramaniam, Weiyi Wu, Cynthia I. Campbell

Dartmouth Scholarship

Introduction: Across the U.S., the prevalence of opioid use disorder (OUD) and the rates of opioid overdoses have risen precipitously in recent years. Several effective medications for OUD (MOUD) exist and have been shown to be life-saving. A large volume of research has identified a confluence of factors that predict attrition and continued substance use during substance use disorder treatment. However, much of this literature has examined a small set of potential moderators or mediators of outcomes in MOUD treatment and may lead to over-simplified accounts of treatment non-adherence. Digital health methodologies offer great promise for capturing intensive, longitudinal ecologically-valid …

A Descriptive Pilot Study On Travel Nurses' Risk Of Burnout During The Covid- 19 Pandemic, Lashanda Head

ATU Theses and Dissertations 2021 - Present

Burnout is a state of emotional, physical, and mental exhaustion that results from long-term involvement in work situations that are difficult (Schaufeli & Greenglass, 2001). Burnout leads to a significant occupational problem in various professions that involve people who work with others, including nurses who work with COVID- 19 patients. This pilot study aims to determine if travel nurses who have worked or are currently working during the COVID-19 pandemic in acute care hospitals are at increased risk for nurse burnout. A convenience sample (N=9) of travel nurses working at CHRISTUS St Michael Health System were asked to …

Individual Trophic Niche Specialization In American Beaver (Castor Canadensis), Jimmy Taylor, Robert Francis, Scott Rush, Bronson Strickland, Guiming Wang

United States Department of Agriculture Wildlife Services: Staff Publications

The American beaver (Castor canadensis) has been described as a choosy generalist at the species/population scale, yet observational studies have shown little variation in diet among individuals. We compared isotopic values of δ¹³C or δ¹⁵N taken from hair of 32 beaver, representing seven colonies in northern Alabama, USA to determine 1) if colonies of beaver show overlap in isotopic niche width as a result of the similar use of food resources and 2) if individual trophic niche specialization occurs within colonies. Total Trophic Niche Width varied across the wetland with the widest being twice …

A Novel Tcr Clustering Method For Sars-Cov-2 Epitopes, Naziba A. Nuha

Mathematics Colloquium Series

T-cell epitopes are peptides generated from antigens that are presented by MHC class I and class II molecules to T-cells. These epitopes are usually identified by T-cell receptors (TCRs) of CD4 T-cells which then causes transformation of CD4 T-cells to helper or regulatory T cells. Recently, there has been growing interest in the role of T cells and their involvement in various ailments including SARS-COV-2, cancer, autoimmune diseases and other infectious diseases. However, the mechanism of TCR epitope recognition by Tcell receptors (TCRs) of CD4 T-cells at a repertoire level is still not fully understood. In this project, we reviewed …

Predicting Covid-19 Fake News, Nilanjana Nambiar

Honors Projects in Data Science

The aim of this project is to use a machine learning model to identify COVID-19 fake news on Twitter and perform additional analysis on the fake news tweets to distinguish any common trends. As misinformation is very common in the information found online, the purpose of the study is to see how machine learning can be used to discern what information can be classified as true versus what is false. Prior research regarding fake news detection, modeling, and analysis was conducted to familiarize on the current studies provided in predicting and analyzing COVID-19 fake news on Twitter. In this study, …

Social Media Discussion On Covid-19 Impact On Mental Health In The Us, Uk, And India, Weixiao Sun

Honors Projects in Data Science

Discovered in December 2019, Coronavirus (Covid-19) is an infectious disease that has spread rapidly around the world. The World Health Organization (WHO) declared Covid-19 a pandemic in March 2020. The pandemic has increased the occurrence of mental health problems including depression, stress, and anxiety. This research used real-life Tweets collected related to Covid-19 from March 2020 until October 2021. The objective is to analyze Tweets from the US, UK, and India to discover what topics people are discussing about Covid-19's impact on mental health. The theme for the US was related to government and politics, some dominant users in the …

Vampires And Other Diseases: Stochastic Infection Dynamics Of Small Populations, Marijn Jaarsma

Honors Projects in Science and Technology

Mathematical models are powerful tools often applied in the field of epidemiology. The type and shape of the model will differ between different types of diseases. In this study, stochastic dynamical models are applied to the entertaining example of vampires, and the results of this analysis are compared to real-life diseases with small populations of infected. The data used comes from pop-culture depictions of vampires in literature, television shows, movies, and fan pages associated with these depictions. The aim of this study is to serve as an educational tool for modeling diseases with small populations to predict and control the …

A Weighted Probability Measure For Objects In Euclidean Space, Alessandro Xello

Mathematics Colloquium Series

Since we were little kids, we developed our own sense dimension as a measure of some kind of extent. Whether it be length, width, or height, we intuitively understand how these features fit in the three-dimensional world we live in, and how to measure it. Nevertheless, mathematicians have found themselves dealing with objects, like fractals, and spaces, like R4 , that challenge our intuitive and self-developed definition of measure, to the point that it is not sufficient anymore. Lebesgue measure and Harsdorf measure for example are ways of assigning a measure to objects that belong to n-dimensional Euclidean spaces, in …

Baseline Health And Nutritional Parameters Of Wild Sand Tigers Carcharias Taurus Sampled In Delaware Bay, Lisa A. Hoopes, Tonya M. Clauss, Bradley M. Wetherbee, Dewayne A. Fox

Marine & Environmental Sciences Faculty Articles

Species-specific hematological reference values are essential for diagnosis and treatment of disease and maintaining overall health of animals. This information is lacking for many species of elasmobranchs maintained in zoos and aquaria, thus reducing the effectiveness of care for these animals. Descriptive statistics and reference intervals were calculated for hematocrit and complete blood cell counts, biochemistry and protein electrophoresis parameters, trace minerals, vitamins, heavy metals, reproductive hormones, and fatty acids in the blood of 153 wild Sand Tigers Carcharias taurus of both sexes and a range of sizes caught in Delaware Bay (Delaware, USA). Mean hematocrit, total white blood cell …